AKAP7_NLS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AKAP7 2'5' RNA ligase-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDG2_LEIBR

TriTrypDb:

LbrM.24.1070 , LBRM2903_240016700

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDG2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.535
CLV_C14_Caspase3-7	200	204	PF00656	0.555
CLV_C14_Caspase3-7	215	219	PF00656	0.556
CLV_NRD_NRD_1	318	320	PF00675	0.319
CLV_NRD_NRD_1	433	435	PF00675	0.312
CLV_NRD_NRD_1	452	454	PF00675	0.216
CLV_NRD_NRD_1	49	51	PF00675	0.777
CLV_PCSK_KEX2_1	135	137	PF00082	0.406
CLV_PCSK_KEX2_1	26	28	PF00082	0.587
CLV_PCSK_KEX2_1	318	320	PF00082	0.319
CLV_PCSK_KEX2_1	433	435	PF00082	0.334
CLV_PCSK_KEX2_1	452	454	PF00082	0.216
CLV_PCSK_KEX2_1	49	51	PF00082	0.652
CLV_PCSK_KEX2_1	58	60	PF00082	0.427
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.406
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.639
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.540
CLV_PCSK_SKI1_1	139	143	PF00082	0.570
CLV_PCSK_SKI1_1	158	162	PF00082	0.695
CLV_PCSK_SKI1_1	231	235	PF00082	0.221
CLV_PCSK_SKI1_1	303	307	PF00082	0.196
CLV_PCSK_SKI1_1	326	330	PF00082	0.321
CLV_PCSK_SKI1_1	433	437	PF00082	0.321
CLV_PCSK_SKI1_1	476	480	PF00082	0.291
CLV_PCSK_SKI1_1	50	54	PF00082	0.657
DEG_APCC_DBOX_1	32	40	PF00400	0.634
DEG_APCC_DBOX_1	364	372	PF00400	0.521
DEG_ODPH_VHL_1	360	371	PF01847	0.514
DOC_CDC14_PxL_1	354	362	PF14671	0.396
DOC_CDC14_PxL_1	478	486	PF14671	0.521
DOC_MAPK_DCC_7	476	486	PF00069	0.521
DOC_MAPK_gen_1	303	313	PF00069	0.425
DOC_MAPK_gen_1	315	324	PF00069	0.471
DOC_MAPK_gen_1	431	440	PF00069	0.509
DOC_MAPK_MEF2A_6	306	313	PF00069	0.480
DOC_MAPK_MEF2A_6	431	440	PF00069	0.509
DOC_MAPK_NFAT4_5	306	314	PF00069	0.454
DOC_PP2B_LxvP_1	314	317	PF13499	0.498
DOC_PP2B_LxvP_1	4	7	PF13499	0.664
DOC_PP4_FxxP_1	221	224	PF00568	0.528
DOC_PP4_FxxP_1	479	482	PF00568	0.521
DOC_USP7_MATH_1	153	157	PF00917	0.641
DOC_USP7_MATH_1	185	189	PF00917	0.700
DOC_USP7_MATH_1	332	336	PF00917	0.509
DOC_USP7_MATH_1	429	433	PF00917	0.493
DOC_USP7_UBL2_3	443	447	PF12436	0.503
DOC_USP7_UBL2_3	58	62	PF12436	0.510
DOC_WW_Pin1_4	194	199	PF00397	0.644
DOC_WW_Pin1_4	79	84	PF00397	0.514
LIG_14-3-3_CanoR_1	139	147	PF00244	0.590
LIG_14-3-3_CanoR_1	158	167	PF00244	0.598
LIG_14-3-3_CanoR_1	213	221	PF00244	0.614
LIG_14-3-3_CanoR_1	231	240	PF00244	0.204
LIG_14-3-3_CanoR_1	452	456	PF00244	0.408
LIG_APCC_ABBA_1	37	42	PF00400	0.641
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_CaM_IQ_9	19	35	PF13499	0.577
LIG_FHA_1	103	109	PF00498	0.618
LIG_FHA_1	135	141	PF00498	0.569
LIG_FHA_1	232	238	PF00498	0.291
LIG_FHA_1	250	256	PF00498	0.523
LIG_FHA_1	302	308	PF00498	0.490
LIG_FHA_1	349	355	PF00498	0.499
LIG_FHA_1	400	406	PF00498	0.459
LIG_FHA_2	118	124	PF00498	0.643
LIG_FHA_2	13	19	PF00498	0.579
LIG_FHA_2	267	273	PF00498	0.396
LIG_FHA_2	279	285	PF00498	0.364
LIG_FHA_2	337	343	PF00498	0.396
LIG_LIR_Apic_2	218	224	PF02991	0.532
LIG_LIR_Gen_1	230	241	PF02991	0.277
LIG_LIR_Nem_3	137	141	PF02991	0.579
LIG_LIR_Nem_3	230	236	PF02991	0.277
LIG_LIR_Nem_3	393	399	PF02991	0.479
LIG_MYND_1	358	362	PF01753	0.396
LIG_PDZ_Class_2	502	507	PF00595	0.454
LIG_Pex14_2	333	337	PF04695	0.521
