DNA replication licensing factor MCM5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM5, putative

Species:

Leishmania braziliensis

UniProt:

A4HDE7_LEIBR

TriTrypDb:

LbrM.24.0920 , LBRM2903_240015200

Length:

802

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0032991	protein-containing complex	1	12
GO:0042555	MCM complex	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HDE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDE7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006270	DNA replication initiation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007049	cell cycle	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003688	DNA replication origin binding	7	12
GO:0003690	double-stranded DNA binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043565	sequence-specific DNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:1990837	sequence-specific double-stranded DNA binding	6	12
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	704	708	PF00656	0.494
CLV_NRD_NRD_1	113	115	PF00675	0.252
CLV_NRD_NRD_1	394	396	PF00675	0.253
CLV_NRD_NRD_1	581	583	PF00675	0.703
CLV_NRD_NRD_1	646	648	PF00675	0.253
CLV_NRD_NRD_1	749	751	PF00675	0.431
CLV_NRD_NRD_1	791	793	PF00675	0.442
CLV_PCSK_KEX2_1	287	289	PF00082	0.522
CLV_PCSK_KEX2_1	396	398	PF00082	0.288
CLV_PCSK_KEX2_1	580	582	PF00082	0.709
CLV_PCSK_KEX2_1	646	648	PF00082	0.253
CLV_PCSK_KEX2_1	748	750	PF00082	0.444
CLV_PCSK_KEX2_1	785	787	PF00082	0.454
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.538
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.288
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.470
CLV_PCSK_SKI1_1	114	118	PF00082	0.368
CLV_PCSK_SKI1_1	256	260	PF00082	0.253
CLV_PCSK_SKI1_1	41	45	PF00082	0.305
CLV_PCSK_SKI1_1	612	616	PF00082	0.295
CLV_PCSK_SKI1_1	636	640	PF00082	0.339
CLV_PCSK_SKI1_1	713	717	PF00082	0.265
CLV_PCSK_SKI1_1	749	753	PF00082	0.476
CLV_PCSK_SKI1_1	795	799	PF00082	0.530
CLV_Separin_Metazoa	253	257	PF03568	0.453
DEG_APCC_DBOX_1	695	703	PF00400	0.478
DEG_APCC_DBOX_1	794	802	PF00400	0.550
DEG_Nend_UBRbox_3	1	3	PF02207	0.659
DEG_SPOP_SBC_1	158	162	PF00917	0.539
DOC_ANK_TNKS_1	26	33	PF00023	0.474
DOC_CYCLIN_RxL_1	111	121	PF00134	0.618
DOC_CYCLIN_RxL_1	633	640	PF00134	0.539
DOC_CYCLIN_RxL_1	94	104	PF00134	0.467
DOC_CYCLIN_yClb5_NLxxxL_5	500	509	PF00134	0.374
DOC_CYCLIN_yClb5_NLxxxL_5	62	71	PF00134	0.453
DOC_MAPK_DCC_7	424	434	PF00069	0.465
DOC_MAPK_gen_1	219	228	PF00069	0.514
DOC_MAPK_gen_1	299	306	PF00069	0.421
DOC_MAPK_gen_1	383	391	PF00069	0.451
DOC_MAPK_gen_1	480	489	PF00069	0.453
DOC_MAPK_MEF2A_6	122	130	PF00069	0.405
DOC_MAPK_MEF2A_6	219	228	PF00069	0.514
DOC_MAPK_MEF2A_6	383	391	PF00069	0.453
DOC_MAPK_MEF2A_6	404	411	PF00069	0.465
DOC_PP2B_PxIxI_1	674	680	PF00149	0.453
DOC_USP7_MATH_1	229	233	PF00917	0.378
