Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDF3_LEIBR

TriTrypDb:

LbrM.24.0980 , LBRM2903_240015800

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.486
CLV_NRD_NRD_1	105	107	PF00675	0.664
CLV_NRD_NRD_1	130	132	PF00675	0.588
CLV_NRD_NRD_1	219	221	PF00675	0.580
CLV_NRD_NRD_1	237	239	PF00675	0.576
CLV_NRD_NRD_1	328	330	PF00675	0.587
CLV_NRD_NRD_1	465	467	PF00675	0.456
CLV_NRD_NRD_1	489	491	PF00675	0.500
CLV_NRD_NRD_1	627	629	PF00675	0.407
CLV_PCSK_KEX2_1	105	107	PF00082	0.664
CLV_PCSK_KEX2_1	130	132	PF00082	0.588
CLV_PCSK_KEX2_1	219	221	PF00082	0.580
CLV_PCSK_KEX2_1	237	239	PF00082	0.576
CLV_PCSK_KEX2_1	328	330	PF00082	0.603
CLV_PCSK_KEX2_1	465	467	PF00082	0.456
CLV_PCSK_KEX2_1	489	491	PF00082	0.500
CLV_PCSK_KEX2_1	627	629	PF00082	0.397
CLV_PCSK_PC7_1	461	467	PF00082	0.447
CLV_PCSK_SKI1_1	159	163	PF00082	0.548
CLV_PCSK_SKI1_1	244	248	PF00082	0.573
CLV_PCSK_SKI1_1	270	274	PF00082	0.546
CLV_PCSK_SKI1_1	466	470	PF00082	0.510
CLV_PCSK_SKI1_1	6	10	PF00082	0.740
CLV_PCSK_SKI1_1	639	643	PF00082	0.408
CLV_PCSK_SKI1_1	89	93	PF00082	0.619
DEG_SPOP_SBC_1	245	249	PF00917	0.386
DEG_SPOP_SBC_1	524	528	PF00917	0.593
DOC_CKS1_1	420	425	PF01111	0.589
DOC_CYCLIN_yCln2_LP_2	470	476	PF00134	0.634
DOC_MAPK_MEF2A_6	256	264	PF00069	0.401
DOC_PP4_FxxP_1	405	408	PF00568	0.233
DOC_PP4_FxxP_1	91	94	PF00568	0.411
DOC_USP7_MATH_1	12	16	PF00917	0.553
DOC_USP7_MATH_1	149	153	PF00917	0.339
DOC_USP7_MATH_1	245	249	PF00917	0.386
DOC_USP7_MATH_1	295	299	PF00917	0.360
DOC_USP7_MATH_1	356	360	PF00917	0.478
DOC_USP7_MATH_1	37	41	PF00917	0.613
DOC_USP7_MATH_1	382	386	PF00917	0.479
DOC_USP7_MATH_1	428	432	PF00917	0.600
DOC_USP7_MATH_1	45	49	PF00917	0.387
DOC_USP7_MATH_1	523	527	PF00917	0.664
DOC_USP7_MATH_1	689	693	PF00917	0.597
DOC_USP7_MATH_1	83	87	PF00917	0.500
DOC_WW_Pin1_4	10	15	PF00397	0.496
DOC_WW_Pin1_4	179	184	PF00397	0.513
DOC_WW_Pin1_4	224	229	PF00397	0.427
DOC_WW_Pin1_4	23	28	PF00397	0.477
DOC_WW_Pin1_4	287	292	PF00397	0.461
DOC_WW_Pin1_4	404	409	PF00397	0.361
DOC_WW_Pin1_4	419	424	PF00397	0.570
DOC_WW_Pin1_4	469	474	PF00397	0.642
DOC_WW_Pin1_4	496	501	PF00397	0.625
DOC_WW_Pin1_4	528	533	PF00397	0.625
DOC_WW_Pin1_4	547	552	PF00397	0.613
DOC_WW_Pin1_4	650	655	PF00397	0.634
DOC_WW_Pin1_4	676	681	PF00397	0.771
LIG_14-3-3_CanoR_1	151	155	PF00244	0.316
