Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDH4_LEIBR

TriTrypDb:

LbrM.24.1190 , LBRM2903_240018000

Length:

1176

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	861	865	PF00656	0.455
CLV_C14_Caspase3-7	877	881	PF00656	0.388
CLV_C14_Caspase3-7	924	928	PF00656	0.713
CLV_C14_Caspase3-7	930	934	PF00656	0.716
CLV_NRD_NRD_1	1129	1131	PF00675	0.564
CLV_NRD_NRD_1	172	174	PF00675	0.744
CLV_NRD_NRD_1	384	386	PF00675	0.616
CLV_NRD_NRD_1	438	440	PF00675	0.593
CLV_NRD_NRD_1	460	462	PF00675	0.636
CLV_NRD_NRD_1	565	567	PF00675	0.596
CLV_NRD_NRD_1	673	675	PF00675	0.447
CLV_PCSK_KEX2_1	172	174	PF00082	0.719
CLV_PCSK_KEX2_1	384	386	PF00082	0.616
CLV_PCSK_KEX2_1	437	439	PF00082	0.588
CLV_PCSK_KEX2_1	460	462	PF00082	0.701
CLV_PCSK_KEX2_1	565	567	PF00082	0.596
CLV_PCSK_KEX2_1	673	675	PF00082	0.447
CLV_PCSK_PC7_1	434	440	PF00082	0.484
CLV_PCSK_SKI1_1	267	271	PF00082	0.709
CLV_PCSK_SKI1_1	441	445	PF00082	0.596
CLV_PCSK_SKI1_1	461	465	PF00082	0.609
CLV_PCSK_SKI1_1	695	699	PF00082	0.626
CLV_PCSK_SKI1_1	70	74	PF00082	0.541
CLV_PCSK_SKI1_1	975	979	PF00082	0.524
DEG_APCC_DBOX_1	694	702	PF00400	0.599
DEG_SCF_FBW7_2	72	77	PF00400	0.516
DEG_SPOP_SBC_1	1001	1005	PF00917	0.575
DOC_CKS1_1	71	76	PF01111	0.518
DOC_MAPK_gen_1	565	575	PF00069	0.570
DOC_MAPK_gen_1	673	681	PF00069	0.431
DOC_MAPK_HePTP_8	563	575	PF00069	0.615
DOC_MAPK_MEF2A_6	550	558	PF00069	0.597
DOC_MAPK_MEF2A_6	566	575	PF00069	0.581
DOC_MAPK_MEF2A_6	722	730	PF00069	0.434
DOC_MAPK_MEF2A_6	749	756	PF00069	0.511
DOC_PP2B_LxvP_1	147	150	PF13499	0.531
DOC_PP2B_LxvP_1	350	353	PF13499	0.657
DOC_PP2B_LxvP_1	517	520	PF13499	0.552
DOC_PP2B_LxvP_1	723	726	PF13499	0.659
DOC_PP4_FxxP_1	71	74	PF00568	0.516
DOC_USP7_MATH_1	100	104	PF00917	0.753
DOC_USP7_MATH_1	1040	1044	PF00917	0.705
DOC_USP7_MATH_1	1058	1062	PF00917	0.505
DOC_USP7_MATH_1	1066	1070	PF00917	0.701
DOC_USP7_MATH_1	123	127	PF00917	0.615
DOC_USP7_MATH_1	20	24	PF00917	0.602
DOC_USP7_MATH_1	582	586	PF00917	0.648
DOC_USP7_MATH_1	703	707	PF00917	0.643
DOC_USP7_MATH_1	914	918	PF00917	0.701
DOC_USP7_MATH_1	943	947	PF00917	0.456
DOC_WW_Pin1_4	1008	1013	PF00397	0.782
DOC_WW_Pin1_4	1032	1037	PF00397	0.785
DOC_WW_Pin1_4	104	109	PF00397	0.672
DOC_WW_Pin1_4	16	21	PF00397	0.572
