2'-phosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphotransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDD9_LEIBR

TriTrypDb:

LbrM.24.0830 , LBRM2903_240014200

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDD9

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000215	tRNA 2'-phosphotransferase activity	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.722
CLV_C14_Caspase3-7	341	345	PF00656	0.574
CLV_NRD_NRD_1	2	4	PF00675	0.656
CLV_NRD_NRD_1	317	319	PF00675	0.694
CLV_NRD_NRD_1	410	412	PF00675	0.463
CLV_NRD_NRD_1	65	67	PF00675	0.337
CLV_PCSK_KEX2_1	2	4	PF00082	0.663
CLV_PCSK_KEX2_1	240	242	PF00082	0.511
CLV_PCSK_KEX2_1	410	412	PF00082	0.223
CLV_PCSK_KEX2_1	65	67	PF00082	0.337
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.455
CLV_PCSK_SKI1_1	160	164	PF00082	0.296
CLV_PCSK_SKI1_1	461	465	PF00082	0.449
CLV_PCSK_SKI1_1	65	69	PF00082	0.364
CLV_PCSK_SKI1_1	83	87	PF00082	0.320
CLV_PCSK_SKI1_1	96	100	PF00082	0.243
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DEG_ODPH_VHL_1	44	57	PF01847	0.486
DEG_SPOP_SBC_1	32	36	PF00917	0.729
DEG_SPOP_SBC_1	358	362	PF00917	0.472
DOC_CDC14_PxL_1	140	148	PF14671	0.430
DOC_CKS1_1	173	178	PF01111	0.563
DOC_CKS1_1	544	549	PF01111	0.348
DOC_CKS1_1	6	11	PF01111	0.769
DOC_CYCLIN_yCln2_LP_2	286	292	PF00134	0.547
DOC_MAPK_gen_1	186	194	PF00069	0.544
DOC_MAPK_gen_1	410	417	PF00069	0.475
DOC_MAPK_MEF2A_6	410	417	PF00069	0.367
DOC_MAPK_MEF2A_6	515	524	PF00069	0.328
DOC_PP1_RVXF_1	382	389	PF00149	0.475
DOC_PP2B_LxvP_1	213	216	PF13499	0.558
DOC_PP2B_LxvP_1	286	289	PF13499	0.541
DOC_PP2B_LxvP_1	332	335	PF13499	0.367
DOC_USP7_MATH_1	145	149	PF00917	0.501
DOC_USP7_MATH_1	27	31	PF00917	0.795
DOC_USP7_MATH_1	32	36	PF00917	0.694
DOC_USP7_MATH_1	358	362	PF00917	0.472
DOC_USP7_MATH_1	391	395	PF00917	0.395
DOC_USP7_MATH_1	413	417	PF00917	0.223
DOC_USP7_MATH_1	7	11	PF00917	0.812
DOC_USP7_UBL2_3	367	371	PF12436	0.616
DOC_USP7_UBL2_3	558	562	PF12436	0.481
DOC_WW_Pin1_4	172	177	PF00397	0.546
DOC_WW_Pin1_4	33	38	PF00397	0.589
DOC_WW_Pin1_4	5	10	PF00397	0.779
DOC_WW_Pin1_4	543	548	PF00397	0.338
LIG_14-3-3_CanoR_1	105	113	PF00244	0.581
LIG_14-3-3_CanoR_1	2	7	PF00244	0.547
LIG_14-3-3_CanoR_1	22	26	PF00244	0.757
LIG_14-3-3_CanoR_1	272	276	PF00244	0.636
LIG_14-3-3_CanoR_1	318	328	PF00244	0.742
LIG_14-3-3_CanoR_1	389	399	PF00244	0.437