LIG_14-3-3_CanoR_1	297	305	PF00244	0.324
LIG_14-3-3_CanoR_1	345	352	PF00244	0.430
LIG_14-3-3_CanoR_1	391	401	PF00244	0.262
LIG_14-3-3_CanoR_1	465	471	PF00244	0.680
LIG_14-3-3_CanoR_1	557	561	PF00244	0.664
LIG_14-3-3_CanoR_1	6	11	PF00244	0.607
LIG_14-3-3_CanoR_1	627	633	PF00244	0.644
LIG_14-3-3_CanoR_1	688	694	PF00244	0.614
LIG_BRCT_BRCA1_1	401	405	PF00533	0.305
LIG_BRCT_BRCA1_1	429	433	PF00533	0.536
LIG_BRCT_BRCA1_1	445	449	PF00533	0.547
LIG_FHA_1	165	171	PF00498	0.547
LIG_FHA_1	175	181	PF00498	0.445
LIG_FHA_1	23	29	PF00498	0.412
LIG_FHA_1	259	265	PF00498	0.451
LIG_FHA_1	267	273	PF00498	0.372
LIG_FHA_1	393	399	PF00498	0.383
LIG_FHA_1	410	416	PF00498	0.212
LIG_FHA_1	420	426	PF00498	0.584
LIG_FHA_1	473	479	PF00498	0.578
LIG_FHA_1	501	507	PF00498	0.717
LIG_FHA_1	548	554	PF00498	0.732
LIG_FHA_1	640	646	PF00498	0.597
LIG_FHA_1	666	672	PF00498	0.653
LIG_FHA_1	677	683	PF00498	0.615
LIG_FHA_2	24	30	PF00498	0.456
LIG_FHA_2	336	342	PF00498	0.343
LIG_FHA_2	557	563	PF00498	0.620
LIG_LIR_Apic_2	402	408	PF02991	0.233
LIG_LIR_Apic_2	462	467	PF02991	0.655
LIG_LIR_Gen_1	430	440	PF02991	0.591
LIG_LIR_Gen_1	441	452	PF02991	0.544
LIG_LIR_Gen_1	668	674	PF02991	0.653
LIG_LIR_Nem_3	430	436	PF02991	0.536
LIG_LIR_Nem_3	441	447	PF02991	0.539
LIG_LIR_Nem_3	668	672	PF02991	0.650
LIG_LIR_Nem_3	685	690	PF02991	0.655
LIG_PCNA_PIPBox_1	437	446	PF02747	0.588
LIG_PTB_Apo_2	280	287	PF02174	0.393
LIG_PTB_Phospho_1	280	286	PF10480	0.391
LIG_SH2_CRK	591	595	PF00017	0.658
LIG_SH2_GRB2like	20	23	PF00017	0.423
LIG_SH2_GRB2like	510	513	PF00017	0.654
LIG_SH2_NCK_1	336	340	PF00017	0.460
LIG_SH2_PTP2	109	112	PF00017	0.434
LIG_SH2_PTP2	669	672	PF00017	0.530
LIG_SH2_SRC	109	112	PF00017	0.390
LIG_SH2_STAP1	118	122	PF00017	0.420
LIG_SH2_STAP1	141	145	PF00017	0.358
LIG_SH2_STAP1	591	595	PF00017	0.658
LIG_SH2_STAP1	621	625	PF00017	0.584
LIG_SH2_STAP1	665	669	PF00017	0.665
LIG_SH2_STAT5	109	112	PF00017	0.351
LIG_SH2_STAT5	271	274	PF00017	0.352
LIG_SH2_STAT5	372	375	PF00017	0.472
LIG_SH2_STAT5	51	54	PF00017	0.386
LIG_SH2_STAT5	510	513	PF00017	0.653
LIG_SH2_STAT5	56	59	PF00017	0.360
LIG_SH2_STAT5	601	604	PF00017	0.609
LIG_SH2_STAT5	669	672	PF00017	0.530
LIG_SH2_STAT5	98	101	PF00017	0.459
LIG_SH3_3	119	125	PF00018	0.378
LIG_SH3_3	167	173	PF00018	0.353
LIG_SH3_3	259	265	PF00018	0.392
LIG_SH3_3	370	376	PF00018	0.468
