Hypothetical predicted multipass transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted multipass transmembrane protein

Species:

Leishmania braziliensis

UniProt:

A4HDG5_LEIBR

TriTrypDb:

LbrM.24.1100 , LBRM2903_240016900

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HDG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.658
CLV_NRD_NRD_1	174	176	PF00675	0.405
CLV_NRD_NRD_1	243	245	PF00675	0.282
CLV_NRD_NRD_1	546	548	PF00675	0.449
CLV_PCSK_KEX2_1	176	178	PF00082	0.399
CLV_PCSK_KEX2_1	382	384	PF00082	0.463
CLV_PCSK_KEX2_1	544	546	PF00082	0.419
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.374
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.440
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.423
CLV_PCSK_SKI1_1	122	126	PF00082	0.371
CLV_PCSK_SKI1_1	265	269	PF00082	0.537
CLV_PCSK_SKI1_1	396	400	PF00082	0.297
CLV_PCSK_SKI1_1	534	538	PF00082	0.392
CLV_PCSK_SKI1_1	549	553	PF00082	0.470
DEG_APCC_DBOX_1	235	243	PF00400	0.534
DEG_Nend_UBRbox_4	1	3	PF02207	0.497
DOC_MAPK_gen_1	175	184	PF00069	0.514
DOC_MAPK_gen_1	28	38	PF00069	0.557
DOC_MAPK_HePTP_8	448	460	PF00069	0.344
DOC_MAPK_HePTP_8	508	520	PF00069	0.371
DOC_MAPK_MEF2A_6	175	184	PF00069	0.430
DOC_MAPK_MEF2A_6	28	36	PF00069	0.624
DOC_MAPK_MEF2A_6	396	404	PF00069	0.512
DOC_MAPK_MEF2A_6	451	460	PF00069	0.368
DOC_MAPK_MEF2A_6	511	520	PF00069	0.371
DOC_MAPK_NFAT4_5	177	185	PF00069	0.397
DOC_MAPK_NFAT4_5	31	39	PF00069	0.397
DOC_MAPK_NFAT4_5	451	459	PF00069	0.368
DOC_PP4_FxxP_1	203	206	PF00568	0.376
DOC_USP7_MATH_1	4	8	PF00917	0.673
DOC_USP7_MATH_1	487	491	PF00917	0.439
DOC_USP7_MATH_1	70	74	PF00917	0.370
DOC_USP7_MATH_1	92	96	PF00917	0.420
DOC_WW_Pin1_4	144	149	PF00397	0.345
DOC_WW_Pin1_4	281	286	PF00397	0.644
DOC_WW_Pin1_4	330	335	PF00397	0.826
DOC_WW_Pin1_4	371	376	PF00397	0.675
DOC_WW_Pin1_4	471	476	PF00397	0.531
LIG_14-3-3_CanoR_1	287	293	PF00244	0.624
LIG_BIR_III_2	418	422	PF00653	0.367
LIG_BRCT_BRCA1_1	180	184	PF00533	0.384
LIG_BRCT_BRCA1_1	224	228	PF00533	0.435
LIG_BRCT_BRCA1_1	438	442	PF00533	0.390
LIG_eIF4E_1	121	127	PF01652	0.549
LIG_FHA_1	334	340	PF00498	0.711
LIG_FHA_1	487	493	PF00498	0.329
LIG_FHA_1	80	86	PF00498	0.372
LIG_FHA_2	14	20	PF00498	0.572
LIG_FHA_2	289	295	PF00498	0.774
LIG_FHA_2	341	347	PF00498	0.611
LIG_GBD_Chelix_1	192	200	PF00786	0.371
LIG_GBD_Chelix_1	222	230	PF00786	0.325
