Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HDG0_LEIBR

TriTrypDb:

LbrM.24.1050 , LBRM2903_240016500

Length:

957

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDG0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.567
CLV_C14_Caspase3-7	699	703	PF00656	0.599
CLV_C14_Caspase3-7	72	76	PF00656	0.731
CLV_NRD_NRD_1	158	160	PF00675	0.817
CLV_NRD_NRD_1	161	163	PF00675	0.745
CLV_NRD_NRD_1	203	205	PF00675	0.629
CLV_NRD_NRD_1	207	209	PF00675	0.622
CLV_NRD_NRD_1	223	225	PF00675	0.375
CLV_NRD_NRD_1	434	436	PF00675	0.520
CLV_NRD_NRD_1	549	551	PF00675	0.685
CLV_NRD_NRD_1	594	596	PF00675	0.785
CLV_NRD_NRD_1	659	661	PF00675	0.793
CLV_PCSK_FUR_1	159	163	PF00082	0.569
CLV_PCSK_FUR_1	21	25	PF00082	0.570
CLV_PCSK_FUR_1	221	225	PF00082	0.451
CLV_PCSK_FUR_1	432	436	PF00082	0.520
CLV_PCSK_FUR_1	657	661	PF00082	0.759
CLV_PCSK_KEX2_1	158	160	PF00082	0.817
CLV_PCSK_KEX2_1	161	163	PF00082	0.745
CLV_PCSK_KEX2_1	202	204	PF00082	0.628
CLV_PCSK_KEX2_1	207	209	PF00082	0.626
CLV_PCSK_KEX2_1	223	225	PF00082	0.375
CLV_PCSK_KEX2_1	23	25	PF00082	0.569
CLV_PCSK_KEX2_1	434	436	PF00082	0.520
CLV_PCSK_KEX2_1	659	661	PF00082	0.768
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.569
CLV_PCSK_PC1ET2_1	659	661	PF00082	0.768
CLV_PCSK_PC7_1	203	209	PF00082	0.745
CLV_PCSK_SKI1_1	178	182	PF00082	0.769
CLV_PCSK_SKI1_1	224	228	PF00082	0.445
CLV_PCSK_SKI1_1	409	413	PF00082	0.569
CLV_PCSK_SKI1_1	500	504	PF00082	0.533
CLV_PCSK_SKI1_1	596	600	PF00082	0.771
CLV_PCSK_SKI1_1	626	630	PF00082	0.764
CLV_PCSK_SKI1_1	632	636	PF00082	0.664
CLV_PCSK_SKI1_1	796	800	PF00082	0.538
DEG_APCC_DBOX_1	338	346	PF00400	0.784
DEG_Nend_UBRbox_3	1	3	PF02207	0.543
DEG_ODPH_VHL_1	917	929	PF01847	0.514
DEG_SCF_FBW7_1	92	97	PF00400	0.565
DEG_SPOP_SBC_1	80	84	PF00917	0.813
DOC_ANK_TNKS_1	681	688	PF00023	0.697
DOC_CKS1_1	564	569	PF01111	0.790
DOC_CYCLIN_RxL_1	593	600	PF00134	0.740
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.789
DOC_CYCLIN_yCln2_LP_2	584	590	PF00134	0.811
DOC_CYCLIN_yCln2_LP_2	739	745	PF00134	0.797
DOC_MAPK_DCC_7	734	743	PF00069	0.562
DOC_MAPK_gen_1	500	510	PF00069	0.522
DOC_MAPK_gen_1	732	741	PF00069	0.575
DOC_MAPK_HePTP_8	731	743	PF00069	0.573
DOC_MAPK_JIP1_4	770	776	PF00069	0.537
DOC_MAPK_MEF2A_6	503	510	PF00069	0.731
DOC_MAPK_MEF2A_6	54	62	PF00069	0.589
