Putative replication factor C, subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

replication factor C, subunit 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HDF5_LEIBR

TriTrypDb:

LbrM.24.1000 , LBRM2903_240016000

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005663	DNA replication factor C complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDF5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006260	DNA replication	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006281	DNA repair	5	5
GO:0006950	response to stress	2	5
GO:0006974	DNA damage response	4	5
GO:0033554	cellular response to stress	3	5
GO:0050896	response to stimulus	1	5
GO:0051716	cellular response to stimulus	2	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003689	DNA clamp loader activity	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0016887	ATP hydrolysis activity	7	9
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.249
CLV_C14_Caspase3-7	251	255	PF00656	0.474
CLV_C14_Caspase3-7	325	329	PF00656	0.345
CLV_C14_Caspase3-7	659	663	PF00656	0.685
CLV_C14_Caspase3-7	8	12	PF00656	0.504
CLV_NRD_NRD_1	102	104	PF00675	0.322
CLV_NRD_NRD_1	235	237	PF00675	0.382
CLV_NRD_NRD_1	395	397	PF00675	0.393
CLV_NRD_NRD_1	533	535	PF00675	0.657
CLV_NRD_NRD_1	577	579	PF00675	0.715
CLV_NRD_NRD_1	618	620	PF00675	0.612
CLV_PCSK_KEX2_1	235	237	PF00082	0.630
CLV_PCSK_KEX2_1	395	397	PF00082	0.266
CLV_PCSK_KEX2_1	512	514	PF00082	0.610
CLV_PCSK_KEX2_1	618	620	PF00082	0.603
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.585
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.624
CLV_PCSK_SKI1_1	171	175	PF00082	0.377
CLV_PCSK_SKI1_1	208	212	PF00082	0.361
CLV_PCSK_SKI1_1	223	227	PF00082	0.334
CLV_PCSK_SKI1_1	377	381	PF00082	0.249
CLV_PCSK_SKI1_1	395	399	PF00082	0.249
CLV_PCSK_SKI1_1	430	434	PF00082	0.380
CLV_PCSK_SKI1_1	490	494	PF00082	0.264
CLV_PCSK_SKI1_1	508	512	PF00082	0.397
DEG_APCC_DBOX_1	170	178	PF00400	0.361
DEG_APCC_DBOX_1	222	230	PF00400	0.314
DEG_APCC_DBOX_1	394	402	PF00400	0.324
DEG_SPOP_SBC_1	347	351	PF00917	0.380
DEG_SPOP_SBC_1	600	604	PF00917	0.713
DEG_SPOP_SBC_1	640	644	PF00917	0.625
DEG_SPOP_SBC_1	645	649	PF00917	0.573
DOC_CYCLIN_RxL_1	165	178	PF00134	0.369
DOC_CYCLIN_RxL_1	205	213	PF00134	0.361
DOC_MAPK_gen_1	62	69	PF00069	0.507
DOC_MAPK_RevD_3	544	560	PF00069	0.478
DOC_PP1_RVXF_1	375	382	PF00149	0.249
DOC_PP2B_LxvP_1	432	435	PF13499	0.380
DOC_PP4_FxxP_1	182	185	PF00568	0.465
