Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HDD8_LEIBR

TriTrypDb:

LbrM.24.0820 , LBRM2903_240014100

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.639
CLV_C14_Caspase3-7	198	202	PF00656	0.558
CLV_C14_Caspase3-7	321	325	PF00656	0.714
CLV_C14_Caspase3-7	380	384	PF00656	0.608
CLV_NRD_NRD_1	100	102	PF00675	0.665
CLV_NRD_NRD_1	182	184	PF00675	0.615
CLV_NRD_NRD_1	23	25	PF00675	0.706
CLV_NRD_NRD_1	26	28	PF00675	0.683
CLV_NRD_NRD_1	311	313	PF00675	0.824
CLV_NRD_NRD_1	315	317	PF00675	0.779
CLV_NRD_NRD_1	459	461	PF00675	0.517
CLV_NRD_NRD_1	505	507	PF00675	0.594
CLV_NRD_NRD_1	56	58	PF00675	0.720
CLV_NRD_NRD_1	76	78	PF00675	0.712
CLV_PCSK_FUR_1	24	28	PF00082	0.713
CLV_PCSK_FUR_1	312	316	PF00082	0.586
CLV_PCSK_KEX2_1	100	102	PF00082	0.665
CLV_PCSK_KEX2_1	124	126	PF00082	0.751
CLV_PCSK_KEX2_1	182	184	PF00082	0.615
CLV_PCSK_KEX2_1	23	25	PF00082	0.706
CLV_PCSK_KEX2_1	26	28	PF00082	0.683
CLV_PCSK_KEX2_1	310	312	PF00082	0.831
CLV_PCSK_KEX2_1	314	316	PF00082	0.786
CLV_PCSK_KEX2_1	429	431	PF00082	0.637
CLV_PCSK_KEX2_1	459	461	PF00082	0.517
CLV_PCSK_KEX2_1	505	507	PF00082	0.545
CLV_PCSK_KEX2_1	56	58	PF00082	0.720
CLV_PCSK_KEX2_1	76	78	PF00082	0.712
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.751
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.593
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.571
CLV_PCSK_PC7_1	310	316	PF00082	0.692
CLV_PCSK_SKI1_1	124	128	PF00082	0.549
CLV_PCSK_SKI1_1	197	201	PF00082	0.560
CLV_PCSK_SKI1_1	311	315	PF00082	0.631
CLV_PCSK_SKI1_1	429	433	PF00082	0.569
CLV_PCSK_SKI1_1	535	539	PF00082	0.560
DEG_SPOP_SBC_1	192	196	PF00917	0.555
DEG_SPOP_SBC_1	3	7	PF00917	0.528
DEG_SPOP_SBC_1	539	543	PF00917	0.623
DEG_SPOP_SBC_1	585	589	PF00917	0.580
DOC_ANK_TNKS_1	319	326	PF00023	0.718
DOC_ANK_TNKS_1	76	83	PF00023	0.690
DOC_CKS1_1	394	399	PF01111	0.571
DOC_MAPK_gen_1	100	107	PF00069	0.605
DOC_MAPK_gen_1	182	189	PF00069	0.620
DOC_MAPK_gen_1	505	513	PF00069	0.523
DOC_MAPK_gen_1	546	553	PF00069	0.609
DOC_PP4_FxxP_1	143	146	PF00568	0.651
DOC_USP7_MATH_1	192	196	PF00917	0.555
DOC_USP7_MATH_1	2	6	PF00917	0.676
DOC_USP7_MATH_1	204	208	PF00917	0.517
DOC_USP7_MATH_1	218	222	PF00917	0.493
DOC_USP7_MATH_1	331	335	PF00917	0.621
DOC_USP7_MATH_1	43	47	PF00917	0.571
