Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HDI2_LEIBR

TriTrypDb:

LbrM.24.1270 , LBRM2903_240018800

Length:

186

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 104
NetGPI	no	yes: 0, no: 113

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	100
GO:0110165	cellular anatomical entity	1	100

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Expansion

Sequence features

A4HDI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDI2

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	68	70	PF00675	0.486
CLV_PCSK_KEX2_1	68	70	PF00082	0.487
DOC_CKS1_1	27	32	PF01111	0.368
DOC_CKS1_1	34	39	PF01111	0.317
DOC_MAPK_gen_1	173	183	PF00069	0.509
DOC_MAPK_MEF2A_6	176	183	PF00069	0.517
DOC_PP4_FxxP_1	34	37	PF00568	0.343
DOC_WW_Pin1_4	26	31	PF00397	0.369
DOC_WW_Pin1_4	33	38	PF00397	0.318
LIG_14-3-3_CanoR_1	68	74	PF00244	0.275

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	37%	100%
A0A0N0P6P9	Leptomonas seymouri	20%	81%
A0A0N1I295	Leptomonas seymouri	30%	100%
A0A1X0NQ58	Trypanosomatidae	32%	100%
A0A1X0NUH1	Trypanosomatidae	30%	82%
A0A1X0NVN5	Trypanosomatidae	33%	100%
A0A1X0NVT7	Trypanosomatidae	32%	100%
A0A1X0NX02	Trypanosomatidae	31%	100%
A0A1X0NX81	Trypanosomatidae	34%	100%
A0A1X0P988	Trypanosomatidae	26%	100%

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