DOC_WW_Pin1_4	240	245	PF00397	0.506
DOC_WW_Pin1_4	277	282	PF00397	0.525
DOC_WW_Pin1_4	445	450	PF00397	0.739
DOC_WW_Pin1_4	62	67	PF00397	0.662
DOC_WW_Pin1_4	662	667	PF00397	0.595
DOC_WW_Pin1_4	683	688	PF00397	0.621
DOC_WW_Pin1_4	70	75	PF00397	0.690
DOC_WW_Pin1_4	878	883	PF00397	0.554
LIG_14-3-3_CanoR_1	148	158	PF00244	0.559
LIG_14-3-3_CanoR_1	22	26	PF00244	0.673
LIG_14-3-3_CanoR_1	267	272	PF00244	0.507
LIG_14-3-3_CanoR_1	441	447	PF00244	0.631
LIG_14-3-3_CanoR_1	476	485	PF00244	0.497
LIG_14-3-3_CanoR_1	550	554	PF00244	0.685
LIG_14-3-3_CanoR_1	579	587	PF00244	0.574
LIG_14-3-3_CanoR_1	659	666	PF00244	0.647
LIG_14-3-3_CanoR_1	673	679	PF00244	0.620
LIG_14-3-3_CanoR_1	986	990	PF00244	0.695
LIG_Actin_WH2_2	1086	1101	PF00022	0.395
LIG_Actin_WH2_2	694	712	PF00022	0.429
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BIR_III_4	543	547	PF00653	0.698
LIG_BRCT_BRCA1_1	102	106	PF00533	0.526
LIG_CSL_BTD_1	517	520	PF09270	0.497
LIG_CtBP_PxDLS_1	244	248	PF00389	0.734
LIG_deltaCOP1_diTrp_1	208	214	PF00928	0.471
LIG_deltaCOP1_diTrp_1	289	294	PF00928	0.613
LIG_deltaCOP1_diTrp_1	417	425	PF00928	0.681
LIG_DLG_GKlike_1	674	681	PF00625	0.359
LIG_eIF4E_1	459	465	PF01652	0.477
LIG_FAT_LD_1	902	910	PF03623	0.355
LIG_FHA_1	1004	1010	PF00498	0.574
LIG_FHA_1	1063	1069	PF00498	0.677
LIG_FHA_1	1103	1109	PF00498	0.749
LIG_FHA_1	1165	1171	PF00498	0.365
LIG_FHA_1	125	131	PF00498	0.586
LIG_FHA_1	136	142	PF00498	0.625
LIG_FHA_1	165	171	PF00498	0.696
LIG_FHA_1	408	414	PF00498	0.479
LIG_FHA_1	442	448	PF00498	0.742
LIG_FHA_1	535	541	PF00498	0.519
LIG_FHA_1	615	621	PF00498	0.500
LIG_FHA_1	637	643	PF00498	0.627
LIG_FHA_1	665	671	PF00498	0.618
LIG_FHA_1	71	77	PF00498	0.651
LIG_FHA_1	710	716	PF00498	0.497
LIG_FHA_1	725	731	PF00498	0.373
LIG_FHA_1	969	975	PF00498	0.653
LIG_FHA_2	1002	1008	PF00498	0.669
LIG_FHA_2	105	111	PF00498	0.542
LIG_FHA_2	1105	1111	PF00498	0.513
LIG_FHA_2	414	420	PF00498	0.449
LIG_FHA_2	479	485	PF00498	0.432
LIG_FHA_2	586	592	PF00498	0.609
LIG_FHA_2	684	690	PF00498	0.508
LIG_FHA_2	733	739	PF00498	0.493
LIG_FHA_2	875	881	PF00498	0.462
LIG_FHA_2	890	896	PF00498	0.534
LIG_FHA_2	917	923	PF00498	0.653
LIG_GBD_Chelix_1	901	909	PF00786	0.589
LIG_LIR_Apic_2	1067	1073	PF02991	0.747