DOC_USP7_MATH_1	449	453	PF00917	0.670
DOC_USP7_MATH_1	524	528	PF00917	0.653
DOC_USP7_MATH_1	537	541	PF00917	0.728
DOC_USP7_MATH_1	575	579	PF00917	0.615
DOC_USP7_MATH_1	583	587	PF00917	0.604
DOC_USP7_MATH_1	96	100	PF00917	0.632
DOC_WW_Pin1_4	225	230	PF00397	0.626
DOC_WW_Pin1_4	287	292	PF00397	0.556
DOC_WW_Pin1_4	348	353	PF00397	0.685
DOC_WW_Pin1_4	393	398	PF00397	0.574
DOC_WW_Pin1_4	442	447	PF00397	0.666
DOC_WW_Pin1_4	498	503	PF00397	0.691
DOC_WW_Pin1_4	504	509	PF00397	0.638
DOC_WW_Pin1_4	517	522	PF00397	0.571
DOC_WW_Pin1_4	577	582	PF00397	0.782
DOC_WW_Pin1_4	58	63	PF00397	0.579
LIG_14-3-3_CanoR_1	100	107	PF00244	0.665
LIG_14-3-3_CanoR_1	125	133	PF00244	0.548
LIG_14-3-3_CanoR_1	193	199	PF00244	0.643
LIG_14-3-3_CanoR_1	24	30	PF00244	0.707
LIG_14-3-3_CanoR_1	354	363	PF00244	0.741
LIG_14-3-3_CanoR_1	430	436	PF00244	0.597
LIG_14-3-3_CanoR_1	450	458	PF00244	0.570
LIG_14-3-3_CanoR_1	477	483	PF00244	0.641
LIG_14-3-3_CanoR_1	526	536	PF00244	0.569
LIG_14-3-3_CanoR_1	548	554	PF00244	0.698
LIG_14-3-3_CanoR_1	607	616	PF00244	0.483
LIG_Actin_WH2_2	239	257	PF00022	0.433
LIG_APCC_ABBAyCdc20_2	420	426	PF00400	0.548
LIG_BIR_II_1	1	5	PF00653	0.757
LIG_BIR_III_2	443	447	PF00653	0.704
LIG_BIR_III_3	1	5	PF00653	0.652
LIG_BRCT_BRCA1_1	451	455	PF00533	0.827
LIG_BRCT_BRCA1_1	478	482	PF00533	0.504
LIG_BRCT_BRCA1_1	506	510	PF00533	0.532
LIG_FHA_1	115	121	PF00498	0.655
LIG_FHA_1	137	143	PF00498	0.519
LIG_FHA_1	220	226	PF00498	0.529
LIG_FHA_1	430	436	PF00498	0.716
LIG_FHA_1	443	449	PF00498	0.569
LIG_FHA_1	9	15	PF00498	0.529
LIG_FHA_2	26	32	PF00498	0.627
LIG_FHA_2	387	393	PF00498	0.573
LIG_FHA_2	528	534	PF00498	0.572
LIG_FHA_2	550	556	PF00498	0.728
LIG_FHA_2	599	605	PF00498	0.706
LIG_LIR_Apic_2	451	457	PF02991	0.695
LIG_LIR_Apic_2	516	522	PF02991	0.530
LIG_LIR_Gen_1	250	257	PF02991	0.439
LIG_LIR_Gen_1	507	517	PF02991	0.525
LIG_LIR_Nem_3	170	176	PF02991	0.678
LIG_LIR_Nem_3	250	254	PF02991	0.421
LIG_LIR_Nem_3	293	297	PF02991	0.538
LIG_LIR_Nem_3	452	458	PF02991	0.821
LIG_LIR_Nem_3	507	513	PF02991	0.518
LIG_LIR_Nem_3	604	609	PF02991	0.571
LIG_LYPXL_S_1	172	176	PF13949	0.526
LIG_LYPXL_yS_3	173	176	PF13949	0.548
LIG_PALB2_WD40_1	450	458	PF16756	0.703
LIG_Pex14_1	241	245	PF04695	0.429
LIG_Pex14_1	340	344	PF04695	0.594
