Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDF1_LEIBR

TriTrypDb:

LbrM.24.0960 , LBRM2903_240015600

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDF1

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.466
CLV_NRD_NRD_1	454	456	PF00675	0.539
CLV_PCSK_SKI1_1	126	130	PF00082	0.428
CLV_PCSK_SKI1_1	195	199	PF00082	0.650
CLV_PCSK_SKI1_1	357	361	PF00082	0.492
CLV_PCSK_SKI1_1	456	460	PF00082	0.532
CLV_PCSK_SKI1_1	467	471	PF00082	0.419
CLV_PCSK_SKI1_1	58	62	PF00082	0.504
DEG_APCC_DBOX_1	356	364	PF00400	0.464
DOC_CDC14_PxL_1	442	450	PF14671	0.545
DOC_CYCLIN_RxL_1	192	201	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	41	44	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	61	67	PF00134	0.500
DOC_MAPK_gen_1	107	116	PF00069	0.591
DOC_MAPK_MEF2A_6	126	133	PF00069	0.400
DOC_PP1_RVXF_1	24	31	PF00149	0.393
DOC_PP1_RVXF_1	56	63	PF00149	0.505
DOC_PP2B_LxvP_1	4	7	PF13499	0.513
DOC_PP2B_LxvP_1	41	44	PF13499	0.484
DOC_USP7_MATH_1	173	177	PF00917	0.747
DOC_USP7_MATH_1	184	188	PF00917	0.516
DOC_USP7_MATH_1	207	211	PF00917	0.732
DOC_USP7_MATH_1	404	408	PF00917	0.492
DOC_WW_Pin1_4	60	65	PF00397	0.502
DOC_WW_Pin1_4	73	78	PF00397	0.463
LIG_14-3-3_CanoR_1	18	27	PF00244	0.400
LIG_14-3-3_CanoR_1	313	323	PF00244	0.492
LIG_Actin_WH2_2	94	111	PF00022	0.457
LIG_BIR_II_1	1	5	PF00653	0.510
LIG_BRCT_BRCA1_1	58	62	PF00533	0.504
LIG_EH1_1	191	199	PF00400	0.647
LIG_EVH1_1	4	8	PF00568	0.512
LIG_FHA_1	203	209	PF00498	0.684
LIG_FHA_1	232	238	PF00498	0.697
LIG_FHA_1	342	348	PF00498	0.476
LIG_FHA_1	425	431	PF00498	0.357
LIG_FHA_1	448	454	PF00498	0.536
LIG_FHA_1	67	73	PF00498	0.575
LIG_FHA_2	11	17	PF00498	0.455
LIG_FHA_2	139	145	PF00498	0.582
LIG_FHA_2	191	197	PF00498	0.651
LIG_FHA_2	35	41	PF00498	0.463
LIG_FHA_2	371	377	PF00498	0.444
LIG_LIR_Gen_1	147	157	PF02991	0.452
LIG_LIR_Gen_1	373	382	PF02991	0.492
LIG_LIR_Nem_3	147	153	PF02991	0.452
LIG_LIR_Nem_3	320	325	PF02991	0.378
LIG_LIR_Nem_3	373	378	PF02991	0.436
LIG_LIR_Nem_3	59	65	PF02991	0.500
LIG_NRBOX	302	308	PF00104	0.492
LIG_Pex14_2	352	356	PF04695	0.357
LIG_PTB_Apo_2	151	158	PF02174	0.593
LIG_PTB_Phospho_1	151	157	PF10480	0.589
LIG_Rb_LxCxE_1	437	450	PF01857	0.543
LIG_REV1ctd_RIR_1	383	391	PF16727	0.492
LIG_SH2_CRK	125	129	PF00017	0.372
LIG_SH2_CRK	20	24	PF00017	0.393
LIG_SH2_CRK	268	272	PF00017	0.421
LIG_SH2_CRK	293	297	PF00017	0.492
LIG_SH2_CRK	417	421	PF00017	0.492
LIG_SH2_SRC	73	76	PF00017	0.512
LIG_SH2_STAP1	157	161	PF00017	0.619
LIG_SH2_STAP1	417	421	PF00017	0.492
LIG_SH2_STAP1	465	469	PF00017	0.588
LIG_SH2_STAT5	127	130	PF00017	0.399
LIG_SH2_STAT5	157	160	PF00017	0.617
LIG_SH2_STAT5	20	23	PF00017	0.567
LIG_SH2_STAT5	268	271	PF00017	0.469
LIG_SH2_STAT5	293	296	PF00017	0.448
LIG_SH2_STAT5	402	405	PF00017	0.357
LIG_SH2_STAT5	440	443	PF00017	0.540
