Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDG9_LEIBR

TriTrypDb:

LbrM.24.1140 , LBRM2903_240017500

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.674
CLV_C14_Caspase3-7	311	315	PF00656	0.491
CLV_C14_Caspase3-7	368	372	PF00656	0.592
CLV_C14_Caspase3-7	44	48	PF00656	0.869
CLV_C14_Caspase3-7	555	559	PF00656	0.443
CLV_C14_Caspase3-7	670	674	PF00656	0.411
CLV_C14_Caspase3-7	732	736	PF00656	0.567
CLV_NRD_NRD_1	238	240	PF00675	0.600
CLV_NRD_NRD_1	260	262	PF00675	0.576
CLV_NRD_NRD_1	329	331	PF00675	0.874
CLV_NRD_NRD_1	332	334	PF00675	0.840
CLV_NRD_NRD_1	347	349	PF00675	0.844
CLV_NRD_NRD_1	488	490	PF00675	0.633
CLV_NRD_NRD_1	510	512	PF00675	0.634
CLV_NRD_NRD_1	56	58	PF00675	0.483
CLV_NRD_NRD_1	59	61	PF00675	0.468
CLV_NRD_NRD_1	98	100	PF00675	0.548
CLV_PCSK_FUR_1	330	334	PF00082	0.762
CLV_PCSK_FUR_1	57	61	PF00082	0.478
CLV_PCSK_KEX2_1	238	240	PF00082	0.560
CLV_PCSK_KEX2_1	328	330	PF00082	0.881
CLV_PCSK_KEX2_1	332	334	PF00082	0.828
CLV_PCSK_KEX2_1	335	337	PF00082	0.794
CLV_PCSK_KEX2_1	347	349	PF00082	0.864
CLV_PCSK_KEX2_1	488	490	PF00082	0.633
CLV_PCSK_KEX2_1	56	58	PF00082	0.483
CLV_PCSK_KEX2_1	59	61	PF00082	0.468
CLV_PCSK_KEX2_1	98	100	PF00082	0.544
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.696
CLV_PCSK_PC7_1	324	330	PF00082	0.698
CLV_PCSK_SKI1_1	452	456	PF00082	0.751
CLV_PCSK_SKI1_1	512	516	PF00082	0.662
CLV_PCSK_SKI1_1	613	617	PF00082	0.709
CLV_Separin_Metazoa	325	329	PF03568	0.496
DEG_SCF_FBW7_1	380	387	PF00400	0.488
DEG_SPOP_SBC_1	364	368	PF00917	0.592
DOC_ANK_TNKS_1	412	419	PF00023	0.548
DOC_CKS1_1	516	521	PF01111	0.431
DOC_CYCLIN_yCln2_LP_2	820	826	PF00134	0.805
DOC_MAPK_gen_1	488	495	PF00069	0.420
DOC_MAPK_gen_1	509	516	PF00069	0.616
DOC_MAPK_MEF2A_6	819	828	PF00069	0.806
DOC_PP2B_LxvP_1	131	134	PF13499	0.780
DOC_PP2B_LxvP_1	21	24	PF13499	0.679
DOC_PP2B_LxvP_1	399	402	PF13499	0.510
DOC_PP4_FxxP_1	414	417	PF00568	0.493
DOC_PP4_MxPP_1	409	412	PF00568	0.503
DOC_USP7_MATH_1	199	203	PF00917	0.851
DOC_USP7_MATH_1	221	225	PF00917	0.857
DOC_USP7_MATH_1	228	232	PF00917	0.778
DOC_USP7_MATH_1	260	264	PF00917	0.637
DOC_USP7_MATH_1	33	37	PF00917	0.689
DOC_USP7_MATH_1	352	356	PF00917	0.481
DOC_USP7_MATH_1	364	368	PF00917	0.568
DOC_USP7_MATH_1	384	388	PF00917	0.557
DOC_USP7_MATH_1	611	615	PF00917	0.549
DOC_USP7_MATH_2	344	350	PF00917	0.550
DOC_WW_Pin1_4	12	17	PF00397	0.705
DOC_WW_Pin1_4	26	31	PF00397	0.644
DOC_WW_Pin1_4	376	381	PF00397	0.505
DOC_WW_Pin1_4	420	425	PF00397	0.533
DOC_WW_Pin1_4	432	437	PF00397	0.492
DOC_WW_Pin1_4	452	457	PF00397	0.513
DOC_WW_Pin1_4	468	473	PF00397	0.594
