PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDI0_LEIBR

TriTrypDb:

LbrM.24.1250 , LBRM2903_240018600

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDI0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.514
CLV_NRD_NRD_1	522	524	PF00675	0.448
CLV_NRD_NRD_1	643	645	PF00675	0.623
CLV_NRD_NRD_1	666	668	PF00675	0.646
CLV_NRD_NRD_1	96	98	PF00675	0.659
CLV_PCSK_FUR_1	641	645	PF00082	0.571
CLV_PCSK_FUR_1	93	97	PF00082	0.739
CLV_PCSK_KEX2_1	554	556	PF00082	0.470
CLV_PCSK_KEX2_1	572	574	PF00082	0.448
CLV_PCSK_KEX2_1	643	645	PF00082	0.623
CLV_PCSK_KEX2_1	93	95	PF00082	0.667
CLV_PCSK_KEX2_1	96	98	PF00082	0.646
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.459
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.336
CLV_PCSK_SKI1_1	212	216	PF00082	0.335
CLV_PCSK_SKI1_1	269	273	PF00082	0.557
CLV_PCSK_SKI1_1	485	489	PF00082	0.451
CLV_PCSK_SKI1_1	545	549	PF00082	0.425
CLV_PCSK_SKI1_1	60	64	PF00082	0.609
DEG_APCC_DBOX_1	522	530	PF00400	0.393
DEG_SCF_FBW7_1	112	118	PF00400	0.541
DEG_SCF_FBW7_1	299	305	PF00400	0.525
DEG_SPOP_SBC_1	102	106	PF00917	0.649
DEG_SPOP_SBC_1	291	295	PF00917	0.515
DEG_SPOP_SBC_1	334	338	PF00917	0.675
DOC_CKS1_1	112	117	PF01111	0.539
DOC_CKS1_1	241	246	PF01111	0.528
DOC_CKS1_1	274	279	PF01111	0.496
DOC_CKS1_1	299	304	PF01111	0.523
DOC_CYCLIN_RxL_1	480	491	PF00134	0.498
DOC_CYCLIN_RxL_1	60	70	PF00134	0.571
DOC_MAPK_DCC_7	649	657	PF00069	0.538
DOC_MAPK_gen_1	543	552	PF00069	0.361
DOC_MAPK_MEF2A_6	649	657	PF00069	0.538
DOC_PP1_RVXF_1	267	273	PF00149	0.549
DOC_PP1_RVXF_1	553	560	PF00149	0.436
DOC_PP2B_LxvP_1	247	250	PF13499	0.610
DOC_PP2B_LxvP_1	331	334	PF13499	0.521
DOC_PP2B_LxvP_1	346	349	PF13499	0.486
DOC_PP2B_LxvP_1	396	399	PF13499	0.396
DOC_PP2B_LxvP_1	44	47	PF13499	0.534
DOC_PP2B_LxvP_1	87	90	PF13499	0.711
DOC_PP2B_PxIxI_1	135	141	PF00149	0.512
DOC_PP4_FxxP_1	214	217	PF00568	0.535
DOC_USP7_MATH_1	103	107	PF00917	0.654
DOC_USP7_MATH_1	115	119	PF00917	0.616
DOC_USP7_MATH_1	120	124	PF00917	0.677
DOC_USP7_MATH_1	148	152	PF00917	0.732
DOC_USP7_MATH_1	226	230	PF00917	0.594
DOC_USP7_MATH_1	236	240	PF00917	0.609
DOC_USP7_MATH_1	297	301	PF00917	0.555
DOC_USP7_MATH_1	302	306	PF00917	0.510
DOC_USP7_MATH_1	323	327	PF00917	0.744
DOC_USP7_MATH_1	335	339	PF00917	0.570
DOC_USP7_MATH_1	34	38	PF00917	0.664
DOC_USP7_MATH_1	340	344	PF00917	0.539
DOC_USP7_MATH_1	372	376	PF00917	0.342
DOC_USP7_MATH_1	568	572	PF00917	0.404
DOC_USP7_MATH_1	629	633	PF00917	0.521
DOC_WW_Pin1_4	111	116	PF00397	0.656
DOC_WW_Pin1_4	132	137	PF00397	0.707
