Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDE8_LEIBR

TriTrypDb:

LbrM.24.0930 , LBRM2903_240015300

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.486
CLV_C14_Caspase3-7	343	347	PF00656	0.514
CLV_C14_Caspase3-7	391	395	PF00656	0.495
CLV_MEL_PAP_1	372	378	PF00089	0.278
CLV_NRD_NRD_1	118	120	PF00675	0.407
CLV_NRD_NRD_1	169	171	PF00675	0.430
CLV_NRD_NRD_1	211	213	PF00675	0.511
CLV_PCSK_FUR_1	64	68	PF00082	0.360
CLV_PCSK_KEX2_1	118	120	PF00082	0.379
CLV_PCSK_KEX2_1	169	171	PF00082	0.558
CLV_PCSK_KEX2_1	211	213	PF00082	0.511
CLV_PCSK_KEX2_1	66	68	PF00082	0.365
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.304
CLV_PCSK_SKI1_1	400	404	PF00082	0.347
CLV_PCSK_SKI1_1	67	71	PF00082	0.515
DOC_MAPK_gen_1	169	177	PF00069	0.399
DOC_MAPK_MEF2A_6	169	177	PF00069	0.544
DOC_PP1_RVXF_1	395	402	PF00149	0.468
DOC_USP7_MATH_1	163	167	PF00917	0.602
DOC_USP7_MATH_1	202	206	PF00917	0.513
DOC_USP7_MATH_1	221	225	PF00917	0.261
DOC_USP7_MATH_1	264	268	PF00917	0.594
DOC_USP7_MATH_1	289	293	PF00917	0.271
DOC_USP7_MATH_1	328	332	PF00917	0.522
DOC_USP7_MATH_1	43	47	PF00917	0.641
DOC_USP7_UBL2_3	268	272	PF12436	0.440
DOC_USP7_UBL2_3	66	70	PF12436	0.418
DOC_WW_Pin1_4	244	249	PF00397	0.737
DOC_WW_Pin1_4	254	259	PF00397	0.563
DOC_WW_Pin1_4	92	97	PF00397	0.556
LIG_14-3-3_CanoR_1	137	141	PF00244	0.481
LIG_14-3-3_CanoR_1	169	173	PF00244	0.482
LIG_14-3-3_CanoR_1	27	36	PF00244	0.557
LIG_14-3-3_CanoR_1	364	369	PF00244	0.419
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_eIF4E_1	227	233	PF01652	0.442
LIG_FHA_1	111	117	PF00498	0.450
LIG_FHA_1	149	155	PF00498	0.580
LIG_FHA_1	182	188	PF00498	0.339
LIG_FHA_1	227	233	PF00498	0.500
LIG_FHA_1	367	373	PF00498	0.509
LIG_FHA_1	78	84	PF00498	0.504
LIG_FHA_2	137	143	PF00498	0.278
LIG_FHA_2	239	245	PF00498	0.583
LIG_FHA_2	341	347	PF00498	0.528
LIG_FHA_2	383	389	PF00498	0.477
LIG_FHA_2	410	416	PF00498	0.351
LIG_GBD_Chelix_1	332	340	PF00786	0.424
LIG_LIR_Gen_1	122	128	PF02991	0.483
LIG_LIR_Gen_1	171	180	PF02991	0.527
LIG_LIR_Gen_1	224	235	PF02991	0.456
LIG_LIR_Gen_1	50	59	PF02991	0.405
LIG_LIR_Nem_3	115	120	PF02991	0.359
LIG_LIR_Nem_3	122	127	PF02991	0.341
LIG_LIR_Nem_3	171	177	PF02991	0.547
LIG_LIR_Nem_3	224	230	PF02991	0.504
LIG_LIR_Nem_3	50	54	PF02991	0.420
LIG_NRBOX	335	341	PF00104	0.392
LIG_Pex14_1	310	314	PF04695	0.344
LIG_Pex14_2	378	382	PF04695	0.360
LIG_REV1ctd_RIR_1	400	410	PF16727	0.495
LIG_SH2_CRK	124	128	PF00017	0.349
LIG_SH2_CRK	227	231	PF00017	0.497
LIG_SH2_NCK_1	227	231	PF00017	0.387
LIG_SH2_STAP1	124	128	PF00017	0.334
LIG_SH2_STAP1	203	207	PF00017	0.394
LIG_SH2_STAP1	368	372	PF00017	0.498
LIG_SH2_STAT5	314	317	PF00017	0.337
LIG_SH2_STAT5	368	371	PF00017	0.506
LIG_SH3_3	102	108	PF00018	0.368
LIG_SH3_3	232	238	PF00018	0.465
LIG_SH3_3	298	304	PF00018	0.254
LIG_SUMO_SIM_anti_2	228	234	PF11976	0.434
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.315
LIG_SUMO_SIM_par_1	335	341	PF11976	0.315
LIG_SUMO_SIM_par_1	348	354	PF11976	0.332
MOD_CDK_SPxK_1	92	98	PF00069	0.553
MOD_CK1_1	205	211	PF00069	0.453
MOD_CK1_1	249	255	PF00069	0.725
MOD_CK1_1	256	262	PF00069	0.540
