DUF523 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF523), putative

Species:

Leishmania braziliensis

UniProt:

A4HDC8_LEIBR

TriTrypDb:

LbrM.24.0720 , LBRM2903_240013100

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.541
CLV_C14_Caspase3-7	335	339	PF00656	0.604
CLV_C14_Caspase3-7	415	419	PF00656	0.616
CLV_C14_Caspase3-7	50	54	PF00656	0.441
CLV_NRD_NRD_1	322	324	PF00675	0.686
CLV_NRD_NRD_1	332	334	PF00675	0.594
CLV_NRD_NRD_1	395	397	PF00675	0.666
CLV_PCSK_KEX2_1	322	324	PF00082	0.686
CLV_PCSK_KEX2_1	332	334	PF00082	0.594
CLV_PCSK_KEX2_1	400	402	PF00082	0.695
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.763
CLV_PCSK_PC7_1	396	402	PF00082	0.502
CLV_PCSK_SKI1_1	346	350	PF00082	0.553
CLV_PCSK_SKI1_1	378	382	PF00082	0.521
CLV_PCSK_SKI1_1	396	400	PF00082	0.647
DEG_APCC_DBOX_1	168	176	PF00400	0.512
DEG_APCC_DBOX_1	345	353	PF00400	0.636
DEG_Nend_UBRbox_1	1	4	PF02207	0.502
DEG_SPOP_SBC_1	246	250	PF00917	0.498
DOC_CDC14_PxL_1	408	416	PF14671	0.424
DOC_CKS1_1	24	29	PF01111	0.510
DOC_CKS1_1	60	65	PF01111	0.637
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.422
DOC_MAPK_DCC_7	164	172	PF00069	0.355
DOC_MAPK_gen_1	396	405	PF00069	0.583
DOC_MAPK_MEF2A_6	133	140	PF00069	0.416
DOC_MAPK_MEF2A_6	164	172	PF00069	0.355
DOC_MAPK_MEF2A_6	99	107	PF00069	0.639
DOC_PP2B_LxvP_1	11	14	PF13499	0.453
DOC_PP2B_LxvP_1	163	166	PF13499	0.503
DOC_PP4_FxxP_1	131	134	PF00568	0.409
DOC_USP7_MATH_1	194	198	PF00917	0.774
DOC_USP7_MATH_1	207	211	PF00917	0.617
DOC_USP7_MATH_1	246	250	PF00917	0.498
DOC_USP7_MATH_1	295	299	PF00917	0.525
DOC_USP7_MATH_1	324	328	PF00917	0.623
DOC_WW_Pin1_4	132	137	PF00397	0.501
DOC_WW_Pin1_4	205	210	PF00397	0.591
DOC_WW_Pin1_4	23	28	PF00397	0.618
DOC_WW_Pin1_4	240	245	PF00397	0.556
DOC_WW_Pin1_4	247	252	PF00397	0.725
DOC_WW_Pin1_4	274	279	PF00397	0.461
DOC_WW_Pin1_4	291	296	PF00397	0.635
DOC_WW_Pin1_4	59	64	PF00397	0.636
DOC_WW_Pin1_4	6	11	PF00397	0.468
DOC_WW_Pin1_4	74	79	PF00397	0.595
LIG_14-3-3_CanoR_1	122	132	PF00244	0.550
LIG_14-3-3_CanoR_1	2	8	PF00244	0.493
LIG_eIF4E_1	19	25	PF01652	0.476
LIG_FHA_1	133	139	PF00498	0.480
LIG_FHA_1	19	25	PF00498	0.476
LIG_FHA_1	340	346	PF00498	0.582
LIG_FHA_1	365	371	PF00498	0.418
LIG_FHA_2	413	419	PF00498	0.527
LIG_LIR_Apic_2	189	194	PF02991	0.570
LIG_LIR_Gen_1	159	170	PF02991	0.340
LIG_LIR_Gen_1	77	87	PF02991	0.394
LIG_LIR_Nem_3	142	148	PF02991	0.482
LIG_LIR_Nem_3	159	165	PF02991	0.481
LIG_LIR_Nem_3	77	83	PF02991	0.657
LIG_NRBOX	257	263	PF00104	0.534
LIG_SH2_NCK_1	237	241	PF00017	0.593
LIG_SH2_SRC	288	291	PF00017	0.667
LIG_SH2_STAP1	288	292	PF00017	0.576
LIG_SH2_STAP1	366	370	PF00017	0.419
LIG_SH2_STAT5	17	20	PF00017	0.479
LIG_SH2_STAT5	223	226	PF00017	0.760
LIG_SH2_STAT5	23	26	PF00017	0.446
LIG_SH2_STAT5	366	369	PF00017	0.654
LIG_SH2_STAT5	384	387	PF00017	0.554
LIG_SH3_1	152	158	PF00018	0.328
LIG_SH3_2	168	173	PF14604	0.510
LIG_SH3_3	100	106	PF00018	0.664
LIG_SH3_3	152	158	PF00018	0.449
LIG_SH3_3	165	171	PF00018	0.503
