Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HDH1_LEIBR

TriTrypDb:

LbrM.24.1160 , LBRM2903_240017700

Length:

286

Annotations

LeishMANIAdb annotations

Related to USP9X animal ubiquitin-specific proteases. Does not appear to be a TM protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.539
CLV_NRD_NRD_1	70	72	PF00675	0.543
CLV_PCSK_KEX2_1	102	104	PF00082	0.412
CLV_PCSK_KEX2_1	11	13	PF00082	0.538
CLV_PCSK_KEX2_1	70	72	PF00082	0.522
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.368
CLV_PCSK_PC7_1	7	13	PF00082	0.475
CLV_PCSK_SKI1_1	189	193	PF00082	0.463
CLV_PCSK_SKI1_1	225	229	PF00082	0.320
CLV_PCSK_SKI1_1	259	263	PF00082	0.354
CLV_PCSK_SKI1_1	48	52	PF00082	0.505
CLV_PCSK_SKI1_1	70	74	PF00082	0.572
DEG_APCC_DBOX_1	188	196	PF00400	0.488
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DOC_MAPK_gen_1	147	156	PF00069	0.413
DOC_MAPK_gen_1	223	231	PF00069	0.235
DOC_MAPK_MEF2A_6	147	156	PF00069	0.397
DOC_MAPK_MEF2A_6	205	214	PF00069	0.460
DOC_MAPK_MEF2A_6	276	283	PF00069	0.385
DOC_PP2B_LxvP_1	176	179	PF13499	0.324
DOC_PP2B_LxvP_1	239	242	PF13499	0.501
DOC_USP7_MATH_1	133	137	PF00917	0.532
DOC_USP7_MATH_1	40	44	PF00917	0.617
DOC_USP7_MATH_1	49	53	PF00917	0.692
DOC_USP7_UBL2_3	102	106	PF12436	0.640
DOC_WW_Pin1_4	161	166	PF00397	0.295
DOC_WW_Pin1_4	58	63	PF00397	0.663
LIG_14-3-3_CanoR_1	48	54	PF00244	0.615
LIG_APCC_ABBA_1	251	256	PF00400	0.320
LIG_FHA_1	278	284	PF00498	0.520
LIG_FHA_1	4	10	PF00498	0.767
LIG_FHA_1	52	58	PF00498	0.730
LIG_FHA_2	162	168	PF00498	0.304
LIG_FHA_2	40	46	PF00498	0.485
LIG_LIR_Gen_1	167	176	PF02991	0.284
LIG_LIR_LC3C_4	190	194	PF02991	0.405
LIG_LIR_Nem_3	167	172	PF02991	0.290
LIG_LIR_Nem_3	201	207	PF02991	0.315
LIG_Pex14_2	73	77	PF04695	0.477
LIG_SH2_CRK	173	177	PF00017	0.315
LIG_SH2_STAT5	173	176	PF00017	0.448
LIG_SH2_STAT5	254	257	PF00017	0.322
LIG_SH3_1	11	17	PF00018	0.470
LIG_SH3_3	11	17	PF00018	0.470
LIG_SUMO_SIM_anti_2	190	197	PF11976	0.480
LIG_SUMO_SIM_par_1	190	197	PF11976	0.320
LIG_SUMO_SIM_par_1	54	61	PF11976	0.451
LIG_TYR_ITIM	171	176	PF00017	0.318
MOD_CK1_1	136	142	PF00069	0.497
MOD_CK1_1	34	40	PF00069	0.595
MOD_CK1_1	52	58	PF00069	0.614
MOD_CK1_1	61	67	PF00069	0.588
MOD_CK1_1	76	82	PF00069	0.521
MOD_CK2_1	161	167	PF00069	0.387
MOD_CK2_1	39	45	PF00069	0.484
MOD_CK2_1	88	94	PF00069	0.665
MOD_GlcNHglycan	129	132	PF01048	0.440
MOD_GlcNHglycan	42	45	PF01048	0.720
MOD_GlcNHglycan	78	81	PF01048	0.663
MOD_GlcNHglycan	85	88	PF01048	0.626
MOD_GSK3_1	31	38	PF00069	0.618
MOD_GSK3_1	48	55	PF00069	0.635
MOD_GSK3_1	56	63	PF00069	0.591
MOD_GSK3_1	78	85	PF00069	0.594
MOD_LATS_1	29	35	PF00433	0.467
MOD_NEK2_1	171	176	PF00069	0.389
MOD_NEK2_1	33	38	PF00069	0.686
MOD_NEK2_1	53	58	PF00069	0.523
MOD_NEK2_1	73	78	PF00069	0.350
MOD_NEK2_1	88	93	PF00069	0.535
MOD_NEK2_2	19	24	PF00069	0.552
MOD_PKA_2	34	40	PF00069	0.565
MOD_Plk_1	218	224	PF00069	0.480
MOD_Plk_4	199	205	PF00069	0.473
MOD_Plk_4	249	255	PF00069	0.396
MOD_Plk_4	53	59	PF00069	0.614
MOD_ProDKin_1	161	167	PF00069	0.293
MOD_ProDKin_1	58	64	PF00069	0.659
TRG_DiLeu_BaEn_1	114	119	PF01217	0.435
TRG_DiLeu_BaEn_1	167	172	PF01217	0.346
TRG_DiLeu_LyEn_5	114	119	PF01217	0.274
TRG_ENDOCYTIC_2	173	176	PF00928	0.316
TRG_ENDOCYTIC_2	204	207	PF00928	0.438
TRG_ER_diArg_1	222	225	PF00400	0.282
TRG_ER_diArg_1	69	71	PF00400	0.624
TRG_NES_CRM1_1	148	160	PF08389	0.462
TRG_NES_CRM1_1	201	216	PF08389	0.237
TRG_NLS_MonoCore_2	11	16	PF00514	0.472
TRG_NLS_MonoExtN_4	11	16	PF00514	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBQ7	Leptomonas seymouri	61%	85%
A0A1X0NX67	Trypanosomatidae	38%	73%
A0A3S7WYF3	Leishmania donovani	70%	69%
A0A422NQ90	Trypanosoma rangeli	44%	89%
A4I0V2	Leishmania infantum	70%	69%
D0A781	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	87%
E9AWV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	75%
V5BR35	Trypanosoma cruzi	39%	85%