LIG_14-3-3_CanoR_1	461	467	PF00244	0.415
LIG_14-3-3_CanoR_1	65	73	PF00244	0.470
LIG_14-3-3_CanoR_1	83	91	PF00244	0.387
LIG_Actin_WH2_2	182	197	PF00022	0.400
LIG_Actin_WH2_2	227	242	PF00022	0.480
LIG_AP2alpha_2	122	124	PF02296	0.581
LIG_APCC_ABBA_1	520	525	PF00400	0.344
LIG_BIR_III_2	142	146	PF00653	0.562
LIG_BRCT_BRCA1_1	361	365	PF00533	0.646
LIG_BRCT_BRCA1_2	361	367	PF00533	0.429
LIG_FHA_1	538	544	PF00498	0.328
LIG_FHA_1	550	556	PF00498	0.399
LIG_FHA_2	151	157	PF00498	0.475
LIG_FHA_2	272	278	PF00498	0.704
LIG_FHA_2	339	345	PF00498	0.520
LIG_FHA_2	462	468	PF00498	0.409
LIG_FHA_2	474	480	PF00498	0.425
LIG_FHA_2	66	72	PF00498	0.502
LIG_GBD_Chelix_1	231	239	PF00786	0.274
LIG_LIR_Apic_2	255	260	PF02991	0.422
LIG_LIR_Gen_1	148	156	PF02991	0.501
LIG_LIR_Gen_1	394	404	PF02991	0.377
LIG_LIR_Gen_1	50	59	PF02991	0.328
LIG_LIR_Nem_3	122	127	PF02991	0.476
LIG_LIR_Nem_3	148	152	PF02991	0.501
LIG_LIR_Nem_3	394	400	PF02991	0.377
LIG_LIR_Nem_3	479	484	PF02991	0.326
LIG_LIR_Nem_3	50	55	PF02991	0.305
LIG_LIR_Nem_3	74	78	PF02991	0.473
LIG_LIR_Nem_3	90	94	PF02991	0.440
LIG_LYPXL_SIV_4	435	443	PF13949	0.475
LIG_NRBOX	234	240	PF00104	0.540
LIG_PDZ_Class_2	570	575	PF00595	0.550
LIG_RPA_C_Fungi	338	350	PF08784	0.587
LIG_SH2_CRK	149	153	PF00017	0.449
LIG_SH2_PTP2	397	400	PF00017	0.385
LIG_SH2_PTP2	52	55	PF00017	0.332
LIG_SH2_PTP2	94	97	PF00017	0.328
LIG_SH2_SRC	523	526	PF00017	0.344
LIG_SH2_STAT5	128	131	PF00017	0.473
LIG_SH2_STAT5	149	152	PF00017	0.360
LIG_SH2_STAT5	397	400	PF00017	0.356
LIG_SH2_STAT5	444	447	PF00017	0.315
LIG_SH2_STAT5	489	492	PF00017	0.355
LIG_SH2_STAT5	52	55	PF00017	0.332
LIG_SH2_STAT5	523	526	PF00017	0.344
LIG_SH2_STAT5	559	562	PF00017	0.376
LIG_SH2_STAT5	94	97	PF00017	0.323
LIG_SH3_3	6	12	PF00018	0.580
LIG_SH3_3	95	101	PF00018	0.362
LIG_SUMO_SIM_par_1	53	58	PF11976	0.223
LIG_SUMO_SIM_par_1	76	81	PF11976	0.330
LIG_TRAF2_1	267	270	PF00917	0.404
LIG_TRAF2_1	345	348	PF00917	0.575
LIG_TRAF2_1	465	468	PF00917	0.444
MOD_CDK_SPxK_1	5	11	PF00069	0.767
MOD_CK1_1	491	497	PF00069	0.333
MOD_CK2_1	461	467	PF00069	0.381
MOD_CK2_1	473	479	PF00069	0.336
MOD_CK2_1	65	71	PF00069	0.413
MOD_CMANNOS	478	481	PF00535	0.449
MOD_Cter_Amidation	63	66	PF01082	0.358
MOD_GlcNHglycan	169	172	PF01048	0.449
MOD_GlcNHglycan	189	192	PF01048	0.367
MOD_GlcNHglycan	222	225	PF01048	0.243
MOD_GlcNHglycan	29	32	PF01048	0.784