DOC_MAPK_MEF2A_6	734	743	PF00069	0.765
DOC_MAPK_MEF2A_6	770	778	PF00069	0.528
DOC_MAPK_MEF2A_6	892	900	PF00069	0.808
DOC_MAPK_MEF2A_6	947	954	PF00069	0.770
DOC_MIT_MIM_1	773	782	PF04212	0.514
DOC_PP2B_LxvP_1	35	38	PF13499	0.549
DOC_PP2B_LxvP_1	519	522	PF13499	0.781
DOC_PP2B_LxvP_1	584	587	PF13499	0.804
DOC_PP2B_LxvP_1	739	742	PF13499	0.795
DOC_PP4_FxxP_1	226	229	PF00568	0.716
DOC_USP7_MATH_1	114	118	PF00917	0.811
DOC_USP7_MATH_1	160	164	PF00917	0.828
DOC_USP7_MATH_1	243	247	PF00917	0.682
DOC_USP7_MATH_1	254	258	PF00917	0.767
DOC_USP7_MATH_1	26	30	PF00917	0.559
DOC_USP7_MATH_1	330	334	PF00917	0.668
DOC_USP7_MATH_1	38	42	PF00917	0.523
DOC_USP7_MATH_1	556	560	PF00917	0.800
DOC_USP7_MATH_1	607	611	PF00917	0.650
DOC_USP7_MATH_1	612	616	PF00917	0.701
DOC_USP7_MATH_1	66	70	PF00917	0.588
DOC_USP7_MATH_1	719	723	PF00917	0.645
DOC_USP7_MATH_1	751	755	PF00917	0.522
DOC_USP7_MATH_1	80	84	PF00917	0.758
DOC_USP7_MATH_1	801	805	PF00917	0.576
DOC_WW_Pin1_4	129	134	PF00397	0.648
DOC_WW_Pin1_4	162	167	PF00397	0.581
DOC_WW_Pin1_4	188	193	PF00397	0.762
DOC_WW_Pin1_4	256	261	PF00397	0.671
DOC_WW_Pin1_4	384	389	PF00397	0.619
DOC_WW_Pin1_4	47	52	PF00397	0.568
DOC_WW_Pin1_4	477	482	PF00397	0.835
DOC_WW_Pin1_4	563	568	PF00397	0.796
DOC_WW_Pin1_4	672	677	PF00397	0.577
DOC_WW_Pin1_4	812	817	PF00397	0.826
DOC_WW_Pin1_4	818	823	PF00397	0.693
DOC_WW_Pin1_4	827	832	PF00397	0.484
DOC_WW_Pin1_4	844	849	PF00397	0.644
DOC_WW_Pin1_4	868	873	PF00397	0.806
DOC_WW_Pin1_4	885	890	PF00397	0.569
DOC_WW_Pin1_4	90	95	PF00397	0.714
DOC_WW_Pin1_4	909	914	PF00397	0.761
DOC_WW_Pin1_4	99	104	PF00397	0.746
LIG_14-3-3_CanoR_1	202	211	PF00244	0.536
LIG_14-3-3_CanoR_1	212	217	PF00244	0.578
LIG_14-3-3_CanoR_1	24	34	PF00244	0.576
LIG_14-3-3_CanoR_1	280	288	PF00244	0.612
LIG_14-3-3_CanoR_1	332	342	PF00244	0.777
LIG_14-3-3_CanoR_1	374	380	PF00244	0.664
LIG_14-3-3_CanoR_1	439	444	PF00244	0.755
LIG_14-3-3_CanoR_1	947	953	PF00244	0.519
LIG_APCC_ABBA_1	741	746	PF00400	0.794
LIG_BIR_III_2	113	117	PF00653	0.739
LIG_Clathr_ClatBox_1	627	631	PF01394	0.664
LIG_DLG_GKlike_1	212	220	PF00625	0.486
LIG_DLG_GKlike_1	439	447	PF00625	0.759
LIG_EH1_1	920	928	PF00400	0.508
LIG_eIF4E_1	571	577	PF01652	0.783
LIG_FHA_1	135	141	PF00498	0.727
LIG_FHA_1	147	153	PF00498	0.561
LIG_FHA_1	240	246	PF00498	0.585
LIG_FHA_1	341	347	PF00498	0.635