LIG_GBD_Chelix_1	400	408	PF00786	0.360
LIG_LIR_Apic_2	201	206	PF02991	0.363
LIG_LIR_Gen_1	178	186	PF02991	0.532
LIG_LIR_Gen_1	187	196	PF02991	0.308
LIG_LIR_Gen_1	214	223	PF02991	0.338
LIG_LIR_Gen_1	411	420	PF02991	0.376
LIG_LIR_Gen_1	95	105	PF02991	0.279
LIG_LIR_Nem_3	178	182	PF02991	0.510
LIG_LIR_Nem_3	187	191	PF02991	0.259
LIG_LIR_Nem_3	214	220	PF02991	0.318
LIG_LIR_Nem_3	411	415	PF02991	0.374
LIG_LIR_Nem_3	95	100	PF02991	0.423
LIG_NRBOX	404	410	PF00104	0.368
LIG_NRBOX	532	538	PF00104	0.611
LIG_Pex14_1	120	124	PF04695	0.515
LIG_Pex14_1	166	170	PF04695	0.424
LIG_Pex14_1	217	221	PF04695	0.352
LIG_Pex14_1	60	64	PF04695	0.335
LIG_Pex14_2	184	188	PF04695	0.382
LIG_Pex14_2	41	45	PF04695	0.391
LIG_Pex14_2	460	464	PF04695	0.435
LIG_Pex14_2	9	13	PF04695	0.588
LIG_REV1ctd_RIR_1	6	15	PF16727	0.584
LIG_SH2_CRK	101	105	PF00017	0.492
LIG_SH2_GRB2like	469	472	PF00017	0.509
LIG_SH2_SRC	238	241	PF00017	0.512
LIG_SH2_SRC	502	505	PF00017	0.413
LIG_SH2_STAP1	142	146	PF00017	0.340
LIG_SH2_STAT5	146	149	PF00017	0.320
LIG_SH2_STAT5	179	182	PF00017	0.372
LIG_SH2_STAT5	221	224	PF00017	0.371
LIG_SH2_STAT5	238	241	PF00017	0.597
LIG_SH2_STAT5	469	472	PF00017	0.507
LIG_SH3_3	113	119	PF00018	0.559
LIG_SH3_3	258	264	PF00018	0.745
LIG_SH3_3	369	375	PF00018	0.708
LIG_Sin3_3	216	223	PF02671	0.443
LIG_SUMO_SIM_anti_2	489	496	PF11976	0.351
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.211
LIG_SUMO_SIM_par_1	276	284	PF11976	0.623
LIG_TRAF2_1	16	19	PF00917	0.606
LIG_TRAF2_1	291	294	PF00917	0.626
LIG_TRAF2_1	557	560	PF00917	0.510
LIG_TYR_ITIM	99	104	PF00017	0.268
LIG_WRC_WIRS_1	185	190	PF05994	0.311
LIG_WRC_WIRS_1	409	414	PF05994	0.424
MOD_CDC14_SPxK_1	284	287	PF00782	0.498
MOD_CDK_SPxK_1	281	287	PF00069	0.511
MOD_CK1_1	129	135	PF00069	0.431
MOD_CK1_1	198	204	PF00069	0.470
MOD_CK1_1	273	279	PF00069	0.640
MOD_CK1_1	320	326	PF00069	0.638
MOD_CK1_1	333	339	PF00069	0.712
MOD_CK2_1	13	19	PF00069	0.457
MOD_CK2_1	288	294	PF00069	0.768
MOD_CK2_1	306	312	PF00069	0.521
MOD_CK2_1	360	366	PF00069	0.718
MOD_GlcNHglycan	128	131	PF01048	0.371
MOD_GlcNHglycan	161	164	PF01048	0.442
MOD_GlcNHglycan	200	203	PF01048	0.519
MOD_GlcNHglycan	275	278	PF01048	0.734
MOD_GlcNHglycan	319	322	PF01048	0.542
MOD_GlcNHglycan	375	378	PF01048	0.580
MOD_GlcNHglycan	90	93	PF01048	0.384
MOD_GlcNHglycan	94	97	PF01048	0.420
