Mnd1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mnd1 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HDF7_LEIBR

TriTrypDb:

LbrM.24.1020 , LBRM2903_240016200

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDF7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035825	homologous recombination	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.613
CLV_NRD_NRD_1	125	127	PF00675	0.445
CLV_NRD_NRD_1	276	278	PF00675	0.543
CLV_NRD_NRD_1	425	427	PF00675	0.564
CLV_NRD_NRD_1	7	9	PF00675	0.637
CLV_PCSK_FUR_1	423	427	PF00082	0.543
CLV_PCSK_KEX2_1	125	127	PF00082	0.445
CLV_PCSK_KEX2_1	276	278	PF00082	0.467
CLV_PCSK_KEX2_1	415	417	PF00082	0.643
CLV_PCSK_KEX2_1	420	422	PF00082	0.645
CLV_PCSK_KEX2_1	425	427	PF00082	0.632
CLV_PCSK_PC1ET2_1	415	417	PF00082	0.643
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.645
CLV_PCSK_PC7_1	416	422	PF00082	0.713
CLV_PCSK_SKI1_1	125	129	PF00082	0.455
CLV_PCSK_SKI1_1	160	164	PF00082	0.363
CLV_PCSK_SKI1_1	20	24	PF00082	0.406
CLV_PCSK_SKI1_1	280	284	PF00082	0.453
CLV_PCSK_SKI1_1	399	403	PF00082	0.662
CLV_PCSK_SKI1_1	425	429	PF00082	0.537
CLV_Separin_Metazoa	122	126	PF03568	0.427
DEG_SCF_FBW7_1	319	326	PF00400	0.562
DOC_CKS1_1	149	154	PF01111	0.363
DOC_CKS1_1	320	325	PF01111	0.563
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.544
DOC_MAPK_gen_1	276	287	PF00069	0.456
DOC_MAPK_gen_1	420	429	PF00069	0.542
DOC_MAPK_gen_1	8	17	PF00069	0.560
DOC_MAPK_MEF2A_6	280	289	PF00069	0.536
DOC_MAPK_NFAT4_5	280	288	PF00069	0.539
DOC_PP1_RVXF_1	178	184	PF00149	0.505
DOC_PP2B_LxvP_1	283	286	PF13499	0.462
DOC_USP7_MATH_1	111	115	PF00917	0.625
DOC_USP7_MATH_1	268	272	PF00917	0.495
DOC_USP7_MATH_1	323	327	PF00917	0.642
DOC_USP7_MATH_1	329	333	PF00917	0.635
DOC_USP7_MATH_1	414	418	PF00917	0.750
DOC_USP7_UBL2_3	9	13	PF12436	0.661
DOC_WW_Pin1_4	148	153	PF00397	0.517
DOC_WW_Pin1_4	319	324	PF00397	0.752
DOC_WW_Pin1_4	45	50	PF00397	0.312
LIG_14-3-3_CanoR_1	169	175	PF00244	0.506
LIG_14-3-3_CanoR_1	243	249	PF00244	0.506
LIG_14-3-3_CanoR_1	254	261	PF00244	0.367
LIG_14-3-3_CanoR_1	346	356	PF00244	0.701
LIG_14-3-3_CanoR_1	72	82	PF00244	0.312
LIG_14-3-3_CterR_2	425	429	PF00244	0.628
LIG_CtBP_PxDLS_1	286	290	PF00389	0.551
LIG_FHA_1	119	125	PF00498	0.400
LIG_FHA_1	392	398	PF00498	0.677
LIG_FHA_1	46	52	PF00498	0.312
LIG_FHA_2	34	40	PF00498	0.314
LIG_Integrin_RGD_1	374	376	PF01839	0.555
LIG_LIR_Apic_2	77	83	PF02991	0.312
LIG_LIR_Gen_1	145	154	PF02991	0.518
LIG_LIR_Nem_3	145	150	PF02991	0.524
LIG_LIR_Nem_3	158	162	PF02991	0.381
LIG_MYND_1	331	335	PF01753	0.558
LIG_PDZ_Class_2	424	429	PF00595	0.532
LIG_Pex14_1	255	259	PF04695	0.417
LIG_PTAP_UEV_1	385	390	PF05743	0.548
LIG_SH2_STAT5	260	263	PF00017	0.423
LIG_SH2_STAT5	291	294	PF00017	0.552
LIG_SH2_STAT5	35	38	PF00017	0.312
LIG_SH3_3	325	331	PF00018	0.668
LIG_SH3_3	383	389	PF00018	0.728
LIG_SUMO_SIM_par_1	285	290	PF11976	0.544
LIG_TRAF2_1	262	265	PF00917	0.508
