Putative DNAJ domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDG4_LEIBR

TriTrypDb:

LbrM.24.1090 , LBRM2903_240019100

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HDG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.578
CLV_NRD_NRD_1	137	139	PF00675	0.390
CLV_NRD_NRD_1	293	295	PF00675	0.345
CLV_NRD_NRD_1	298	300	PF00675	0.377
CLV_NRD_NRD_1	305	307	PF00675	0.380
CLV_NRD_NRD_1	343	345	PF00675	0.514
CLV_NRD_NRD_1	37	39	PF00675	0.415
CLV_NRD_NRD_1	422	424	PF00675	0.304
CLV_PCSK_FUR_1	303	307	PF00082	0.448
CLV_PCSK_KEX2_1	293	295	PF00082	0.337
CLV_PCSK_KEX2_1	298	300	PF00082	0.370
CLV_PCSK_KEX2_1	305	307	PF00082	0.374
CLV_PCSK_KEX2_1	343	345	PF00082	0.532
CLV_PCSK_KEX2_1	37	39	PF00082	0.415
CLV_PCSK_KEX2_1	421	423	PF00082	0.267
CLV_PCSK_KEX2_1	88	90	PF00082	0.405
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.308
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.405
CLV_PCSK_PC7_1	294	300	PF00082	0.416
CLV_PCSK_PC7_1	301	307	PF00082	0.456
CLV_PCSK_PC7_1	418	424	PF00082	0.264
CLV_PCSK_SKI1_1	54	58	PF00082	0.322
DEG_Nend_Nbox_1	1	3	PF02207	0.626
DEG_SCF_FBW7_2	49	55	PF00400	0.493
DEG_SPOP_SBC_1	318	322	PF00917	0.580
DEG_SPOP_SBC_1	354	358	PF00917	0.771
DEG_SPOP_SBC_1	78	82	PF00917	0.554
DOC_AGCK_PIF_1	194	199	PF00069	0.571
DOC_CKS1_1	12	17	PF01111	0.502
DOC_CKS1_1	49	54	PF01111	0.518
DOC_CYCLIN_RxL_1	369	380	PF00134	0.452
DOC_MAPK_gen_1	303	311	PF00069	0.631
DOC_PP1_RVXF_1	14	21	PF00149	0.528
DOC_PP2B_LxvP_1	259	262	PF13499	0.483
DOC_USP7_MATH_1	318	322	PF00917	0.623
DOC_USP7_MATH_1	354	358	PF00917	0.750
DOC_WW_Pin1_4	11	16	PF00397	0.543
DOC_WW_Pin1_4	202	207	PF00397	0.517
DOC_WW_Pin1_4	48	53	PF00397	0.611
LIG_14-3-3_CanoR_1	222	226	PF00244	0.567
LIG_14-3-3_CanoR_1	247	254	PF00244	0.285
LIG_14-3-3_CanoR_1	317	325	PF00244	0.630
LIG_14-3-3_CanoR_1	343	351	PF00244	0.692
LIG_14-3-3_CanoR_1	65	71	PF00244	0.499
LIG_14-3-3_CanoR_1	89	95	PF00244	0.598
LIG_APCC_ABBA_1	374	379	PF00400	0.432
LIG_BRCT_BRCA1_1	52	56	PF00533	0.501
LIG_FHA_1	147	153	PF00498	0.533
LIG_FHA_1	222	228	PF00498	0.498
LIG_FHA_1	246	252	PF00498	0.324
LIG_FHA_1	3	9	PF00498	0.702
LIG_FHA_1	359	365	PF00498	0.652
LIG_FHA_1	90	96	PF00498	0.621
LIG_FHA_2	331	337	PF00498	0.758
LIG_FHA_2	79	85	PF00498	0.678
LIG_Integrin_RGD_1	129	131	PF01839	0.333
LIG_LIR_Apic_2	346	351	PF02991	0.670
LIG_LIR_Gen_1	278	286	PF02991	0.417
