Inhibitor of apoptosis-promoting Bax1-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Inhibitor of apoptosis-promoting Bax1, putative

Species:

Leishmania braziliensis

UniProt:

A4HDH6_LEIBR

TriTrypDb:

LbrM.24.1210 , LBRM2903_240018200

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HDH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.644
CLV_NRD_NRD_1	31	33	PF00675	0.416
CLV_PCSK_KEX2_1	31	33	PF00082	0.433
CLV_PCSK_SKI1_1	169	173	PF00082	0.232
CLV_PCSK_SKI1_1	194	198	PF00082	0.457
CLV_PCSK_SKI1_1	31	35	PF00082	0.439
DEG_APCC_DBOX_1	108	116	PF00400	0.457
DEG_APCC_DBOX_1	70	78	PF00400	0.643
DEG_Nend_Nbox_1	1	3	PF02207	0.671
DEG_SPOP_SBC_1	196	200	PF00917	0.422
DOC_CKS1_1	134	139	PF01111	0.330
DOC_CYCLIN_RxL_1	28	37	PF00134	0.567
DOC_PP4_FxxP_1	160	163	PF00568	0.422
DOC_USP7_MATH_1	13	17	PF00917	0.695
DOC_USP7_MATH_1	164	168	PF00917	0.509
DOC_USP7_MATH_1	219	223	PF00917	0.457
DOC_USP7_MATH_1	52	56	PF00917	0.683
DOC_USP7_MATH_1	93	97	PF00917	0.679
DOC_WW_Pin1_4	102	107	PF00397	0.449
DOC_WW_Pin1_4	133	138	PF00397	0.330
DOC_WW_Pin1_4	39	44	PF00397	0.741
DOC_WW_Pin1_4	85	90	PF00397	0.666
LIG_14-3-3_CanoR_1	114	119	PF00244	0.422
LIG_14-3-3_CanoR_1	220	224	PF00244	0.457
LIG_14-3-3_CanoR_1	24	29	PF00244	0.713
LIG_14-3-3_CanoR_1	64	74	PF00244	0.538
LIG_14-3-3_CanoR_1	8	18	PF00244	0.678
LIG_FHA_1	103	109	PF00498	0.554
LIG_FHA_1	123	129	PF00498	0.125
LIG_FHA_1	196	202	PF00498	0.314
LIG_HP1_1	186	190	PF01393	0.422
LIG_LIR_Apic_2	159	163	PF02991	0.374
LIG_LIR_Apic_2	213	219	PF02991	0.202
LIG_LIR_Gen_1	130	138	PF02991	0.353
LIG_LIR_Gen_1	175	184	PF02991	0.353
LIG_LIR_Nem_3	130	134	PF02991	0.403
LIG_LIR_Nem_3	175	179	PF02991	0.353
LIG_PTB_Apo_2	241	248	PF02174	0.311
LIG_PTB_Phospho_1	241	247	PF10480	0.311
LIG_SH2_CRK	116	120	PF00017	0.311
LIG_SH2_CRK	258	262	PF00017	0.311
LIG_SH2_STAT5	116	119	PF00017	0.360
LIG_SH2_STAT5	216	219	PF00017	0.509
LIG_SH2_STAT5	66	69	PF00017	0.705
LIG_SH3_3	131	137	PF00018	0.422
LIG_SH3_3	160	166	PF00018	0.311
LIG_SH3_3	242	248	PF00018	0.455
LIG_SUMO_SIM_par_1	185	192	PF11976	0.356
LIG_SUMO_SIM_par_1	236	241	PF11976	0.311
LIG_SUMO_SIM_par_1	265	272	PF11976	0.383
LIG_TYR_ITIM	256	261	PF00017	0.311
LIG_UBA3_1	189	194	PF00899	0.455
LIG_WRC_WIRS_1	128	133	PF05994	0.353
LIG_WRC_WIRS_1	173	178	PF05994	0.353
MOD_CDK_SPxxK_3	102	109	PF00069	0.549
MOD_CDK_SPxxK_3	85	92	PF00069	0.589
MOD_CK1_1	23	29	PF00069	0.702
MOD_CK1_1	50	56	PF00069	0.579
MOD_CK1_1	88	94	PF00069	0.647
