RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA-binding protein 38, putative

Species:

Leishmania braziliensis

UniProt:

A4HDH9_LEIBR

TriTrypDb:

LbrM.24.1240 , LBRM2903_240018500

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDH9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003723	RNA binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.584
CLV_NRD_NRD_1	114	116	PF00675	0.600
CLV_NRD_NRD_1	177	179	PF00675	0.634
CLV_NRD_NRD_1	297	299	PF00675	0.493
CLV_NRD_NRD_1	464	466	PF00675	0.511
CLV_PCSK_KEX2_1	114	116	PF00082	0.626
CLV_PCSK_KEX2_1	297	299	PF00082	0.499
CLV_PCSK_KEX2_1	409	411	PF00082	0.557
CLV_PCSK_KEX2_1	464	466	PF00082	0.509
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.711
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.557
CLV_PCSK_SKI1_1	14	18	PF00082	0.502
CLV_PCSK_SKI1_1	173	177	PF00082	0.657
CLV_PCSK_SKI1_1	290	294	PF00082	0.440
CLV_PCSK_SKI1_1	311	315	PF00082	0.459
CLV_PCSK_SKI1_1	353	357	PF00082	0.450
CLV_PCSK_SKI1_1	379	383	PF00082	0.498
CLV_PCSK_SKI1_1	385	389	PF00082	0.438
CLV_PCSK_SKI1_1	437	441	PF00082	0.447
CLV_PCSK_SKI1_1	464	468	PF00082	0.547
CLV_PCSK_SKI1_1	531	535	PF00082	0.688
CLV_Separin_Metazoa	414	418	PF03568	0.529
DEG_SPOP_SBC_1	190	194	PF00917	0.704
DEG_SPOP_SBC_1	61	65	PF00917	0.587
DOC_CKS1_1	160	165	PF01111	0.586
DOC_CKS1_1	485	490	PF01111	0.634
DOC_CKS1_1	492	497	PF01111	0.519
DOC_PP1_RVXF_1	171	177	PF00149	0.653
DOC_PP1_RVXF_1	288	295	PF00149	0.498
DOC_PP1_RVXF_1	355	362	PF00149	0.377
DOC_PP1_RVXF_1	386	392	PF00149	0.390
DOC_PP2B_LxvP_1	223	226	PF13499	0.629
DOC_USP7_MATH_1	102	106	PF00917	0.589
DOC_USP7_MATH_1	121	125	PF00917	0.760
DOC_USP7_MATH_1	146	150	PF00917	0.431
DOC_USP7_MATH_1	163	167	PF00917	0.675
DOC_USP7_MATH_1	18	22	PF00917	0.528
DOC_USP7_MATH_1	217	221	PF00917	0.554
DOC_USP7_MATH_1	238	242	PF00917	0.726
DOC_USP7_MATH_1	244	248	PF00917	0.657
DOC_USP7_MATH_1	302	306	PF00917	0.454
DOC_USP7_MATH_1	307	311	PF00917	0.481
DOC_USP7_MATH_1	33	37	PF00917	0.596
DOC_USP7_MATH_1	397	401	PF00917	0.591
DOC_USP7_MATH_1	477	481	PF00917	0.613
DOC_USP7_MATH_1	83	87	PF00917	0.586
DOC_USP7_UBL2_3	112	116	PF12436	0.736
DOC_USP7_UBL2_3	388	392	PF12436	0.415
DOC_USP7_UBL2_3	437	441	PF12436	0.392
DOC_USP7_UBL2_3	91	95	PF12436	0.702
DOC_WW_Pin1_4	159	164	PF00397	0.497
DOC_WW_Pin1_4	186	191	PF00397	0.611
DOC_WW_Pin1_4	205	210	PF00397	0.593
DOC_WW_Pin1_4	22	27	PF00397	0.564
DOC_WW_Pin1_4	265	270	PF00397	0.650
DOC_WW_Pin1_4	28	33	PF00397	0.584
DOC_WW_Pin1_4	38	43	PF00397	0.579
DOC_WW_Pin1_4	475	480	PF00397	0.611
DOC_WW_Pin1_4	484	489	PF00397	0.600
DOC_WW_Pin1_4	491	496	PF00397	0.553