MOD_GlcNHglycan	321	324	PF01048	0.774
MOD_GlcNHglycan	328	331	PF01048	0.682
MOD_GlcNHglycan	377	380	PF01048	0.423
MOD_GlcNHglycan	490	493	PF01048	0.298
MOD_GlcNHglycan	511	514	PF01048	0.334
MOD_GlcNHglycan	567	570	PF01048	0.451
MOD_GSK3_1	1	8	PF00069	0.734
MOD_GSK3_1	101	108	PF00069	0.328
MOD_GSK3_1	158	165	PF00069	0.279
MOD_GSK3_1	244	251	PF00069	0.372
MOD_GSK3_1	27	34	PF00069	0.794
MOD_GSK3_1	288	295	PF00069	0.794
MOD_GSK3_1	350	357	PF00069	0.535
MOD_GSK3_1	371	378	PF00069	0.361
MOD_GSK3_1	445	452	PF00069	0.358
MOD_NEK2_1	1	6	PF00069	0.721
MOD_NEK2_1	271	276	PF00069	0.567
MOD_NEK2_1	350	355	PF00069	0.629
MOD_NEK2_1	370	375	PF00069	0.145
MOD_NEK2_1	443	448	PF00069	0.223
MOD_NEK2_1	536	541	PF00069	0.338
MOD_PIKK_1	111	117	PF00454	0.355
MOD_PIKK_1	162	168	PF00454	0.298
MOD_PIKK_1	312	318	PF00454	0.570
MOD_PIKK_1	321	327	PF00454	0.674
MOD_PIKK_1	445	451	PF00454	0.320
MOD_PIKK_1	83	89	PF00454	0.223
MOD_PKA_1	2	8	PF00069	0.548
MOD_PKA_1	65	71	PF00069	0.320
MOD_PKA_2	1	7	PF00069	0.619
MOD_PKA_2	167	173	PF00069	0.449
MOD_PKA_2	21	27	PF00069	0.808
MOD_PKA_2	271	277	PF00069	0.696
MOD_PKA_2	424	430	PF00069	0.440
MOD_PKA_2	565	571	PF00069	0.312
MOD_PKA_2	65	71	PF00069	0.320
MOD_Plk_1	245	251	PF00069	0.532
MOD_Plk_4	158	164	PF00069	0.338
MOD_Plk_4	473	479	PF00069	0.332
MOD_ProDKin_1	172	178	PF00069	0.427
MOD_ProDKin_1	33	39	PF00069	0.591
MOD_ProDKin_1	5	11	PF00069	0.783
MOD_ProDKin_1	543	549	PF00069	0.338
MOD_SUMO_rev_2	156	162	PF00179	0.344
MOD_SUMO_rev_2	366	373	PF00179	0.615
MOD_SUMO_rev_2	452	460	PF00179	0.438
TRG_DiLeu_BaEn_2	129	135	PF01217	0.449
TRG_ENDOCYTIC_2	149	152	PF00928	0.363
TRG_ENDOCYTIC_2	397	400	PF00928	0.385
TRG_ENDOCYTIC_2	52	55	PF00928	0.321
TRG_ENDOCYTIC_2	523	526	PF00928	0.342
TRG_ER_diArg_1	1	3	PF00400	0.544
TRG_ER_diArg_1	409	411	PF00400	0.223
TRG_ER_diArg_1	65	67	PF00400	0.420
TRG_NES_CRM1_1	205	218	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWH5	Leptomonas seymouri	60%	93%
A0A0S4J7G0	Bodo saltans	41%	88%
A0A1X0NVN6	Trypanosomatidae	44%	98%
A0A3Q8IBU9	Leishmania donovani	77%	100%
A0A422MZ86	Trypanosoma rangeli	47%	100%
A4I0S0	Leishmania infantum	77%	100%
D0A750	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AWS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	98%
Q4QAQ2	Leishmania major	77%	100%
V5C0L6	Trypanosoma cruzi	46%	90%