Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDF6_LEIBR

TriTrypDb:

LbrM.24.1010 , LBRM2903_240016100

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.650
CLV_NRD_NRD_1	179	181	PF00675	0.701
CLV_NRD_NRD_1	313	315	PF00675	0.516
CLV_NRD_NRD_1	356	358	PF00675	0.660
CLV_NRD_NRD_1	436	438	PF00675	0.533
CLV_NRD_NRD_1	95	97	PF00675	0.595
CLV_PCSK_KEX2_1	178	180	PF00082	0.722
CLV_PCSK_KEX2_1	3	5	PF00082	0.658
CLV_PCSK_KEX2_1	313	315	PF00082	0.516
CLV_PCSK_KEX2_1	355	357	PF00082	0.647
CLV_PCSK_KEX2_1	436	438	PF00082	0.533
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.658
CLV_PCSK_SKI1_1	359	363	PF00082	0.524
CLV_PCSK_SKI1_1	40	44	PF00082	0.437
CLV_PCSK_SKI1_1	429	433	PF00082	0.561
CLV_PCSK_SKI1_1	50	54	PF00082	0.396
DEG_Nend_UBRbox_1	1	4	PF02207	0.678
DOC_ANK_TNKS_1	312	319	PF00023	0.520
DOC_CDC14_PxL_1	274	282	PF14671	0.686
DOC_CKS1_1	132	137	PF01111	0.543
DOC_CKS1_1	360	365	PF01111	0.529
DOC_MAPK_MEF2A_6	367	375	PF00069	0.549
DOC_PP2B_LxvP_1	232	235	PF13499	0.565
DOC_PP2B_LxvP_1	414	417	PF13499	0.668
DOC_PP4_FxxP_1	468	471	PF00568	0.567
DOC_USP7_MATH_1	118	122	PF00917	0.585
DOC_USP7_MATH_1	146	150	PF00917	0.759
DOC_USP7_MATH_1	170	174	PF00917	0.805
DOC_USP7_MATH_1	227	231	PF00917	0.744
DOC_USP7_MATH_1	269	273	PF00917	0.688
DOC_USP7_MATH_1	301	305	PF00917	0.711
DOC_USP7_MATH_1	323	327	PF00917	0.656
DOC_USP7_MATH_1	386	390	PF00917	0.504
DOC_USP7_MATH_1	462	466	PF00917	0.814
DOC_USP7_MATH_1	64	68	PF00917	0.421
DOC_USP7_MATH_1	86	90	PF00917	0.514
DOC_WW_Pin1_4	131	136	PF00397	0.573
DOC_WW_Pin1_4	148	153	PF00397	0.724
DOC_WW_Pin1_4	261	266	PF00397	0.695
DOC_WW_Pin1_4	280	285	PF00397	0.688
DOC_WW_Pin1_4	359	364	PF00397	0.632
DOC_WW_Pin1_4	400	405	PF00397	0.562
DOC_WW_Pin1_4	87	92	PF00397	0.749
LIG_14-3-3_CanoR_1	268	274	PF00244	0.542
LIG_14-3-3_CanoR_1	300	308	PF00244	0.623
LIG_14-3-3_CanoR_1	398	406	PF00244	0.540
LIG_14-3-3_CanoR_1	464	469	PF00244	0.568
LIG_APCC_ABBA_1	343	348	PF00400	0.429
LIG_BRCT_BRCA1_1	304	308	PF00533	0.667
LIG_BRCT_BRCA1_1	464	468	PF00533	0.592
LIG_CtBP_PxDLS_1	372	376	PF00389	0.545
LIG_deltaCOP1_diTrp_1	24	31	PF00928	0.478
LIG_EH1_1	70	78	PF00400	0.380
LIG_EVH1_1	414	418	PF00568	0.658
LIG_FHA_1	194	200	PF00498	0.553
LIG_FHA_1	286	292	PF00498	0.590
LIG_FHA_1	317	323	PF00498	0.777
LIG_FHA_1	478	484	PF00498	0.624
LIG_FHA_1	8	14	PF00498	0.545
LIG_FHA_2	240	246	PF00498	0.650
LIG_FHA_2	420	426	PF00498	0.597
LIG_LIR_Apic_2	465	471	PF02991	0.566
LIG_LIR_Gen_1	173	182	PF02991	0.558
LIG_LIR_Gen_1	272	282	PF02991	0.624
LIG_LIR_Gen_1	305	315	PF02991	0.527
LIG_LIR_Gen_1	337	347	PF02991	0.606
LIG_LIR_Gen_1	9	19	PF02991	0.497
LIG_LIR_Nem_3	166	171	PF02991	0.530
LIG_LIR_Nem_3	173	177	PF02991	0.518
LIG_LIR_Nem_3	272	277	PF02991	0.631
LIG_LIR_Nem_3	9	14	PF02991	0.503
LIG_LYPXL_yS_3	168	171	PF13949	0.531
LIG_NRBOX	105	111	PF00104	0.571
LIG_Pex14_1	27	31	PF04695	0.474
LIG_SH2_CRK	11	15	PF00017	0.499
LIG_SH2_CRK	274	278	PF00017	0.691
LIG_SH2_NCK_1	11	15	PF00017	0.499
LIG_SH2_STAP1	11	15	PF00017	0.499
LIG_SH2_STAT5	11	14	PF00017	0.500
LIG_SH2_STAT5	163	166	PF00017	0.621
LIG_SH2_STAT5	406	409	PF00017	0.687
LIG_SH2_STAT5	453	456	PF00017	0.535
LIG_SH3_2	479	484	PF14604	0.748
LIG_SH3_3	11	17	PF00018	0.500
LIG_SH3_3	117	123	PF00018	0.764
LIG_SH3_3	126	132	PF00018	0.621
LIG_SH3_3	178	184	PF00018	0.738
LIG_SH3_3	357	363	PF00018	0.519
LIG_SH3_3	412	418	PF00018	0.682
LIG_SH3_3	473	479	PF00018	0.734
LIG_SUMO_SIM_par_1	208	213	PF11976	0.628
LIG_SUMO_SIM_par_1	474	481	PF11976	0.562
LIG_SUMO_SIM_par_1	61	67	PF11976	0.402
LIG_TRFH_1	274	278	PF08558	0.691
LIG_WW_3	418	422	PF00397	0.612
MOD_CDK_SPxxK_3	261	268	PF00069	0.570
MOD_CDK_SPxxK_3	280	287	PF00069	0.525
MOD_CK1_1	193	199	PF00069	0.694
MOD_CK1_1	238	244	PF00069	0.697
MOD_CK1_1	259	265	PF00069	0.621
MOD_CK1_1	272	278	PF00069	0.641
MOD_CK1_1	302	308	PF00069	0.663
MOD_CK1_1	397	403	PF00069	0.565
MOD_CK1_1	89	95	PF00069	0.494
MOD_CK2_1	18	24	PF00069	0.603
MOD_CK2_1	304	310	PF00069	0.687
MOD_CK2_1	419	425	PF00069	0.605
MOD_DYRK1A_RPxSP_1	359	363	PF00069	0.524
MOD_GlcNHglycan	192	195	PF01048	0.779
MOD_GlcNHglycan	20	23	PF01048	0.473
MOD_GlcNHglycan	217	220	PF01048	0.559
MOD_GlcNHglycan	229	232	PF01048	0.581
MOD_GlcNHglycan	237	240	PF01048	0.622
MOD_GlcNHglycan	245	248	PF01048	0.683
MOD_GlcNHglycan	258	261	PF01048	0.613
MOD_GlcNHglycan	383	386	PF01048	0.665
MOD_GlcNHglycan	66	69	PF01048	0.387
MOD_GSK3_1	190	197	PF00069	0.761
MOD_GSK3_1	235	242	PF00069	0.722
MOD_GSK3_1	256	263	PF00069	0.599
MOD_GSK3_1	272	279	PF00069	0.718
MOD_GSK3_1	295	302	PF00069	0.778
MOD_GSK3_1	394	401	PF00069	0.610
MOD_GSK3_1	449	456	PF00069	0.654
MOD_GSK3_1	87	94	PF00069	0.504
MOD_N-GLC_1	227	232	PF02516	0.566
MOD_N-GLC_1	260	265	PF02516	0.578
MOD_N-GLC_1	373	378	PF02516	0.582
MOD_N-GLC_1	92	97	PF02516	0.525
MOD_N-GLC_2	350	352	PF02516	0.624
MOD_NEK2_1	215	220	PF00069	0.553
MOD_NEK2_1	237	242	PF00069	0.652
MOD_NEK2_1	256	261	PF00069	0.578
MOD_NEK2_1	286	291	PF00069	0.541
MOD_NEK2_1	292	297	PF00069	0.516
MOD_NEK2_1	373	378	PF00069	0.549
MOD_NEK2_1	7	12	PF00069	0.591
MOD_NEK2_2	269	274	PF00069	0.639
MOD_NEK2_2	386	391	PF00069	0.505
MOD_PIKK_1	101	107	PF00454	0.420
MOD_PIKK_1	184	190	PF00454	0.727
MOD_PIKK_1	299	305	PF00454	0.530
MOD_PIKK_1	71	77	PF00454	0.531
MOD_PK_1	208	214	PF00069	0.532
MOD_PK_1	287	293	PF00069	0.545
MOD_PK_1	398	404	PF00069	0.498
MOD_PKA_2	299	305	PF00069	0.620
MOD_PKA_2	381	387	PF00069	0.620
MOD_PKA_2	397	403	PF00069	0.472
MOD_PKA_2	463	469	PF00069	0.565
MOD_Plk_1	227	233	PF00069	0.568
MOD_Plk_1	367	373	PF00069	0.548
MOD_Plk_4	125	131	PF00069	0.570
MOD_Plk_4	194	200	PF00069	0.593
MOD_Plk_4	269	275	PF00069	0.677
MOD_Plk_4	287	293	PF00069	0.702
MOD_Plk_4	449	455	PF00069	0.616
MOD_Plk_4	9	15	PF00069	0.496
MOD_ProDKin_1	131	137	PF00069	0.569
MOD_ProDKin_1	148	154	PF00069	0.724
MOD_ProDKin_1	261	267	PF00069	0.694
MOD_ProDKin_1	280	286	PF00069	0.689
MOD_ProDKin_1	359	365	PF00069	0.632
MOD_ProDKin_1	400	406	PF00069	0.567
MOD_ProDKin_1	87	93	PF00069	0.752
MOD_SUMO_rev_2	245	251	PF00179	0.564
MOD_SUMO_rev_2	82	89	PF00179	0.490
TRG_ENDOCYTIC_2	11	14	PF00928	0.500
TRG_ENDOCYTIC_2	168	171	PF00928	0.531
TRG_ENDOCYTIC_2	174	177	PF00928	0.522
TRG_ENDOCYTIC_2	274	277	PF00928	0.694
TRG_ER_diArg_1	177	180	PF00400	0.631
TRG_ER_diArg_1	313	315	PF00400	0.516
TRG_ER_diArg_1	354	357	PF00400	0.639
TRG_NLS_MonoExtN_4	436	441	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEV1	Leishmania donovani	59%	88%
E9AH58	Leishmania infantum	58%	88%
E9AWU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	88%
Q4QAN3	Leishmania major	59%	100%