LeishMANIAdb
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Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical predicted transmembrane protein
Gene product:
hypothetical predicted transmembrane protein
Species:
Leishmania braziliensis
UniProt:
A4HDE4_LEIBR
TriTrypDb:
LbrM.24.0890 , LBRM2903_240014900
Length:
117

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4HDE4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDE4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 87 89 PF00675 0.448
CLV_PCSK_KEX2_1 87 89 PF00082 0.448
CLV_PCSK_SKI1_1 53 57 PF00082 0.430
DEG_Nend_UBRbox_3 1 3 PF02207 0.417
DOC_MAPK_RevD_3 73 88 PF00069 0.543
DOC_PP1_RVXF_1 85 92 PF00149 0.611
DOC_PP4_FxxP_1 74 77 PF00568 0.635
DOC_USP7_MATH_1 83 87 PF00917 0.631
LIG_14-3-3_CanoR_1 53 62 PF00244 0.606
LIG_Actin_WH2_2 40 55 PF00022 0.653
LIG_BRCT_BRCA1_1 70 74 PF00533 0.627
LIG_GBD_Chelix_1 6 14 PF00786 0.240
LIG_LIR_Apic_2 71 77 PF02991 0.632
LIG_LIR_Nem_3 15 21 PF02991 0.455
LIG_PTB_Apo_2 37 44 PF02174 0.563
LIG_REV1ctd_RIR_1 48 57 PF16727 0.490
LIG_SH2_STAT5 18 21 PF00017 0.292
LIG_SH3_3 104 110 PF00018 0.536
LIG_SH3_3 74 80 PF00018 0.611
LIG_TYR_ITSM 14 21 PF00017 0.331
MOD_GlcNHglycan 28 31 PF01048 0.441
MOD_GlcNHglycan 70 73 PF01048 0.475
MOD_N-GLC_1 67 72 PF02516 0.329
MOD_NEK2_1 43 48 PF00069 0.605
MOD_NEK2_2 13 18 PF00069 0.331
MOD_PKA_2 68 74 PF00069 0.627
MOD_Plk_4 13 19 PF00069 0.402
MOD_Plk_4 43 49 PF00069 0.566
TRG_ENDOCYTIC_2 18 21 PF00928 0.292
TRG_ER_diArg_1 87 89 PF00400 0.652

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I448 Leptomonas seymouri 68% 100%
A0A0S4J172 Bodo saltans 38% 90%
A0A1X0NVP0 Trypanosomatidae 32% 100%
A0A3R7MLX5 Trypanosoma rangeli 45% 82%
A0A3S5H7D0 Leishmania donovani 82% 100%
E9AWS9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4QAP5 Leishmania major 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS