Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDG8_LEIBR

TriTrypDb:

LbrM.24.1130 , LBRM2903_240017400

Length:

947

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.630
CLV_C14_Caspase3-7	664	668	PF00656	0.549
CLV_C14_Caspase3-7	859	863	PF00656	0.688
CLV_C14_Caspase3-7	899	903	PF00656	0.669
CLV_NRD_NRD_1	566	568	PF00675	0.757
CLV_NRD_NRD_1	641	643	PF00675	0.608
CLV_NRD_NRD_1	707	709	PF00675	0.598
CLV_NRD_NRD_1	752	754	PF00675	0.557
CLV_NRD_NRD_1	775	777	PF00675	0.490
CLV_NRD_NRD_1	81	83	PF00675	0.762
CLV_NRD_NRD_1	811	813	PF00675	0.720
CLV_NRD_NRD_1	879	881	PF00675	0.869
CLV_PCSK_KEX2_1	414	416	PF00082	0.691
CLV_PCSK_KEX2_1	437	439	PF00082	0.764
CLV_PCSK_KEX2_1	566	568	PF00082	0.757
CLV_PCSK_KEX2_1	641	643	PF00082	0.645
CLV_PCSK_KEX2_1	679	681	PF00082	0.513
CLV_PCSK_KEX2_1	707	709	PF00082	0.598
CLV_PCSK_KEX2_1	752	754	PF00082	0.714
CLV_PCSK_KEX2_1	81	83	PF00082	0.762
CLV_PCSK_KEX2_1	811	813	PF00082	0.720
CLV_PCSK_KEX2_1	879	881	PF00082	0.797
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.691
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.764
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.513
CLV_PCSK_PC1ET2_1	752	754	PF00082	0.714
CLV_PCSK_SKI1_1	109	113	PF00082	0.620
CLV_PCSK_SKI1_1	156	160	PF00082	0.596
CLV_PCSK_SKI1_1	320	324	PF00082	0.575
CLV_PCSK_SKI1_1	357	361	PF00082	0.601
CLV_PCSK_SKI1_1	415	419	PF00082	0.735
CLV_PCSK_SKI1_1	429	433	PF00082	0.557
CLV_PCSK_SKI1_1	469	473	PF00082	0.607
CLV_PCSK_SKI1_1	52	56	PF00082	0.561
CLV_PCSK_SKI1_1	658	662	PF00082	0.520
CLV_PCSK_SKI1_1	930	934	PF00082	0.484
CLV_PCSK_SKI1_1	99	103	PF00082	0.587
DEG_APCC_DBOX_1	468	476	PF00400	0.598
DOC_CKS1_1	303	308	PF01111	0.721
DOC_CKS1_1	340	345	PF01111	0.627
DOC_CKS1_1	618	623	PF01111	0.814
DOC_CKS1_1	69	74	PF01111	0.765
DOC_CYCLIN_RxL_1	49	60	PF00134	0.551
DOC_CYCLIN_RxL_1	72	83	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.773
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	846	849	PF00134	0.797
DOC_MAPK_gen_1	382	391	PF00069	0.467
DOC_MAPK_gen_1	751	762	PF00069	0.570
DOC_MAPK_MEF2A_6	156	163	PF00069	0.605
DOC_MAPK_MEF2A_6	658	665	PF00069	0.511
DOC_PP1_RVXF_1	50	57	PF00149	0.557
DOC_PP1_RVXF_1	678	685	PF00149	0.485
DOC_PP2B_LxvP_1	187	190	PF13499	0.690
DOC_PP2B_LxvP_1	300	303	PF13499	0.681
DOC_PP2B_LxvP_1	330	333	PF13499	0.698
DOC_PP2B_LxvP_1	846	849	PF13499	0.794