DOC_USP7_MATH_1	327	331	PF00917	0.532
DOC_USP7_MATH_1	528	532	PF00917	0.465
DOC_USP7_MATH_1	587	591	PF00917	0.623
DOC_USP7_MATH_1	597	601	PF00917	0.672
DOC_USP7_MATH_1	602	606	PF00917	0.629
DOC_USP7_MATH_1	669	673	PF00917	0.516
DOC_USP7_MATH_1	703	707	PF00917	0.532
DOC_USP7_MATH_1	722	726	PF00917	0.289
DOC_USP7_MATH_2	349	355	PF00917	0.426
DOC_USP7_UBL2_3	356	360	PF12436	0.514
DOC_USP7_UBL2_3	424	428	PF12436	0.465
DOC_WW_Pin1_4	268	273	PF00397	0.453
DOC_WW_Pin1_4	671	676	PF00397	0.465
LIG_14-3-3_CanoR_1	256	261	PF00244	0.453
LIG_14-3-3_CanoR_1	299	306	PF00244	0.421
LIG_14-3-3_CanoR_1	340	346	PF00244	0.579
LIG_14-3-3_CanoR_1	367	374	PF00244	0.378
LIG_14-3-3_CanoR_1	512	516	PF00244	0.453
LIG_14-3-3_CanoR_1	623	630	PF00244	0.467
LIG_14-3-3_CanoR_1	64	74	PF00244	0.519
LIG_14-3-3_CanoR_1	689	697	PF00244	0.444
LIG_14-3-3_CanoR_1	748	754	PF00244	0.502
LIG_14-3-3_CanoR_1	761	769	PF00244	0.434
LIG_14-3-3_CanoR_1	792	798	PF00244	0.465
LIG_APCC_ABBA_1	51	56	PF00400	0.482
LIG_APCC_ABBAyCdc20_2	50	56	PF00400	0.408
LIG_Clathr_ClatBox_1	227	231	PF01394	0.465
LIG_CtBP_PxDLS_1	136	140	PF00389	0.278
LIG_FHA_1	123	129	PF00498	0.432
LIG_FHA_1	249	255	PF00498	0.451
LIG_FHA_1	257	263	PF00498	0.437
LIG_FHA_1	319	325	PF00498	0.381
LIG_FHA_1	445	451	PF00498	0.453
LIG_FHA_1	495	501	PF00498	0.453
LIG_FHA_1	5	11	PF00498	0.719
LIG_FHA_1	504	510	PF00498	0.453
LIG_FHA_1	511	517	PF00498	0.453
LIG_FHA_1	614	620	PF00498	0.453
LIG_FHA_1	672	678	PF00498	0.465
LIG_FHA_1	689	695	PF00498	0.450
LIG_FHA_1	95	101	PF00498	0.460
LIG_FHA_2	318	324	PF00498	0.521
LIG_FHA_2	729	735	PF00498	0.543
LIG_HP1_1	224	228	PF01393	0.514
LIG_IBAR_NPY_1	223	225	PF08397	0.453
LIG_Integrin_isoDGR_2	25	27	PF01839	0.498
LIG_Integrin_isoDGR_2	578	580	PF01839	0.472
LIG_Integrin_RGD_1	404	406	PF01839	0.265
LIG_LIR_Gen_1	476	485	PF02991	0.453
LIG_LIR_Gen_1	544	553	PF02991	0.453
LIG_LIR_Gen_1	56	67	PF02991	0.460
LIG_LIR_Gen_1	640	649	PF02991	0.453
LIG_LIR_Nem_3	352	358	PF02991	0.453
LIG_LIR_Nem_3	525	529	PF02991	0.464
LIG_LIR_Nem_3	544	549	PF02991	0.357
LIG_LIR_Nem_3	616	621	PF02991	0.460
LIG_LIR_Nem_3	640	645	PF02991	0.453
LIG_NRP_CendR_1	800	802	PF00754	0.457
LIG_PCNA_PIPBox_1	635	644	PF02747	0.453
LIG_PCNA_yPIPBox_3	140	151	PF02747	0.453
LIG_Pex14_2	47	51	PF04695	0.453
LIG_Pex14_2	546	550	PF04695	0.453
LIG_REV1ctd_RIR_1	612	621	PF16727	0.295
LIG_RPA_C_Fungi	507	519	PF08784	0.306
LIG_RPA_C_Fungi	700	712	PF08784	0.322
LIG_RPA_C_Fungi	756	768	PF08784	0.452
LIG_SH2_CRK	526	530	PF00017	0.322
LIG_SH2_CRK	781	785	PF00017	0.447
LIG_SH2_GRB2like	182	185	PF00017	0.340
LIG_SH2_PTP2	225	228	PF00017	0.391
LIG_SH2_PTP2	642	645	PF00017	0.322
LIG_SH2_PTP2	73	76	PF00017	0.335
LIG_SH2_SRC	182	185	PF00017	0.340
LIG_SH2_STAT3	234	237	PF00017	0.306
LIG_SH2_STAT5	182	185	PF00017	0.322
