GOLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

emp24/gp25L/p24 family/GOLD, putative

Species:

Leishmania braziliensis

UniProt:

A4HDE3_LEIBR

TriTrypDb:

LbrM.24.0880 , LBRM2903_240014800

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 3
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HDE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.231
CLV_NRD_NRD_1	222	224	PF00675	0.359
CLV_PCSK_KEX2_1	222	224	PF00082	0.397
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.310
CLV_PCSK_SKI1_1	170	174	PF00082	0.492
CLV_PCSK_SKI1_1	40	44	PF00082	0.421
CLV_PCSK_SKI1_1	60	64	PF00082	0.339
DEG_APCC_DBOX_1	169	177	PF00400	0.263
DEG_SCF_FBW7_1	62	67	PF00400	0.231
DEG_SPOP_SBC_1	114	118	PF00917	0.174
DOC_MAPK_MEF2A_6	192	200	PF00069	0.325
DOC_MAPK_MEF2A_6	3	11	PF00069	0.511
DOC_MAPK_MEF2A_6	60	68	PF00069	0.231
DOC_PP4_FxxP_1	83	86	PF00568	0.267
DOC_SPAK_OSR1_1	31	35	PF12202	0.325
DOC_USP7_MATH_1	113	117	PF00917	0.258
DOC_USP7_MATH_1	172	176	PF00917	0.224
DOC_USP7_MATH_1	64	68	PF00917	0.245
DOC_USP7_MATH_1	69	73	PF00917	0.139
DOC_USP7_UBL2_3	85	89	PF12436	0.325
DOC_WW_Pin1_4	140	145	PF00397	0.306
DOC_WW_Pin1_4	60	65	PF00397	0.238
LIG_14-3-3_CanoR_1	184	188	PF00244	0.277
LIG_14-3-3_CanoR_1	192	196	PF00244	0.242
LIG_14-3-3_CanoR_1	31	35	PF00244	0.262
LIG_14-3-3_CanoR_1	57	63	PF00244	0.316
LIG_BRCT_BRCA1_1	100	104	PF00533	0.325
LIG_BRCT_BRCA1_1	193	197	PF00533	0.212
LIG_FHA_1	118	124	PF00498	0.245
LIG_FHA_1	61	67	PF00498	0.344
LIG_FHA_2	175	181	PF00498	0.282
LIG_LIR_Apic_2	80	86	PF02991	0.174
LIG_LIR_Gen_1	164	174	PF02991	0.290
LIG_LIR_Gen_1	182	193	PF02991	0.325
LIG_LIR_Gen_1	194	204	PF02991	0.240
LIG_LIR_Gen_1	212	220	PF02991	0.332
LIG_LIR_Gen_1	63	70	PF02991	0.245
LIG_LIR_Nem_3	191	196	PF02991	0.292
LIG_LIR_Nem_3	212	216	PF02991	0.255
LIG_LIR_Nem_3	63	68	PF02991	0.240
LIG_Pex14_1	195	199	PF04695	0.324
LIG_Pex14_2	193	197	PF04695	0.253
LIG_SH2_PTP2	199	202	PF00017	0.275
LIG_SH2_STAP1	163	167	PF00017	0.260
LIG_SH2_STAP1	52	56	PF00017	0.245
LIG_SH2_STAT5	161	164	PF00017	0.260
LIG_SH2_STAT5	199	202	PF00017	0.277
LIG_SH3_4	85	92	PF00018	0.325
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.231
LIG_SUMO_SIM_anti_2	90	95	PF11976	0.174
LIG_SUMO_SIM_par_1	116	125	PF11976	0.248
LIG_SUMO_SIM_par_1	172	177	PF11976	0.221
LIG_SUMO_SIM_par_1	206	212	PF11976	0.242
LIG_WRC_WIRS_1	163	168	PF05994	0.260
LIG_WRC_WIRS_1	210	215	PF05994	0.344
MOD_CK1_1	138	144	PF00069	0.232
MOD_CK1_1	98	104	PF00069	0.338
MOD_CK2_1	183	189	PF00069	0.275
MOD_DYRK1A_RPxSP_1	60	64	PF00069	0.221
MOD_GlcNHglycan	152	155	PF01048	0.454
MOD_GSK3_1	104	111	PF00069	0.271
MOD_GSK3_1	113	120	PF00069	0.224
MOD_GSK3_1	135	142	PF00069	0.282
MOD_GSK3_1	60	67	PF00069	0.259
MOD_NEK2_1	30	35	PF00069	0.248
MOD_NEK2_1	58	63	PF00069	0.255
MOD_PKA_1	135	141	PF00069	0.245
MOD_PKA_2	183	189	PF00069	0.250
MOD_PKA_2	191	197	PF00069	0.235
MOD_PKA_2	30	36	PF00069	0.244
MOD_Plk_1	129	135	PF00069	0.308
MOD_Plk_4	183	189	PF00069	0.381
MOD_Plk_4	209	215	PF00069	0.230
MOD_Plk_4	95	101	PF00069	0.260
MOD_ProDKin_1	140	146	PF00069	0.306
MOD_ProDKin_1	60	66	PF00069	0.238
MOD_SUMO_rev_2	82	91	PF00179	0.257
TRG_ENDOCYTIC_2	163	166	PF00928	0.356
TRG_ENDOCYTIC_2	185	188	PF00928	0.315
TRG_ENDOCYTIC_2	199	202	PF00928	0.292
TRG_ENDOCYTIC_2	56	59	PF00928	0.308
TRG_ER_diArg_1	214	217	PF00400	0.382
TRG_ER_diLys_1	222	226	PF00400	0.576
TRG_NLS_MonoCore_2	220	225	PF00514	0.469
TRG_NLS_MonoExtN_4	221	226	PF00514	0.483
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X9	Leptomonas seymouri	76%	99%
A0A0S4J7E6	Bodo saltans	31%	100%
A0A1X0NX41	Trypanosomatidae	53%	93%
A0A3S7WY78	Leishmania donovani	83%	100%
A0A422NHH2	Trypanosoma rangeli	54%	99%
D0A756	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AWS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QAP6	Leishmania major	83%	100%
V5DSH1	Trypanosoma cruzi	57%	85%