Actin-interacting protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-interacting protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HDH0_LEIBR

TriTrypDb:

LbrM.24.1150 , LBRM2903_240017600

Length:

1019

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDH0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.567
CLV_C14_Caspase3-7	313	317	PF00656	0.486
CLV_C14_Caspase3-7	604	608	PF00656	0.695
CLV_C14_Caspase3-7	753	757	PF00656	0.670
CLV_NRD_NRD_1	119	121	PF00675	0.494
CLV_NRD_NRD_1	185	187	PF00675	0.598
CLV_NRD_NRD_1	219	221	PF00675	0.457
CLV_NRD_NRD_1	299	301	PF00675	0.371
CLV_NRD_NRD_1	30	32	PF00675	0.414
CLV_NRD_NRD_1	35	37	PF00675	0.421
CLV_NRD_NRD_1	412	414	PF00675	0.474
CLV_NRD_NRD_1	431	433	PF00675	0.628
CLV_NRD_NRD_1	48	50	PF00675	0.461
CLV_NRD_NRD_1	491	493	PF00675	0.474
CLV_NRD_NRD_1	55	57	PF00675	0.349
CLV_NRD_NRD_1	614	616	PF00675	0.550
CLV_NRD_NRD_1	652	654	PF00675	0.497
CLV_NRD_NRD_1	744	746	PF00675	0.436
CLV_NRD_NRD_1	765	767	PF00675	0.556
CLV_NRD_NRD_1	773	775	PF00675	0.529
CLV_NRD_NRD_1	799	801	PF00675	0.571
CLV_NRD_NRD_1	84	86	PF00675	0.427
CLV_PCSK_FUR_1	769	773	PF00082	0.428
CLV_PCSK_KEX2_1	119	121	PF00082	0.494
CLV_PCSK_KEX2_1	219	221	PF00082	0.457
CLV_PCSK_KEX2_1	299	301	PF00082	0.371
CLV_PCSK_KEX2_1	412	414	PF00082	0.474
CLV_PCSK_KEX2_1	431	433	PF00082	0.628
CLV_PCSK_KEX2_1	491	493	PF00082	0.474
CLV_PCSK_KEX2_1	613	615	PF00082	0.548
CLV_PCSK_KEX2_1	652	654	PF00082	0.490
CLV_PCSK_KEX2_1	744	746	PF00082	0.438
CLV_PCSK_KEX2_1	771	773	PF00082	0.475
CLV_PCSK_KEX2_1	84	86	PF00082	0.379
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.454
CLV_PCSK_SKI1_1	259	263	PF00082	0.533
CLV_PCSK_SKI1_1	299	303	PF00082	0.379
CLV_PCSK_SKI1_1	36	40	PF00082	0.506
CLV_PCSK_SKI1_1	529	533	PF00082	0.384
CLV_Separin_Metazoa	501	505	PF03568	0.526
DEG_APCC_DBOX_1	55	63	PF00400	0.442
DEG_Nend_UBRbox_1	1	4	PF02207	0.511
DOC_ANK_TNKS_1	239	246	PF00023	0.382
DOC_ANK_TNKS_1	367	374	PF00023	0.434
DOC_CKS1_1	96	101	PF01111	0.675
DOC_CKS1_1	971	976	PF01111	0.564
DOC_MAPK_gen_1	5	13	PF00069	0.455
DOC_MAPK_gen_1	525	533	PF00069	0.464
DOC_MAPK_MEF2A_6	5	13	PF00069	0.492
DOC_USP7_MATH_1	191	195	PF00917	0.684
DOC_USP7_MATH_1	386	390	PF00917	0.651
DOC_USP7_MATH_1	632	636	PF00917	0.436
DOC_USP7_MATH_1	726	730	PF00917	0.599
DOC_USP7_MATH_1	813	817	PF00917	0.643
DOC_USP7_MATH_1	821	825	PF00917	0.472
DOC_USP7_MATH_1	956	960	PF00917	0.562
DOC_USP7_UBL2_3	767	771	PF12436	0.501
DOC_WW_Pin1_4	5	10	PF00397	0.459
DOC_WW_Pin1_4	588	593	PF00397	0.621
DOC_WW_Pin1_4	697	702	PF00397	0.669
DOC_WW_Pin1_4	704	709	PF00397	0.660
DOC_WW_Pin1_4	866	871	PF00397	0.580
DOC_WW_Pin1_4	892	897	PF00397	0.582