DOC_WW_Pin1_4	515	520	PF00397	0.434
DOC_WW_Pin1_4	60	65	PF00397	0.855
DOC_WW_Pin1_4	617	622	PF00397	0.619
DOC_WW_Pin1_4	652	657	PF00397	0.466
DOC_WW_Pin1_4	755	760	PF00397	0.441
DOC_WW_Pin1_4	775	780	PF00397	0.519
LIG_14-3-3_CanoR_1	135	140	PF00244	0.786
LIG_14-3-3_CanoR_1	232	240	PF00244	0.698
LIG_14-3-3_CanoR_1	261	265	PF00244	0.673
LIG_14-3-3_CanoR_1	32	42	PF00244	0.688
LIG_14-3-3_CanoR_1	445	454	PF00244	0.459
LIG_14-3-3_CanoR_1	652	656	PF00244	0.469
LIG_BRCT_BRCA1_1	179	183	PF00533	0.663
LIG_BRCT_BRCA1_1	782	786	PF00533	0.566
LIG_deltaCOP1_diTrp_1	706	716	PF00928	0.378
LIG_EVH1_2	410	414	PF00568	0.493
LIG_FHA_1	140	146	PF00498	0.687
LIG_FHA_1	425	431	PF00498	0.463
LIG_FHA_1	449	455	PF00498	0.468
LIG_FHA_1	465	471	PF00498	0.433
LIG_FHA_1	560	566	PF00498	0.466
LIG_FHA_1	715	721	PF00498	0.373
LIG_FHA_1	787	793	PF00498	0.257
LIG_FHA_2	183	189	PF00498	0.715
LIG_FHA_2	309	315	PF00498	0.491
LIG_FHA_2	421	427	PF00498	0.653
LIG_FHA_2	668	674	PF00498	0.405
LIG_FHA_2	730	736	PF00498	0.570
LIG_FHA_2	765	771	PF00498	0.452
LIG_LIR_Apic_2	272	276	PF02991	0.552
LIG_LIR_Apic_2	706	712	PF02991	0.414
LIG_LIR_Gen_1	127	137	PF02991	0.714
LIG_LIR_Gen_1	286	295	PF02991	0.597
LIG_LIR_Gen_1	435	444	PF02991	0.556
LIG_LIR_Gen_1	583	591	PF02991	0.450
LIG_LIR_Gen_1	634	645	PF02991	0.620
LIG_LIR_Nem_3	127	133	PF02991	0.738
LIG_LIR_Nem_3	180	186	PF02991	0.660
LIG_LIR_Nem_3	245	251	PF02991	0.665
LIG_LIR_Nem_3	286	292	PF02991	0.782
LIG_LIR_Nem_3	435	440	PF02991	0.558
LIG_LIR_Nem_3	542	547	PF02991	0.618
LIG_LIR_Nem_3	583	588	PF02991	0.454
LIG_LIR_Nem_3	634	640	PF02991	0.618
LIG_LIR_Nem_3	783	788	PF02991	0.482
LIG_LYPXL_yS_3	822	825	PF13949	0.809
LIG_MYND_1	64	68	PF01753	0.856
LIG_PDZ_Class_3	830	835	PF00595	0.635
LIG_Pex14_2	183	187	PF04695	0.663
LIG_PTB_Apo_2	3	10	PF02174	0.670
LIG_PTB_Phospho_1	3	9	PF10480	0.668
LIG_SH2_CRK	289	293	PF00017	0.794
LIG_SH2_CRK	637	641	PF00017	0.621
LIG_SH2_CRK	726	730	PF00017	0.589
LIG_SH2_GRB2like	4	7	PF00017	0.663
LIG_SH2_NCK_1	585	589	PF00017	0.460
LIG_SH2_SRC	4	7	PF00017	0.663
LIG_SH2_SRC	551	554	PF00017	0.597
LIG_SH2_SRC	564	567	PF00017	0.489
LIG_SH2_STAP1	4	8	PF00017	0.665
LIG_SH2_STAP1	553	557	PF00017	0.443
LIG_SH2_STAP1	637	641	PF00017	0.441
LIG_SH2_STAT5	282	285	PF00017	0.752
LIG_SH2_STAT5	437	440	PF00017	0.512
LIG_SH2_STAT5	523	526	PF00017	0.612
LIG_SH2_STAT5	545	548	PF00017	0.618
LIG_SH2_STAT5	551	554	PF00017	0.554
LIG_SH2_STAT5	564	567	PF00017	0.428
LIG_SH2_STAT5	687	690	PF00017	0.602
LIG_SH2_STAT5	694	697	PF00017	0.509
LIG_SH2_STAT5	745	748	PF00017	0.542
LIG_SH2_STAT5	757	760	PF00017	0.436