DOC_USP7_MATH_1	10	14	PF00917	0.804
DOC_USP7_MATH_1	125	129	PF00917	0.719
DOC_USP7_MATH_1	180	184	PF00917	0.624
DOC_USP7_MATH_1	238	242	PF00917	0.687
DOC_USP7_MATH_1	284	288	PF00917	0.538
DOC_USP7_MATH_1	294	298	PF00917	0.710
DOC_USP7_MATH_1	519	523	PF00917	0.559
DOC_USP7_MATH_1	59	63	PF00917	0.673
DOC_USP7_MATH_1	607	611	PF00917	0.665
DOC_USP7_MATH_1	627	631	PF00917	0.742
DOC_USP7_MATH_1	764	768	PF00917	0.705
DOC_USP7_MATH_1	793	797	PF00917	0.329
DOC_USP7_MATH_1	827	831	PF00917	0.689
DOC_USP7_MATH_1	851	855	PF00917	0.827
DOC_USP7_MATH_1	874	878	PF00917	0.766
DOC_USP7_MATH_2	10	16	PF00917	0.569
DOC_USP7_UBL2_3	423	427	PF12436	0.741
DOC_USP7_UBL2_3	748	752	PF12436	0.588
DOC_WW_Pin1_4	289	294	PF00397	0.787
DOC_WW_Pin1_4	302	307	PF00397	0.547
DOC_WW_Pin1_4	339	344	PF00397	0.635
DOC_WW_Pin1_4	596	601	PF00397	0.615
DOC_WW_Pin1_4	614	619	PF00397	0.807
DOC_WW_Pin1_4	68	73	PF00397	0.701
DOC_WW_Pin1_4	765	770	PF00397	0.676
DOC_WW_Pin1_4	820	825	PF00397	0.655
DOC_WW_Pin1_4	847	852	PF00397	0.595
DOC_WW_Pin1_4	864	869	PF00397	0.575
DOC_WW_Pin1_4	889	894	PF00397	0.727
LIG_14-3-3_CanoR_1	311	317	PF00244	0.728
LIG_14-3-3_CanoR_1	320	327	PF00244	0.619
LIG_14-3-3_CanoR_1	329	333	PF00244	0.552
LIG_14-3-3_CanoR_1	393	397	PF00244	0.698
LIG_14-3-3_CanoR_1	415	424	PF00244	0.729
LIG_14-3-3_CanoR_1	450	454	PF00244	0.598
LIG_14-3-3_CanoR_1	52	57	PF00244	0.631
LIG_14-3-3_CanoR_1	582	587	PF00244	0.721
LIG_14-3-3_CanoR_1	641	646	PF00244	0.650
LIG_14-3-3_CanoR_1	776	784	PF00244	0.500
LIG_14-3-3_CanoR_1	81	89	PF00244	0.617
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BIR_III_4	606	610	PF00653	0.566
LIG_BRCT_BRCA1_1	731	735	PF00533	0.568
LIG_BRCT_BRCA1_1	795	799	PF00533	0.315
LIG_CaM_IQ_9	349	365	PF13499	0.665
LIG_CSL_BTD_1	802	805	PF09270	0.484
LIG_CtBP_PxDLS_1	76	80	PF00389	0.666
LIG_EH_1	8	12	PF12763	0.571
LIG_EVH1_2	275	279	PF00568	0.522
LIG_FHA_1	149	155	PF00498	0.679
LIG_FHA_1	179	185	PF00498	0.602
LIG_FHA_1	192	198	PF00498	0.532
LIG_FHA_1	23	29	PF00498	0.783
LIG_FHA_1	308	314	PF00498	0.668
LIG_FHA_1	449	455	PF00498	0.556
LIG_FHA_1	512	518	PF00498	0.670
LIG_FHA_1	53	59	PF00498	0.650
LIG_FHA_1	586	592	PF00498	0.586
LIG_FHA_1	618	624	PF00498	0.790
LIG_FHA_1	676	682	PF00498	0.531
LIG_FHA_1	84	90	PF00498	0.617
LIG_FHA_1	841	847	PF00498	0.710
LIG_FHA_2	321	327	PF00498	0.578
LIG_FHA_2	340	346	PF00498	0.624
LIG_FHA_2	738	744	PF00498	0.602
