YL1_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDH7_LEIBR

TriTrypDb:

LbrM.24.1220 , LBRM2903_240018300

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HDH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDH7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	9
GO:0009889	regulation of biosynthetic process	4	9
GO:0010468	regulation of gene expression	5	9
GO:0010556	regulation of macromolecule biosynthetic process	5	9
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	9
GO:0019222	regulation of metabolic process	3	9
GO:0031323	regulation of cellular metabolic process	4	9
GO:0031326	regulation of cellular biosynthetic process	5	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0051171	regulation of nitrogen compound metabolic process	4	9
GO:0051252	regulation of RNA metabolic process	5	9
GO:0060255	regulation of macromolecule metabolic process	4	9
GO:0065007	biological regulation	1	9
GO:0080090	regulation of primary metabolic process	4	9
GO:1903506	regulation of nucleic acid-templated transcription	7	9
GO:2001141	regulation of RNA biosynthetic process	6	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.670
CLV_NRD_NRD_1	12	14	PF00675	0.357
CLV_NRD_NRD_1	178	180	PF00675	0.561
CLV_NRD_NRD_1	231	233	PF00675	0.675
CLV_NRD_NRD_1	244	246	PF00675	0.647
CLV_NRD_NRD_1	255	257	PF00675	0.636
CLV_NRD_NRD_1	85	87	PF00675	0.395
CLV_NRD_NRD_1	96	98	PF00675	0.325
CLV_PCSK_FUR_1	10	14	PF00082	0.357
CLV_PCSK_FUR_1	175	179	PF00082	0.665
CLV_PCSK_FUR_1	242	246	PF00082	0.794
CLV_PCSK_KEX2_1	12	14	PF00082	0.357
CLV_PCSK_KEX2_1	126	128	PF00082	0.453
CLV_PCSK_KEX2_1	177	179	PF00082	0.570
CLV_PCSK_KEX2_1	231	233	PF00082	0.666
CLV_PCSK_KEX2_1	244	246	PF00082	0.652
CLV_PCSK_KEX2_1	255	257	PF00082	0.646
CLV_PCSK_KEX2_1	85	87	PF00082	0.427
CLV_PCSK_KEX2_1	96	98	PF00082	0.367
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.453
CLV_PCSK_PC7_1	173	179	PF00082	0.722
CLV_PCSK_PC7_1	92	98	PF00082	0.444
CLV_PCSK_SKI1_1	284	288	PF00082	0.644
DEG_Nend_UBRbox_2	1	3	PF02207	0.659
DEG_SCF_FBW7_1	265	271	PF00400	0.499
DOC_CKS1_1	265	270	PF01111	0.520
DOC_PP4_FxxP_1	280	283	PF00568	0.552
DOC_PP4_FxxP_1	307	310	PF00568	0.567
DOC_SPAK_OSR1_1	306	310	PF12202	0.631
DOC_USP7_MATH_1	254	258	PF00917	0.640
DOC_USP7_MATH_1	268	272	PF00917	0.458
DOC_USP7_UBL2_3	122	126	PF12436	0.475
DOC_WW_Pin1_4	264	269	PF00397	0.669
DOC_WW_Pin1_4	279	284	PF00397	0.617
LIG_14-3-3_CanoR_1	294	304	PF00244	0.532
LIG_FHA_1	260	266	PF00498	0.517
LIG_FHA_1	299	305	PF00498	0.513
LIG_FHA_2	265	271	PF00498	0.718
LIG_MYND_1	321	325	PF01753	0.701
LIG_NRBOX	19	25	PF00104	0.391
LIG_RPA_C_Fungi	227	239	PF08784	0.526
LIG_SH3_1	179	185	PF00018	0.586
LIG_SH3_3	179	185	PF00018	0.586
LIG_SH3_3	319	325	PF00018	0.651
LIG_SH3_3	5	11	PF00018	0.701
LIG_TRAF2_1	52	55	PF00917	0.360
LIG_WRC_WIRS_1	312	317	PF05994	0.561
MOD_CDK_SPK_2	279	284	PF00069	0.628
MOD_CK1_1	219	225	PF00069	0.632
MOD_CK1_1	250	256	PF00069	0.770
MOD_CK1_1	298	304	PF00069	0.575
MOD_CK1_1	40	46	PF00069	0.361
MOD_CK2_1	254	260	PF00069	0.728
MOD_CK2_1	49	55	PF00069	0.363
MOD_GlcNHglycan	221	224	PF01048	0.739
MOD_GlcNHglycan	256	259	PF01048	0.761
MOD_GlcNHglycan	298	301	PF01048	0.596
MOD_GlcNHglycan	315	318	PF01048	0.650
MOD_GSK3_1	100	107	PF00069	0.492
MOD_GSK3_1	180	187	PF00069	0.678
MOD_GSK3_1	250	257	PF00069	0.728
MOD_GSK3_1	259	266	PF00069	0.738
MOD_GSK3_1	295	302	PF00069	0.582
MOD_GSK3_1	37	44	PF00069	0.360
MOD_N-GLC_1	104	109	PF02516	0.492
MOD_N-GLC_1	131	136	PF02516	0.364
MOD_N-GLC_1	248	253	PF02516	0.772
MOD_NEK2_1	100	105	PF00069	0.457
MOD_PIKK_1	100	106	PF00454	0.492
MOD_PIKK_1	184	190	PF00454	0.656
MOD_PKA_2	128	134	PF00069	0.492
MOD_PKA_2	254	260	PF00069	0.608
MOD_PKA_2	295	301	PF00069	0.459
MOD_PKB_1	294	302	PF00069	0.477
MOD_Plk_1	269	275	PF00069	0.644
MOD_Plk_1	44	50	PF00069	0.391
MOD_Plk_2-3	163	169	PF00069	0.776
MOD_Plk_2-3	59	65	PF00069	0.422
MOD_Plk_2-3	74	80	PF00069	0.326
MOD_Plk_4	299	305	PF00069	0.534
MOD_Plk_4	308	314	PF00069	0.543
MOD_ProDKin_1	264	270	PF00069	0.670
MOD_ProDKin_1	279	285	PF00069	0.611
MOD_SUMO_rev_2	29	36	PF00179	0.393
TRG_DiLeu_BaEn_4	31	37	PF01217	0.438
TRG_ENDOCYTIC_2	288	291	PF00928	0.654
TRG_ER_diArg_1	10	13	PF00400	0.358
TRG_ER_diArg_1	138	141	PF00400	0.780
TRG_ER_diArg_1	172	175	PF00400	0.607
TRG_ER_diArg_1	176	179	PF00400	0.557
TRG_ER_diArg_1	230	232	PF00400	0.755
TRG_ER_diArg_1	242	245	PF00400	0.700
TRG_ER_diArg_1	294	297	PF00400	0.484
TRG_ER_diArg_1	84	86	PF00400	0.427
TRG_NLS_Bipartite_1	85	101	PF00514	0.492
TRG_NLS_MonoExtN_4	96	101	PF00514	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKA2	Leptomonas seymouri	52%	100%
A0A3Q8IBX0	Leishmania donovani	79%	100%
A0A422NQ25	Trypanosoma rangeli	33%	100%
A4I0V8	Leishmania infantum	79%	100%
D0A789	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AWW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAL2	Leishmania major	79%	100%