LIG_SH3_3	530	536	PF00018	0.674
LIG_SH3_3	550	556	PF00018	0.619
LIG_SUMO_SIM_anti_2	412	417	PF11976	0.315
LIG_SUMO_SIM_anti_2	668	676	PF11976	0.543
LIG_SUMO_SIM_par_1	152	158	PF11976	0.326
LIG_SUMO_SIM_par_1	466	472	PF11976	0.704
LIG_SUMO_SIM_par_1	668	676	PF11976	0.603
LIG_TYR_ITIM	667	672	PF00017	0.568
MOD_CDC14_SPxK_1	227	230	PF00782	0.424
MOD_CDK_SPxK_1	224	230	PF00069	0.420
MOD_CDK_SPxK_1	496	502	PF00069	0.602
MOD_CK1_1	13	19	PF00069	0.578
MOD_CK1_1	153	159	PF00069	0.489
MOD_CK1_1	174	180	PF00069	0.383
MOD_CK1_1	189	195	PF00069	0.452
MOD_CK1_1	266	272	PF00069	0.447
MOD_CK1_1	287	293	PF00069	0.337
MOD_CK1_1	390	396	PF00069	0.538
MOD_CK1_1	40	46	PF00069	0.583
MOD_CK1_1	409	415	PF00069	0.193
MOD_CK1_1	427	433	PF00069	0.546
MOD_CK1_1	472	478	PF00069	0.598
MOD_CK1_1	527	533	PF00069	0.792
MOD_CK1_1	634	640	PF00069	0.776
MOD_CK2_1	23	29	PF00069	0.421
MOD_CK2_1	556	562	PF00069	0.635
MOD_CK2_1	74	80	PF00069	0.442
MOD_Cter_Amidation	326	329	PF01082	0.569
MOD_Cter_Amidation	487	490	PF01082	0.467
MOD_GlcNHglycan	10	13	PF01048	0.713
MOD_GlcNHglycan	15	18	PF01048	0.688
MOD_GlcNHglycan	275	278	PF01048	0.525
MOD_GlcNHglycan	306	309	PF01048	0.538
MOD_GlcNHglycan	310	313	PF01048	0.525
MOD_GlcNHglycan	369	372	PF01048	0.660
MOD_GlcNHglycan	380	383	PF01048	0.667
MOD_GlcNHglycan	39	42	PF01048	0.695
MOD_GlcNHglycan	408	411	PF01048	0.308
MOD_GlcNHglycan	636	639	PF01048	0.552
MOD_GlcNHglycan	655	658	PF01048	0.406
MOD_GlcNHglycan	85	88	PF01048	0.715
MOD_GlcNHglycan	93	97	PF01048	0.641
MOD_GSK3_1	145	152	PF00069	0.314
MOD_GSK3_1	155	162	PF00069	0.416
MOD_GSK3_1	224	231	PF00069	0.447
MOD_GSK3_1	247	254	PF00069	0.448
MOD_GSK3_1	295	302	PF00069	0.442
MOD_GSK3_1	304	311	PF00069	0.339
MOD_GSK3_1	367	374	PF00069	0.540
MOD_GSK3_1	378	385	PF00069	0.468
MOD_GSK3_1	387	394	PF00069	0.368
MOD_GSK3_1	39	46	PF00069	0.441
MOD_GSK3_1	399	406	PF00069	0.271
MOD_GSK3_1	424	431	PF00069	0.601
MOD_GSK3_1	492	499	PF00069	0.648
MOD_GSK3_1	523	530	PF00069	0.643
MOD_GSK3_1	6	13	PF00069	0.514
MOD_GSK3_1	603	610	PF00069	0.753
MOD_GSK3_1	649	656	PF00069	0.619
MOD_GSK3_1	69	76	PF00069	0.566
MOD_GSK3_1	79	86	PF00069	0.518
MOD_N-GLC_1	23	28	PF02516	0.688
MOD_N-GLC_1	32	37	PF02516	0.652
MOD_N-GLC_1	356	361	PF02516	0.762
MOD_NEK2_1	145	150	PF00069	0.343
MOD_NEK2_1	273	278	PF00069	0.384