LIG_GBD_Chelix_1	535	543	PF00786	0.550
LIG_Integrin_isoDGR_2	639	641	PF01839	0.597
LIG_Integrin_isoDGR_2	809	811	PF01839	0.692
LIG_LIR_Gen_1	685	692	PF02991	0.498
LIG_LIR_Gen_1	732	739	PF02991	0.480
LIG_LIR_Gen_1	781	789	PF02991	0.492
LIG_LIR_Gen_1	796	807	PF02991	0.403
LIG_LIR_LC3C_4	659	663	PF02991	0.372
LIG_LIR_Nem_3	655	660	PF02991	0.463
LIG_LIR_Nem_3	685	690	PF02991	0.488
LIG_LIR_Nem_3	732	738	PF02991	0.481
LIG_LIR_Nem_3	781	785	PF02991	0.584
LIG_LIR_Nem_3	796	802	PF02991	0.418
LIG_LIR_Nem_3	87	93	PF02991	0.594
LIG_NRBOX	467	473	PF00104	0.591
LIG_NRBOX	668	674	PF00104	0.483
LIG_PCNA_yPIPBox_3	904	912	PF02747	0.723
LIG_Pex14_2	785	789	PF04695	0.460
LIG_Pex14_2	799	803	PF04695	0.469
LIG_PTB_Apo_2	271	278	PF02174	0.531
LIG_Rb_LxCxE_1	451	464	PF01857	0.611
LIG_SH2_CRK	69	73	PF00017	0.664
LIG_SH2_NCK_1	69	73	PF00017	0.665
LIG_SH2_STAT3	203	206	PF00017	0.521
LIG_SH2_STAT5	188	191	PF00017	0.754
LIG_SH2_STAT5	203	206	PF00017	0.511
LIG_SH2_STAT5	232	235	PF00017	0.767
LIG_SH2_STAT5	697	700	PF00017	0.452
LIG_SH2_STAT5	746	749	PF00017	0.562
LIG_SH2_STAT5	93	96	PF00017	0.442
LIG_SH3_3	187	193	PF00018	0.773
LIG_SH3_3	295	301	PF00018	0.717
LIG_SH3_3	4	10	PF00018	0.700
LIG_SH3_3	430	436	PF00018	0.719
LIG_SH3_3	594	600	PF00018	0.655
LIG_SH3_3	615	621	PF00018	0.817
LIG_SH3_3	799	805	PF00018	0.528
LIG_SH3_3	845	851	PF00018	0.821
LIG_SUMO_SIM_anti_2	60	71	PF11976	0.526
LIG_SUMO_SIM_anti_2	659	664	PF11976	0.401
LIG_SUMO_SIM_anti_2	892	900	PF11976	0.730
LIG_SUMO_SIM_anti_2	929	937	PF11976	0.694
LIG_SUMO_SIM_par_1	336	342	PF11976	0.578
LIG_SUMO_SIM_par_1	659	664	PF11976	0.507
LIG_SxIP_EBH_1	763	777	PF03271	0.587
LIG_TRAF2_1	215	218	PF00917	0.591
LIG_TRAF2_1	342	345	PF00917	0.736
LIG_TRAF2_1	716	719	PF00917	0.643
LIG_TRAF2_1	739	742	PF00917	0.503
LIG_TRAF2_2	193	198	PF00917	0.663
MOD_CDK_SPK_2	614	619	PF00069	0.823
MOD_CDK_SPxxK_3	68	75	PF00069	0.532
MOD_CK1_1	142	148	PF00069	0.701
MOD_CK1_1	202	208	PF00069	0.723
MOD_CK1_1	269	275	PF00069	0.580
MOD_CK1_1	30	36	PF00069	0.725
MOD_CK1_1	331	337	PF00069	0.786
MOD_CK1_1	416	422	PF00069	0.552
MOD_CK1_1	522	528	PF00069	0.708
MOD_CK1_1	556	562	PF00069	0.685
MOD_CK1_1	584	590	PF00069	0.674
MOD_CK1_1	593	599	PF00069	0.701
MOD_CK1_1	675	681	PF00069	0.538
MOD_CK1_1	850	856	PF00069	0.831
MOD_CK2_1	100	106	PF00069	0.666
MOD_CK2_1	320	326	PF00069	0.579
MOD_CK2_1	339	345	PF00069	0.632