LIG_LIR_Apic_2	775	780	PF02991	0.603
LIG_LIR_Apic_2	8	14	PF02991	0.683
LIG_LIR_Gen_1	208	215	PF02991	0.542
LIG_LIR_Gen_1	297	308	PF02991	0.579
LIG_LIR_Gen_1	37	45	PF02991	0.436
LIG_LIR_Gen_1	410	418	PF02991	0.548
LIG_LIR_Gen_1	588	594	PF02991	0.583
LIG_LIR_Gen_1	718	728	PF02991	0.680
LIG_LIR_Gen_1	800	810	PF02991	0.499
LIG_LIR_Gen_1	84	93	PF02991	0.658
LIG_LIR_LC3C_4	965	968	PF02991	0.527
LIG_LIR_Nem_3	208	214	PF02991	0.486
LIG_LIR_Nem_3	289	294	PF02991	0.605
LIG_LIR_Nem_3	297	303	PF02991	0.534
LIG_LIR_Nem_3	37	42	PF02991	0.439
LIG_LIR_Nem_3	410	414	PF02991	0.629
LIG_LIR_Nem_3	419	425	PF02991	0.679
LIG_LIR_Nem_3	480	485	PF02991	0.497
LIG_LIR_Nem_3	552	556	PF02991	0.505
LIG_LIR_Nem_3	588	593	PF02991	0.591
LIG_LIR_Nem_3	718	723	PF02991	0.703
LIG_LIR_Nem_3	800	805	PF02991	0.423
LIG_LIR_Nem_3	82	86	PF02991	0.619
LIG_LIR_Nem_3	933	938	PF02991	0.670
LIG_LIR_Nem_3	960	966	PF02991	0.618
LIG_LYPXL_yS_3	553	556	PF13949	0.580
LIG_NRBOX	644	650	PF00104	0.632
LIG_PCNA_PIPBox_1	488	497	PF02747	0.616
LIG_PCNA_yPIPBox_3	486	495	PF02747	0.622
LIG_PTB_Apo_2	129	136	PF02174	0.501
LIG_PTB_Apo_2	463	470	PF02174	0.556
LIG_PTB_Phospho_1	463	469	PF10480	0.555
LIG_Rb_LxCxE_1	588	606	PF01857	0.535
LIG_REV1ctd_RIR_1	480	490	PF16727	0.669
LIG_RPA_C_Fungi	669	681	PF08784	0.409
LIG_SH2_CRK	194	198	PF00017	0.632
LIG_SH2_CRK	361	365	PF00017	0.589
LIG_SH2_CRK	459	463	PF00017	0.679
LIG_SH2_CRK	469	473	PF00017	0.630
LIG_SH2_CRK	777	781	PF00017	0.629
LIG_SH2_CRK	86	90	PF00017	0.721
LIG_SH2_NCK_1	300	304	PF00017	0.595
LIG_SH2_NCK_1	777	781	PF00017	0.608
LIG_SH2_PTP2	802	805	PF00017	0.494
LIG_SH2_PTP2	935	938	PF00017	0.658
LIG_SH2_SRC	119	122	PF00017	0.681
LIG_SH2_SRC	935	938	PF00017	0.658
LIG_SH2_STAP1	300	304	PF00017	0.532
LIG_SH2_STAP1	469	473	PF00017	0.548
LIG_SH2_STAP1	590	594	PF00017	0.565
LIG_SH2_STAT3	494	497	PF00017	0.628
LIG_SH2_STAT5	11	14	PF00017	0.651
LIG_SH2_STAT5	119	122	PF00017	0.657
LIG_SH2_STAT5	134	137	PF00017	0.409
LIG_SH2_STAT5	293	296	PF00017	0.454
LIG_SH2_STAT5	5	8	PF00017	0.600
LIG_SH2_STAT5	720	723	PF00017	0.706
LIG_SH2_STAT5	760	763	PF00017	0.497
LIG_SH2_STAT5	802	805	PF00017	0.494
LIG_SH2_STAT5	86	89	PF00017	0.545
LIG_SH2_STAT5	866	869	PF00017	0.652