DOC_WW_Pin1_4	175	180	PF00397	0.477
DOC_WW_Pin1_4	221	226	PF00397	0.663
DOC_WW_Pin1_4	240	245	PF00397	0.670
DOC_WW_Pin1_4	248	253	PF00397	0.687
DOC_WW_Pin1_4	270	275	PF00397	0.579
DOC_WW_Pin1_4	298	303	PF00397	0.521
DOC_WW_Pin1_4	30	35	PF00397	0.759
DOC_WW_Pin1_4	336	341	PF00397	0.581
DOC_WW_Pin1_4	365	370	PF00397	0.580
DOC_WW_Pin1_4	491	496	PF00397	0.478
DOC_WW_Pin1_4	564	569	PF00397	0.410
DOC_WW_Pin1_4	81	86	PF00397	0.652
LIG_14-3-3_CanoR_1	129	138	PF00244	0.672
LIG_14-3-3_CanoR_1	154	162	PF00244	0.514
LIG_14-3-3_CanoR_1	169	179	PF00244	0.410
LIG_14-3-3_CanoR_1	456	461	PF00244	0.426
LIG_14-3-3_CanoR_1	528	534	PF00244	0.448
LIG_14-3-3_CanoR_1	595	603	PF00244	0.471
LIG_14-3-3_CanoR_1	68	74	PF00244	0.662
LIG_14-3-3_CanoR_1	94	103	PF00244	0.562
LIG_Actin_WH2_2	155	171	PF00022	0.614
LIG_Actin_WH2_2	465	482	PF00022	0.472
LIG_Actin_WH2_2	522	539	PF00022	0.363
LIG_BRCT_BRCA1_1	130	134	PF00533	0.508
LIG_BRCT_BRCA1_1	576	580	PF00533	0.364
LIG_Clathr_ClatBox_1	530	534	PF01394	0.331
LIG_EVH1_1	331	335	PF00568	0.527
LIG_FHA_1	171	177	PF00498	0.429
LIG_FHA_1	241	247	PF00498	0.643
LIG_FHA_1	259	265	PF00498	0.558
LIG_FHA_1	414	420	PF00498	0.350
LIG_FHA_1	530	536	PF00498	0.411
LIG_FHA_1	61	67	PF00498	0.557
LIG_FHA_1	68	74	PF00498	0.581
LIG_FHA_2	112	118	PF00498	0.541
LIG_FHA_2	180	186	PF00498	0.458
LIG_FHA_2	381	387	PF00498	0.319
LIG_FHA_2	589	595	PF00498	0.474
LIG_Integrin_isoDGR_2	91	93	PF01839	0.713
LIG_LIR_Apic_2	213	217	PF02991	0.517
LIG_LIR_Gen_1	201	207	PF02991	0.490
LIG_LIR_Gen_1	508	516	PF02991	0.360
LIG_LIR_Gen_1	577	587	PF02991	0.369
LIG_LIR_Nem_3	201	205	PF02991	0.490
LIG_LIR_Nem_3	342	347	PF02991	0.683
LIG_LIR_Nem_3	425	431	PF02991	0.406
LIG_LIR_Nem_3	467	472	PF02991	0.488
LIG_LIR_Nem_3	508	512	PF02991	0.352
LIG_LIR_Nem_3	576	581	PF02991	0.372
LIG_LIR_Nem_3	582	587	PF02991	0.371
LIG_MAD2	269	277	PF02301	0.494
LIG_MYND_1	329	333	PF01753	0.665
LIG_MYND_1	85	89	PF01753	0.566
LIG_NRBOX	525	531	PF00104	0.361
LIG_NRP_CendR_1	667	669	PF00754	0.526
LIG_Pex14_2	214	218	PF04695	0.517
LIG_PTB_Apo_2	606	613	PF02174	0.372
LIG_SH2_CRK	319	323	PF00017	0.523
LIG_SH2_CRK	393	397	PF00017	0.401
LIG_SH2_CRK	469	473	PF00017	0.481
LIG_SH2_CRK	587	591	PF00017	0.454
LIG_SH2_NCK_1	234	238	PF00017	0.521
LIG_SH2_NCK_1	319	323	PF00017	0.548
LIG_SH2_NCK_1	587	591	PF00017	0.454
LIG_SH2_SRC	587	590	PF00017	0.453
LIG_SH2_STAP1	319	323	PF00017	0.548
LIG_SH2_STAT5	234	237	PF00017	0.521
LIG_SH2_STAT5	431	434	PF00017	0.379
LIG_SH2_STAT5	443	446	PF00017	0.374
