SURF6 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surfeit locus protein 6, putative

Species:

Leishmania braziliensis

UniProt:

A4HDH5_LEIBR

TriTrypDb:

LbrM.24.1200 , LBRM2903_240018100

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HDH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDH5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0042274	ribosomal small subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.309
CLV_NRD_NRD_1	16	18	PF00675	0.584
CLV_NRD_NRD_1	160	162	PF00675	0.332
CLV_NRD_NRD_1	197	199	PF00675	0.309
CLV_NRD_NRD_1	209	211	PF00675	0.473
CLV_NRD_NRD_1	250	252	PF00675	0.691
CLV_NRD_NRD_1	257	259	PF00675	0.658
CLV_NRD_NRD_1	52	54	PF00675	0.674
CLV_PCSK_FUR_1	161	165	PF00082	0.239
CLV_PCSK_KEX2_1	109	111	PF00082	0.309
CLV_PCSK_KEX2_1	16	18	PF00082	0.584
CLV_PCSK_KEX2_1	160	162	PF00082	0.333
CLV_PCSK_KEX2_1	163	165	PF00082	0.336
CLV_PCSK_KEX2_1	168	170	PF00082	0.339
CLV_PCSK_KEX2_1	172	174	PF00082	0.345
CLV_PCSK_KEX2_1	208	210	PF00082	0.548
CLV_PCSK_KEX2_1	250	252	PF00082	0.557
CLV_PCSK_KEX2_1	257	259	PF00082	0.620
CLV_PCSK_KEX2_1	52	54	PF00082	0.693
CLV_PCSK_KEX2_1	93	95	PF00082	0.309
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.323
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.329
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.340
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.548
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.669
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.309
CLV_PCSK_PC7_1	164	170	PF00082	0.350
CLV_PCSK_PC7_1	204	210	PF00082	0.453
CLV_PCSK_SKI1_1	111	115	PF00082	0.323
CLV_PCSK_SKI1_1	169	173	PF00082	0.297
CLV_PCSK_SKI1_1	210	214	PF00082	0.672
CLV_PCSK_SKI1_1	53	57	PF00082	0.333
DEG_Nend_UBRbox_1	1	4	PF02207	0.651
DOC_AGCK_PIF_2	80	85	PF00069	0.309
DOC_MAPK_gen_1	52	62	PF00069	0.229
DOC_MAPK_MEF2A_6	53	62	PF00069	0.359
DOC_MAPK_MEF2A_6	71	80	PF00069	0.215
DOC_MAPK_NFAT4_5	71	79	PF00069	0.229
DOC_USP7_MATH_1	21	25	PF00917	0.563
DOC_USP7_MATH_1	34	38	PF00917	0.534
DOC_USP7_MATH_1	45	49	PF00917	0.646
DOC_USP7_MATH_1	58	62	PF00917	0.392
DOC_USP7_UBL2_3	154	158	PF12436	0.299
DOC_USP7_UBL2_3	168	172	PF12436	0.250
DOC_USP7_UBL2_3	192	196	PF12436	0.460
DOC_USP7_UBL2_3	89	93	PF12436	0.309
LIG_14-3-3_CanoR_1	110	119	PF00244	0.323
LIG_14-3-3_CanoR_1	164	170	PF00244	0.309
LIG_14-3-3_CanoR_1	57	63	PF00244	0.504
LIG_14-3-3_CanoR_1	65	69	PF00244	0.271
LIG_CtBP_PxDLS_1	75	79	PF00389	0.309
LIG_FHA_1	65	71	PF00498	0.224
LIG_LIR_Gen_1	84	91	PF02991	0.309
LIG_LIR_Nem_3	77	83	PF02991	0.309
LIG_NRBOX	100	106	PF00104	0.309
LIG_NRP_CendR_1	257	260	PF00754	0.699
LIG_PTB_Apo_2	79	86	PF02174	0.334
LIG_SUMO_SIM_par_1	74	79	PF11976	0.328
MOD_CK1_1	24	30	PF00069	0.553
MOD_Cter_Amidation	14	17	PF01082	0.616
MOD_Cter_Amidation	255	258	PF01082	0.605
MOD_Cter_Amidation	91	94	PF01082	0.309
MOD_GlcNHglycan	133	136	PF01048	0.302
MOD_GlcNHglycan	139	142	PF01048	0.319
MOD_GlcNHglycan	165	168	PF01048	0.309
MOD_GlcNHglycan	19	22	PF01048	0.616
MOD_GlcNHglycan	216	219	PF01048	0.623
MOD_GlcNHglycan	25	29	PF01048	0.532
MOD_GlcNHglycan	253	256	PF01048	0.594
MOD_GSK3_1	159	166	PF00069	0.229
MOD_GSK3_1	17	24	PF00069	0.561
MOD_GSK3_1	210	217	PF00069	0.610
MOD_GSK3_1	43	50	PF00069	0.664
MOD_LATS_1	51	57	PF00433	0.515
MOD_N-GLC_1	17	22	PF02516	0.631
MOD_NEK2_1	118	123	PF00069	0.381
MOD_NEK2_1	76	81	PF00069	0.340
MOD_PIKK_1	118	124	PF00454	0.229
MOD_PIKK_1	34	40	PF00454	0.525
MOD_PIKK_1	64	70	PF00454	0.224
MOD_PK_1	186	192	PF00069	0.309
MOD_PKA_1	163	169	PF00069	0.315
MOD_PKA_1	198	204	PF00069	0.229
MOD_PKA_1	53	59	PF00069	0.338
MOD_PKA_2	159	165	PF00069	0.399
MOD_PKA_2	56	62	PF00069	0.469
MOD_PKA_2	64	70	PF00069	0.277
MOD_Plk_1	177	183	PF00069	0.348
MOD_Plk_1	186	192	PF00069	0.345
MOD_Plk_1	76	82	PF00069	0.309
MOD_Plk_1	99	105	PF00069	0.309
MOD_Plk_4	100	106	PF00069	0.309
MOD_SUMO_rev_2	84	91	PF00179	0.309
TRG_DiLeu_BaEn_1	100	105	PF01217	0.309
TRG_ER_diArg_1	257	260	PF00400	0.548
TRG_NLS_Bipartite_1	160	176	PF00514	0.228
TRG_NLS_MonoExtN_4	169	176	PF00514	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5P3	Leptomonas seymouri	69%	100%
A0A3S7WYB0	Leishmania donovani	77%	100%
A4I0V6	Leishmania infantum	77%	100%
E9AWW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QAL4	Leishmania major	78%	100%