DOC_WW_Pin1_4	78	83	PF00397	0.575
DOC_WW_Pin1_4	95	100	PF00397	0.461
LIG_14-3-3_CanoR_1	309	314	PF00244	0.436
LIG_14-3-3_CanoR_1	347	356	PF00244	0.539
LIG_14-3-3_CanoR_1	420	428	PF00244	0.469
LIG_14-3-3_CanoR_1	513	522	PF00244	0.646
LIG_Actin_WH2_2	150	167	PF00022	0.562
LIG_BIR_III_2	187	191	PF00653	0.559
LIG_BRCT_BRCA1_1	278	282	PF00533	0.417
LIG_EH1_1	137	145	PF00400	0.481
LIG_FHA_1	191	197	PF00498	0.691
LIG_FHA_1	315	321	PF00498	0.409
LIG_FHA_1	327	333	PF00498	0.420
LIG_FHA_1	516	522	PF00498	0.662
LIG_FHA_1	96	102	PF00498	0.747
LIG_FHA_2	421	427	PF00498	0.405
LIG_FHA_2	431	437	PF00498	0.382
LIG_LIR_Gen_1	136	146	PF02991	0.404
LIG_LIR_Gen_1	344	349	PF02991	0.394
LIG_LIR_Nem_3	136	142	PF02991	0.404
LIG_LIR_Nem_3	344	348	PF02991	0.397
LIG_LIR_Nem_3	502	506	PF02991	0.535
LIG_LIR_Nem_3	507	512	PF02991	0.504
LIG_LIR_Nem_3	6	10	PF02991	0.516
LIG_MYND_1	479	483	PF01753	0.586
LIG_SH2_GRB2like	364	367	PF00017	0.443
LIG_SH2_PTP2	345	348	PF00017	0.390
LIG_SH2_PTP2	7	10	PF00017	0.624
LIG_SH2_SRC	229	232	PF00017	0.504
LIG_SH2_STAT5	229	232	PF00017	0.504
LIG_SH2_STAT5	345	348	PF00017	0.390
LIG_SH2_STAT5	7	10	PF00017	0.624
LIG_SH3_1	482	488	PF00018	0.484
LIG_SH3_3	166	172	PF00018	0.539
LIG_SH3_3	174	180	PF00018	0.620
LIG_SH3_3	337	343	PF00018	0.470
LIG_SH3_3	482	488	PF00018	0.649
LIG_SH3_3	489	495	PF00018	0.586
LIG_SH3_3	521	527	PF00018	0.543
LIG_Sin3_3	316	323	PF02671	0.393
LIG_TRAF2_1	411	414	PF00917	0.526
LIG_WW_1	226	229	PF00397	0.504
MOD_CDC14_SPxK_1	208	211	PF00782	0.512
MOD_CDK_SPxK_1	159	165	PF00069	0.532
MOD_CDK_SPxK_1	205	211	PF00069	0.506
MOD_CDK_SPxxK_3	475	482	PF00069	0.564
MOD_CK1_1	105	111	PF00069	0.674
MOD_CK1_1	119	125	PF00069	0.734
MOD_CK1_1	149	155	PF00069	0.527
MOD_CK1_1	189	195	PF00069	0.637
MOD_CK1_1	247	253	PF00069	0.785
MOD_CK1_1	305	311	PF00069	0.486
MOD_CK1_1	36	42	PF00069	0.651
MOD_CK1_1	408	414	PF00069	0.512
MOD_CK1_1	514	520	PF00069	0.585
MOD_CK2_1	408	414	PF00069	0.482
MOD_CK2_1	420	426	PF00069	0.420
MOD_CK2_1	430	436	PF00069	0.338
MOD_Cter_Amidation	109	112	PF01082	0.700
MOD_GlcNHglycan	104	107	PF01048	0.547
MOD_GlcNHglycan	116	119	PF01048	0.759
MOD_GlcNHglycan	123	126	PF01048	0.687
MOD_GlcNHglycan	127	130	PF01048	0.621
MOD_GlcNHglycan	148	151	PF01048	0.330
MOD_GlcNHglycan	201	204	PF01048	0.717
MOD_GlcNHglycan	212	216	PF01048	0.550
MOD_GlcNHglycan	242	245	PF01048	0.610
MOD_GlcNHglycan	35	38	PF01048	0.638
MOD_GlcNHglycan	399	402	PF01048	0.563
MOD_GlcNHglycan	45	48	PF01048	0.560
MOD_GlcNHglycan	71	74	PF01048	0.478
MOD_GSK3_1	102	109	PF00069	0.494
MOD_GSK3_1	121	128	PF00069	0.583
MOD_GSK3_1	159	166	PF00069	0.533
MOD_GSK3_1	18	25	PF00069	0.543