LIG_SH3_1	108	114	PF00018	0.864
LIG_SH3_1	390	396	PF00018	0.627
LIG_SH3_2	398	403	PF14604	0.560
LIG_SH3_2	408	413	PF14604	0.616
LIG_SH3_3	108	114	PF00018	0.864
LIG_SH3_3	142	148	PF00018	0.815
LIG_SH3_3	211	217	PF00018	0.668
LIG_SH3_3	289	295	PF00018	0.783
LIG_SH3_3	334	340	PF00018	0.670
LIG_SH3_3	36	42	PF00018	0.764
LIG_SH3_3	390	396	PF00018	0.637
LIG_SH3_3	399	405	PF00018	0.597
LIG_SH3_3	565	571	PF00018	0.471
LIG_SH3_3	615	621	PF00018	0.622
LIG_SH3_3	642	648	PF00018	0.449
LIG_SH3_3	67	73	PF00018	0.856
LIG_SH3_3	823	829	PF00018	0.806
LIG_SH3_CIN85_PxpxPR_1	398	403	PF14604	0.532
LIG_SH3_CIN85_PxpxPR_1	408	413	PF14604	0.560
LIG_SUMO_SIM_anti_2	426	433	PF11976	0.522
LIG_TRAF2_1	462	465	PF00917	0.479
LIG_TRFH_1	726	730	PF08558	0.705
LIG_TYR_ITIM	820	825	PF00017	0.771
LIG_UBA3_1	429	434	PF00899	0.559
LIG_WW_3	325	329	PF00397	0.828
LIG_WW_3	400	404	PF00397	0.686
LIG_WW_3	410	414	PF00397	0.746
MOD_CDC14_SPxK_1	29	32	PF00782	0.592
MOD_CDK_SPK_2	14	19	PF00069	0.590
MOD_CDK_SPK_2	380	385	PF00069	0.606
MOD_CDK_SPxK_1	26	32	PF00069	0.596
MOD_CDK_SPxxK_3	12	19	PF00069	0.589
MOD_CDK_SPxxK_3	515	522	PF00069	0.526
MOD_CK1_1	194	200	PF00069	0.816
MOD_CK1_1	224	230	PF00069	0.799
MOD_CK1_1	233	239	PF00069	0.679
MOD_CK1_1	351	357	PF00069	0.684
MOD_CK1_1	376	382	PF00069	0.714
MOD_CK1_1	446	452	PF00069	0.567
MOD_CK1_1	468	474	PF00069	0.759
MOD_CK1_1	655	661	PF00069	0.720
MOD_CK1_1	763	769	PF00069	0.602
MOD_CK1_1	778	784	PF00069	0.685
MOD_CK2_1	319	325	PF00069	0.617
MOD_CK2_1	369	375	PF00069	0.609
MOD_CK2_1	386	392	PF00069	0.538
MOD_CK2_1	420	426	PF00069	0.838
MOD_CK2_1	74	80	PF00069	0.852
MOD_CK2_1	764	770	PF00069	0.612
MOD_CK2_1	827	833	PF00069	0.519
MOD_DYRK1A_RPxSP_1	652	656	PF00069	0.576
MOD_GlcNHglycan	201	204	PF01048	0.661
MOD_GlcNHglycan	208	212	PF01048	0.649
MOD_GlcNHglycan	225	229	PF01048	0.816
MOD_GlcNHglycan	235	238	PF01048	0.688
MOD_GlcNHglycan	350	353	PF01048	0.690
MOD_GlcNHglycan	448	451	PF01048	0.560
MOD_GlcNHglycan	467	470	PF01048	0.608
MOD_GlcNHglycan	554	557	PF01048	0.567
MOD_GlcNHglycan	585	588	PF01048	0.568
MOD_GlcNHglycan	657	660	PF01048	0.661
MOD_GlcNHglycan	762	765	PF01048	0.789
MOD_GSK3_1	119	126	PF00069	0.597
MOD_GSK3_1	135	142	PF00069	0.840
MOD_GSK3_1	224	231	PF00069	0.824
MOD_GSK3_1	284	291	PF00069	0.571
MOD_GSK3_1	348	355	PF00069	0.693
MOD_GSK3_1	365	372	PF00069	0.599
MOD_GSK3_1	376	383	PF00069	0.618
MOD_GSK3_1	420	427	PF00069	0.633
MOD_GSK3_1	432	439	PF00069	0.729
MOD_GSK3_1	448	455	PF00069	0.571
MOD_GSK3_1	464	471	PF00069	0.515
MOD_GSK3_1	569	576	PF00069	0.819
MOD_GSK3_1	60	67	PF00069	0.743
MOD_GSK3_1	613	620	PF00069	0.598
