Dynein heavy chain

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein heavy chain

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDI1_LEIBR

TriTrypDb:

LbrM.24.1260 , LBRM2903_240018700

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.274
CLV_C14_Caspase3-7	540	544	PF00656	0.454
CLV_NRD_NRD_1	17	19	PF00675	0.399
CLV_NRD_NRD_1	178	180	PF00675	0.360
CLV_NRD_NRD_1	353	355	PF00675	0.450
CLV_NRD_NRD_1	398	400	PF00675	0.387
CLV_NRD_NRD_1	440	442	PF00675	0.586
CLV_PCSK_KEX2_1	178	180	PF00082	0.378
CLV_PCSK_KEX2_1	355	357	PF00082	0.460
CLV_PCSK_KEX2_1	398	400	PF00082	0.440
CLV_PCSK_KEX2_1	413	415	PF00082	0.264
CLV_PCSK_KEX2_1	475	477	PF00082	0.501
CLV_PCSK_KEX2_1	564	566	PF00082	0.416
CLV_PCSK_KEX2_1	594	596	PF00082	0.482
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.509
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.317
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.512
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.431
CLV_PCSK_PC1ET2_1	594	596	PF00082	0.482
CLV_PCSK_SKI1_1	115	119	PF00082	0.467
CLV_PCSK_SKI1_1	18	22	PF00082	0.416
CLV_PCSK_SKI1_1	356	360	PF00082	0.492
CLV_PCSK_SKI1_1	389	393	PF00082	0.392
CLV_PCSK_SKI1_1	468	472	PF00082	0.461
CLV_PCSK_SKI1_1	525	529	PF00082	0.447
CLV_PCSK_SKI1_1	553	557	PF00082	0.660
CLV_PCSK_SKI1_1	594	598	PF00082	0.399
DEG_APCC_KENBOX_2	527	531	PF00400	0.262
DEG_MDM2_SWIB_1	78	85	PF02201	0.262
DEG_Nend_Nbox_1	1	3	PF02207	0.619
DOC_ANK_TNKS_1	446	453	PF00023	0.338
DOC_CYCLIN_RxL_1	592	599	PF00134	0.448
DOC_CYCLIN_yClb5_NLxxxL_5	401	410	PF00134	0.349
DOC_MAPK_gen_1	178	186	PF00069	0.331
DOC_MAPK_gen_1	286	296	PF00069	0.332
DOC_MAPK_gen_1	412	419	PF00069	0.327
DOC_MAPK_gen_1	509	518	PF00069	0.406
DOC_MAPK_gen_1	525	534	PF00069	0.323
DOC_MAPK_gen_1	563	569	PF00069	0.364
DOC_MAPK_JIP1_4	253	259	PF00069	0.468
DOC_MAPK_MEF2A_6	178	186	PF00069	0.331
DOC_MAPK_MEF2A_6	286	294	PF00069	0.345
DOC_MAPK_MEF2A_6	511	520	PF00069	0.401
DOC_PP1_RVXF_1	342	348	PF00149	0.295
DOC_PP1_RVXF_1	440	447	PF00149	0.454
DOC_PP1_RVXF_1	451	457	PF00149	0.247
DOC_PP2B_LxvP_1	326	329	PF13499	0.339
DOC_PP2B_PxIxI_1	289	295	PF00149	0.241
DOC_PP4_FxxP_1	304	307	PF00568	0.401
DOC_SPAK_OSR1_1	179	183	PF12202	0.365
DOC_SPAK_OSR1_1	268	272	PF12202	0.472
DOC_USP7_MATH_1	307	311	PF00917	0.463
DOC_USP7_UBL2_3	403	407	PF12436	0.384
DOC_USP7_UBL2_3	471	475	PF12436	0.428
DOC_USP7_UBL2_3	559	563	PF12436	0.379
DOC_WW_Pin1_4	106	111	PF00397	0.455
DOC_WW_Pin1_4	371	376	PF00397	0.520