DOC_PP4_MxPP_1	479	482	PF00568	0.191
DOC_SPAK_OSR1_1	344	348	PF12202	0.380
DOC_USP7_MATH_1	15	19	PF00917	0.692
DOC_USP7_MATH_1	248	252	PF00917	0.432
DOC_USP7_MATH_1	320	324	PF00917	0.365
DOC_USP7_MATH_1	582	586	PF00917	0.637
DOC_USP7_MATH_1	600	604	PF00917	0.649
DOC_USP7_MATH_1	624	628	PF00917	0.589
DOC_USP7_MATH_1	640	644	PF00917	0.539
DOC_USP7_MATH_1	646	650	PF00917	0.715
DOC_USP7_UBL2_3	508	512	PF12436	0.568
DOC_USP7_UBL2_3	558	562	PF12436	0.687
DOC_USP7_UBL2_3	579	583	PF12436	0.639
DOC_USP7_UBL2_3	597	601	PF12436	0.579
DOC_WW_Pin1_4	472	477	PF00397	0.334
DOC_WW_Pin1_4	49	54	PF00397	0.501
DOC_WW_Pin1_4	583	588	PF00397	0.780
DOC_WW_Pin1_4	608	613	PF00397	0.631
DOC_WW_Pin1_4	69	74	PF00397	0.119
LIG_14-3-3_CanoR_1	101	107	PF00244	0.263
LIG_14-3-3_CanoR_1	117	126	PF00244	0.299
LIG_14-3-3_CanoR_1	181	185	PF00244	0.471
LIG_14-3-3_CanoR_1	235	240	PF00244	0.466
LIG_14-3-3_CanoR_1	430	435	PF00244	0.364
LIG_14-3-3_CanoR_1	581	587	PF00244	0.663
LIG_14-3-3_CanoR_1	593	600	PF00244	0.477
LIG_Actin_WH2_2	137	154	PF00022	0.464
LIG_Actin_WH2_2	219	237	PF00022	0.265
LIG_CtBP_PxDLS_1	203	208	PF00389	0.371
LIG_deltaCOP1_diTrp_1	337	345	PF00928	0.262
LIG_eIF4E_1	126	132	PF01652	0.249
LIG_eIF4E_1	286	292	PF01652	0.466
LIG_FHA_1	125	131	PF00498	0.345
LIG_FHA_1	431	437	PF00498	0.249
LIG_FHA_1	484	490	PF00498	0.228
LIG_FHA_1	76	82	PF00498	0.249
LIG_FHA_2	159	165	PF00498	0.305
LIG_FHA_2	516	522	PF00498	0.639
LIG_FHA_2	584	590	PF00498	0.545
LIG_FHA_2	623	629	PF00498	0.547
LIG_FHA_2	89	95	PF00498	0.382
LIG_Integrin_RGD_1	513	515	PF01839	0.570
LIG_LIR_Apic_2	179	185	PF02991	0.464
LIG_LIR_Gen_1	124	133	PF02991	0.294
LIG_LIR_Gen_1	343	353	PF02991	0.327
LIG_LIR_Gen_1	452	460	PF02991	0.249
LIG_LIR_Gen_1	500	511	PF02991	0.552
LIG_LIR_Nem_3	124	129	PF02991	0.323
LIG_LIR_Nem_3	264	268	PF02991	0.439
LIG_LIR_Nem_3	298	303	PF02991	0.298
LIG_LIR_Nem_3	343	348	PF02991	0.327
LIG_LIR_Nem_3	459	464	PF02991	0.254
LIG_LIR_Nem_3	49	54	PF02991	0.445
LIG_LIR_Nem_3	500	506	PF02991	0.574
LIG_NRBOX	169	175	PF00104	0.393
LIG_PCNA_yPIPBox_3	285	295	PF02747	0.239
LIG_Pex14_1	23	27	PF04695	0.339
LIG_Pex14_1	47	51	PF04695	0.355
LIG_Pex14_2	493	497	PF04695	0.249
LIG_PTB_Apo_2	113	120	PF02174	0.267
LIG_SH2_CRK	126	130	PF00017	0.327
LIG_SH2_GRB2like	286	289	PF00017	0.465
LIG_SH2_STAP1	126	130	PF00017	0.267
LIG_SH2_STAP1	336	340	PF00017	0.209
LIG_SH2_STAP1	362	366	PF00017	0.267
LIG_SH2_STAT3	303	306	PF00017	0.387