MOD_CK1_1	335	341	PF00069	0.458
MOD_CK1_1	366	372	PF00069	0.462
MOD_CK2_1	136	142	PF00069	0.427
MOD_CK2_1	238	244	PF00069	0.451
MOD_CK2_1	264	270	PF00069	0.582
MOD_CK2_1	382	388	PF00069	0.448
MOD_CMANNOS	444	447	PF00535	0.362
MOD_GlcNHglycan	164	168	PF01048	0.671
MOD_GlcNHglycan	219	222	PF01048	0.468
MOD_GlcNHglycan	223	226	PF01048	0.490
MOD_GlcNHglycan	248	251	PF01048	0.680
MOD_GlcNHglycan	274	277	PF01048	0.516
MOD_GlcNHglycan	33	36	PF01048	0.638
MOD_GlcNHglycan	358	361	PF01048	0.565
MOD_GlcNHglycan	417	420	PF01048	0.750
MOD_GlcNHglycan	430	433	PF01048	0.606
MOD_GlcNHglycan	45	48	PF01048	0.630
MOD_GlcNHglycan	50	54	PF01048	0.518
MOD_GlcNHglycan	61	64	PF01048	0.547
MOD_GlcNHglycan	98	101	PF01048	0.640
MOD_GSK3_1	17	24	PF00069	0.600
MOD_GSK3_1	217	224	PF00069	0.385
MOD_GSK3_1	249	256	PF00069	0.562
MOD_GSK3_1	264	271	PF00069	0.510
MOD_GSK3_1	289	296	PF00069	0.418
MOD_GSK3_1	31	38	PF00069	0.714
MOD_GSK3_1	328	335	PF00069	0.515
MOD_GSK3_1	356	363	PF00069	0.484
MOD_GSK3_1	378	385	PF00069	0.444
MOD_GSK3_1	438	445	PF00069	0.345
MOD_GSK3_1	49	56	PF00069	0.389
MOD_GSK3_1	92	99	PF00069	0.677
MOD_LATS_1	266	272	PF00433	0.437
MOD_N-GLC_1	131	136	PF02516	0.489
MOD_N-GLC_1	356	361	PF02516	0.428
MOD_NEK2_1	1	6	PF00069	0.486
MOD_NEK2_1	17	22	PF00069	0.589
MOD_NEK2_1	214	219	PF00069	0.472
MOD_NEK2_1	295	300	PF00069	0.434
MOD_NEK2_1	340	345	PF00069	0.379
MOD_NEK2_1	376	381	PF00069	0.453
MOD_NEK2_1	438	443	PF00069	0.440
MOD_NEK2_1	83	88	PF00069	0.553
MOD_PIKK_1	168	174	PF00454	0.518
MOD_PIKK_1	295	301	PF00454	0.436
MOD_PIKK_1	366	372	PF00454	0.512
MOD_PKA_2	136	142	PF00069	0.443
MOD_PKA_2	168	174	PF00069	0.656
MOD_PKA_2	26	32	PF00069	0.579
MOD_PKA_2	363	369	PF00069	0.494
MOD_PKA_2	83	89	PF00069	0.577
MOD_Plk_1	131	137	PF00069	0.412
MOD_Plk_1	205	211	PF00069	0.469
MOD_Plk_1	49	55	PF00069	0.315
MOD_Plk_4	101	107	PF00069	0.614
MOD_Plk_4	136	142	PF00069	0.434
MOD_Plk_4	205	211	PF00069	0.533
MOD_Plk_4	228	234	PF00069	0.442
MOD_Plk_4	256	262	PF00069	0.347
MOD_Plk_4	310	316	PF00069	0.310
MOD_Plk_4	328	334	PF00069	0.428
MOD_Plk_4	335	341	PF00069	0.391
MOD_Plk_4	68	74	PF00069	0.543
MOD_ProDKin_1	244	250	PF00069	0.737
MOD_ProDKin_1	254	260	PF00069	0.558
MOD_ProDKin_1	92	98	PF00069	0.553
MOD_SUMO_for_1	11	14	PF00179	0.700
MOD_SUMO_for_1	65	68	PF00179	0.404
MOD_SUMO_rev_2	265	274	PF00179	0.431
MOD_SUMO_rev_2	386	392	PF00179	0.497
MOD_SUMO_rev_2	62	72	PF00179	0.568
TRG_DiLeu_BaEn_1	122	127	PF01217	0.410
TRG_ENDOCYTIC_2	117	120	PF00928	0.369
TRG_ENDOCYTIC_2	124	127	PF00928	0.334
TRG_ENDOCYTIC_2	227	230	PF00928	0.499
TRG_ER_diArg_1	117	119	PF00400	0.405
TRG_ER_diArg_1	210	212	PF00400	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYW2	Leptomonas seymouri	58%	100%
A0A0S4IXA1	Bodo saltans	35%	100%
A0A1X0NVG3	Trypanosomatidae	31%	89%
A0A3Q8ICU5	Leishmania donovani	76%	98%
A0A3R7KEJ9	Trypanosoma rangeli	44%	100%
A4I0T1	Leishmania infantum	76%	98%
D0A760	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AWT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QAP1	Leishmania major	75%	100%
V5BVT1	Trypanosoma cruzi	43%	100%