DOC_WW_Pin1_4	59	64	PF00397	0.610
LIG_14-3-3_CanoR_1	178	183	PF00244	0.397
LIG_14-3-3_CanoR_1	369	373	PF00244	0.478
LIG_14-3-3_CanoR_1	453	457	PF00244	0.469
LIG_14-3-3_CanoR_1	545	554	PF00244	0.602
LIG_14-3-3_CanoR_1	55	63	PF00244	0.610
LIG_14-3-3_CanoR_1	573	578	PF00244	0.373
LIG_Actin_WH2_2	462	477	PF00022	0.279
LIG_APCC_ABBA_1	108	113	PF00400	0.497
LIG_APCC_ABBA_1	516	521	PF00400	0.362
LIG_BRCT_BRCA1_1	570	574	PF00533	0.375
LIG_CaM_IQ_9	1	17	PF13499	0.370
LIG_Clathr_ClatBox_1	183	187	PF01394	0.292
LIG_deltaCOP1_diTrp_1	342	347	PF00928	0.299
LIG_FHA_1	198	204	PF00498	0.517
LIG_FHA_1	210	216	PF00498	0.714
LIG_FHA_2	297	303	PF00498	0.329
LIG_FHA_2	524	530	PF00498	0.263
LIG_GBD_Chelix_1	419	427	PF00786	0.453
LIG_GBD_Chelix_1	534	542	PF00786	0.392
LIG_HCF-1_HBM_1	421	424	PF13415	0.504
LIG_Integrin_RGD_1	169	171	PF01839	0.370
LIG_LIR_Apic_2	302	307	PF02991	0.396
LIG_LIR_Apic_2	572	578	PF02991	0.297
LIG_LIR_Gen_1	421	432	PF02991	0.561
LIG_LIR_Gen_1	587	598	PF02991	0.434
LIG_LIR_LC3C_4	181	186	PF02991	0.368
LIG_LIR_Nem_3	363	368	PF02991	0.302
LIG_LIR_Nem_3	421	427	PF02991	0.518
LIG_LIR_Nem_3	571	577	PF02991	0.478
LIG_LIR_Nem_3	587	593	PF02991	0.272
LIG_Pex14_1	343	347	PF04695	0.306
LIG_Pex14_2	269	273	PF04695	0.308
LIG_Pex14_2	586	590	PF04695	0.406
LIG_Pex14_2	78	82	PF04695	0.385
LIG_SH2_CRK	424	428	PF00017	0.553
LIG_SH2_CRK	575	579	PF00017	0.415
LIG_SH2_NCK_1	575	579	PF00017	0.415
LIG_SH2_SRC	226	229	PF00017	0.569
LIG_SH2_STAP1	211	215	PF00017	0.714
LIG_SH2_STAT5	167	170	PF00017	0.371
LIG_SH2_STAT5	193	196	PF00017	0.332
LIG_SH2_STAT5	211	214	PF00017	0.571
LIG_SH2_STAT5	226	229	PF00017	0.440
LIG_SH2_STAT5	519	522	PF00017	0.266
LIG_SH2_STAT5	575	578	PF00017	0.390
LIG_SH3_2	225	230	PF14604	0.651
LIG_SH3_3	192	198	PF00018	0.383
LIG_SH3_3	222	228	PF00018	0.673
LIG_SH3_3	551	557	PF00018	0.576
LIG_SH3_3	57	63	PF00018	0.592
LIG_SH3_3	579	585	PF00018	0.318
LIG_SUMO_SIM_anti_2	181	189	PF11976	0.387
LIG_SUMO_SIM_par_1	181	189	PF11976	0.321
LIG_SUMO_SIM_par_1	192	200	PF11976	0.363
LIG_SUMO_SIM_par_1	294	300	PF11976	0.361
LIG_TRAF2_1	320	323	PF00917	0.361
LIG_UBA3_1	16	21	PF00899	0.366
LIG_UBA3_1	466	475	PF00899	0.360
LIG_WRC_WIRS_1	477	482	PF05994	0.360
LIG_WRC_WIRS_1	534	539	PF05994	0.359
MOD_CK1_1	262	268	PF00069	0.414
MOD_CK1_1	297	303	PF00069	0.366
MOD_CK1_1	503	509	PF00069	0.353
MOD_CK1_1	62	68	PF00069	0.634
MOD_CK2_1	193	199	PF00069	0.370
MOD_CK2_1	261	267	PF00069	0.375
MOD_CK2_1	523	529	PF00069	0.260
MOD_GlcNHglycan	162	165	PF01048	0.450
