Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HDH3_LEIBR

TriTrypDb:

LbrM.24.1180 , LBRM2903_240017900

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.528
CLV_C14_Caspase3-7	324	328	PF00656	0.508
CLV_NRD_NRD_1	291	293	PF00675	0.376
CLV_NRD_NRD_1	349	351	PF00675	0.519
CLV_NRD_NRD_1	407	409	PF00675	0.661
CLV_NRD_NRD_1	52	54	PF00675	0.617
CLV_NRD_NRD_1	529	531	PF00675	0.573
CLV_NRD_NRD_1	689	691	PF00675	0.477
CLV_NRD_NRD_1	694	696	PF00675	0.435
CLV_NRD_NRD_1	714	716	PF00675	0.510
CLV_NRD_NRD_1	718	720	PF00675	0.512
CLV_PCSK_FUR_1	527	531	PF00082	0.570
CLV_PCSK_FUR_1	715	719	PF00082	0.545
CLV_PCSK_KEX2_1	291	293	PF00082	0.376
CLV_PCSK_KEX2_1	348	350	PF00082	0.521
CLV_PCSK_KEX2_1	407	409	PF00082	0.661
CLV_PCSK_KEX2_1	52	54	PF00082	0.617
CLV_PCSK_KEX2_1	529	531	PF00082	0.573
CLV_PCSK_KEX2_1	585	587	PF00082	0.576
CLV_PCSK_KEX2_1	689	691	PF00082	0.477
CLV_PCSK_KEX2_1	694	696	PF00082	0.435
CLV_PCSK_KEX2_1	714	716	PF00082	0.510
CLV_PCSK_KEX2_1	717	719	PF00082	0.512
CLV_PCSK_KEX2_1	791	793	PF00082	0.496
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.576
CLV_PCSK_PC1ET2_1	791	793	PF00082	0.496
CLV_PCSK_PC7_1	344	350	PF00082	0.513
CLV_PCSK_PC7_1	690	696	PF00082	0.366
CLV_PCSK_PC7_1	714	720	PF00082	0.543
CLV_PCSK_SKI1_1	213	217	PF00082	0.356
CLV_PCSK_SKI1_1	256	260	PF00082	0.516
CLV_PCSK_SKI1_1	690	694	PF00082	0.531
CLV_PCSK_SKI1_1	791	795	PF00082	0.331
DEG_APCC_DBOX_1	130	138	PF00400	0.580
DEG_APCC_DBOX_1	681	689	PF00400	0.467
DEG_Nend_UBRbox_2	1	3	PF02207	0.478
DOC_ANK_TNKS_1	512	519	PF00023	0.575
DOC_CYCLIN_RxL_1	207	218	PF00134	0.368
DOC_CYCLIN_RxL_1	533	546	PF00134	0.705
DOC_MAPK_gen_1	223	230	PF00069	0.358
DOC_MAPK_gen_1	314	321	PF00069	0.536
DOC_MAPK_gen_1	717	728	PF00069	0.559
DOC_MAPK_MEF2A_6	719	728	PF00069	0.402
DOC_PP2B_LxvP_1	634	637	PF13499	0.633
DOC_USP7_MATH_1	195	199	PF00917	0.512
DOC_USP7_MATH_1	270	274	PF00917	0.400
DOC_USP7_MATH_1	286	290	PF00917	0.391
DOC_USP7_MATH_1	364	368	PF00917	0.571
DOC_USP7_MATH_1	437	441	PF00917	0.523
DOC_USP7_MATH_1	466	470	PF00917	0.631
DOC_USP7_MATH_1	47	51	PF00917	0.667
DOC_USP7_MATH_1	472	476	PF00917	0.599
DOC_USP7_MATH_1	549	553	PF00917	0.650
DOC_USP7_MATH_1	588	592	PF00917	0.630
DOC_USP7_MATH_1	676	680	PF00917	0.634
DOC_USP7_MATH_1	705	709	PF00917	0.381
DOC_USP7_MATH_1	737	741	PF00917	0.715
DOC_USP7_MATH_1	91	95	PF00917	0.582
DOC_USP7_UBL2_3	310	314	PF12436	0.499
DOC_WW_Pin1_4	342	347	PF00397	0.613
DOC_WW_Pin1_4	43	48	PF00397	0.599
DOC_WW_Pin1_4	443	448	PF00397	0.579
DOC_WW_Pin1_4	452	457	PF00397	0.693
DOC_WW_Pin1_4	533	538	PF00397	0.723
