RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDD7_LEIBR

TriTrypDb:

LbrM.24.0810 , LBRM2903_240014000

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HDD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDD7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.541
CLV_C14_Caspase3-7	3	7	PF00656	0.570
CLV_NRD_NRD_1	182	184	PF00675	0.692
CLV_NRD_NRD_1	251	253	PF00675	0.544
CLV_NRD_NRD_1	310	312	PF00675	0.557
CLV_NRD_NRD_1	513	515	PF00675	0.577
CLV_NRD_NRD_1	73	75	PF00675	0.618
CLV_PCSK_KEX2_1	11	13	PF00082	0.711
CLV_PCSK_KEX2_1	182	184	PF00082	0.692
CLV_PCSK_KEX2_1	19	21	PF00082	0.727
CLV_PCSK_KEX2_1	513	515	PF00082	0.490
CLV_PCSK_KEX2_1	73	75	PF00082	0.618
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.711
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.727
CLV_PCSK_SKI1_1	315	319	PF00082	0.591
CLV_PCSK_SKI1_1	376	380	PF00082	0.452
DEG_Nend_UBRbox_3	1	3	PF02207	0.548
DEG_SPOP_SBC_1	137	141	PF00917	0.512
DEG_SPOP_SBC_1	265	269	PF00917	0.695
DEG_SPOP_SBC_1	274	278	PF00917	0.715
DEG_SPOP_SBC_1	399	403	PF00917	0.546
DEG_SPOP_SBC_1	82	86	PF00917	0.531
DOC_CKS1_1	388	393	PF01111	0.515
DOC_MAPK_gen_1	501	510	PF00069	0.509
DOC_MAPK_gen_1	540	547	PF00069	0.497
DOC_PP1_RVXF_1	347	353	PF00149	0.466
DOC_PP2B_LxvP_1	408	411	PF13499	0.652
DOC_USP7_MATH_1	136	140	PF00917	0.504
DOC_USP7_MATH_1	159	163	PF00917	0.799
DOC_USP7_MATH_1	260	264	PF00917	0.732
DOC_USP7_MATH_1	265	269	PF00917	0.698
DOC_USP7_MATH_1	348	352	PF00917	0.448
DOC_USP7_MATH_1	82	86	PF00917	0.785
DOC_USP7_MATH_1	97	101	PF00917	0.639
DOC_USP7_UBL2_3	441	445	PF12436	0.408
DOC_WW_Pin1_4	258	263	PF00397	0.552
DOC_WW_Pin1_4	270	275	PF00397	0.768
DOC_WW_Pin1_4	304	309	PF00397	0.620
DOC_WW_Pin1_4	384	389	PF00397	0.695
DOC_WW_Pin1_4	400	405	PF00397	0.686
DOC_WW_Pin1_4	95	100	PF00397	0.650
LIG_14-3-3_CanoR_1	301	307	PF00244	0.543
LIG_14-3-3_CanoR_1	347	353	PF00244	0.559
LIG_14-3-3_CanoR_1	90	99	PF00244	0.711
LIG_BIR_III_2	6	10	PF00653	0.671
LIG_BIR_III_4	124	128	PF00653	0.543
LIG_BIR_III_4	129	133	PF00653	0.527
LIG_BRCT_BRCA1_1	139	143	PF00533	0.530
LIG_BRCT_BRCA1_1	14	18	PF00533	0.527
LIG_BRCT_BRCA1_1	209	213	PF00533	0.654
LIG_Clathr_ClatBox_1	489	493	PF01394	0.487
LIG_Clathr_ClatBox_1	531	535	PF01394	0.306
LIG_FHA_1	320	326	PF00498	0.456
LIG_FHA_1	455	461	PF00498	0.337
LIG_FHA_1	539	545	PF00498	0.496
LIG_FHA_1	96	102	PF00498	0.517
LIG_FHA_2	175	181	PF00498	0.668
LIG_FHA_2	305	311	PF00498	0.540
LIG_FHA_2	327	333	PF00498	0.498
LIG_LIR_Gen_1	210	221	PF02991	0.653
LIG_LIR_Nem_3	210	216	PF02991	0.611
LIG_LIR_Nem_3	218	222	PF02991	0.565
LIG_LIR_Nem_3	351	355	PF02991	0.450
LIG_MYND_1	406	410	PF01753	0.658
LIG_PAM2_1	410	422	PF00658	0.554
LIG_PTAP_UEV_1	390	395	PF05743	0.519
LIG_REV1ctd_RIR_1	350	356	PF16727	0.465
LIG_SH2_PTP2	219	222	PF00017	0.548
LIG_SH2_STAT3	313	316	PF00017	0.460
LIG_SH2_STAT3	360	363	PF00017	0.409
LIG_SH2_STAT5	219	222	PF00017	0.551
LIG_SH2_STAT5	360	363	PF00017	0.633
LIG_SH3_3	385	391	PF00018	0.571
LIG_SH3_3	86	92	PF00018	0.738
LIG_SH3_3	98	104	PF00018	0.615
LIG_TRAF2_1	307	310	PF00917	0.537
LIG_UBA3_1	248	253	PF00899	0.341
MOD_CDK_SPxxK_3	304	311	PF00069	0.425