LIG_SH2_STAT5	887	890	PF00017	0.454
LIG_SH2_STAT5	935	938	PF00017	0.658
LIG_SH3_3	305	311	PF00018	0.459
LIG_SH3_3	399	405	PF00018	0.746
LIG_SH3_3	443	449	PF00018	0.740
LIG_SH3_3	469	475	PF00018	0.633
LIG_SH3_3	507	513	PF00018	0.567
LIG_SH3_3	619	625	PF00018	0.537
LIG_SH3_3	787	793	PF00018	0.539
LIG_SH3_3	824	830	PF00018	0.641
LIG_SH3_3	864	870	PF00018	0.456
LIG_SUMO_SIM_anti_2	136	143	PF11976	0.593
LIG_SUMO_SIM_anti_2	570	577	PF11976	0.566
LIG_SUMO_SIM_anti_2	599	606	PF11976	0.417
LIG_SUMO_SIM_anti_2	677	682	PF11976	0.326
LIG_SUMO_SIM_anti_2	880	887	PF11976	0.541
LIG_SUMO_SIM_par_1	136	143	PF11976	0.589
LIG_SUMO_SIM_par_1	570	577	PF11976	0.493
LIG_SUMO_SIM_par_1	616	621	PF11976	0.680
LIG_TRAF2_1	416	419	PF00917	0.461
LIG_TRAF2_1	687	690	PF00917	0.464
LIG_TRAF2_1	810	813	PF00917	0.501
LIG_TYR_ITIM	457	462	PF00017	0.484
LIG_WW_3	309	313	PF00397	0.601
MOD_CDC14_SPxK_1	19	22	PF00782	0.493
MOD_CDK_SPK_2	1008	1013	PF00069	0.651
MOD_CDK_SPK_2	1032	1037	PF00069	0.549
MOD_CDK_SPxK_1	16	22	PF00069	0.491
MOD_CK1_1	1020	1026	PF00069	0.674
MOD_CK1_1	104	110	PF00069	0.668
MOD_CK1_1	1050	1056	PF00069	0.642
MOD_CK1_1	176	182	PF00069	0.724
MOD_CK1_1	280	286	PF00069	0.519
MOD_CK1_1	320	326	PF00069	0.752
MOD_CK1_1	407	413	PF00069	0.483
MOD_CK1_1	445	451	PF00069	0.736
MOD_CK1_1	585	591	PF00069	0.553
MOD_CK1_1	614	620	PF00069	0.533
MOD_CK1_1	785	791	PF00069	0.580
MOD_CK1_1	839	845	PF00069	0.603
MOD_CK1_1	872	878	PF00069	0.574
MOD_CK1_1	917	923	PF00069	0.610
MOD_CK1_1	925	931	PF00069	0.601
MOD_CK1_1	952	958	PF00069	0.561
MOD_CK2_1	1001	1007	PF00069	0.662
MOD_CK2_1	1156	1162	PF00069	0.393
MOD_CK2_1	413	419	PF00069	0.453
MOD_CK2_1	585	591	PF00069	0.610
MOD_CK2_1	683	689	PF00069	0.503
MOD_CK2_1	894	900	PF00069	0.536
MOD_CK2_1	943	949	PF00069	0.447
MOD_GlcNHglycan	1019	1022	PF01048	0.671
MOD_GlcNHglycan	103	106	PF01048	0.574
MOD_GlcNHglycan	1042	1045	PF01048	0.659
MOD_GlcNHglycan	1048	1052	PF01048	0.696
MOD_GlcNHglycan	1112	1115	PF01048	0.543
MOD_GlcNHglycan	1133	1136	PF01048	0.618
MOD_GlcNHglycan	175	178	PF01048	0.739
MOD_GlcNHglycan	183	186	PF01048	0.801
MOD_GlcNHglycan	216	219	PF01048	0.640
MOD_GlcNHglycan	322	325	PF01048	0.769
MOD_GlcNHglycan	327	331	PF01048	0.745
MOD_GlcNHglycan	343	346	PF01048	0.470