LIG_SH2_STAT5	225	228	PF00017	0.306
LIG_SH2_STAT5	265	268	PF00017	0.306
LIG_SH2_STAT5	310	313	PF00017	0.358
LIG_SH2_STAT5	435	438	PF00017	0.306
LIG_SH2_STAT5	618	621	PF00017	0.306
LIG_SH2_STAT5	642	645	PF00017	0.322
LIG_SH2_STAT5	73	76	PF00017	0.426
LIG_SH3_3	223	229	PF00018	0.391
LIG_SH3_3	549	555	PF00018	0.306
LIG_SUMO_SIM_par_1	258	263	PF11976	0.306
LIG_SUMO_SIM_par_1	280	286	PF11976	0.306
LIG_TRAF2_1	283	286	PF00917	0.432
LIG_TRAF2_1	349	352	PF00917	0.542
LIG_TRFH_1	225	229	PF08558	0.322
LIG_TYR_ITIM	71	76	PF00017	0.335
LIG_UBA3_1	376	384	PF00899	0.306
MOD_CDK_SPxxK_3	268	275	PF00069	0.306
MOD_CK1_1	121	127	PF00069	0.481
MOD_CK1_1	160	166	PF00069	0.373
MOD_CK1_1	176	182	PF00069	0.188
MOD_CK1_1	271	277	PF00069	0.306
MOD_CK1_1	341	347	PF00069	0.597
MOD_CK1_1	449	455	PF00069	0.306
MOD_CK1_1	511	517	PF00069	0.306
MOD_CK1_1	541	547	PF00069	0.306
MOD_CK1_1	592	598	PF00069	0.719
MOD_CK1_1	65	71	PF00069	0.453
MOD_CK1_1	671	677	PF00069	0.381
MOD_CK2_1	229	235	PF00069	0.200
MOD_CK2_1	280	286	PF00069	0.306
MOD_CK2_1	602	608	PF00069	0.676
MOD_CK2_1	703	709	PF00069	0.426
MOD_CK2_1	728	734	PF00069	0.494
MOD_Cter_Amidation	578	581	PF01082	0.717
MOD_GlcNHglycan	153	156	PF01048	0.309
MOD_GlcNHglycan	19	22	PF01048	0.714
MOD_GlcNHglycan	197	201	PF01048	0.453
MOD_GlcNHglycan	210	213	PF01048	0.369
MOD_GlcNHglycan	216	219	PF01048	0.336
MOD_GlcNHglycan	368	371	PF01048	0.404
MOD_GlcNHglycan	397	400	PF01048	0.364
MOD_GlcNHglycan	436	439	PF01048	0.306
MOD_GlcNHglycan	441	444	PF01048	0.306
MOD_GlcNHglycan	573	576	PF01048	0.540
MOD_GlcNHglycan	589	592	PF01048	0.568
MOD_GlcNHglycan	594	597	PF01048	0.611
MOD_GlcNHglycan	599	602	PF01048	0.678
MOD_GlcNHglycan	657	660	PF01048	0.336
MOD_GlcNHglycan	661	664	PF01048	0.299
MOD_GlcNHglycan	67	70	PF01048	0.385
MOD_GlcNHglycan	724	727	PF01048	0.492
MOD_GlcNHglycan	84	87	PF01048	0.228
MOD_GSK3_1	118	125	PF00069	0.536
MOD_GSK3_1	13	20	PF00069	0.728
MOD_GSK3_1	172	179	PF00069	0.306
MOD_GSK3_1	208	215	PF00069	0.369
MOD_GSK3_1	31	38	PF00069	0.602
MOD_GSK3_1	334	341	PF00069	0.522
MOD_GSK3_1	391	398	PF00069	0.364
MOD_GSK3_1	4	11	PF00069	0.720
MOD_GSK3_1	413	420	PF00069	0.306
MOD_GSK3_1	434	441	PF00069	0.301
MOD_GSK3_1	504	511	PF00069	0.306
MOD_GSK3_1	537	544	PF00069	0.322
MOD_GSK3_1	597	604	PF00069	0.638
MOD_GSK3_1	613	620	PF00069	0.308
MOD_GSK3_1	655	662	PF00069	0.332
MOD_GSK3_1	667	674	PF00069	0.266
MOD_GSK3_1	730	737	PF00069	0.517
MOD_GSK3_1	749	756	PF00069	0.256
MOD_LATS_1	759	765	PF00433	0.499
MOD_N-GLC_1	333	338	PF02516	0.509
MOD_N-GLC_1	503	508	PF02516	0.306
MOD_N-GLC_1	65	70	PF02516	0.424
MOD_N-GLC_1	659	664	PF02516	0.452
MOD_NEK2_1	196	201	PF00069	0.439
MOD_NEK2_1	317	322	PF00069	0.414
MOD_NEK2_1	391	396	PF00069	0.322
MOD_NEK2_1	446	451	PF00069	0.306
MOD_NEK2_1	508	513	PF00069	0.306
MOD_NEK2_1	538	543	PF00069	0.294