LIG_SH3_3	198	204	PF00018	0.546
LIG_SH3_3	289	295	PF00018	0.716
LIG_SH3_3	4	10	PF00018	0.467
LIG_SUMO_SIM_par_1	104	111	PF11976	0.465
LIG_UBA3_1	24	29	PF00899	0.470
LIG_WRC_WIRS_1	417	422	PF05994	0.591
MOD_CDK_SPxK_1	23	29	PF00069	0.607
MOD_CK1_1	189	195	PF00069	0.684
MOD_CK1_1	294	300	PF00069	0.582
MOD_CK1_1	3	9	PF00069	0.483
MOD_CK1_1	351	357	PF00069	0.433
MOD_CK1_1	360	366	PF00069	0.454
MOD_CK1_1	416	422	PF00069	0.594
MOD_CK1_1	94	100	PF00069	0.650
MOD_CK2_1	224	230	PF00069	0.713
MOD_CK2_1	362	368	PF00069	0.474
MOD_Cter_Amidation	320	323	PF01082	0.785
MOD_GlcNHglycan	110	113	PF01048	0.552
MOD_GlcNHglycan	178	181	PF01048	0.577
MOD_GlcNHglycan	188	191	PF01048	0.757
MOD_GlcNHglycan	198	201	PF01048	0.618
MOD_GlcNHglycan	209	212	PF01048	0.789
MOD_GlcNHglycan	226	229	PF01048	0.489
MOD_GlcNHglycan	254	257	PF01048	0.645
MOD_GlcNHglycan	326	329	PF01048	0.726
MOD_GlcNHglycan	393	396	PF01048	0.468
MOD_GlcNHglycan	82	86	PF01048	0.479
MOD_GSK3_1	117	124	PF00069	0.599
MOD_GSK3_1	203	210	PF00069	0.691
MOD_GSK3_1	272	279	PF00069	0.439
MOD_GSK3_1	290	297	PF00069	0.451
MOD_GSK3_1	358	365	PF00069	0.601
MOD_GSK3_1	378	385	PF00069	0.564
MOD_GSK3_1	412	419	PF00069	0.632
MOD_GSK3_1	87	94	PF00069	0.621
MOD_N-GLC_1	240	245	PF02516	0.707
MOD_N-GLC_1	412	417	PF02516	0.549
MOD_N-GLC_2	306	308	PF02516	0.721
MOD_NEK2_1	1	6	PF00069	0.567
MOD_NEK2_1	224	229	PF00069	0.548
MOD_NEK2_1	348	353	PF00069	0.559
MOD_NEK2_1	420	425	PF00069	0.513
MOD_NEK2_1	91	96	PF00069	0.494
MOD_PIKK_1	295	301	PF00454	0.487
MOD_PIKK_1	339	345	PF00454	0.577
MOD_PK_1	313	319	PF00069	0.623
MOD_PKA_2	1	7	PF00069	0.488
MOD_PKA_2	121	127	PF00069	0.581
MOD_PKA_2	186	192	PF00069	0.684
MOD_PKA_2	430	436	PF00069	0.644
MOD_PKB_1	176	184	PF00069	0.462
MOD_Plk_1	412	418	PF00069	0.413
MOD_Plk_4	416	422	PF00069	0.509
MOD_ProDKin_1	132	138	PF00069	0.496
MOD_ProDKin_1	205	211	PF00069	0.590
MOD_ProDKin_1	23	29	PF00069	0.620
MOD_ProDKin_1	240	246	PF00069	0.566
MOD_ProDKin_1	247	253	PF00069	0.711
MOD_ProDKin_1	274	280	PF00069	0.459
MOD_ProDKin_1	291	297	PF00069	0.635
MOD_ProDKin_1	59	65	PF00069	0.639
MOD_ProDKin_1	6	12	PF00069	0.465
MOD_ProDKin_1	74	80	PF00069	0.586
TRG_AP2beta_CARGO_1	142	152	PF09066	0.326
TRG_DiLeu_BaEn_1	220	225	PF01217	0.783
TRG_DiLeu_BaEn_1	230	235	PF01217	0.515
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.486
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.487
TRG_ER_diArg_1	175	178	PF00400	0.393
TRG_ER_diArg_1	19	22	PF00400	0.480
TRG_ER_diArg_1	322	324	PF00400	0.658
TRG_ER_diArg_1	332	334	PF00400	0.594
TRG_NES_CRM1_1	147	159	PF08389	0.462
TRG_NLS_MonoExtC_3	395	400	PF00514	0.490
TRG_NLS_MonoExtN_4	393	400	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.770

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3F4	Leptomonas seymouri	41%	100%
A0A3S7WY61	Leishmania donovani	72%	100%
A4I0Q9	Leishmania infantum	72%	100%
E9AWR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QAR2	Leishmania major	73%	100%