LIG_SH2_STAT3	335	338	PF00017	0.267
LIG_SH2_STAT5	126	129	PF00017	0.292
LIG_SH2_STAT5	176	179	PF00017	0.356
LIG_SH2_STAT5	193	196	PF00017	0.374
LIG_SH2_STAT5	265	268	PF00017	0.425
LIG_SH2_STAT5	300	303	PF00017	0.301
LIG_SH2_STAT5	357	360	PF00017	0.359
LIG_SH2_STAT5	82	85	PF00017	0.277
LIG_SH3_3	376	382	PF00018	0.273
LIG_SH3_3	58	64	PF00018	0.500
LIG_SH3_4	208	215	PF00018	0.485
LIG_SH3_4	579	586	PF00018	0.668
LIG_SUMO_SIM_anti_2	127	135	PF11976	0.331
LIG_SUMO_SIM_anti_2	542	548	PF11976	0.469
LIG_SUMO_SIM_par_1	127	135	PF11976	0.327
LIG_SUMO_SIM_par_1	545	550	PF11976	0.471
LIG_SxIP_EBH_1	152	162	PF03271	0.347
LIG_TRAF2_1	629	632	PF00917	0.546
LIG_TYR_ITSM	122	129	PF00017	0.324
LIG_UBA3_1	210	216	PF00899	0.488
LIG_WRC_WIRS_1	362	367	PF05994	0.249
LIG_WRC_WIRS_1	503	508	PF05994	0.524
MOD_CK1_1	102	108	PF00069	0.249
MOD_CK1_1	125	131	PF00069	0.273
MOD_CK1_1	475	481	PF00069	0.445
MOD_CK1_1	5	11	PF00069	0.513
MOD_CK1_1	611	617	PF00069	0.598
MOD_CK1_1	626	632	PF00069	0.588
MOD_CK1_1	633	639	PF00069	0.592
MOD_CK1_1	641	647	PF00069	0.572
MOD_CK1_1	648	654	PF00069	0.614
MOD_CK1_1	655	661	PF00069	0.486
MOD_CK2_1	102	108	PF00069	0.229
MOD_CK2_1	15	21	PF00069	0.554
MOD_CK2_1	269	275	PF00069	0.389
MOD_CK2_1	28	34	PF00069	0.338
MOD_CK2_1	622	628	PF00069	0.594
MOD_CK2_1	658	664	PF00069	0.772
MOD_CK2_1	88	94	PF00069	0.297
MOD_GlcNHglycan	119	122	PF01048	0.446
MOD_GlcNHglycan	217	220	PF01048	0.422
MOD_GlcNHglycan	389	392	PF01048	0.296
MOD_GlcNHglycan	4	7	PF01048	0.634
MOD_GlcNHglycan	412	415	PF01048	0.253
MOD_GlcNHglycan	508	511	PF01048	0.442
MOD_GlcNHglycan	638	641	PF01048	0.754
MOD_GlcNHglycan	643	646	PF01048	0.728
MOD_GlcNHglycan	69	72	PF01048	0.302
MOD_GSK3_1	117	124	PF00069	0.262
MOD_GSK3_1	217	224	PF00069	0.288
MOD_GSK3_1	248	255	PF00069	0.502
MOD_GSK3_1	315	322	PF00069	0.483
MOD_GSK3_1	484	491	PF00069	0.265
MOD_GSK3_1	49	56	PF00069	0.512
MOD_GSK3_1	502	509	PF00069	0.495
MOD_GSK3_1	566	573	PF00069	0.760
MOD_GSK3_1	608	615	PF00069	0.670
MOD_GSK3_1	622	629	PF00069	0.526
MOD_GSK3_1	632	639	PF00069	0.557
MOD_GSK3_1	640	647	PF00069	0.504
MOD_GSK3_1	648	655	PF00069	0.583
MOD_GSK3_1	95	102	PF00069	0.249
MOD_LATS_1	167	173	PF00433	0.370
MOD_N-GLC_1	108	113	PF02516	0.249
MOD_N-GLC_1	338	343	PF02516	0.249
MOD_N-GLC_1	387	392	PF02516	0.267
MOD_N-GLC_1	483	488	PF02516	0.278
MOD_N-GLC_1	49	54	PF02516	0.337
MOD_N-GLC_1	497	502	PF02516	0.398
MOD_N-GLC_1	95	100	PF02516	0.249
MOD_NEK2_1	150	155	PF00069	0.342