LIG_FHA_1	410	416	PF00498	0.524
LIG_FHA_1	452	458	PF00498	0.594
LIG_FHA_1	558	564	PF00498	0.764
LIG_FHA_1	598	604	PF00498	0.770
LIG_FHA_1	616	622	PF00498	0.512
LIG_FHA_1	623	629	PF00498	0.745
LIG_FHA_1	650	656	PF00498	0.652
LIG_FHA_1	66	72	PF00498	0.777
LIG_FHA_1	673	679	PF00498	0.582
LIG_FHA_1	819	825	PF00498	0.751
LIG_FHA_1	886	892	PF00498	0.788
LIG_FHA_1	95	101	PF00498	0.742
LIG_FHA_2	242	248	PF00498	0.580
LIG_FHA_2	788	794	PF00498	0.638
LIG_FHA_2	897	903	PF00498	0.806
LIG_LIR_Apic_2	74	80	PF02991	0.784
LIG_LIR_Gen_1	102	111	PF02991	0.804
LIG_LIR_Gen_1	748	758	PF02991	0.775
LIG_LIR_Nem_3	102	107	PF02991	0.796
LIG_LIR_Nem_3	210	216	PF02991	0.762
LIG_LIR_Nem_3	284	290	PF02991	0.565
LIG_LIR_Nem_3	298	302	PF02991	0.543
LIG_LIR_Nem_3	371	376	PF02991	0.601
LIG_LIR_Nem_3	748	753	PF02991	0.779
LIG_MYND_1	32	36	PF01753	0.555
LIG_MYND_1	915	919	PF01753	0.544
LIG_MYND_3	756	760	PF01753	0.762
LIG_NRBOX	341	347	PF00104	0.752
LIG_PCNA_PIPBox_1	305	314	PF02747	0.735
LIG_Pex14_1	213	217	PF04695	0.496
LIG_Pex14_1	536	540	PF04695	0.778
LIG_RPA_C_Fungi	457	469	PF08784	0.691
LIG_SH2_CRK	943	947	PF00017	0.794
LIG_SH2_GRB2like	311	314	PF00017	0.492
LIG_SH2_NCK_1	73	77	PF00017	0.732
LIG_SH2_PTP2	77	80	PF00017	0.803
LIG_SH2_SRC	311	314	PF00017	0.745
LIG_SH2_SRC	540	543	PF00017	0.774
LIG_SH2_SRC	571	574	PF00017	0.785
LIG_SH2_STAP1	73	77	PF00017	0.791
LIG_SH2_STAT5	217	220	PF00017	0.460
LIG_SH2_STAT5	288	291	PF00017	0.427
LIG_SH2_STAT5	311	314	PF00017	0.745
LIG_SH2_STAT5	518	521	PF00017	0.528
LIG_SH2_STAT5	571	574	PF00017	0.785
LIG_SH2_STAT5	590	593	PF00017	0.492
LIG_SH2_STAT5	73	76	PF00017	0.737
LIG_SH2_STAT5	761	764	PF00017	0.771
LIG_SH2_STAT5	77	80	PF00017	0.787
LIG_SH2_STAT5	788	791	PF00017	0.751
LIG_SH3_3	383	389	PF00018	0.610
LIG_SH3_3	795	801	PF00018	0.791
LIG_SH3_3	810	816	PF00018	0.606
LIG_SH3_3	828	834	PF00018	0.641
LIG_SH3_3	869	875	PF00018	0.824
LIG_SUMO_SIM_anti_2	507	512	PF11976	0.610
LIG_SUMO_SIM_anti_2	625	631	PF11976	0.667
LIG_SUMO_SIM_par_1	148	153	PF11976	0.737
LIG_SUMO_SIM_par_1	625	631	PF11976	0.667
LIG_SUMO_SIM_par_1	924	931	PF11976	0.755
LIG_TRAF2_1	471	474	PF00917	0.566
LIG_UBA3_1	783	791	PF00899	0.509
LIG_WW_1	486	489	PF00397	0.582
MOD_CDK_SPxxK_3	47	54	PF00069	0.567
MOD_CDK_SPxxK_3	477	484	PF00069	0.592