LIG_TRAF2_1	349	352	PF00917	0.533
LIG_TRAF2_1	54	57	PF00917	0.316
LIG_TYR_ITIM	50	55	PF00017	0.312
MOD_CK1_1	106	112	PF00069	0.560
MOD_CK1_1	140	146	PF00069	0.607
MOD_CK1_1	290	296	PF00069	0.569
MOD_CK1_1	361	367	PF00069	0.593
MOD_CK2_1	116	122	PF00069	0.446
MOD_CK2_1	13	19	PF00069	0.522
MOD_CK2_1	170	176	PF00069	0.418
MOD_CK2_1	293	299	PF00069	0.612
MOD_CK2_1	33	39	PF00069	0.189
MOD_CK2_1	346	352	PF00069	0.536
MOD_CK2_1	51	57	PF00069	0.312
MOD_Cter_Amidation	10	13	PF01082	0.649
MOD_Cter_Amidation	418	421	PF01082	0.713
MOD_GlcNHglycan	106	109	PF01048	0.644
MOD_GlcNHglycan	113	116	PF01048	0.497
MOD_GlcNHglycan	139	142	PF01048	0.436
MOD_GlcNHglycan	185	189	PF01048	0.704
MOD_GlcNHglycan	325	328	PF01048	0.557
MOD_GlcNHglycan	360	363	PF01048	0.559
MOD_GlcNHglycan	386	389	PF01048	0.605
MOD_GlcNHglycan	399	402	PF01048	0.633
MOD_GlcNHglycan	412	415	PF01048	0.707
MOD_GSK3_1	102	109	PF00069	0.624
MOD_GSK3_1	111	118	PF00069	0.455
MOD_GSK3_1	268	275	PF00069	0.424
MOD_GSK3_1	293	300	PF00069	0.619
MOD_GSK3_1	310	317	PF00069	0.604
MOD_GSK3_1	319	326	PF00069	0.597
MOD_GSK3_1	357	364	PF00069	0.601
MOD_GSK3_1	384	391	PF00069	0.699
MOD_GSK3_1	410	417	PF00069	0.660
MOD_GSK3_1	421	428	PF00069	0.590
MOD_LATS_1	31	37	PF00433	0.231
MOD_N-GLC_1	226	231	PF02516	0.430
MOD_N-GLC_1	90	95	PF02516	0.549
MOD_N-GLC_2	340	342	PF02516	0.727
MOD_NEK2_1	1	6	PF00069	0.539
MOD_NEK2_1	103	108	PF00069	0.786
MOD_NEK2_1	183	188	PF00069	0.647
MOD_NEK2_1	272	277	PF00069	0.572
MOD_NEK2_1	287	292	PF00069	0.393
MOD_NEK2_1	397	402	PF00069	0.588
MOD_PIKK_1	347	353	PF00454	0.606
MOD_PIKK_1	403	409	PF00454	0.627
MOD_PIKK_1	84	90	PF00454	0.555
MOD_PIKK_1	91	97	PF00454	0.620
MOD_PK_1	13	19	PF00069	0.536
MOD_PK_1	243	249	PF00069	0.356
MOD_PKA_1	125	131	PF00069	0.467
MOD_PKA_1	415	421	PF00069	0.638
MOD_PKA_2	125	131	PF00069	0.467
MOD_PKA_2	242	248	PF00069	0.514
MOD_PKA_2	253	259	PF00069	0.359
MOD_PKA_2	415	421	PF00069	0.638
MOD_Plk_1	167	173	PF00069	0.375
MOD_Plk_1	287	293	PF00069	0.549
MOD_Plk_4	287	293	PF00069	0.549
MOD_Plk_4	352	358	PF00069	0.599
MOD_Plk_4	74	80	PF00069	0.312
MOD_ProDKin_1	148	154	PF00069	0.518
MOD_ProDKin_1	319	325	PF00069	0.752
MOD_ProDKin_1	45	51	PF00069	0.312
MOD_SUMO_rev_2	16	22	PF00179	0.433
TRG_DiLeu_BaEn_1	19	24	PF01217	0.387
TRG_DiLeu_BaEn_1	352	357	PF01217	0.540
TRG_DiLeu_BaEn_1	39	44	PF01217	0.243
TRG_DiLeu_BaEn_1	57	62	PF01217	0.312
TRG_DiLeu_BaEn_2	178	184	PF01217	0.577
TRG_DiLeu_BaEn_4	176	182	PF01217	0.399
TRG_ENDOCYTIC_2	52	55	PF00928	0.312
TRG_ER_diArg_1	124	126	PF00400	0.441
TRG_ER_diArg_1	423	426	PF00400	0.564
TRG_NLS_MonoExtC_3	7	12	PF00514	0.672
TRG_NLS_MonoExtN_4	8	13	PF00514	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI5	Leptomonas seymouri	49%	100%
A0A3S7WY90	Leishmania donovani	73%	100%
A4I0T8	Leishmania infantum	73%	100%
E9AWU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QAN2	Leishmania major	73%	100%