MOD_NEK2_1	180	185	PF00069	0.410
MOD_NEK2_1	268	273	PF00069	0.344
MOD_NEK2_1	348	353	PF00069	0.327
MOD_NEK2_1	4	9	PF00069	0.623
MOD_NEK2_1	403	408	PF00069	0.271
MOD_NEK2_1	463	468	PF00069	0.184
MOD_NEK2_1	497	502	PF00069	0.408
MOD_NEK2_1	506	511	PF00069	0.447
MOD_NEK2_1	88	93	PF00069	0.327
MOD_PIKK_1	315	321	PF00454	0.407
MOD_PIKK_1	515	521	PF00454	0.616
MOD_PK_1	28	34	PF00069	0.470
MOD_PKA_1	235	241	PF00069	0.375
MOD_PKA_2	102	108	PF00069	0.308
MOD_PKA_2	121	127	PF00069	0.382
MOD_PKA_2	180	186	PF00069	0.354
MOD_PKA_2	235	241	PF00069	0.445
MOD_PKA_2	275	281	PF00069	0.504
MOD_PKA_2	592	598	PF00069	0.734
MOD_PKA_2	622	628	PF00069	0.521
MOD_PKB_1	621	629	PF00069	0.640
MOD_Plk_1	338	344	PF00069	0.249
MOD_Plk_1	630	636	PF00069	0.497
MOD_Plk_2-3	275	281	PF00069	0.504
MOD_Plk_4	125	131	PF00069	0.250
MOD_Plk_4	361	367	PF00069	0.262
MOD_Plk_4	380	386	PF00069	0.249
MOD_Plk_4	542	548	PF00069	0.469
MOD_Plk_4	77	83	PF00069	0.249
MOD_ProDKin_1	472	478	PF00069	0.334
MOD_ProDKin_1	49	55	PF00069	0.510
MOD_ProDKin_1	583	589	PF00069	0.782
MOD_ProDKin_1	608	614	PF00069	0.630
MOD_ProDKin_1	69	75	PF00069	0.119
MOD_SUMO_rev_2	56	64	PF00179	0.557
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.480
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.292
TRG_ENDOCYTIC_2	126	129	PF00928	0.292
TRG_ENDOCYTIC_2	265	268	PF00928	0.425
TRG_ENDOCYTIC_2	362	365	PF00928	0.265
TRG_ENDOCYTIC_2	454	457	PF00928	0.249
TRG_ENDOCYTIC_2	470	473	PF00928	0.324
TRG_ER_diArg_1	100	103	PF00400	0.318
TRG_ER_diArg_1	234	236	PF00400	0.330
TRG_ER_diArg_1	395	397	PF00400	0.397
TRG_NLS_MonoCore_2	577	582	PF00514	0.722
TRG_NLS_MonoCore_2	617	622	PF00514	0.639
TRG_NLS_MonoExtC_3	557	562	PF00514	0.588
TRG_NLS_MonoExtC_3	618	623	PF00514	0.617
TRG_NLS_MonoExtN_4	558	563	PF00514	0.588
TRG_NLS_MonoExtN_4	618	624	PF00514	0.645
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X2	Leptomonas seymouri	79%	100%
A0A1X0NVJ4	Trypanosomatidae	68%	100%
A0A3R7KMZ0	Trypanosoma rangeli	66%	100%
A0A3S7WYE5	Leishmania donovani	89%	100%
A4I0T7	Leishmania infantum	89%	100%
D0A768	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AWU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O60182	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	71%
P35600	Drosophila melanogaster	31%	67%
P38630	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	77%
Q4QAN4	Leishmania major	88%	100%
Q9C587	Arabidopsis thaliana	31%	69%
V5BAM4	Trypanosoma cruzi	61%	100%