LIG_SH3_3	238	244	PF00018	0.707
LIG_SH3_3	246	252	PF00018	0.639
LIG_SH3_3	268	274	PF00018	0.485
LIG_SH3_3	296	302	PF00018	0.521
LIG_SH3_3	326	332	PF00018	0.688
LIG_SH3_3	346	352	PF00018	0.468
LIG_SH3_3	366	372	PF00018	0.588
LIG_SH3_3	45	51	PF00018	0.583
LIG_SUMO_SIM_par_1	502	508	PF11976	0.301
LIG_TYR_ITIM	200	205	PF00017	0.333
LIG_TYR_ITIM	317	322	PF00017	0.510
LIG_UBA3_1	395	402	PF00899	0.327
LIG_UBA3_1	529	537	PF00899	0.334
LIG_WRC_WIRS_1	575	580	PF05994	0.362
MOD_CDK_SPK_2	111	116	PF00069	0.544
MOD_CDK_SPK_2	81	86	PF00069	0.558
MOD_CDK_SPxK_1	298	304	PF00069	0.522
MOD_CK1_1	132	138	PF00069	0.689
MOD_CK1_1	156	162	PF00069	0.598
MOD_CK1_1	227	233	PF00069	0.662
MOD_CK1_1	239	245	PF00069	0.798
MOD_CK1_1	248	254	PF00069	0.591
MOD_CK1_1	259	265	PF00069	0.665
MOD_CK1_1	273	279	PF00069	0.500
MOD_CK1_1	339	345	PF00069	0.703
MOD_CK1_1	42	48	PF00069	0.586
MOD_CK1_1	474	480	PF00069	0.356
MOD_CK1_1	491	497	PF00069	0.538
MOD_CK1_1	630	636	PF00069	0.583
MOD_CK1_1	69	75	PF00069	0.766
MOD_CK2_1	111	117	PF00069	0.547
MOD_CK2_1	175	181	PF00069	0.315
MOD_CK2_1	260	266	PF00069	0.676
MOD_CK2_1	34	40	PF00069	0.691
MOD_CK2_1	558	564	PF00069	0.458
MOD_CK2_1	588	594	PF00069	0.466
MOD_CK2_1	615	621	PF00069	0.321
MOD_Cter_Amidation	641	644	PF01082	0.570
MOD_Cter_Amidation	91	94	PF01082	0.739
MOD_GlcNHglycan	122	125	PF01048	0.705
MOD_GlcNHglycan	131	134	PF01048	0.490
MOD_GlcNHglycan	146	149	PF01048	0.698
MOD_GlcNHglycan	150	153	PF01048	0.789
MOD_GlcNHglycan	155	158	PF01048	0.598
MOD_GlcNHglycan	226	229	PF01048	0.607
MOD_GlcNHglycan	325	328	PF01048	0.632
MOD_GlcNHglycan	424	427	PF01048	0.427
MOD_GlcNHglycan	44	47	PF01048	0.626
MOD_GlcNHglycan	463	466	PF01048	0.445
MOD_GlcNHglycan	489	493	PF01048	0.471
MOD_GlcNHglycan	514	517	PF01048	0.403
MOD_GlcNHglycan	99	102	PF01048	0.703
MOD_GSK3_1	111	118	PF00069	0.612
MOD_GSK3_1	120	127	PF00069	0.663
MOD_GSK3_1	128	135	PF00069	0.506
MOD_GSK3_1	144	151	PF00069	0.738
MOD_GSK3_1	175	182	PF00069	0.296
MOD_GSK3_1	217	224	PF00069	0.450
MOD_GSK3_1	228	235	PF00069	0.577
MOD_GSK3_1	236	243	PF00069	0.612
MOD_GSK3_1	256	263	PF00069	0.646
MOD_GSK3_1	298	305	PF00069	0.573
MOD_GSK3_1	30	37	PF00069	0.558
MOD_GSK3_1	335	342	PF00069	0.738
MOD_GSK3_1	380	387	PF00069	0.307
MOD_GSK3_1	444	451	PF00069	0.311
MOD_GSK3_1	456	463	PF00069	0.415
MOD_GSK3_1	510	517	PF00069	0.356
MOD_GSK3_1	564	571	PF00069	0.422
MOD_GSK3_1	615	622	PF00069	0.436
MOD_GSK3_1	62	69	PF00069	0.666
MOD_GSK3_1	76	83	PF00069	0.560
MOD_GSK3_1	97	104	PF00069	0.651