LIG_SH2_STAT5	73	76	PF00017	0.512
LIG_SH3_3	2	8	PF00018	0.510
LIG_SH3_3	232	238	PF00018	0.768
LIG_SH3_3	356	362	PF00018	0.492
LIG_SH3_3	41	47	PF00018	0.478
LIG_SH3_3	69	75	PF00018	0.506
LIG_SUMO_SIM_anti_2	37	43	PF11976	0.476
LIG_TRAF2_1	141	144	PF00917	0.605
LIG_TRAF2_1	258	261	PF00917	0.556
LIG_TYR_ITIM	123	128	PF00017	0.524
LIG_UBA3_1	328	334	PF00899	0.240
MOD_CK1_1	201	207	PF00069	0.521
MOD_CK1_1	380	386	PF00069	0.486
MOD_CK1_1	424	430	PF00069	0.492
MOD_CK1_1	463	469	PF00069	0.435
MOD_CK2_1	10	16	PF00069	0.461
MOD_CK2_1	138	144	PF00069	0.607
MOD_CK2_1	190	196	PF00069	0.615
MOD_CK2_1	207	213	PF00069	0.688
MOD_CK2_1	254	260	PF00069	0.322
MOD_CK2_1	370	376	PF00069	0.379
MOD_CK2_1	422	428	PF00069	0.492
MOD_GlcNHglycan	175	178	PF01048	0.743
MOD_GlcNHglycan	209	212	PF01048	0.656
MOD_GlcNHglycan	213	217	PF01048	0.607
MOD_GlcNHglycan	221	224	PF01048	0.501
MOD_GlcNHglycan	229	232	PF01048	0.641
MOD_GlcNHglycan	252	255	PF01048	0.572
MOD_GlcNHglycan	256	259	PF01048	0.497
MOD_GlcNHglycan	283	286	PF01048	0.450
MOD_GlcNHglycan	316	319	PF01048	0.492
MOD_GSK3_1	134	141	PF00069	0.484
MOD_GSK3_1	198	205	PF00069	0.632
MOD_GSK3_1	227	234	PF00069	0.651
MOD_GSK3_1	250	257	PF00069	0.504
MOD_GSK3_1	314	321	PF00069	0.408
MOD_GSK3_1	52	59	PF00069	0.576
MOD_N-GLC_1	10	15	PF02516	0.467
MOD_N-GLC_1	294	299	PF02516	0.492
MOD_NEK2_1	152	157	PF00069	0.486
MOD_NEK2_1	198	203	PF00069	0.652
MOD_NEK2_1	218	223	PF00069	0.446
MOD_NEK2_1	422	427	PF00069	0.492
MOD_NEK2_1	56	61	PF00069	0.661
MOD_NEK2_1	65	70	PF00069	0.462
MOD_NEK2_1	9	14	PF00069	0.477
MOD_NEK2_2	190	195	PF00069	0.598
MOD_NEK2_2	318	323	PF00069	0.492
MOD_PK_1	242	248	PF00069	0.576
MOD_PKA_2	318	324	PF00069	0.492
MOD_PKA_2	460	466	PF00069	0.550
MOD_Plk_1	109	115	PF00069	0.519
MOD_Plk_1	134	140	PF00069	0.463
MOD_Plk_1	28	34	PF00069	0.497
MOD_Plk_1	294	300	PF00069	0.492
MOD_Plk_1	56	62	PF00069	0.506
MOD_Plk_2-3	365	371	PF00069	0.412
MOD_Plk_4	242	248	PF00069	0.678
MOD_Plk_4	318	324	PF00069	0.412
MOD_Plk_4	377	383	PF00069	0.383
MOD_Plk_4	460	466	PF00069	0.433
MOD_ProDKin_1	60	66	PF00069	0.501
MOD_ProDKin_1	73	79	PF00069	0.462
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.385
TRG_ENDOCYTIC_2	125	128	PF00928	0.363
TRG_ENDOCYTIC_2	157	160	PF00928	0.617
TRG_ENDOCYTIC_2	20	23	PF00928	0.396
TRG_ENDOCYTIC_2	293	296	PF00928	0.492
TRG_ENDOCYTIC_2	364	367	PF00928	0.339
TRG_ENDOCYTIC_2	417	420	PF00928	0.369
TRG_NES_CRM1_1	376	388	PF08389	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WY95	Leishmania donovani	87%	100%
A0A422NHQ9	Trypanosoma rangeli	39%	100%
A4I0T4	Leishmania infantum	87%	100%
D0A763	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AWT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAN8	Leishmania major	87%	100%
V5BAM9	Trypanosoma cruzi	38%	100%