DOC_WW_Pin1_4	916	921	PF00397	0.642
DOC_WW_Pin1_4	95	100	PF00397	0.657
DOC_WW_Pin1_4	952	957	PF00397	0.629
DOC_WW_Pin1_4	970	975	PF00397	0.587
DOC_WW_Pin1_4	987	992	PF00397	0.590
LIG_14-3-3_CanoR_1	169	174	PF00244	0.663
LIG_14-3-3_CanoR_1	299	308	PF00244	0.537
LIG_14-3-3_CanoR_1	36	42	PF00244	0.522
LIG_14-3-3_CanoR_1	362	370	PF00244	0.479
LIG_14-3-3_CanoR_1	456	465	PF00244	0.632
LIG_14-3-3_CanoR_1	491	500	PF00244	0.463
LIG_14-3-3_CanoR_1	56	60	PF00244	0.312
LIG_14-3-3_CanoR_1	645	654	PF00244	0.468
LIG_14-3-3_CanoR_1	861	870	PF00244	0.554
LIG_14-3-3_CanoR_1	887	897	PF00244	0.670
LIG_APCC_ABBA_1	419	424	PF00400	0.453
LIG_BIR_III_2	203	207	PF00653	0.444
LIG_BIR_III_4	625	629	PF00653	0.630
LIG_BRCT_BRCA1_1	939	943	PF00533	0.504
LIG_eIF4E_1	565	571	PF01652	0.548
LIG_FHA_1	188	194	PF00498	0.542
LIG_FHA_1	272	278	PF00498	0.505
LIG_FHA_1	301	307	PF00498	0.592
LIG_FHA_1	497	503	PF00498	0.451
LIG_FHA_1	56	62	PF00498	0.518
LIG_FHA_1	8	14	PF00498	0.452
LIG_FHA_1	883	889	PF00498	0.595
LIG_FHA_2	138	144	PF00498	0.716
LIG_FHA_2	265	271	PF00498	0.440
LIG_FHA_2	300	306	PF00498	0.373
LIG_FHA_2	496	502	PF00498	0.499
LIG_FHA_2	734	740	PF00498	0.473
LIG_FHA_2	751	757	PF00498	0.549
LIG_FHA_2	962	968	PF00498	0.595
LIG_LIR_Nem_3	28	33	PF02991	0.349
LIG_LYPXL_yS_3	1010	1013	PF13949	0.619
LIG_MYND_1	992	996	PF01753	0.501
LIG_OCRL_FandH_1	37	49	PF00620	0.335
LIG_PCNA_yPIPBox_3	64	78	PF02747	0.360
LIG_PTAP_UEV_1	686	691	PF05743	0.557
LIG_SH2_CRK	30	34	PF00017	0.333
LIG_SH2_NCK_1	330	334	PF00017	0.450
LIG_SH2_PTP2	640	643	PF00017	0.487
LIG_SH2_SRC	330	333	PF00017	0.453
LIG_SH2_STAP1	404	408	PF00017	0.380
LIG_SH2_STAT5	310	313	PF00017	0.465
LIG_SH2_STAT5	404	407	PF00017	0.541
LIG_SH2_STAT5	565	568	PF00017	0.468
LIG_SH2_STAT5	640	643	PF00017	0.487
LIG_SH3_2	810	815	PF14604	0.608
LIG_SH3_2	993	998	PF14604	0.508
LIG_SH3_3	1005	1011	PF00018	0.546
LIG_SH3_3	380	386	PF00018	0.668
LIG_SH3_3	589	595	PF00018	0.646
LIG_SH3_3	684	690	PF00018	0.809
LIG_SH3_3	807	813	PF00018	0.621
LIG_SH3_3	950	956	PF00018	0.595
LIG_SH3_3	968	974	PF00018	0.559
LIG_SH3_3	990	996	PF00018	0.669
LIG_SUMO_SIM_anti_2	498	505	PF11976	0.527
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.520
LIG_SUMO_SIM_anti_2	756	762	PF11976	0.591
LIG_SUMO_SIM_par_1	75	82	PF11976	0.378
LIG_SUMO_SIM_par_1	8	15	PF11976	0.451
LIG_TRAF2_1	267	270	PF00917	0.460
LIG_TRAF2_1	333	336	PF00917	0.575
LIG_TRAF2_1	551	554	PF00917	0.469
LIG_TRAF2_1	691	694	PF00917	0.559
LIG_TYR_ITIM	1008	1013	PF00017	0.618
LIG_WW_1	1006	1009	PF00397	0.641
MOD_CDK_SPK_2	957	962	PF00069	0.697
MOD_CDK_SPxxK_3	95	102	PF00069	0.631
MOD_CDK_SPxxK_3	970	977	PF00069	0.568