LIG_SH2_CRK	277	281	PF00017	0.549
LIG_SH2_CRK	414	418	PF00017	0.557
LIG_SH2_CRK	606	610	PF00017	0.485
LIG_SH2_GRB2like	414	417	PF00017	0.557
LIG_SH2_NCK_1	414	418	PF00017	0.581
LIG_SH2_SRC	328	331	PF00017	0.663
LIG_SH2_STAP1	344	348	PF00017	0.623
LIG_SH2_STAP1	414	418	PF00017	0.557
LIG_SH2_STAP1	480	484	PF00017	0.492
LIG_SH2_STAT3	245	248	PF00017	0.483
LIG_SH2_STAT5	245	248	PF00017	0.483
LIG_SH2_STAT5	395	398	PF00017	0.599
LIG_SH2_STAT5	414	417	PF00017	0.557
LIG_SH3_1	518	524	PF00018	0.523
LIG_SH3_2	521	526	PF14604	0.530
LIG_SH3_3	212	218	PF00018	0.673
LIG_SH3_3	277	283	PF00018	0.542
LIG_SH3_3	443	449	PF00018	0.776
LIG_SH3_3	496	502	PF00018	0.530
LIG_SH3_3	518	524	PF00018	0.532
LIG_SH3_3	75	81	PF00018	0.700
LIG_SUMO_SIM_par_1	549	555	PF11976	0.617
LIG_WW_3	351	355	PF00397	0.570
MOD_CDK_SPxK_1	348	354	PF00069	0.564
MOD_CDK_SPxxK_3	225	232	PF00069	0.623
MOD_CDK_SPxxK_3	498	505	PF00069	0.535
MOD_CK1_1	195	201	PF00069	0.678
MOD_CK1_1	228	234	PF00069	0.660
MOD_CK1_1	287	293	PF00069	0.574
MOD_CK1_1	386	392	PF00069	0.618
MOD_CK1_1	470	476	PF00069	0.496
MOD_CK1_1	498	504	PF00069	0.690
MOD_CK1_1	509	515	PF00069	0.581
MOD_CK1_1	527	533	PF00069	0.647
MOD_CK1_1	540	546	PF00069	0.654
MOD_CK1_1	586	592	PF00069	0.660
MOD_CK1_1	7	13	PF00069	0.726
MOD_CK1_1	99	105	PF00069	0.662
MOD_CK2_1	25	31	PF00069	0.629
MOD_CK2_1	386	392	PF00069	0.576
MOD_CK2_1	43	49	PF00069	0.509
MOD_CK2_1	527	533	PF00069	0.569
MOD_Cter_Amidation	21	24	PF01082	0.692
MOD_GlcNHglycan	101	104	PF01048	0.642
MOD_GlcNHglycan	152	155	PF01048	0.649
MOD_GlcNHglycan	201	204	PF01048	0.711
MOD_GlcNHglycan	206	209	PF01048	0.663
MOD_GlcNHglycan	235	238	PF01048	0.561
MOD_GlcNHglycan	286	289	PF01048	0.614
MOD_GlcNHglycan	298	301	PF01048	0.644
MOD_GlcNHglycan	316	319	PF01048	0.592
MOD_GlcNHglycan	389	392	PF01048	0.708
MOD_GlcNHglycan	451	454	PF01048	0.768
MOD_GlcNHglycan	543	546	PF01048	0.812
MOD_GlcNHglycan	577	580	PF01048	0.735
MOD_GlcNHglycan	588	591	PF01048	0.612
MOD_GlcNHglycan	611	614	PF01048	0.572
MOD_GSK3_1	115	122	PF00069	0.627
MOD_GSK3_1	168	175	PF00069	0.685
MOD_GSK3_1	191	198	PF00069	0.676
MOD_GSK3_1	3	10	PF00069	0.649
MOD_GSK3_1	348	355	PF00069	0.796
MOD_GSK3_1	382	389	PF00069	0.601
MOD_GSK3_1	463	470	PF00069	0.492