DOC_WW_Pin1_4	543	548	PF00397	0.622
DOC_WW_Pin1_4	604	609	PF00397	0.702
DOC_WW_Pin1_4	65	70	PF00397	0.626
DOC_WW_Pin1_4	672	677	PF00397	0.655
DOC_WW_Pin1_4	733	738	PF00397	0.690
LIG_14-3-3_CanoR_1	24	29	PF00244	0.496
LIG_14-3-3_CanoR_1	370	378	PF00244	0.558
LIG_14-3-3_CanoR_1	420	429	PF00244	0.562
LIG_14-3-3_CanoR_1	438	442	PF00244	0.498
LIG_14-3-3_CanoR_1	457	466	PF00244	0.686
LIG_14-3-3_CanoR_1	500	509	PF00244	0.567
LIG_14-3-3_CanoR_1	52	59	PF00244	0.528
LIG_14-3-3_CanoR_1	539	544	PF00244	0.709
LIG_14-3-3_CanoR_1	725	731	PF00244	0.498
LIG_14-3-3_CanoR_1	748	752	PF00244	0.553
LIG_Actin_WH2_2	681	696	PF00022	0.525
LIG_CaM_NSCaTE_8	138	145	PF13499	0.525
LIG_FHA_1	118	124	PF00498	0.590
LIG_FHA_1	224	230	PF00498	0.521
LIG_FHA_1	371	377	PF00498	0.565
LIG_FHA_1	592	598	PF00498	0.625
LIG_FHA_1	651	657	PF00498	0.566
LIG_FHA_1	721	727	PF00498	0.566
LIG_FHA_1	748	754	PF00498	0.580
LIG_FHA_2	431	437	PF00498	0.524
LIG_FHA_2	479	485	PF00498	0.646
LIG_FHA_2	562	568	PF00498	0.545
LIG_HCF-1_HBM_1	782	785	PF13415	0.378
LIG_LIR_Apic_2	570	576	PF02991	0.550
LIG_LIR_Apic_2	627	633	PF02991	0.532
LIG_LIR_Gen_1	136	146	PF02991	0.706
LIG_LIR_Gen_1	355	364	PF02991	0.498
LIG_LIR_Gen_1	565	576	PF02991	0.552
LIG_LIR_Gen_1	782	793	PF02991	0.516
LIG_LIR_Nem_3	136	141	PF02991	0.703
LIG_LIR_Nem_3	355	361	PF02991	0.502
LIG_LIR_Nem_3	552	558	PF02991	0.562
LIG_LIR_Nem_3	565	571	PF02991	0.554
LIG_LIR_Nem_3	782	788	PF02991	0.526
LIG_LYPXL_yS_3	587	590	PF13949	0.561
LIG_PTB_Apo_2	393	400	PF02174	0.541
LIG_PTB_Phospho_1	393	399	PF10480	0.542
LIG_RPA_C_Fungi	704	716	PF08784	0.480
LIG_SH2_NCK_1	188	192	PF00017	0.587
LIG_SH2_NCK_1	399	403	PF00017	0.529
LIG_SH2_NCK_1	573	577	PF00017	0.550
LIG_SH2_NCK_1	785	789	PF00017	0.510
LIG_SH2_SRC	573	576	PF00017	0.551
LIG_SH2_SRC	785	788	PF00017	0.510
LIG_SH2_STAP1	188	192	PF00017	0.587
LIG_SH2_STAP1	264	268	PF00017	0.374
LIG_SH2_STAP1	558	562	PF00017	0.555
LIG_SH2_STAT3	264	267	PF00017	0.370
LIG_SH2_STAT5	140	143	PF00017	0.587
LIG_SH3_3	173	179	PF00018	0.672
LIG_SH3_3	187	193	PF00018	0.562
LIG_SH3_3	453	459	PF00018	0.732
LIG_SH3_3	460	466	PF00018	0.657
LIG_SH3_3	532	538	PF00018	0.565
LIG_SH3_3	550	556	PF00018	0.523
LIG_SH3_3	602	608	PF00018	0.585
LIG_SUMO_SIM_par_1	14	20	PF11976	0.601
LIG_SxIP_EBH_1	545	554	PF03271	0.558
LIG_SxIP_EBH_1	601	610	PF03271	0.565
LIG_TRAF2_1	179	182	PF00917	0.526
LIG_TRAF2_1	20	23	PF00917	0.452
LIG_UBA3_1	215	223	PF00899	0.356
LIG_WW_3	536	540	PF00397	0.560
MOD_CDC14_SPxK_1	345	348	PF00782	0.513
MOD_CDC14_SPxK_1	46	49	PF00782	0.533
MOD_CDC14_SPxK_1	536	539	PF00782	0.697