MOD_GlcNHglycan	380	383	PF01048	0.695
MOD_GlcNHglycan	406	409	PF01048	0.742
MOD_GlcNHglycan	580	583	PF01048	0.521
MOD_GlcNHglycan	584	587	PF01048	0.629
MOD_GlcNHglycan	715	718	PF01048	0.690
MOD_GlcNHglycan	738	742	PF01048	0.749
MOD_GlcNHglycan	784	787	PF01048	0.687
MOD_GlcNHglycan	836	839	PF01048	0.744
MOD_GlcNHglycan	916	919	PF01048	0.608
MOD_GlcNHglycan	955	958	PF01048	0.653
MOD_GSK3_1	100	107	PF00069	0.617
MOD_GSK3_1	1017	1024	PF00069	0.709
MOD_GSK3_1	1058	1065	PF00069	0.675
MOD_GSK3_1	16	23	PF00069	0.603
MOD_GSK3_1	176	183	PF00069	0.636
MOD_GSK3_1	273	280	PF00069	0.526
MOD_GSK3_1	34	41	PF00069	0.437
MOD_GSK3_1	441	448	PF00069	0.741
MOD_GSK3_1	578	585	PF00069	0.495
MOD_GSK3_1	654	661	PF00069	0.487
MOD_GSK3_1	699	706	PF00069	0.547
MOD_GSK3_1	709	716	PF00069	0.608
MOD_GSK3_1	818	825	PF00069	0.517
MOD_GSK3_1	832	839	PF00069	0.611
MOD_GSK3_1	842	849	PF00069	0.576
MOD_GSK3_1	868	875	PF00069	0.693
MOD_GSK3_1	889	896	PF00069	0.607
MOD_GSK3_1	910	917	PF00069	0.484
MOD_GSK3_1	941	948	PF00069	0.519
MOD_GSK3_1	949	956	PF00069	0.610
MOD_GSK3_1	999	1006	PF00069	0.652
MOD_LATS_1	1129	1135	PF00433	0.531
MOD_N-GLC_1	267	272	PF02516	0.507
MOD_N-GLC_1	709	714	PF02516	0.509
MOD_NEK2_1	1156	1161	PF00069	0.520
MOD_NEK2_1	135	140	PF00069	0.526
MOD_NEK2_1	304	309	PF00069	0.710
MOD_NEK2_1	354	359	PF00069	0.539
MOD_NEK2_1	364	369	PF00069	0.455
MOD_NEK2_1	380	385	PF00069	0.619
MOD_NEK2_1	442	447	PF00069	0.713
MOD_NEK2_1	477	482	PF00069	0.610
MOD_NEK2_1	7	12	PF00069	0.624
MOD_NEK2_1	709	714	PF00069	0.638
MOD_NEK2_1	732	737	PF00069	0.533
MOD_NEK2_2	262	267	PF00069	0.534
MOD_PIKK_1	1143	1149	PF00454	0.366
MOD_PIKK_1	34	40	PF00454	0.436
MOD_PIKK_1	779	785	PF00454	0.776
MOD_PIKK_1	848	854	PF00454	0.351
MOD_PIKK_1	987	993	PF00454	0.529
MOD_PK_1	611	617	PF00069	0.600
MOD_PKA_2	179	185	PF00069	0.616
MOD_PKA_2	21	27	PF00069	0.512
MOD_PKA_2	534	540	PF00069	0.573
MOD_PKA_2	549	555	PF00069	0.673
MOD_PKA_2	578	584	PF00069	0.590
MOD_PKA_2	636	642	PF00069	0.480
MOD_PKA_2	658	664	PF00069	0.574
MOD_PKA_2	822	828	PF00069	0.690
MOD_PKA_2	910	916	PF00069	0.593
MOD_PKA_2	985	991	PF00069	0.747
MOD_PKA_2	994	1000	PF00069	0.819
MOD_PKB_1	439	447	PF00069	0.695
MOD_Plk_1	1066	1072	PF00069	0.729