LIG_LIR_Gen_1	45	52	PF02991	0.533
LIG_LIR_Nem_3	111	117	PF02991	0.472
LIG_LIR_Nem_3	193	197	PF02991	0.483
LIG_LIR_Nem_3	221	226	PF02991	0.499
LIG_LIR_Nem_3	278	283	PF02991	0.418
LIG_LIR_Nem_3	387	392	PF02991	0.476
LIG_LIR_Nem_3	412	417	PF02991	0.480
LIG_LIR_Nem_3	45	49	PF02991	0.521
LIG_LIR_Nem_3	53	59	PF02991	0.464
LIG_Pex14_2	208	212	PF04695	0.527
LIG_Pex14_2	284	288	PF04695	0.355
LIG_PTB_Apo_2	238	245	PF02174	0.500
LIG_PTB_Apo_2	70	77	PF02174	0.484
LIG_PTB_Phospho_1	238	244	PF10480	0.516
LIG_PTB_Phospho_1	70	76	PF10480	0.477
LIG_REV1ctd_RIR_1	281	289	PF16727	0.349
LIG_SH2_CRK	371	375	PF00017	0.434
LIG_SH2_CRK	389	393	PF00017	0.464
LIG_SH2_CRK	414	418	PF00017	0.457
LIG_SH2_STAP1	223	227	PF00017	0.477
LIG_SH2_STAP1	280	284	PF00017	0.301
LIG_SH2_STAT5	10	13	PF00017	0.590
LIG_SH2_STAT5	223	226	PF00017	0.466
LIG_SH2_STAT5	238	241	PF00017	0.477
LIG_SH2_STAT5	244	247	PF00017	0.290
LIG_SH2_STAT5	46	49	PF00017	0.521
LIG_SH2_STAT5	60	63	PF00017	0.417
LIG_SH2_STAT5	94	97	PF00017	0.558
LIG_SH3_3	231	237	PF00018	0.493
LIG_SH3_3	361	367	PF00018	0.624
LIG_SH3_3	9	15	PF00018	0.542
LIG_TYR_ITIM	44	49	PF00017	0.614
LIG_WRC_WIRS_1	180	185	PF05994	0.568
MOD_CDK_SPK_2	11	16	PF00069	0.520
MOD_CDK_SPxK_1	48	54	PF00069	0.501
MOD_CK1_1	156	162	PF00069	0.520
MOD_CK1_1	186	192	PF00069	0.530
MOD_CK1_1	353	359	PF00069	0.743
MOD_CK1_1	360	366	PF00069	0.654
MOD_CK1_1	77	83	PF00069	0.598
MOD_CK1_1	87	93	PF00069	0.583
MOD_CK1_1	98	104	PF00069	0.582
MOD_CK2_1	101	107	PF00069	0.576
MOD_CK2_1	343	349	PF00069	0.686
MOD_CK2_1	378	384	PF00069	0.440
MOD_Cter_Amidation	35	38	PF01082	0.418
MOD_GlcNHglycan	185	188	PF01048	0.347
MOD_GlcNHglycan	21	25	PF01048	0.410
MOD_GlcNHglycan	227	230	PF01048	0.302
MOD_GlcNHglycan	352	355	PF01048	0.554
MOD_GlcNHglycan	386	389	PF01048	0.265
MOD_GlcNHglycan	62	65	PF01048	0.303
MOD_GlcNHglycan	81	84	PF01048	0.485
MOD_GSK3_1	142	149	PF00069	0.554
MOD_GSK3_1	175	182	PF00069	0.564
MOD_GSK3_1	221	228	PF00069	0.506
MOD_GSK3_1	246	253	PF00069	0.355
MOD_GSK3_1	330	337	PF00069	0.636
MOD_GSK3_1	350	357	PF00069	0.763
MOD_GSK3_1	358	365	PF00069	0.753
MOD_GSK3_1	74	81	PF00069	0.558
MOD_GSK3_1	83	90	PF00069	0.596
MOD_GSK3_1	94	101	PF00069	0.550
MOD_N-GLC_1	108	113	PF02516	0.295
MOD_N-GLC_1	318	323	PF02516	0.521
MOD_N-GLC_1	72	77	PF02516	0.414
MOD_N-GLC_1	78	83	PF02516	0.484
MOD_NEK2_1	133	138	PF00069	0.615