MOD_CK2_1	627	633	PF00069	0.811
MOD_CK2_1	712	718	PF00069	0.648
MOD_CK2_1	737	743	PF00069	0.595
MOD_CK2_1	850	856	PF00069	0.597
MOD_CK2_1	889	895	PF00069	0.756
MOD_Cter_Amidation	639	642	PF01082	0.600
MOD_Cter_Amidation	809	812	PF01082	0.696
MOD_GlcNHglycan	127	130	PF01048	0.544
MOD_GlcNHglycan	139	142	PF01048	0.551
MOD_GlcNHglycan	144	147	PF01048	0.551
MOD_GlcNHglycan	170	173	PF01048	0.649
MOD_GlcNHglycan	29	32	PF01048	0.679
MOD_GlcNHglycan	330	333	PF01048	0.731
MOD_GlcNHglycan	407	410	PF01048	0.535
MOD_GlcNHglycan	41	44	PF01048	0.769
MOD_GlcNHglycan	485	488	PF01048	0.544
MOD_GlcNHglycan	522	525	PF01048	0.560
MOD_GlcNHglycan	571	574	PF01048	0.560
MOD_GlcNHglycan	611	614	PF01048	0.726
MOD_GlcNHglycan	633	637	PF01048	0.699
MOD_GlcNHglycan	649	652	PF01048	0.543
MOD_GlcNHglycan	713	717	PF01048	0.648
MOD_GlcNHglycan	795	798	PF01048	0.411
MOD_GlcNHglycan	853	856	PF01048	0.705
MOD_GlcNHglycan	939	942	PF01048	0.648
MOD_GSK3_1	100	107	PF00069	0.546
MOD_GSK3_1	12	19	PF00069	0.558
MOD_GSK3_1	145	152	PF00069	0.772
MOD_GSK3_1	174	181	PF00069	0.682
MOD_GSK3_1	198	205	PF00069	0.577
MOD_GSK3_1	262	269	PF00069	0.636
MOD_GSK3_1	307	314	PF00069	0.774
MOD_GSK3_1	316	323	PF00069	0.640
MOD_GSK3_1	413	420	PF00069	0.768
MOD_GSK3_1	478	485	PF00069	0.579
MOD_GSK3_1	539	546	PF00069	0.691
MOD_GSK3_1	569	576	PF00069	0.593
MOD_GSK3_1	581	588	PF00069	0.591
MOD_GSK3_1	818	825	PF00069	0.748
MOD_GSK3_1	836	843	PF00069	0.698
MOD_GSK3_1	847	854	PF00069	0.711
MOD_GSK3_1	933	940	PF00069	0.693
MOD_N-GLC_1	149	154	PF02516	0.524
MOD_N-GLC_1	270	275	PF02516	0.536
MOD_N-GLC_1	38	43	PF02516	0.549
MOD_N-GLC_1	50	55	PF02516	0.501
MOD_N-GLC_1	593	598	PF02516	0.728
MOD_N-GLC_1	889	894	PF02516	0.756
MOD_NEK2_1	139	144	PF00069	0.579
MOD_NEK2_1	149	154	PF00069	0.664
MOD_NEK2_1	197	202	PF00069	0.593
MOD_NEK2_1	312	317	PF00069	0.640
MOD_NEK2_1	418	423	PF00069	0.608
MOD_NEK2_1	448	453	PF00069	0.507
MOD_NEK2_1	482	487	PF00069	0.602
MOD_NEK2_1	520	525	PF00069	0.667
MOD_NEK2_1	539	544	PF00069	0.654
MOD_NEK2_1	551	556	PF00069	0.608
MOD_NEK2_1	581	586	PF00069	0.687
MOD_NEK2_1	590	595	PF00069	0.656
MOD_NEK2_1	67	72	PF00069	0.755
MOD_NEK2_1	775	780	PF00069	0.466
MOD_NEK2_1	896	901	PF00069	0.717
MOD_NEK2_2	627	632	PF00069	0.555
MOD_PIKK_1	191	197	PF00454	0.708
MOD_PIKK_1	202	208	PF00454	0.592
MOD_PIKK_1	585	591	PF00454	0.553
MOD_PIKK_1	698	704	PF00454	0.522