MOD_GSK3_1	509	516	PF00069	0.702
MOD_GSK3_1	524	531	PF00069	0.688
MOD_GSK3_1	535	542	PF00069	0.722
MOD_GSK3_1	555	562	PF00069	0.635
MOD_GSK3_1	573	580	PF00069	0.666
MOD_N-GLC_1	136	141	PF02516	0.521
MOD_N-GLC_1	32	37	PF02516	0.694
MOD_N-GLC_1	383	388	PF02516	0.636
MOD_NEK2_1	167	172	PF00069	0.676
MOD_NEK2_1	584	589	PF00069	0.765
MOD_NEK2_1	609	614	PF00069	0.574
MOD_NEK2_2	478	483	PF00069	0.566
MOD_NEK2_2	549	554	PF00069	0.532
MOD_PIKK_1	124	130	PF00454	0.556
MOD_PIKK_1	160	166	PF00454	0.548
MOD_PIKK_1	32	38	PF00454	0.694
MOD_PKA_1	124	130	PF00069	0.549
MOD_PKA_1	314	320	PF00069	0.586
MOD_PKA_1	429	435	PF00069	0.634
MOD_PKA_2	124	130	PF00069	0.549
MOD_PKA_2	192	198	PF00069	0.643
MOD_PKA_2	25	31	PF00069	0.707
MOD_PKA_2	314	320	PF00069	0.812
MOD_PKA_2	355	361	PF00069	0.744
MOD_PKA_2	377	383	PF00069	0.564
MOD_PKA_2	429	435	PF00069	0.652
MOD_PKA_2	449	455	PF00069	0.574
MOD_PKA_2	470	476	PF00069	0.606
MOD_PKA_2	573	579	PF00069	0.570
MOD_PKA_2	609	615	PF00069	0.478
MOD_PKA_2	72	78	PF00069	0.699
MOD_PKA_2	99	105	PF00069	0.662
MOD_PKB_1	460	468	PF00069	0.494
MOD_Plk_1	136	142	PF00069	0.519
MOD_Plk_1	14	20	PF00069	0.551
MOD_Plk_1	32	38	PF00069	0.650
MOD_Plk_4	168	174	PF00069	0.527
MOD_Plk_4	506	512	PF00069	0.532
MOD_ProDKin_1	225	231	PF00069	0.623
MOD_ProDKin_1	287	293	PF00069	0.556
MOD_ProDKin_1	348	354	PF00069	0.690
MOD_ProDKin_1	393	399	PF00069	0.575
MOD_ProDKin_1	442	448	PF00069	0.664
MOD_ProDKin_1	498	504	PF00069	0.693
MOD_ProDKin_1	517	523	PF00069	0.566
MOD_ProDKin_1	577	583	PF00069	0.776
MOD_ProDKin_1	58	64	PF00069	0.578
TRG_ENDOCYTIC_2	173	176	PF00928	0.548
TRG_ENDOCYTIC_2	277	280	PF00928	0.554
TRG_ENDOCYTIC_2	414	417	PF00928	0.714
TRG_ENDOCYTIC_2	606	609	PF00928	0.496
TRG_ER_diArg_1	23	26	PF00400	0.709
TRG_ER_diArg_1	310	312	PF00400	0.715
TRG_ER_diArg_1	353	356	PF00400	0.738
TRG_ER_diArg_1	458	460	PF00400	0.528
TRG_ER_diArg_1	468	471	PF00400	0.489
TRG_ER_diArg_1	504	506	PF00400	0.549
TRG_ER_diArg_1	55	57	PF00400	0.717
TRG_ER_diArg_1	76	79	PF00400	0.709
TRG_NLS_MonoExtN_4	311	318	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IG29	Leishmania donovani	58%	100%
A4I0R9	Leishmania infantum	59%	100%
E9AWS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	97%
Q4QAQ3	Leishmania major	57%	97%