MOD_CK1_1	168	174	PF00069	0.669
MOD_CK1_1	194	200	PF00069	0.686
MOD_CK1_1	55	61	PF00069	0.440
MOD_CK1_1	596	602	PF00069	0.763
MOD_CK1_1	667	673	PF00069	0.622
MOD_CK1_1	729	735	PF00069	0.486
MOD_CK1_1	791	797	PF00069	0.840
MOD_CK1_1	816	822	PF00069	0.535
MOD_CK1_1	957	963	PF00069	0.645
MOD_CK2_1	1009	1015	PF00069	0.501
MOD_CK2_1	105	111	PF00069	0.559
MOD_CK2_1	137	143	PF00069	0.737
MOD_CK2_1	264	270	PF00069	0.458
MOD_CK2_1	299	305	PF00069	0.421
MOD_CK2_1	37	43	PF00069	0.429
MOD_CK2_1	438	444	PF00069	0.386
MOD_CK2_1	495	501	PF00069	0.500
MOD_CK2_1	502	508	PF00069	0.528
MOD_CK2_1	667	673	PF00069	0.627
MOD_CK2_1	733	739	PF00069	0.551
MOD_CK2_1	781	787	PF00069	0.635
MOD_CK2_1	957	963	PF00069	0.721
MOD_CK2_1	97	103	PF00069	0.530
MOD_DYRK1A_RPxSP_1	5	9	PF00069	0.510
MOD_GlcNHglycan	107	110	PF01048	0.649
MOD_GlcNHglycan	160	164	PF01048	0.634
MOD_GlcNHglycan	187	190	PF01048	0.642
MOD_GlcNHglycan	193	196	PF01048	0.594
MOD_GlcNHglycan	319	322	PF01048	0.739
MOD_GlcNHglycan	323	326	PF01048	0.609
MOD_GlcNHglycan	584	588	PF01048	0.650
MOD_GlcNHglycan	666	669	PF01048	0.549
MOD_GlcNHglycan	776	779	PF01048	0.525
MOD_GlcNHglycan	790	793	PF01048	0.679
MOD_GlcNHglycan	878	881	PF01048	0.660
MOD_GlcNHglycan	890	893	PF01048	0.542
MOD_GlcNHglycan	944	947	PF01048	0.707
MOD_GlcNHglycan	978	981	PF01048	0.773
MOD_GSK3_1	1	8	PF00069	0.545
MOD_GSK3_1	161	168	PF00069	0.782
MOD_GSK3_1	169	176	PF00069	0.691
MOD_GSK3_1	187	194	PF00069	0.564
MOD_GSK3_1	308	315	PF00069	0.543
MOD_GSK3_1	317	324	PF00069	0.728
MOD_GSK3_1	491	498	PF00069	0.464
MOD_GSK3_1	593	600	PF00069	0.593
MOD_GSK3_1	660	667	PF00069	0.788
MOD_GSK3_1	685	692	PF00069	0.663
MOD_GSK3_1	729	736	PF00069	0.562
MOD_GSK3_1	774	781	PF00069	0.508
MOD_GSK3_1	821	828	PF00069	0.722
MOD_GSK3_1	838	845	PF00069	0.625
MOD_GSK3_1	866	873	PF00069	0.549
MOD_GSK3_1	882	889	PF00069	0.582
MOD_GSK3_1	916	923	PF00069	0.573
MOD_GSK3_1	948	955	PF00069	0.648
MOD_GSK3_1	957	964	PF00069	0.720
MOD_GSK3_1	966	973	PF00069	0.650
MOD_N-GLC_1	438	443	PF02516	0.417
MOD_N-GLC_1	750	755	PF02516	0.564
MOD_N-GLC_1	838	843	PF02516	0.556
MOD_N-GLC_1	866	871	PF02516	0.580
MOD_NEK2_1	1	6	PF00069	0.533
MOD_NEK2_1	173	178	PF00069	0.524
MOD_NEK2_1	344	349	PF00069	0.538
MOD_NEK2_1	52	57	PF00069	0.433
MOD_NEK2_1	695	700	PF00069	0.578
MOD_NEK2_1	733	738	PF00069	0.487
MOD_NEK2_1	942	947	PF00069	0.574
MOD_OGLYCOS	917	922	PF02709	0.558
MOD_PIKK_1	361	367	PF00454	0.468
MOD_PIKK_1	502	508	PF00454	0.523
MOD_PIKK_1	679	685	PF00454	0.725
MOD_PIKK_1	726	732	PF00454	0.482
MOD_PIKK_1	816	822	PF00454	0.620
MOD_PIKK_1	937	943	PF00454	0.503
MOD_PIKK_1	954	960	PF00454	0.825
MOD_PIKK_1	97	103	PF00454	0.554