MOD_CDK_SPxxK_3	844	851	PF00069	0.727
MOD_CDK_SPxxK_3	885	892	PF00069	0.824
MOD_CK1_1	146	152	PF00069	0.739
MOD_CK1_1	165	171	PF00069	0.620
MOD_CK1_1	236	242	PF00069	0.550
MOD_CK1_1	246	252	PF00069	0.575
MOD_CK1_1	270	276	PF00069	0.677
MOD_CK1_1	333	339	PF00069	0.660
MOD_CK1_1	387	393	PF00069	0.828
MOD_CK1_1	615	621	PF00069	0.564
MOD_CK1_1	671	677	PF00069	0.801
MOD_CK1_1	713	719	PF00069	0.873
MOD_CK1_1	814	820	PF00069	0.651
MOD_CK1_1	829	835	PF00069	0.712
MOD_CK1_1	880	886	PF00069	0.775
MOD_CK2_1	16	22	PF00069	0.566
MOD_CK2_1	47	53	PF00069	0.656
MOD_CK2_1	498	504	PF00069	0.544
MOD_CK2_1	661	667	PF00069	0.779
MOD_CK2_1	787	793	PF00069	0.636
MOD_CK2_1	80	86	PF00069	0.564
MOD_CK2_1	844	850	PF00069	0.765
MOD_CK2_1	896	902	PF00069	0.554
MOD_DYRK1A_RPxSP_1	162	166	PF00069	0.585
MOD_GlcNHglycan	109	112	PF01048	0.645
MOD_GlcNHglycan	11	15	PF01048	0.559
MOD_GlcNHglycan	252	255	PF01048	0.576
MOD_GlcNHglycan	493	496	PF01048	0.837
MOD_GlcNHglycan	560	563	PF01048	0.807
MOD_GlcNHglycan	568	571	PF01048	0.651
MOD_GlcNHglycan	609	612	PF01048	0.749
MOD_GlcNHglycan	615	618	PF01048	0.786
MOD_GlcNHglycan	631	635	PF01048	0.490
MOD_GlcNHglycan	670	673	PF01048	0.672
MOD_GlcNHglycan	767	770	PF01048	0.695
MOD_GlcNHglycan	902	906	PF01048	0.807
MOD_GlcNHglycan	933	936	PF01048	0.525
MOD_GSK3_1	12	19	PF00069	0.561
MOD_GSK3_1	122	129	PF00069	0.708
MOD_GSK3_1	160	167	PF00069	0.740
MOD_GSK3_1	212	219	PF00069	0.525
MOD_GSK3_1	22	29	PF00069	0.530
MOD_GSK3_1	233	240	PF00069	0.775
MOD_GSK3_1	243	250	PF00069	0.665
MOD_GSK3_1	254	261	PF00069	0.677
MOD_GSK3_1	263	270	PF00069	0.505
MOD_GSK3_1	489	496	PF00069	0.840
MOD_GSK3_1	525	532	PF00069	0.734
MOD_GSK3_1	62	69	PF00069	0.617
MOD_GSK3_1	668	675	PF00069	0.755
MOD_GSK3_1	713	720	PF00069	0.657
MOD_GSK3_1	78	85	PF00069	0.576
MOD_GSK3_1	811	818	PF00069	0.713
MOD_GSK3_1	822	829	PF00069	0.725
MOD_GSK3_1	86	93	PF00069	0.720
MOD_GSK3_1	880	887	PF00069	0.718
MOD_GSK3_1	896	903	PF00069	0.634
MOD_LATS_1	809	815	PF00433	0.600
MOD_N-GLC_1	384	389	PF02516	0.594
MOD_N-GLC_1	885	890	PF02516	0.573
MOD_N-GLC_2	955	957	PF02516	0.744
MOD_NEK2_1	10	15	PF00069	0.562
MOD_NEK2_1	181	186	PF00069	0.668
MOD_NEK2_1	216	221	PF00069	0.561
MOD_NEK2_1	267	272	PF00069	0.685
MOD_NEK2_1	491	496	PF00069	0.588
MOD_NEK2_1	557	562	PF00069	0.648
MOD_NEK2_1	62	67	PF00069	0.530