MOD_CK1_1	139	145	PF00069	0.675
MOD_CK1_1	268	274	PF00069	0.720
MOD_CK1_1	281	287	PF00069	0.585
MOD_CK1_1	302	308	PF00069	0.616
MOD_CK1_1	36	42	PF00069	0.474
MOD_CK1_1	383	389	PF00069	0.677
MOD_CK1_1	402	408	PF00069	0.687
MOD_CK1_1	465	471	PF00069	0.580
MOD_CK2_1	304	310	PF00069	0.544
MOD_CK2_1	321	327	PF00069	0.478
MOD_CK2_1	348	354	PF00069	0.444
MOD_CK2_1	461	467	PF00069	0.473
MOD_Cter_Amidation	438	441	PF01082	0.404
MOD_GlcNHglycan	157	160	PF01048	0.607
MOD_GlcNHglycan	183	186	PF01048	0.724
MOD_GlcNHglycan	209	212	PF01048	0.543
MOD_GlcNHglycan	255	258	PF01048	0.499
MOD_GlcNHglycan	286	289	PF01048	0.561
MOD_GlcNHglycan	3	6	PF01048	0.566
MOD_GlcNHglycan	301	304	PF01048	0.489
MOD_GlcNHglycan	35	38	PF01048	0.554
MOD_GlcNHglycan	391	394	PF01048	0.639
MOD_GlcNHglycan	464	467	PF01048	0.724
MOD_GlcNHglycan	475	478	PF01048	0.570
MOD_GlcNHglycan	67	70	PF01048	0.535
MOD_GlcNHglycan	85	88	PF01048	0.629
MOD_GSK3_1	138	145	PF00069	0.658
MOD_GSK3_1	151	158	PF00069	0.559
MOD_GSK3_1	203	210	PF00069	0.646
MOD_GSK3_1	211	218	PF00069	0.598
MOD_GSK3_1	260	267	PF00069	0.679
MOD_GSK3_1	269	276	PF00069	0.638
MOD_GSK3_1	278	285	PF00069	0.651
MOD_GSK3_1	29	36	PF00069	0.549
MOD_GSK3_1	295	302	PF00069	0.473
MOD_GSK3_1	315	322	PF00069	0.367
MOD_GSK3_1	372	379	PF00069	0.543
MOD_GSK3_1	380	387	PF00069	0.605
MOD_GSK3_1	398	405	PF00069	0.775
MOD_GSK3_1	443	450	PF00069	0.411
MOD_GSK3_1	461	468	PF00069	0.747
MOD_GSK3_1	469	476	PF00069	0.704
MOD_GSK3_1	61	68	PF00069	0.541
MOD_GSK3_1	91	98	PF00069	0.711
MOD_LATS_1	10	16	PF00433	0.698
MOD_N-GLC_1	1	6	PF02516	0.540
MOD_N-GLC_1	149	154	PF02516	0.594
MOD_N-GLC_1	175	180	PF02516	0.731
MOD_N-GLC_1	21	26	PF02516	0.496
MOD_N-GLC_1	383	388	PF02516	0.670
MOD_NEK2_1	205	210	PF00069	0.499
MOD_NEK2_1	227	232	PF00069	0.540
MOD_NEK2_1	321	326	PF00069	0.458
MOD_NEK2_1	343	348	PF00069	0.514
MOD_NEK2_1	62	67	PF00069	0.536
MOD_NEK2_2	348	353	PF00069	0.482
MOD_NEK2_2	469	474	PF00069	0.726
MOD_PIKK_1	203	209	PF00454	0.506
MOD_PKA_2	181	187	PF00069	0.718
MOD_PKA_2	427	433	PF00069	0.453
MOD_PKA_2	454	460	PF00069	0.374
MOD_Plk_1	21	27	PF00069	0.543
MOD_Plk_1	211	217	PF00069	0.479
MOD_Plk_1	326	332	PF00069	0.431
MOD_Plk_4	139	145	PF00069	0.706
MOD_Plk_4	215	221	PF00069	0.541
MOD_Plk_4	321	327	PF00069	0.345
MOD_Plk_4	348	354	PF00069	0.444
MOD_Plk_4	376	382	PF00069	0.455
MOD_Plk_4	494	500	PF00069	0.396
MOD_ProDKin_1	258	264	PF00069	0.555
MOD_ProDKin_1	270	276	PF00069	0.768
MOD_ProDKin_1	304	310	PF00069	0.616
MOD_ProDKin_1	384	390	PF00069	0.696
MOD_ProDKin_1	400	406	PF00069	0.684
MOD_ProDKin_1	95	101	PF00069	0.650
TRG_DiLeu_BaEn_1	485	490	PF01217	0.457
TRG_ENDOCYTIC_2	219	222	PF00928	0.551
TRG_ER_diArg_1	41	44	PF00400	0.586
TRG_ER_diArg_1	453	456	PF00400	0.525
TRG_ER_diArg_1	520	523	PF00400	0.506
TRG_ER_diArg_1	72	74	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD00	Leptomonas seymouri	46%	100%
A0A3R7R9R9	Trypanosoma rangeli	35%	100%
A0A3S7WYC4	Leishmania donovani	73%	96%
A4I0R8	Leishmania infantum	73%	96%
D0A749	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AWS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	97%
Q4QAQ4	Leishmania major	72%	100%