MOD_N-GLC_1	179	184	PF02516	0.233
MOD_N-GLC_2	191	193	PF02516	0.315
MOD_NEK2_1	1	6	PF00069	0.562
MOD_NEK2_1	108	113	PF00069	0.558
MOD_NEK2_1	125	130	PF00069	0.640
MOD_NEK2_1	184	189	PF00069	0.227
MOD_NEK2_1	264	269	PF00069	0.553
MOD_NEK2_1	290	295	PF00069	0.537
MOD_NEK2_1	39	44	PF00069	0.573
MOD_NEK2_1	460	465	PF00069	0.340
MOD_NEK2_1	472	477	PF00069	0.379
MOD_NEK2_1	479	484	PF00069	0.530
MOD_NEK2_1	514	519	PF00069	0.402
MOD_NEK2_1	536	541	PF00069	0.454
MOD_NEK2_1	574	579	PF00069	0.367
MOD_NEK2_1	66	71	PF00069	0.647
MOD_PIKK_1	156	162	PF00454	0.582
MOD_PIKK_1	251	257	PF00454	0.686
MOD_PIKK_1	39	45	PF00454	0.554
MOD_PIKK_1	448	454	PF00454	0.455
MOD_PIKK_1	474	480	PF00454	0.378
MOD_PKA_1	95	101	PF00069	0.727
MOD_PKA_2	115	121	PF00069	0.538
MOD_PKA_2	128	134	PF00069	0.675
MOD_PKA_2	153	159	PF00069	0.520
MOD_PKA_2	594	600	PF00069	0.446
MOD_PKA_2	630	636	PF00069	0.532
MOD_PKA_2	67	73	PF00069	0.768
MOD_PKA_2	95	101	PF00069	0.716
MOD_PKB_1	93	101	PF00069	0.731
MOD_Plk_1	179	185	PF00069	0.233
MOD_Plk_1	39	45	PF00069	0.616
MOD_Plk_1	420	426	PF00069	0.438
MOD_Plk_4	179	185	PF00069	0.288
MOD_Plk_4	444	450	PF00069	0.384
MOD_Plk_4	456	462	PF00069	0.332
MOD_Plk_4	651	657	PF00069	0.532
MOD_Plk_4	69	75	PF00069	0.585
MOD_ProDKin_1	111	117	PF00069	0.656
MOD_ProDKin_1	132	138	PF00069	0.709
MOD_ProDKin_1	175	181	PF00069	0.315
MOD_ProDKin_1	221	227	PF00069	0.667
MOD_ProDKin_1	240	246	PF00069	0.672
MOD_ProDKin_1	248	254	PF00069	0.688
MOD_ProDKin_1	270	276	PF00069	0.577
MOD_ProDKin_1	298	304	PF00069	0.522
MOD_ProDKin_1	30	36	PF00069	0.753
MOD_ProDKin_1	336	342	PF00069	0.578
MOD_ProDKin_1	365	371	PF00069	0.578
MOD_ProDKin_1	491	497	PF00069	0.469
MOD_ProDKin_1	564	570	PF00069	0.416
MOD_ProDKin_1	81	87	PF00069	0.655
TRG_DiLeu_BaEn_1	376	381	PF01217	0.482
TRG_DiLeu_BaEn_2	575	581	PF01217	0.372
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.446
TRG_ENDOCYTIC_2	202	205	PF00928	0.333
TRG_ENDOCYTIC_2	319	322	PF00928	0.524
TRG_ENDOCYTIC_2	393	396	PF00928	0.435
TRG_ENDOCYTIC_2	469	472	PF00928	0.399
TRG_ENDOCYTIC_2	575	578	PF00928	0.369
TRG_ENDOCYTIC_2	587	590	PF00928	0.453
TRG_ER_diArg_1	2	5	PF00400	0.701
TRG_ER_diArg_1	540	543	PF00400	0.360
TRG_ER_diArg_1	641	644	PF00400	0.677
TRG_ER_diArg_1	93	96	PF00400	0.728
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYY8	Leptomonas seymouri	50%	80%
A0A3S7WYC3	Leishmania donovani	77%	88%
A4I0W1	Leishmania infantum	78%	88%
E9AWW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QAK9	Leishmania major	74%	100%