MOD_NEK2_1	630	635	PF00069	0.504
MOD_NEK2_1	717	722	PF00069	0.622
MOD_NEK2_1	884	889	PF00069	0.834
MOD_NEK2_1	896	901	PF00069	0.607
MOD_NEK2_1	950	955	PF00069	0.763
MOD_NEK2_2	822	827	PF00069	0.523
MOD_PIKK_1	16	22	PF00454	0.566
MOD_PIKK_1	2	8	PF00454	0.543
MOD_PIKK_1	363	369	PF00454	0.686
MOD_PIKK_1	445	451	PF00454	0.809
MOD_PIKK_1	511	517	PF00454	0.741
MOD_PIKK_1	710	716	PF00454	0.870
MOD_PK_1	734	740	PF00069	0.570
MOD_PKA_1	202	208	PF00069	0.523
MOD_PKA_2	160	166	PF00069	0.653
MOD_PKA_2	202	208	PF00069	0.523
MOD_PKA_2	279	285	PF00069	0.624
MOD_PKA_2	489	495	PF00069	0.806
MOD_Plk_1	354	360	PF00069	0.577
MOD_Plk_1	529	535	PF00069	0.520
MOD_Plk_1	630	636	PF00069	0.591
MOD_Plk_2-3	241	247	PF00069	0.581
MOD_Plk_4	263	269	PF00069	0.746
MOD_Plk_4	30	36	PF00069	0.562
MOD_Plk_4	411	417	PF00069	0.521
MOD_Plk_4	439	445	PF00069	0.756
MOD_Plk_4	571	577	PF00069	0.783
MOD_Plk_4	734	740	PF00069	0.570
MOD_Plk_4	877	883	PF00069	0.804
MOD_ProDKin_1	129	135	PF00069	0.640
MOD_ProDKin_1	162	168	PF00069	0.584
MOD_ProDKin_1	188	194	PF00069	0.761
MOD_ProDKin_1	256	262	PF00069	0.671
MOD_ProDKin_1	384	390	PF00069	0.622
MOD_ProDKin_1	47	53	PF00069	0.568
MOD_ProDKin_1	477	483	PF00069	0.833
MOD_ProDKin_1	563	569	PF00069	0.792
MOD_ProDKin_1	672	678	PF00069	0.580
MOD_ProDKin_1	812	818	PF00069	0.825
MOD_ProDKin_1	827	833	PF00069	0.485
MOD_ProDKin_1	844	850	PF00069	0.643
MOD_ProDKin_1	868	874	PF00069	0.803
MOD_ProDKin_1	885	891	PF00069	0.568
MOD_ProDKin_1	90	96	PF00069	0.712
MOD_ProDKin_1	909	915	PF00069	0.762
MOD_ProDKin_1	99	105	PF00069	0.749
MOD_SUMO_for_1	196	199	PF00179	0.761
TRG_ENDOCYTIC_2	287	290	PF00928	0.601
TRG_ENDOCYTIC_2	299	302	PF00928	0.487
TRG_ENDOCYTIC_2	518	521	PF00928	0.528
TRG_ENDOCYTIC_2	943	946	PF00928	0.792
TRG_ER_diArg_1	157	159	PF00400	0.807
TRG_ER_diArg_1	160	162	PF00400	0.776
TRG_ER_diArg_1	202	204	PF00400	0.761
TRG_ER_diArg_1	221	224	PF00400	0.454
TRG_ER_diArg_1	432	435	PF00400	0.522
TRG_ER_diArg_1	592	595	PF00400	0.690
TRG_NES_CRM1_1	773	786	PF08389	0.517
TRG_NLS_MonoExtC_3	658	663	PF00514	0.543
TRG_NLS_MonoExtN_4	657	664	PF00514	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYA9	Leishmania donovani	70%	100%
A4I0U1	Leishmania infantum	70%	100%
E9AWU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	94%
Q4QAM9	Leishmania major	69%	99%