MOD_CDK_SPK_2	452	457	PF00069	0.576
MOD_CDK_SPxK_1	342	348	PF00069	0.494
MOD_CDK_SPxK_1	43	49	PF00069	0.535
MOD_CDK_SPxK_1	533	539	PF00069	0.702
MOD_CDK_SPxxK_3	342	349	PF00069	0.497
MOD_CK1_1	27	33	PF00069	0.681
MOD_CK1_1	369	375	PF00069	0.597
MOD_CK1_1	385	391	PF00069	0.537
MOD_CK1_1	440	446	PF00069	0.613
MOD_CK1_1	475	481	PF00069	0.679
MOD_CK1_1	488	494	PF00069	0.598
MOD_CK1_1	522	528	PF00069	0.729
MOD_CK1_1	591	597	PF00069	0.627
MOD_CK1_1	599	605	PF00069	0.618
MOD_CK1_1	615	621	PF00069	0.565
MOD_CK1_1	642	648	PF00069	0.562
MOD_CK1_1	668	674	PF00069	0.644
MOD_CK1_1	729	735	PF00069	0.653
MOD_CK1_1	736	742	PF00069	0.642
MOD_CK2_1	141	147	PF00069	0.509
MOD_CK2_1	17	23	PF00069	0.448
MOD_CK2_1	287	293	PF00069	0.371
MOD_CK2_1	356	362	PF00069	0.664
MOD_CK2_1	430	436	PF00069	0.525
MOD_CK2_1	561	567	PF00069	0.587
MOD_CK2_1	574	580	PF00069	0.523
MOD_CK2_1	735	741	PF00069	0.546
MOD_GlcNHglycan	127	130	PF01048	0.427
MOD_GlcNHglycan	143	146	PF01048	0.559
MOD_GlcNHglycan	162	165	PF01048	0.488
MOD_GlcNHglycan	29	32	PF01048	0.703
MOD_GlcNHglycan	358	361	PF01048	0.663
MOD_GlcNHglycan	366	369	PF01048	0.588
MOD_GlcNHglycan	391	394	PF01048	0.579
MOD_GlcNHglycan	474	477	PF01048	0.714
MOD_GlcNHglycan	49	52	PF01048	0.599
MOD_GlcNHglycan	524	527	PF01048	0.589
MOD_GlcNHglycan	53	56	PF01048	0.594
MOD_GlcNHglycan	590	593	PF01048	0.687
MOD_GlcNHglycan	601	604	PF01048	0.601
MOD_GlcNHglycan	644	647	PF01048	0.688
MOD_GlcNHglycan	731	734	PF01048	0.631
MOD_GlcNHglycan	93	96	PF01048	0.588
MOD_GSK3_1	155	162	PF00069	0.515
MOD_GSK3_1	219	226	PF00069	0.535
MOD_GSK3_1	287	294	PF00069	0.371
MOD_GSK3_1	35	42	PF00069	0.625
MOD_GSK3_1	362	369	PF00069	0.659
MOD_GSK3_1	376	383	PF00069	0.589
MOD_GSK3_1	385	392	PF00069	0.688
MOD_GSK3_1	403	410	PF00069	0.532
MOD_GSK3_1	43	50	PF00069	0.566
MOD_GSK3_1	436	443	PF00069	0.670
MOD_GSK3_1	474	481	PF00069	0.663
MOD_GSK3_1	488	495	PF00069	0.572
MOD_GSK3_1	539	546	PF00069	0.571
MOD_GSK3_1	61	68	PF00069	0.763
MOD_GSK3_1	615	622	PF00069	0.559
MOD_GSK3_1	642	649	PF00069	0.586
MOD_GSK3_1	668	675	PF00069	0.644
MOD_GSK3_1	729	736	PF00069	0.659
MOD_LATS_1	221	227	PF00433	0.352
MOD_N-GLC_1	452	457	PF02516	0.576
MOD_N-GLC_1	485	490	PF02516	0.655
MOD_N-GLC_1	519	524	PF02516	0.567
MOD_N-GLC_1	650	655	PF02516	0.641
MOD_N-GLC_1	726	731	PF02516	0.615
MOD_N-GLC_2	380	382	PF02516	0.690
MOD_NEK2_1	117	122	PF00069	0.442
MOD_NEK2_1	141	146	PF00069	0.593
MOD_NEK2_1	160	165	PF00069	0.560
MOD_NEK2_1	26	31	PF00069	0.615
MOD_NEK2_1	309	314	PF00069	0.525
MOD_NEK2_1	340	345	PF00069	0.483
MOD_NEK2_1	403	408	PF00069	0.599