MOD_CK1_1	96	102	PF00069	0.641
MOD_GlcNHglycan	212	215	PF01048	0.312
MOD_GlcNHglycan	34	37	PF01048	0.461
MOD_GlcNHglycan	49	52	PF01048	0.424
MOD_GlcNHglycan	95	98	PF01048	0.485
MOD_GSK3_1	197	204	PF00069	0.422
MOD_GSK3_1	20	27	PF00069	0.669
MOD_GSK3_1	88	95	PF00069	0.668
MOD_GSK3_1	9	16	PF00069	0.702
MOD_GSK3_1	96	103	PF00069	0.631
MOD_NEK2_1	14	19	PF00069	0.663
MOD_NEK2_1	156	161	PF00069	0.348
MOD_NEK2_1	172	177	PF00069	0.311
MOD_NEK2_1	189	194	PF00069	0.290
MOD_NEK2_1	197	202	PF00069	0.320
MOD_NEK2_1	34	39	PF00069	0.666
MOD_PIKK_1	269	275	PF00454	0.311
MOD_PIKK_1	82	88	PF00454	0.733
MOD_PIKK_1	96	102	PF00454	0.701
MOD_PKA_2	219	225	PF00069	0.457
MOD_PKA_2	23	29	PF00069	0.699
MOD_Plk_4	114	120	PF00069	0.370
MOD_Plk_4	127	133	PF00069	0.234
MOD_Plk_4	197	203	PF00069	0.422
MOD_Plk_4	219	225	PF00069	0.457
MOD_Plk_4	238	244	PF00069	0.311
MOD_Plk_4	251	257	PF00069	0.288
MOD_ProDKin_1	102	108	PF00069	0.436
MOD_ProDKin_1	133	139	PF00069	0.330
MOD_ProDKin_1	39	45	PF00069	0.741
MOD_ProDKin_1	85	91	PF00069	0.666
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.311
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.568
TRG_ENDOCYTIC_2	116	119	PF00928	0.311
TRG_ENDOCYTIC_2	258	261	PF00928	0.311
TRG_ER_diArg_1	31	33	PF00400	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P543	Leptomonas seymouri	74%	98%
A0A1X0NWZ2	Trypanosomatidae	65%	99%
A0A3Q8IG51	Leishmania donovani	88%	100%
A0A422NQ32	Trypanosoma rangeli	71%	100%
A4I0V7	Leishmania infantum	88%	100%
D0A788	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AWW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O25578	Helicobacter pylori (strain ATCC 700392 / 26695)	27%	100%
P0DA10	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	27%	100%
P0DA11	Streptococcus pyogenes serotype M3 (strain SSI-1)	27%	100%
P55061	Homo sapiens	28%	100%
Q0V882	Bos taurus	30%	100%
Q4QAL3	Leishmania major	87%	100%
Q5R7R1	Pongo abelii	29%	100%
Q5XDQ1	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	27%	100%
Q66RM2	Sus scrofa	29%	100%
Q8P2D4	Streptococcus pyogenes serotype M18 (strain MGAS8232)	27%	100%
Q9A1B9	Streptococcus pyogenes serotype M1	26%	100%
Q9D2C7	Mus musculus	30%	100%
Q9IA79	Paralichthys olivaceus	28%	100%
Q9LD45	Arabidopsis thaliana	35%	100%
Q9PIQ8	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	26%	100%
Q9VSH3	Drosophila melanogaster	25%	100%
Q9ZKT1	Helicobacter pylori (strain J99 / ATCC 700824)	28%	100%
V5BAK0	Trypanosoma cruzi	71%	100%