LIG_SH2_GRB2like	87	90	PF00017	0.517
LIG_SH2_STAT5	499	502	PF00017	0.556
LIG_SH2_STAT5	79	82	PF00017	0.378
LIG_SH3_3	105	111	PF00018	0.681
LIG_SH3_3	112	118	PF00018	0.741
LIG_SH3_3	192	198	PF00018	0.600
LIG_SH3_3	234	240	PF00018	0.521
LIG_SH3_CIN85_PxpxPR_1	147	152	PF14604	0.602
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.581
LIG_SUMO_SIM_anti_2	310	315	PF11976	0.500
LIG_TRAF2_1	198	201	PF00917	0.639
LIG_TRAF2_1	269	272	PF00917	0.396
LIG_TRFH_1	79	83	PF08558	0.548
LIG_TYR_ITIM	394	399	PF00017	0.454
LIG_WRC_WIRS_1	258	263	PF05994	0.521
MOD_CK1_1	156	162	PF00069	0.667
MOD_CK1_1	289	295	PF00069	0.557
MOD_CK1_1	347	353	PF00069	0.571
MOD_CK1_1	88	94	PF00069	0.504
MOD_CK2_1	194	200	PF00069	0.636
MOD_CK2_1	250	256	PF00069	0.396
MOD_CK2_1	261	267	PF00069	0.378
MOD_CK2_1	278	284	PF00069	0.396
MOD_CK2_1	336	342	PF00069	0.396
MOD_CK2_1	415	421	PF00069	0.474
MOD_CK2_1	456	462	PF00069	0.482
MOD_Cter_Amidation	47	50	PF01082	0.728
MOD_GlcNHglycan	158	161	PF01048	0.711
MOD_GlcNHglycan	214	217	PF01048	0.745
MOD_GlcNHglycan	272	275	PF01048	0.220
MOD_GlcNHglycan	334	337	PF01048	0.308
MOD_GlcNHglycan	354	357	PF01048	0.320
MOD_GlcNHglycan	9	12	PF01048	0.588
MOD_GlcNHglycan	90	93	PF01048	0.693
MOD_GSK3_1	185	192	PF00069	0.510
MOD_GSK3_1	231	238	PF00069	0.338
MOD_GSK3_1	257	264	PF00069	0.444
MOD_GSK3_1	266	273	PF00069	0.417
MOD_GSK3_1	283	290	PF00069	0.533
MOD_GSK3_1	291	298	PF00069	0.524
MOD_GSK3_1	332	339	PF00069	0.596
MOD_GSK3_1	344	351	PF00069	0.523
MOD_GSK3_1	352	359	PF00069	0.507
MOD_N-GLC_1	185	190	PF02516	0.500
MOD_N-GLC_1	249	254	PF02516	0.321
MOD_N-GLC_1	495	500	PF02516	0.196
MOD_N-GLC_1	88	93	PF02516	0.574
MOD_NEK2_1	128	133	PF00069	0.547
MOD_NEK2_1	141	146	PF00069	0.611
MOD_NEK2_1	261	266	PF00069	0.396
MOD_NEK2_1	291	296	PF00069	0.541
MOD_NEK2_1	307	312	PF00069	0.399
MOD_NEK2_1	415	420	PF00069	0.521
MOD_NEK2_1	436	441	PF00069	0.454
MOD_NEK2_1	500	505	PF00069	0.509
MOD_PIKK_1	266	272	PF00454	0.456
MOD_PKA_2	189	195	PF00069	0.639
MOD_PKA_2	212	218	PF00069	0.616
MOD_PKA_2	451	457	PF00069	0.405
MOD_Plk_1	177	183	PF00069	0.516
MOD_Plk_1	249	255	PF00069	0.521
MOD_Plk_1	348	354	PF00069	0.563
MOD_Plk_1	501	507	PF00069	0.590
MOD_Plk_2-3	177	183	PF00069	0.516
MOD_Plk_2-3	456	462	PF00069	0.396
MOD_Plk_4	250	256	PF00069	0.586
MOD_Plk_4	307	313	PF00069	0.488
MOD_Plk_4	390	396	PF00069	0.521
MOD_Plk_4	436	442	PF00069	0.454
MOD_Plk_4	456	462	PF00069	0.438
MOD_Plk_4	495	501	PF00069	0.509
MOD_ProDKin_1	194	200	PF00069	0.646
MOD_ProDKin_1	79	85	PF00069	0.519
MOD_SUMO_for_1	103	106	PF00179	0.533
MOD_SUMO_for_1	57	60	PF00179	0.508
TRG_ENDOCYTIC_2	138	141	PF00928	0.505
TRG_ENDOCYTIC_2	396	399	PF00928	0.454
TRG_ER_diArg_1	317	319	PF00400	0.509
TRG_ER_diArg_1	433	435	PF00400	0.539
TRG_ER_diArg_1	49	51	PF00400	0.761
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.196

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X3	Leptomonas seymouri	57%	100%
A0A1X0NQT7	Trypanosomatidae	26%	100%
A0A3S7WYE0	Leishmania donovani	77%	85%
A4I0U3	Leishmania infantum	78%	85%
C9ZVE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AWU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QAM7	Leishmania major	77%	100%