MOD_Plk_1	267	273	PF00069	0.742
MOD_Plk_1	34	40	PF00069	0.436
MOD_Plk_1	7	13	PF00069	0.628
MOD_Plk_2-3	156	162	PF00069	0.474
MOD_Plk_4	1066	1072	PF00069	0.685
MOD_Plk_4	124	130	PF00069	0.561
MOD_Plk_4	364	370	PF00069	0.500
MOD_Plk_4	38	44	PF00069	0.581
MOD_Plk_4	407	413	PF00069	0.576
MOD_Plk_4	442	448	PF00069	0.695
MOD_Plk_4	478	484	PF00069	0.428
MOD_Plk_4	559	565	PF00069	0.458
MOD_Plk_4	589	595	PF00069	0.381
MOD_Plk_4	674	680	PF00069	0.366
MOD_Plk_4	7	13	PF00069	0.601
MOD_Plk_4	756	762	PF00069	0.582
MOD_Plk_4	772	778	PF00069	0.621
MOD_Plk_4	84	90	PF00069	0.597
MOD_Plk_4	842	848	PF00069	0.554
MOD_Plk_4	931	937	PF00069	0.465
MOD_ProDKin_1	1008	1014	PF00069	0.782
MOD_ProDKin_1	1032	1038	PF00069	0.780
MOD_ProDKin_1	104	110	PF00069	0.670
MOD_ProDKin_1	16	22	PF00069	0.576
MOD_ProDKin_1	240	246	PF00069	0.505
MOD_ProDKin_1	277	283	PF00069	0.516
MOD_ProDKin_1	445	451	PF00069	0.739
MOD_ProDKin_1	62	68	PF00069	0.665
MOD_ProDKin_1	662	668	PF00069	0.593
MOD_ProDKin_1	683	689	PF00069	0.619
MOD_ProDKin_1	70	76	PF00069	0.688
MOD_ProDKin_1	878	884	PF00069	0.543
TRG_DiLeu_BaEn_1	84	89	PF01217	0.532
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.468
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.501
TRG_ENDOCYTIC_2	194	197	PF00928	0.635
TRG_ENDOCYTIC_2	300	303	PF00928	0.631
TRG_ENDOCYTIC_2	361	364	PF00928	0.596
TRG_ENDOCYTIC_2	459	462	PF00928	0.684
TRG_ENDOCYTIC_2	469	472	PF00928	0.636
TRG_ENDOCYTIC_2	553	556	PF00928	0.580
TRG_ENDOCYTIC_2	590	593	PF00928	0.522
TRG_ENDOCYTIC_2	720	723	PF00928	0.706
TRG_ENDOCYTIC_2	802	805	PF00928	0.494
TRG_ENDOCYTIC_2	86	89	PF00928	0.632
TRG_ENDOCYTIC_2	935	938	PF00928	0.658
TRG_ENDOCYTIC_2	963	966	PF00928	0.653
TRG_ER_diArg_1	171	173	PF00400	0.719
TRG_ER_diArg_1	436	439	PF00400	0.589
TRG_ER_diArg_1	459	461	PF00400	0.706
TRG_ER_diArg_1	564	566	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	848	852	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I480	Leptomonas seymouri	35%	100%
A0A3S7WYG5	Leishmania donovani	68%	95%
A0A422NQA5	Trypanosoma rangeli	25%	100%
A4I0V5	Leishmania infantum	68%	92%
E9AWV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QAL5	Leishmania major	67%	100%
V5BVQ3	Trypanosoma cruzi	24%	100%