MOD_NEK2_1	571	576	PF00069	0.612
MOD_NEK2_1	62	67	PF00069	0.362
MOD_NEK2_1	76	81	PF00069	0.286
MOD_NEK2_2	622	627	PF00069	0.391
MOD_PIKK_1	318	324	PF00454	0.584
MOD_PIKK_1	417	423	PF00454	0.322
MOD_PKA_1	395	401	PF00069	0.200
MOD_PKA_1	749	755	PF00069	0.333
MOD_PKA_2	121	127	PF00069	0.449
MOD_PKA_2	26	32	PF00069	0.581
MOD_PKA_2	318	324	PF00069	0.584
MOD_PKA_2	341	347	PF00069	0.655
MOD_PKA_2	366	372	PF00069	0.200
MOD_PKA_2	511	517	PF00069	0.306
MOD_PKA_2	622	628	PF00069	0.306
MOD_PKA_2	688	694	PF00069	0.306
MOD_PKA_2	749	755	PF00069	0.333
MOD_PKB_1	338	346	PF00069	0.555
MOD_PKB_1	395	403	PF00069	0.363
MOD_Plk_1	122	128	PF00069	0.534
MOD_Plk_1	351	357	PF00069	0.391
MOD_Plk_1	503	509	PF00069	0.306
MOD_Plk_1	728	734	PF00069	0.404
MOD_Plk_4	256	262	PF00069	0.318
MOD_Plk_4	446	452	PF00069	0.306
MOD_Plk_4	461	467	PF00069	0.306
MOD_Plk_4	504	510	PF00069	0.306
MOD_Plk_4	511	517	PF00069	0.306
MOD_Plk_4	538	544	PF00069	0.296
MOD_Plk_4	683	689	PF00069	0.302
MOD_ProDKin_1	268	274	PF00069	0.306
MOD_ProDKin_1	671	677	PF00069	0.322
MOD_SUMO_for_1	784	787	PF00179	0.455
MOD_SUMO_rev_2	109	117	PF00179	0.322
MOD_SUMO_rev_2	380	385	PF00179	0.340
TRG_DiLeu_BaEn_1	758	763	PF01217	0.414
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.543
TRG_DiLeu_LyEn_5	758	763	PF01217	0.430
TRG_ENDOCYTIC_2	225	228	PF00928	0.306
TRG_ENDOCYTIC_2	526	529	PF00928	0.306
TRG_ENDOCYTIC_2	59	62	PF00928	0.306
TRG_ENDOCYTIC_2	642	645	PF00928	0.322
TRG_ENDOCYTIC_2	73	76	PF00928	0.296
TRG_ENDOCYTIC_2	781	784	PF00928	0.416
TRG_ER_diArg_1	339	342	PF00400	0.657
TRG_ER_diArg_1	580	582	PF00400	0.496
TRG_ER_diArg_1	645	647	PF00400	0.306
TRG_ER_diArg_1	696	699	PF00400	0.322
TRG_ER_diArg_1	747	750	PF00400	0.425
TRG_NES_CRM1_1	633	648	PF08389	0.322
TRG_NLS_Bipartite_1	383	399	PF00514	0.322
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	761	765	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P686	Leptomonas seymouri	35%	93%
A0A0N0P860	Leptomonas seymouri	31%	81%
A0A0N1I2J6	Leptomonas seymouri	29%	90%
A0A0N1I371	Leptomonas seymouri	30%	100%
A0A0N1I383	Leptomonas seymouri	32%	78%
A0A0N1PC47	Leptomonas seymouri	88%	100%
A0A0S4IVB8	Bodo saltans	29%	92%
A0A0S4IW18	Bodo saltans	30%	100%
A0A0S4IYQ3	Bodo saltans	61%	100%
A0A0S4J5X8	Bodo saltans	29%	100%
A0A1X0NNF6	Trypanosomatidae	30%	88%
A0A1X0NQM5	Trypanosomatidae	30%	90%
A0A1X0NT66	Trypanosomatidae	30%	100%
A0A1X0NVE7	Trypanosomatidae	73%	100%
A0A1X0NZT6	Trypanosomatidae	31%	85%
A0A1X0P1Q1	Trypanosomatidae	27%	100%
A0A3Q8IAX4	Leishmania donovani	31%	83%
A0A3R7NBN0	Trypanosoma rangeli	30%	84%
A0A3S5H7J9	Leishmania donovani	29%	91%
A0A3S5H7S8	Leishmania donovani	30%	100%
A0A3S7WQI8	Leishmania donovani	30%	90%
A0A3S7WY81	Leishmania donovani	93%	100%
A0A422N694	Trypanosoma rangeli	30%	100%