MOD_NEK2_1	153	158	PF00069	0.522
MOD_NEK2_1	179	184	PF00069	0.558
MOD_NEK2_1	2	7	PF00069	0.626
MOD_NEK2_1	225	230	PF00069	0.478
MOD_NEK2_1	239	244	PF00069	0.457
MOD_NEK2_1	269	274	PF00069	0.426
MOD_NEK2_1	8	13	PF00069	0.532
MOD_PIKK_1	108	114	PF00454	0.488
MOD_PIKK_1	319	325	PF00454	0.661
MOD_PIKK_1	358	364	PF00454	0.655
MOD_PKA_1	343	349	PF00069	0.721
MOD_PKA_1	88	94	PF00069	0.585
MOD_PKA_2	221	227	PF00069	0.565
MOD_PKA_2	246	252	PF00069	0.334
MOD_PKA_2	343	349	PF00069	0.676
MOD_PKA_2	88	94	PF00069	0.656
MOD_Plk_1	108	114	PF00069	0.508
MOD_Plk_1	195	201	PF00069	0.582
MOD_Plk_1	378	384	PF00069	0.507
MOD_Plk_1	72	78	PF00069	0.629
MOD_Plk_4	101	107	PF00069	0.549
MOD_Plk_4	156	162	PF00069	0.584
MOD_Plk_4	204	210	PF00069	0.567
MOD_Plk_4	221	227	PF00069	0.397
MOD_Plk_4	239	245	PF00069	0.467
MOD_Plk_4	275	281	PF00069	0.273
MOD_Plk_4	330	336	PF00069	0.629
MOD_Plk_4	66	72	PF00069	0.549
MOD_ProDKin_1	11	17	PF00069	0.538
MOD_ProDKin_1	202	208	PF00069	0.515
MOD_ProDKin_1	48	54	PF00069	0.610
MOD_SUMO_for_1	214	217	PF00179	0.579
MOD_SUMO_rev_2	103	111	PF00179	0.611
MOD_SUMO_rev_2	188	197	PF00179	0.593
TRG_ENDOCYTIC_2	280	283	PF00928	0.277
TRG_ENDOCYTIC_2	371	374	PF00928	0.461
TRG_ENDOCYTIC_2	389	392	PF00928	0.464
TRG_ENDOCYTIC_2	414	417	PF00928	0.457
TRG_ENDOCYTIC_2	46	49	PF00928	0.568
TRG_ER_diArg_1	292	294	PF00400	0.553
TRG_ER_diArg_1	298	301	PF00400	0.573
TRG_ER_diArg_1	3	6	PF00400	0.717
TRG_ER_diArg_1	303	306	PF00400	0.562
TRG_ER_diArg_1	37	39	PF00400	0.615
TRG_NLS_MonoExtN_4	418	425	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.231

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B2	Leptomonas seymouri	71%	99%
A0A0S4IP86	Bodo saltans	46%	98%
A0A0S4ITI3	Bodo saltans	25%	84%
A0A1X0NQB1	Trypanosomatidae	24%	85%
A0A1X0NVK2	Trypanosomatidae	55%	100%
A0A3S7WSV3	Leishmania donovani	25%	82%
A0A3S7WYG6	Leishmania donovani	88%	99%
A0A422N8L2	Trypanosoma rangeli	55%	100%
A4H7H2	Leishmania braziliensis	23%	100%
A4HVV3	Leishmania infantum	26%	100%
A4I0U5	Leishmania infantum	88%	99%
D0A774	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9APK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	82%
E9AWU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QAM5	Leishmania major	89%	100%
Q4QFX4	Leishmania major	25%	100%
V5BD52	Trypanosoma cruzi	25%	84%
V5DSF1	Trypanosoma cruzi	56%	100%