MOD_NEK2_1	485	490	PF00069	0.622
MOD_NEK2_1	531	536	PF00069	0.708
MOD_NEK2_1	86	91	PF00069	0.629
MOD_NEK2_2	353	358	PF00069	0.512
MOD_NEK2_2	639	644	PF00069	0.559
MOD_PIKK_1	270	276	PF00454	0.517
MOD_PIKK_1	291	297	PF00454	0.418
MOD_PIKK_1	421	427	PF00454	0.538
MOD_PIKK_1	615	621	PF00454	0.562
MOD_PK_1	24	30	PF00069	0.503
MOD_PKA_1	291	297	PF00069	0.377
MOD_PKA_1	407	413	PF00069	0.628
MOD_PKA_2	147	153	PF00069	0.650
MOD_PKA_2	275	281	PF00069	0.474
MOD_PKA_2	291	297	PF00069	0.366
MOD_PKA_2	340	346	PF00069	0.490
MOD_PKA_2	369	375	PF00069	0.554
MOD_PKA_2	389	395	PF00069	0.517
MOD_PKA_2	407	413	PF00069	0.594
MOD_PKA_2	437	443	PF00069	0.532
MOD_PKA_2	499	505	PF00069	0.565
MOD_PKA_2	51	57	PF00069	0.611
MOD_PKA_2	720	726	PF00069	0.557
MOD_PKA_2	747	753	PF00069	0.623
MOD_Plk_1	184	190	PF00069	0.529
MOD_Plk_1	223	229	PF00069	0.421
MOD_Plk_1	485	491	PF00069	0.626
MOD_Plk_1	531	537	PF00069	0.643
MOD_Plk_1	650	656	PF00069	0.564
MOD_Plk_1	726	732	PF00069	0.619
MOD_Plk_1	98	104	PF00069	0.492
MOD_Plk_2-3	17	23	PF00069	0.448
MOD_Plk_2-3	561	567	PF00069	0.568
MOD_Plk_4	133	139	PF00069	0.579
MOD_Plk_4	353	359	PF00069	0.549
MOD_Plk_4	437	443	PF00069	0.530
MOD_Plk_4	747	753	PF00069	0.523
MOD_ProDKin_1	342	348	PF00069	0.617
MOD_ProDKin_1	43	49	PF00069	0.601
MOD_ProDKin_1	443	449	PF00069	0.581
MOD_ProDKin_1	452	458	PF00069	0.687
MOD_ProDKin_1	533	539	PF00069	0.724
MOD_ProDKin_1	543	549	PF00069	0.620
MOD_ProDKin_1	604	610	PF00069	0.702
MOD_ProDKin_1	65	71	PF00069	0.620
MOD_ProDKin_1	672	678	PF00069	0.650
MOD_ProDKin_1	733	739	PF00069	0.693
MOD_SUMO_for_1	280	283	PF00179	0.405
MOD_SUMO_for_1	793	796	PF00179	0.338
MOD_SUMO_rev_2	181	186	PF00179	0.530
MOD_SUMO_rev_2	324	330	PF00179	0.512
MOD_SUMO_rev_2	801	807	PF00179	0.319
TRG_DiLeu_BaEn_1	204	209	PF01217	0.404
TRG_DiLeu_BaEn_4	39	45	PF01217	0.537
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.597
TRG_ENDOCYTIC_2	302	305	PF00928	0.537
TRG_ENDOCYTIC_2	587	590	PF00928	0.561
TRG_ENDOCYTIC_2	785	788	PF00928	0.510
TRG_ENDOCYTIC_2	79	82	PF00928	0.581
TRG_ER_diArg_1	347	350	PF00400	0.521
TRG_ER_diArg_1	527	530	PF00400	0.731
TRG_ER_diArg_1	682	685	PF00400	0.524
TRG_ER_diArg_1	688	690	PF00400	0.502
TRG_ER_diArg_1	693	695	PF00400	0.451
TRG_ER_diArg_1	714	717	PF00400	0.537
TRG_ER_diArg_1	82	85	PF00400	0.583
TRG_NES_CRM1_1	761	776	PF08389	0.527
TRG_NLS_MonoExtC_3	790	796	PF00514	0.336
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYH7	Leishmania donovani	64%	78%
A4I0V4	Leishmania infantum	64%	78%
E9AWV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	83%
Q4QAL6	Leishmania major	62%	100%