MOD_PKA_1	219	225	PF00069	0.455
MOD_PKA_1	299	305	PF00069	0.370
MOD_PKA_1	491	497	PF00069	0.466
MOD_PKA_1	774	780	PF00069	0.476
MOD_PKA_2	1	7	PF00069	0.550
MOD_PKA_2	168	174	PF00069	0.560
MOD_PKA_2	185	191	PF00069	0.507
MOD_PKA_2	219	225	PF00069	0.455
MOD_PKA_2	299	305	PF00069	0.418
MOD_PKA_2	361	367	PF00069	0.468
MOD_PKA_2	490	496	PF00069	0.472
MOD_PKA_2	55	61	PF00069	0.440
MOD_PKA_2	778	784	PF00069	0.623
MOD_PKA_2	821	827	PF00069	0.517
MOD_PKA_2	860	866	PF00069	0.572
MOD_PKA_2	886	892	PF00069	0.556
MOD_PKA_2	961	967	PF00069	0.723
MOD_PKA_2	976	982	PF00069	0.686
MOD_PKB_1	5	13	PF00069	0.455
MOD_PKB_1	772	780	PF00069	0.469
MOD_PKB_1	827	835	PF00069	0.585
MOD_Plk_1	23	29	PF00069	0.364
MOD_Plk_1	438	444	PF00069	0.386
MOD_Plk_1	750	756	PF00069	0.563
MOD_Plk_1	838	844	PF00069	0.721
MOD_Plk_1	966	972	PF00069	0.570
MOD_Plk_2-3	438	444	PF00069	0.386
MOD_Plk_2-3	750	756	PF00069	0.563
MOD_Plk_4	1000	1006	PF00069	0.592
MOD_Plk_4	1009	1015	PF00069	0.536
MOD_Plk_4	122	128	PF00069	0.494
MOD_Plk_4	7	13	PF00069	0.447
MOD_Plk_4	729	735	PF00069	0.402
MOD_ProDKin_1	5	11	PF00069	0.455
MOD_ProDKin_1	588	594	PF00069	0.616
MOD_ProDKin_1	697	703	PF00069	0.668
MOD_ProDKin_1	704	710	PF00069	0.656
MOD_ProDKin_1	866	872	PF00069	0.580
MOD_ProDKin_1	892	898	PF00069	0.580
MOD_ProDKin_1	916	922	PF00069	0.644
MOD_ProDKin_1	95	101	PF00069	0.664
MOD_ProDKin_1	952	958	PF00069	0.633
MOD_ProDKin_1	970	976	PF00069	0.589
MOD_ProDKin_1	987	993	PF00069	0.589
MOD_SUMO_for_1	543	546	PF00179	0.479
MOD_SUMO_rev_2	313	320	PF00179	0.495
TRG_DiLeu_BaEn_1	111	116	PF01217	0.493
TRG_DiLeu_BaEn_1	743	748	PF01217	0.569
TRG_DiLeu_BaEn_2	42	48	PF01217	0.416
TRG_DiLeu_BaEn_4	424	430	PF01217	0.449
TRG_DiLeu_BaEn_4	43	49	PF01217	0.415
TRG_ENDOCYTIC_2	1010	1013	PF00928	0.619
TRG_ENDOCYTIC_2	30	33	PF00928	0.412
TRG_ENDOCYTIC_2	640	643	PF00928	0.487
TRG_ER_diArg_1	237	240	PF00400	0.468
TRG_ER_diArg_1	299	301	PF00400	0.371
TRG_ER_diArg_1	411	413	PF00400	0.473
TRG_ER_diArg_1	431	433	PF00400	0.429
TRG_ER_diArg_1	490	492	PF00400	0.482
TRG_ER_diArg_1	524	527	PF00400	0.488
TRG_ER_diArg_1	613	615	PF00400	0.548
TRG_ER_diArg_1	652	654	PF00400	0.491
TRG_ER_diArg_1	826	829	PF00400	0.585
TRG_ER_diArg_1	83	85	PF00400	0.378
TRG_NES_CRM1_1	361	376	PF08389	0.424
TRG_NLS_MonoExtC_3	770	775	PF00514	0.440
TRG_NLS_MonoExtN_4	763	770	PF00514	0.402
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	745	749	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P545	Leptomonas seymouri	43%	92%
A0A3Q8IBC2	Leishmania donovani	69%	100%
A4I0V1	Leishmania infantum	69%	100%
E9AWV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QAL9	Leishmania major	69%	98%