A0A422NDD9	Trypanosoma rangeli	31%	92%
A0A422NDR0	Trypanosoma rangeli	27%	100%
A0A422NHH5	Trypanosoma rangeli	71%	100%
A0A422NZW3	Trypanosoma rangeli	30%	100%
A4FUD9	Bos taurus	33%	99%
A4HGC9	Leishmania braziliensis	31%	83%
A4HGU2	Leishmania braziliensis	29%	91%
A4HKT9	Leishmania braziliensis	30%	100%
A4HNF5	Leishmania braziliensis	26%	88%
A4HTX2	Leishmania infantum	29%	90%
A4I0T0	Leishmania infantum	93%	100%
A4I3G2	Leishmania infantum	31%	83%
A4I3W9	Leishmania infantum	29%	91%
A4I8B8	Leishmania infantum	30%	100%
B8AEH3	Oryza sativa subsp. indica	41%	100%
B8AZ14	Oryza sativa subsp. indica	32%	100%
B8AZ99	Oryza sativa subsp. indica	33%	100%
B8AZX3	Oryza sativa subsp. indica	31%	97%
B8B406	Oryza sativa subsp. indica	29%	100%
B8BKI8	Oryza sativa subsp. indica	31%	83%
B8BMI1	Oryza sativa subsp. indica	31%	100%
B9FKM7	Oryza sativa subsp. japonica	32%	100%
C9ZYH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A4I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A759	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
D0A7X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	85%
D0A936	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
D0A999	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
D0AAI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D3ZVK1	Rattus norvegicus	31%	97%
E1BPX4	Bos taurus	30%	98%
E9AFW6	Leishmania major	26%	100%
E9AMM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	90%
E9AWT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AZQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	83%
E9B059	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	91%
E9B377	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
F1M5F3	Rattus norvegicus	30%	71%
F1QDI9	Danio rerio	28%	71%
F4KAB8	Arabidopsis thaliana	32%	97%
I0IUP3	Gallus gallus	31%	97%
I0IUP4	Gallus gallus	27%	69%
O75001	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O80786	Arabidopsis thaliana	39%	100%
P24279	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	83%
P25205	Homo sapiens	33%	99%
P25206	Mus musculus	32%	99%
P29458	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	86%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	92%
P29496	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P30664	Xenopus laevis	32%	93%
P30665	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	86%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	91%
P33991	Homo sapiens	31%	93%
P33992	Homo sapiens	39%	100%
P33993	Homo sapiens	31%	100%
P34647	Caenorhabditis elegans	31%	99%
P38132	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	95%
P40377	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	97%
P41389	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P43299	Arabidopsis thaliana	31%	100%
P49717	Mus musculus	31%	93%
P49718	Mus musculus	38%	100%