MOD_GSK3_1	129	136	PF00069	0.446
MOD_GSK3_1	266	273	PF00069	0.646
MOD_GSK3_1	288	295	PF00069	0.725
MOD_GSK3_1	317	324	PF00069	0.597
MOD_GSK3_1	360	367	PF00069	0.496
MOD_GSK3_1	88	95	PF00069	0.434
MOD_N-GLC_1	271	276	PF02516	0.536
MOD_N-GLC_1	71	76	PF02516	0.450
MOD_NEK2_1	126	131	PF00069	0.425
MOD_NEK2_1	184	189	PF00069	0.356
MOD_NEK2_1	196	201	PF00069	0.427
MOD_NEK2_1	222	227	PF00069	0.392
MOD_NEK2_1	292	297	PF00069	0.749
MOD_NEK2_1	408	413	PF00069	0.482
MOD_NEK2_1	423	428	PF00069	0.422
MOD_NEK2_1	454	459	PF00069	0.382
MOD_NEK2_1	460	465	PF00069	0.361
MOD_NEK2_1	88	93	PF00069	0.445
MOD_NEK2_2	4	9	PF00069	0.595
MOD_PIKK_1	384	390	PF00454	0.584
MOD_PIKK_1	71	77	PF00454	0.409
MOD_PKA_2	27	33	PF00069	0.563
MOD_PKA_2	288	294	PF00069	0.738
MOD_PKA_2	436	442	PF00069	0.479
MOD_PKA_2	567	573	PF00069	0.539
MOD_PKB_1	547	555	PF00069	0.605
MOD_Plk_1	503	509	PF00069	0.489
MOD_Plk_1	71	77	PF00069	0.414
MOD_Plk_2-3	308	314	PF00069	0.537
MOD_Plk_2-3	364	370	PF00069	0.613
MOD_Plk_4	134	140	PF00069	0.451
MOD_Plk_4	184	190	PF00069	0.345
MOD_Plk_4	222	228	PF00069	0.365
MOD_Plk_4	4	10	PF00069	0.504
MOD_Plk_4	408	414	PF00069	0.415
MOD_Plk_4	425	431	PF00069	0.255
MOD_Plk_4	443	449	PF00069	0.423
MOD_Plk_4	460	466	PF00069	0.237
MOD_Plk_4	476	482	PF00069	0.311
MOD_Plk_4	487	493	PF00069	0.342
MOD_Plk_4	79	85	PF00069	0.440
MOD_ProDKin_1	144	150	PF00069	0.416
MOD_ProDKin_1	281	287	PF00069	0.559
MOD_ProDKin_1	330	336	PF00069	0.811
MOD_ProDKin_1	371	377	PF00069	0.593
MOD_ProDKin_1	471	477	PF00069	0.403
MOD_SUMO_for_1	538	541	PF00179	0.482
MOD_SUMO_rev_2	249	255	PF00179	0.443
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.379
TRG_ENDOCYTIC_2	101	104	PF00928	0.494
TRG_ENDOCYTIC_2	121	124	PF00928	0.163
TRG_ENDOCYTIC_2	179	182	PF00928	0.382
TRG_ER_diArg_1	113	116	PF00400	0.483
TRG_ER_diArg_1	545	547	PF00400	0.552
TRG_NES_CRM1_1	407	418	PF08389	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P8U7	Trypanosomatidae	25%	100%
A0A3R7KUT2	Trypanosoma rangeli	45%	100%
A0A3S5H7D1	Leishmania donovani	74%	100%
A0A422NMM7	Trypanosoma rangeli	26%	100%
A4H3M7	Leishmania braziliensis	24%	72%
A4I0U6	Leishmania infantum	75%	100%
E9AJU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	71%
E9AWV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QAM4	Leishmania major	73%	90%
V5BAL2	Trypanosoma cruzi	50%	100%