MOD_GSK3_1	186	193	PF00069	0.639
MOD_GSK3_1	240	247	PF00069	0.547
MOD_GSK3_1	27	34	PF00069	0.582
MOD_GSK3_1	305	312	PF00069	0.474
MOD_GSK3_1	393	400	PF00069	0.544
MOD_GSK3_1	471	478	PF00069	0.650
MOD_GSK3_1	511	518	PF00069	0.571
MOD_GSK3_1	59	66	PF00069	0.667
MOD_GSK3_1	83	90	PF00069	0.530
MOD_N-GLC_1	28	33	PF02516	0.623
MOD_N-GLC_1	314	319	PF02516	0.399
MOD_N-GLC_1	69	74	PF02516	0.495
MOD_NEK2_1	100	105	PF00069	0.503
MOD_NEK2_1	276	281	PF00069	0.412
MOD_NEK2_1	314	319	PF00069	0.388
MOD_NEK2_1	381	386	PF00069	0.342
MOD_NEK2_1	405	410	PF00069	0.377
MOD_NEK2_1	428	433	PF00069	0.530
MOD_NEK2_1	446	451	PF00069	0.426
MOD_NEK2_1	59	64	PF00069	0.560
MOD_NEK2_1	68	73	PF00069	0.540
MOD_PIKK_1	251	257	PF00454	0.501
MOD_PIKK_1	511	517	PF00454	0.569
MOD_PK_1	309	315	PF00069	0.491
MOD_PKA_1	114	120	PF00069	0.519
MOD_PKA_1	392	398	PF00069	0.530
MOD_PKA_2	114	120	PF00069	0.597
MOD_PKA_2	210	216	PF00069	0.523
MOD_PKA_2	419	425	PF00069	0.445
MOD_Plk_1	288	294	PF00069	0.544
MOD_Plk_1	314	320	PF00069	0.394
MOD_Plk_4	276	282	PF00069	0.524
MOD_Plk_4	290	296	PF00069	0.434
MOD_Plk_4	314	320	PF00069	0.396
MOD_Plk_4	341	347	PF00069	0.377
MOD_ProDKin_1	159	165	PF00069	0.497
MOD_ProDKin_1	186	192	PF00069	0.610
MOD_ProDKin_1	205	211	PF00069	0.598
MOD_ProDKin_1	22	28	PF00069	0.564
MOD_ProDKin_1	265	271	PF00069	0.624
MOD_ProDKin_1	38	44	PF00069	0.578
MOD_ProDKin_1	475	481	PF00069	0.610
MOD_ProDKin_1	484	490	PF00069	0.600
MOD_ProDKin_1	491	497	PF00069	0.553
MOD_ProDKin_1	78	84	PF00069	0.576
MOD_ProDKin_1	95	101	PF00069	0.461
MOD_SUMO_for_1	327	330	PF00179	0.454
MOD_SUMO_for_1	387	390	PF00179	0.398
MOD_SUMO_rev_2	368	375	PF00179	0.384
MOD_SUMO_rev_2	402	411	PF00179	0.528
MOD_SUMO_rev_2	528	533	PF00179	0.665
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.515
TRG_ENDOCYTIC_2	345	348	PF00928	0.390
TRG_ENDOCYTIC_2	450	453	PF00928	0.512
TRG_ENDOCYTIC_2	7	10	PF00928	0.624
TRG_ER_diArg_1	297	299	PF00400	0.493
TRG_ER_diArg_1	463	465	PF00400	0.469
TRG_ER_diArg_1	538	541	PF00400	0.593
TRG_NLS_MonoCore_2	110	115	PF00514	0.704
TRG_NLS_MonoExtC_3	110	115	PF00514	0.704
TRG_NLS_MonoExtN_4	111	118	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	385	390	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	523	528	PF00026	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC49	Leptomonas seymouri	64%	100%
A0A0S4J510	Bodo saltans	36%	100%
A0A1X0NW66	Trypanosomatidae	43%	100%
A0A3S7WYC8	Leishmania donovani	79%	100%
A4I0W0	Leishmania infantum	79%	100%
D0A792	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AWW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QAL0	Leishmania major	79%	99%