Archaic_translocase_outer_membrane_12_kDa_subunit_-_putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Archaic Translocase of outer membrane 14 kDa subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HDF0_LEIBR

TriTrypDb:

LbrM.24.0950 , LBRM2903_240015500

Length:

115

Annotations

LeishMANIAdb annotations

Potential organellar protein (an N-terminal mitochondrial transit peptide cannot be excluded). Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDF0

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.289
CLV_NRD_NRD_1	105	107	PF00675	0.606
CLV_PCSK_KEX2_1	105	107	PF00082	0.606
CLV_PCSK_SKI1_1	11	15	PF00082	0.282
CLV_PCSK_SKI1_1	54	58	PF00082	0.564
CLV_PCSK_SKI1_1	78	82	PF00082	0.572
DEG_APCC_DBOX_1	28	36	PF00400	0.581
DOC_MAPK_MEF2A_6	11	18	PF00069	0.478
DOC_USP7_MATH_1	49	53	PF00917	0.521
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_deltaCOP1_diTrp_1	94	104	PF00928	0.402
LIG_EVH1_2	100	104	PF00568	0.290
LIG_FHA_2	70	76	PF00498	0.310
LIG_HCF-1_HBM_1	59	62	PF13415	0.396
LIG_IRF3_LxIS_1	10	17	PF10401	0.479
LIG_LIR_Apic_2	94	100	PF02991	0.290
LIG_LIR_Gen_1	43	51	PF02991	0.407
LIG_LIR_Nem_3	30	36	PF02991	0.496
LIG_LIR_Nem_3	43	48	PF02991	0.291
LIG_LIR_Nem_3	59	65	PF02991	0.295
LIG_PCNA_PIPBox_1	18	27	PF02747	0.470
LIG_SH2_STAP1	36	40	PF00017	0.373
LIG_SUMO_SIM_par_1	46	53	PF11976	0.398
LIG_WRC_WIRS_1	21	26	PF05994	0.468
MOD_GlcNHglycan	1	4	PF01048	0.470
MOD_GlcNHglycan	36	39	PF01048	0.459
MOD_GSK3_1	107	114	PF00069	0.307
MOD_GSK3_1	16	23	PF00069	0.483
MOD_NEK2_1	14	19	PF00069	0.585
MOD_Plk_1	86	92	PF00069	0.283
MOD_Plk_4	16	22	PF00069	0.603
MOD_SUMO_rev_2	64	69	PF00179	0.432
MOD_SUMO_rev_2	74	83	PF00179	0.404
TRG_ENDOCYTIC_2	62	65	PF00928	0.430
TRG_ER_diArg_1	104	106	PF00400	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NVH1	Trypanosomatidae	46%	91%
A0A3Q8IBB3	Leishmania donovani	87%	100%
A0A3R7NMN1	Trypanosoma rangeli	42%	97%
A4I0T3	Leishmania infantum	87%	100%
D0A762	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
E9AWT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QAN9	Leishmania major	87%	100%