FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDD2_LEIBR

TriTrypDb:

LbrM.24.0760 , LBRM2903_240013500

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HDD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	80	84	PF00656	0.419
CLV_NRD_NRD_1	290	292	PF00675	0.474
CLV_NRD_NRD_1	306	308	PF00675	0.297
CLV_PCSK_KEX2_1	270	272	PF00082	0.463
CLV_PCSK_KEX2_1	290	292	PF00082	0.441
CLV_PCSK_KEX2_1	43	45	PF00082	0.441
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.507
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.444
DEG_SPOP_SBC_1	58	62	PF00917	0.413
DOC_CYCLIN_yClb5_NLxxxL_5	242	249	PF00134	0.315
DOC_MAPK_gen_1	52	59	PF00069	0.389
DOC_MAPK_MEF2A_6	10	17	PF00069	0.341
DOC_MAPK_MEF2A_6	298	305	PF00069	0.423
DOC_MAPK_MEF2A_6	52	59	PF00069	0.413
DOC_PP1_RVXF_1	8	15	PF00149	0.318
DOC_PP2B_LxvP_1	22	25	PF13499	0.315
DOC_USP7_UBL2_3	308	312	PF12436	0.442
DOC_WW_Pin1_4	182	187	PF00397	0.452
DOC_WW_Pin1_4	89	94	PF00397	0.296
LIG_14-3-3_CanoR_1	124	134	PF00244	0.317
LIG_14-3-3_CanoR_1	72	77	PF00244	0.399
LIG_14-3-3_CterR_2	322	325	PF00244	0.435
LIG_APCC_ABBAyCdc20_2	10	16	PF00400	0.300
LIG_BIR_II_1	1	5	PF00653	0.428
LIG_DLG_GKlike_1	271	279	PF00625	0.284
LIG_FHA_1	223	229	PF00498	0.480
LIG_FHA_1	54	60	PF00498	0.325
LIG_FHA_1	94	100	PF00498	0.304
LIG_FHA_2	160	166	PF00498	0.318
LIG_FHA_2	167	173	PF00498	0.318
LIG_FHA_2	284	290	PF00498	0.375
LIG_LIR_Gen_1	299	305	PF02991	0.513
LIG_LIR_Gen_1	9	17	PF02991	0.396
LIG_LIR_Nem_3	120	126	PF02991	0.362
LIG_LIR_Nem_3	299	303	PF02991	0.521
LIG_LIR_Nem_3	9	14	PF02991	0.418
LIG_LYPXL_SIV_4	189	197	PF13949	0.498
LIG_LYPXL_yS_3	272	275	PF13949	0.489
LIG_SH2_NCK_1	190	194	PF00017	0.295
LIG_SH2_SRC	190	193	PF00017	0.293
LIG_SH2_STAP1	105	109	PF00017	0.295
LIG_SH2_STAP1	190	194	PF00017	0.508
LIG_SH2_STAT5	11	14	PF00017	0.413
LIG_SH3_3	17	23	PF00018	0.310
LIG_SUMO_SIM_anti_2	53	62	PF11976	0.350
LIG_SUMO_SIM_par_1	234	239	PF11976	0.310
LIG_SUMO_SIM_par_1	55	62	PF11976	0.301
LIG_SUMO_SIM_par_1	95	101	PF11976	0.388
LIG_WRC_WIRS_1	297	302	PF05994	0.489
LIG_WRC_WIRS_1	73	78	PF05994	0.362
MOD_CK1_1	100	106	PF00069	0.372
MOD_CK1_1	182	188	PF00069	0.505
MOD_CK2_1	212	218	PF00069	0.506
MOD_CK2_1	283	289	PF00069	0.429
MOD_GlcNHglycan	238	241	PF01048	0.528
MOD_GlcNHglycan	33	37	PF01048	0.381
MOD_GSK3_1	178	185	PF00069	0.555
MOD_GSK3_1	279	286	PF00069	0.487
MOD_GSK3_1	53	60	PF00069	0.315
MOD_GSK3_1	89	96	PF00069	0.293
MOD_N-GLC_1	93	98	PF02516	0.281
MOD_NEK2_1	159	164	PF00069	0.360
MOD_NEK2_1	179	184	PF00069	0.242
MOD_NEK2_1	281	286	PF00069	0.482
MOD_NEK2_1	59	64	PF00069	0.275
MOD_NEK2_1	98	103	PF00069	0.425
MOD_PIKK_1	159	165	PF00454	0.362
MOD_Plk_1	3	9	PF00069	0.251
MOD_Plk_4	100	106	PF00069	0.262
MOD_Plk_4	53	59	PF00069	0.322
MOD_Plk_4	72	78	PF00069	0.362
MOD_Plk_4	93	99	PF00069	0.302
MOD_ProDKin_1	182	188	PF00069	0.452
MOD_ProDKin_1	89	95	PF00069	0.296
MOD_SUMO_for_1	202	205	PF00179	0.370
MOD_SUMO_rev_2	145	149	PF00179	0.295
MOD_SUMO_rev_2	239	245	PF00179	0.410
MOD_SUMO_rev_2	280	286	PF00179	0.321
MOD_SUMO_rev_2	316	321	PF00179	0.558
TRG_DiLeu_BaEn_1	241	246	PF01217	0.470
TRG_ENDOCYTIC_2	11	14	PF00928	0.413
TRG_ENDOCYTIC_2	272	275	PF00928	0.489
TRG_NES_CRM1_1	208	220	PF08389	0.320
TRG_NES_CRM1_1	292	306	PF08389	0.400
TRG_NLS_Bipartite_1	307	323	PF00514	0.444
TRG_NLS_MonoExtC_3	311	317	PF00514	0.476
TRG_NLS_MonoExtN_4	309	316	PF00514	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B2	Leptomonas seymouri	67%	100%
A0A1X0NJ52	Trypanosomatidae	51%	96%
A0A3Q8ICT7	Leishmania donovani	82%	100%
A0A3R7RGD3	Trypanosoma rangeli	53%	100%
A4I0R3	Leishmania infantum	82%	100%
D0A742	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
E9AWR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QAQ8	Leishmania major	81%	100%
V5C0M0	Trypanosoma cruzi	53%	71%