MOD_NEK2_1	285	290	PF00069	0.315
MOD_NEK2_1	304	309	PF00069	0.398
MOD_NEK2_1	403	408	PF00069	0.315
MOD_NEK2_1	478	483	PF00069	0.621
MOD_NEK2_1	537	542	PF00069	0.602
MOD_NEK2_2	428	433	PF00069	0.596
MOD_PIKK_1	189	195	PF00454	0.410
MOD_PIKK_1	296	302	PF00454	0.350
MOD_PIKK_1	537	543	PF00454	0.601
MOD_PKA_2	150	156	PF00069	0.431
MOD_PKA_2	296	302	PF00069	0.378
MOD_PKA_2	344	350	PF00069	0.419
MOD_PKA_2	367	373	PF00069	0.512
MOD_PKA_2	390	396	PF00069	0.448
MOD_PKA_2	556	562	PF00069	0.627
MOD_PKA_2	603	609	PF00069	0.584
MOD_PKA_2	83	89	PF00069	0.523
MOD_Plk_1	478	484	PF00069	0.580
MOD_Plk_1	73	79	PF00069	0.464
MOD_Plk_2-3	74	80	PF00069	0.406
MOD_Plk_4	150	156	PF00069	0.387
MOD_Plk_4	382	388	PF00069	0.510
MOD_Plk_4	428	434	PF00069	0.543
MOD_Plk_4	448	454	PF00069	0.458
MOD_Plk_4	466	472	PF00069	0.567
MOD_Plk_4	619	625	PF00069	0.684
MOD_Plk_4	631	637	PF00069	0.680
MOD_Plk_4	665	671	PF00069	0.610
MOD_Plk_4	689	695	PF00069	0.583
MOD_ProDKin_1	10	16	PF00069	0.496
MOD_ProDKin_1	179	185	PF00069	0.513
MOD_ProDKin_1	224	230	PF00069	0.432
MOD_ProDKin_1	23	29	PF00069	0.477
MOD_ProDKin_1	287	293	PF00069	0.460
MOD_ProDKin_1	404	410	PF00069	0.361
MOD_ProDKin_1	419	425	PF00069	0.570
MOD_ProDKin_1	469	475	PF00069	0.639
MOD_ProDKin_1	496	502	PF00069	0.624
MOD_ProDKin_1	528	534	PF00069	0.626
MOD_ProDKin_1	547	553	PF00069	0.613
MOD_ProDKin_1	650	656	PF00069	0.637
MOD_ProDKin_1	676	682	PF00069	0.771
TRG_DiLeu_BaEn_2	444	450	PF01217	0.543
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.453
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.296
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.370
TRG_ENDOCYTIC_2	591	594	PF00928	0.604
TRG_ENDOCYTIC_2	669	672	PF00928	0.570
TRG_ENDOCYTIC_2	687	690	PF00928	0.647
TRG_ER_diArg_1	129	131	PF00400	0.467
TRG_ER_diArg_1	218	220	PF00400	0.379
TRG_ER_diArg_1	229	232	PF00400	0.421
TRG_ER_diArg_1	236	238	PF00400	0.385
TRG_ER_diArg_1	464	466	PF00400	0.661
TRG_ER_diArg_1	519	522	PF00400	0.588
TRG_ER_diArg_1	596	599	PF00400	0.561
TRG_NES_CRM1_1	341	355	PF08389	0.315
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM5	Leptomonas seymouri	39%	91%
A0A3Q8IG41	Leishmania donovani	73%	91%
A4I0T6	Leishmania infantum	73%	91%
E9AWT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	93%
Q4QAN6	Leishmania major	70%	100%