MOD_GSK3_1	651	658	PF00069	0.818
MOD_GSK3_1	747	754	PF00069	0.726
MOD_GSK3_1	760	767	PF00069	0.576
MOD_GSK3_1	769	776	PF00069	0.616
MOD_N-GLC_1	118	123	PF02516	0.752
MOD_N-GLC_2	674	676	PF02516	0.489
MOD_NEK2_1	139	144	PF00069	0.595
MOD_NEK2_1	177	182	PF00069	0.651
MOD_NEK2_1	283	288	PF00069	0.546
MOD_NEK2_1	543	548	PF00069	0.784
MOD_NEK2_1	552	557	PF00069	0.644
MOD_NEK2_1	686	691	PF00069	0.524
MOD_NEK2_1	751	756	PF00069	0.482
MOD_NEK2_1	786	791	PF00069	0.475
MOD_PIKK_1	373	379	PF00454	0.868
MOD_PIKK_1	573	579	PF00454	0.812
MOD_PIKK_1	751	757	PF00454	0.486
MOD_PKA_2	103	109	PF00069	0.597
MOD_PKA_2	191	197	PF00069	0.714
MOD_PKA_2	260	266	PF00069	0.695
MOD_PKA_2	331	337	PF00069	0.700
MOD_PKA_2	346	352	PF00069	0.687
MOD_PKA_2	384	390	PF00069	0.607
MOD_PKA_2	651	657	PF00069	0.735
MOD_PKB_1	102	110	PF00069	0.593
MOD_Plk_1	284	290	PF00069	0.566
MOD_Plk_1	559	565	PF00069	0.567
MOD_Plk_1	672	678	PF00069	0.491
MOD_Plk_1	705	711	PF00069	0.503
MOD_Plk_2-3	159	165	PF00069	0.810
MOD_Plk_2-3	667	673	PF00069	0.488
MOD_Plk_4	135	141	PF00069	0.585
MOD_Plk_4	182	188	PF00069	0.563
MOD_Plk_4	284	290	PF00069	0.566
MOD_ProDKin_1	12	18	PF00069	0.624
MOD_ProDKin_1	26	32	PF00069	0.543
MOD_ProDKin_1	376	382	PF00069	0.629
MOD_ProDKin_1	420	426	PF00069	0.667
MOD_ProDKin_1	432	438	PF00069	0.609
MOD_ProDKin_1	452	458	PF00069	0.637
MOD_ProDKin_1	468	474	PF00069	0.751
MOD_ProDKin_1	515	521	PF00069	0.525
MOD_ProDKin_1	60	66	PF00069	0.838
MOD_ProDKin_1	617	623	PF00069	0.786
MOD_ProDKin_1	652	658	PF00069	0.567
MOD_ProDKin_1	755	761	PF00069	0.541
MOD_ProDKin_1	775	781	PF00069	0.645
TRG_DiLeu_BaEn_1	510	515	PF01217	0.782
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.606
TRG_DiLeu_BaLyEn_6	716	721	PF01217	0.535
TRG_ENDOCYTIC_2	248	251	PF00928	0.574
TRG_ENDOCYTIC_2	289	292	PF00928	0.753
TRG_ENDOCYTIC_2	437	440	PF00928	0.637
TRG_ENDOCYTIC_2	544	547	PF00928	0.791
TRG_ENDOCYTIC_2	585	588	PF00928	0.568
TRG_ENDOCYTIC_2	637	640	PF00928	0.792
TRG_ENDOCYTIC_2	726	729	PF00928	0.743
TRG_ENDOCYTIC_2	822	825	PF00928	0.773
TRG_ER_diArg_1	152	155	PF00400	0.607
TRG_ER_diArg_1	238	240	PF00400	0.760
TRG_ER_diArg_1	327	330	PF00400	0.871
TRG_ER_diArg_1	55	57	PF00400	0.598
TRG_ER_diArg_1	579	582	PF00400	0.567
TRG_ER_diArg_1	59	61	PF00400	0.571
TRG_ER_diArg_1	98	100	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	719	724	PF00026	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICW0	Leishmania donovani	64%	100%
A4I0V0	Leishmania infantum	64%	100%
E9AWV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4QAM0	Leishmania major	64%	100%