MOD_GlcNHglycan	424	427	PF01048	0.424
MOD_GlcNHglycan	485	488	PF01048	0.396
MOD_GlcNHglycan	578	581	PF01048	0.353
MOD_GlcNHglycan	67	70	PF01048	0.620
MOD_GlcNHglycan	88	91	PF01048	0.644
MOD_GSK3_1	189	196	PF00069	0.369
MOD_GSK3_1	199	206	PF00069	0.586
MOD_GSK3_1	307	314	PF00069	0.416
MOD_GSK3_1	428	435	PF00069	0.678
MOD_GSK3_1	452	459	PF00069	0.379
MOD_GSK3_1	533	540	PF00069	0.341
MOD_GSK3_1	61	68	PF00069	0.662
MOD_N-GLC_1	456	461	PF02516	0.370
MOD_N-GLC_1	65	70	PF02516	0.639
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	160	165	PF00069	0.426
MOD_NEK2_1	259	264	PF00069	0.396
MOD_NEK2_1	296	301	PF00069	0.315
MOD_NEK2_1	324	329	PF00069	0.342
MOD_NEK2_1	456	461	PF00069	0.375
MOD_NEK2_1	523	528	PF00069	0.336
MOD_NEK2_1	537	542	PF00069	0.470
MOD_NEK2_1	596	601	PF00069	0.573
MOD_PIKK_1	1	7	PF00454	0.615
MOD_PIKK_1	197	203	PF00454	0.601
MOD_PIKK_1	377	383	PF00454	0.424
MOD_PIKK_1	54	60	PF00454	0.675
MOD_PK_1	178	184	PF00069	0.391
MOD_PKA_1	178	184	PF00069	0.391
MOD_PKA_2	178	184	PF00069	0.391
MOD_PKA_2	288	294	PF00069	0.404
MOD_PKA_2	368	374	PF00069	0.488
MOD_PKA_2	452	458	PF00069	0.445
MOD_PKA_2	54	60	PF00069	0.524
MOD_PKA_2	86	92	PF00069	0.630
MOD_PKB_1	354	362	PF00069	0.407
MOD_Plk_1	104	110	PF00069	0.412
MOD_Plk_1	392	398	PF00069	0.495
MOD_Plk_1	456	462	PF00069	0.375
MOD_Plk_1	500	506	PF00069	0.348
MOD_Plk_4	144	150	PF00069	0.424
MOD_Plk_4	162	168	PF00069	0.328
MOD_Plk_4	189	195	PF00069	0.418
MOD_Plk_4	307	313	PF00069	0.424
MOD_Plk_4	456	462	PF00069	0.408
MOD_Plk_4	47	53	PF00069	0.421
MOD_Plk_4	533	539	PF00069	0.312
MOD_ProDKin_1	106	112	PF00069	0.457
MOD_ProDKin_1	371	377	PF00069	0.522
MOD_ProDKin_1	59	65	PF00069	0.614
MOD_SUMO_for_1	391	394	PF00179	0.380
TRG_DiLeu_BaEn_4	43	49	PF01217	0.383
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.518
TRG_ENDOCYTIC_2	131	134	PF00928	0.419
TRG_ENDOCYTIC_2	424	427	PF00928	0.502
TRG_ER_diArg_1	177	179	PF00400	0.369
TRG_ER_diArg_1	397	399	PF00400	0.489
TRG_NES_CRM1_1	175	189	PF08389	0.358
TRG_NES_CRM1_1	363	373	PF08389	0.358
TRG_NLS_MonoExtN_4	561	567	PF00514	0.410
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JET7	Bodo saltans	50%	100%
A0A1X0NW11	Trypanosomatidae	58%	100%
A0A3Q8IC34	Leishmania donovani	88%	99%
A0A422NQ83	Trypanosoma rangeli	60%	100%
C6K3X8	Leptomonas seymouri	79%	100%
D0A795	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AWW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QAK8	Leishmania major	88%	100%
V5C0H3	Trypanosoma cruzi	60%	100%