P49731	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	90%
P49735	Drosophila melanogaster	29%	90%
P49736	Homo sapiens	29%	89%
P49739	Xenopus laevis	35%	99%
P53091	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	79%
P55861	Xenopus laevis	30%	91%
P55862	Xenopus laevis	37%	100%
P97310	Mus musculus	29%	89%
P97311	Mus musculus	30%	98%
Q0DHC4	Oryza sativa subsp. japonica	33%	100%
Q0V8B7	Bos taurus	39%	100%
Q0V9Q6	Xenopus tropicalis	30%	95%
Q0WVF5	Arabidopsis thaliana	32%	95%
Q14566	Homo sapiens	29%	98%
Q21902	Caenorhabditis elegans	38%	100%
Q24849	Entamoeba histolytica	31%	100%
Q26454	Drosophila melanogaster	29%	93%
Q28BS0	Xenopus tropicalis	33%	99%
Q28CM3	Xenopus tropicalis	31%	98%
Q29JI9	Drosophila pseudoobscura pseudoobscura	29%	98%
Q2KHI9	Mus musculus	29%	71%
Q2KIZ8	Bos taurus	30%	98%
Q2QNM1	Oryza sativa subsp. japonica	31%	100%
Q2R482	Oryza sativa subsp. japonica	31%	83%
Q3ZBH9	Bos taurus	31%	100%
Q43704	Zea mays	33%	100%
Q498J7	Xenopus laevis	31%	97%
Q4Q826	Leishmania major	28%	100%
Q4Q8I2	Leishmania major	30%	83%
Q4QAP2	Leishmania major	92%	99%
Q4QI01	Leishmania major	29%	90%
Q54CP4	Dictyostelium discoideum	40%	100%
Q561P5	Xenopus tropicalis	37%	100%
Q58884	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5F310	Xenopus laevis	30%	97%
Q5FWY4	Xenopus laevis	31%	98%
Q5JKB0	Oryza sativa subsp. japonica	33%	93%
Q5R8G6	Pongo abelii	33%	99%
Q5XK83	Xenopus laevis	32%	93%
Q5ZMN2	Gallus gallus	32%	99%
Q61881	Mus musculus	31%	100%
Q61J08	Caenorhabditis briggsae	30%	99%
Q69QA6	Oryza sativa subsp. japonica	29%	100%
Q6DIH3	Xenopus tropicalis	30%	91%
Q6F353	Oryza sativa subsp. japonica	31%	97%
Q6GL41	Xenopus tropicalis	31%	93%
Q6KAJ4	Oryza sativa subsp. japonica	41%	100%
Q6NX31	Xenopus tropicalis	30%	100%
Q6P1V8	Xenopus tropicalis	30%	97%
Q6PCI7	Xenopus laevis	37%	100%
Q7Q0Q1	Anopheles gambiae	30%	99%
Q7ZXB1	Xenopus laevis	31%	100%
Q7ZXZ0	Xenopus laevis	33%	100%
Q7ZY18	Xenopus laevis	30%	97%
Q86B14	Dictyostelium discoideum	32%	93%
Q91876	Xenopus laevis	30%	100%
Q95XQ8	Caenorhabditis elegans	30%	97%
Q9CWV1	Mus musculus	31%	96%
Q9FL33	Arabidopsis thaliana	31%	100%
Q9LPD9	Arabidopsis thaliana	30%	86%
Q9SF37	Arabidopsis thaliana	30%	100%
Q9SX03	Zea mays	33%	100%
Q9SX04	Zea mays	33%	100%
Q9U1E0	Leishmania major	30%	100%
Q9UJA3	Homo sapiens	30%	95%
Q9UXG1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	32%	100%
Q9V461	Drosophila melanogaster	29%	98%
Q9VF30	Drosophila melanogaster	23%	91%
Q9VGW6	Drosophila melanogaster	39%	100%
Q9XYU0	Drosophila melanogaster	30%	100%
Q9XYU1	Drosophila melanogaster	35%	98%
V5B8T3	Trypanosoma cruzi	26%	100%
V5BGQ5	Trypanosoma cruzi	28%	94%
V5BHZ8	Trypanosoma cruzi	31%	100%
V5BQA9	Trypanosoma cruzi	31%	100%
V5BSG2	Trypanosoma cruzi	31%	92%
V5C0K6	Trypanosoma cruzi	71%	100%