MOD_PIKK_1	872	878	PF00454	0.852
MOD_PK_1	413	419	PF00069	0.554
MOD_PKA_1	413	419	PF00069	0.661
MOD_PKA_1	429	435	PF00069	0.766
MOD_PKA_1	641	647	PF00069	0.640
MOD_PKA_1	811	817	PF00069	0.764
MOD_PKA_2	137	143	PF00069	0.799
MOD_PKA_2	191	197	PF00069	0.599
MOD_PKA_2	328	334	PF00069	0.723
MOD_PKA_2	385	391	PF00069	0.628
MOD_PKA_2	392	398	PF00069	0.588
MOD_PKA_2	449	455	PF00069	0.602
MOD_PKA_2	556	562	PF00069	0.645
MOD_PKA_2	581	587	PF00069	0.657
MOD_PKA_2	641	647	PF00069	0.640
MOD_PKA_2	775	781	PF00069	0.481
MOD_PKA_2	80	86	PF00069	0.636
MOD_PKA_2	811	817	PF00069	0.764
MOD_PKA_2	836	842	PF00069	0.615
MOD_Plk_1	149	155	PF00069	0.532
MOD_Plk_1	238	244	PF00069	0.529
MOD_Plk_1	364	370	PF00069	0.473
MOD_Plk_1	50	56	PF00069	0.558
MOD_Plk_1	593	599	PF00069	0.734
MOD_Plk_2-3	100	106	PF00069	0.464
MOD_Plk_4	180	186	PF00069	0.710
MOD_Plk_4	284	290	PF00069	0.539
MOD_Plk_4	364	370	PF00069	0.436
MOD_Plk_4	449	455	PF00069	0.521
MOD_Plk_4	539	545	PF00069	0.597
MOD_Plk_4	593	599	PF00069	0.750
MOD_Plk_4	619	625	PF00069	0.583
MOD_Plk_4	656	662	PF00069	0.444
MOD_Plk_4	842	848	PF00069	0.764
MOD_ProDKin_1	289	295	PF00069	0.791
MOD_ProDKin_1	302	308	PF00069	0.548
MOD_ProDKin_1	339	345	PF00069	0.632
MOD_ProDKin_1	596	602	PF00069	0.618
MOD_ProDKin_1	614	620	PF00069	0.807
MOD_ProDKin_1	68	74	PF00069	0.702
MOD_ProDKin_1	765	771	PF00069	0.673
MOD_ProDKin_1	820	826	PF00069	0.655
MOD_ProDKin_1	847	853	PF00069	0.598
MOD_ProDKin_1	864	870	PF00069	0.574
MOD_ProDKin_1	889	895	PF00069	0.727
MOD_SUMO_for_1	436	439	PF00179	0.797
MOD_SUMO_rev_2	650	660	PF00179	0.458
MOD_SUMO_rev_2	675	681	PF00179	0.538
TRG_DiLeu_BaEn_1	221	226	PF01217	0.507
TRG_DiLeu_BaEn_1	24	29	PF01217	0.556
TRG_DiLeu_BaEn_1	929	934	PF01217	0.483
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.715
TRG_DiLeu_BaLyEn_6	802	807	PF01217	0.496
TRG_ENDOCYTIC_2	188	191	PF00928	0.772
TRG_ENDOCYTIC_2	782	785	PF00928	0.583
TRG_ENDOCYTIC_2	92	95	PF00928	0.618
TRG_ENDOCYTIC_2	98	101	PF00928	0.548
TRG_ER_diArg_1	222	225	PF00400	0.617
TRG_ER_diArg_1	706	708	PF00400	0.678
TRG_NLS_MonoCore_2	750	755	PF00514	0.706
TRG_NLS_MonoExtC_3	750	755	PF00514	0.607
TRG_NLS_MonoExtN_4	748	755	PF00514	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX7	Leptomonas seymouri	38%	100%
A0A3Q8ICV2	Leishmania donovani	65%	100%
E9AWV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QAM1	Leishmania major	66%	96%