Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania braziliensis

UniProt:

A4HDC7_LEIBR

TriTrypDb:

LbrM.24.0700 , LBRM2903_240012700

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HDC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.623
CLV_NRD_NRD_1	26	28	PF00675	0.443
CLV_NRD_NRD_1	55	57	PF00675	0.553
CLV_PCSK_FUR_1	53	57	PF00082	0.403
CLV_PCSK_KEX2_1	108	110	PF00082	0.754
CLV_PCSK_KEX2_1	116	118	PF00082	0.701
CLV_PCSK_KEX2_1	25	27	PF00082	0.487
CLV_PCSK_KEX2_1	55	57	PF00082	0.553
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.754
CLV_PCSK_SKI1_1	103	107	PF00082	0.649
CLV_PCSK_SKI1_1	66	70	PF00082	0.557
CLV_PCSK_SKI1_1	96	100	PF00082	0.614
DEG_Nend_Nbox_1	1	3	PF02207	0.708
DOC_ANK_TNKS_1	118	125	PF00023	0.438
DOC_CYCLIN_RxL_1	60	72	PF00134	0.750
DOC_PP1_RVXF_1	101	108	PF00149	0.431
DOC_PP4_FxxP_1	10	13	PF00568	0.759
DOC_USP7_MATH_1	18	22	PF00917	0.727
DOC_WW_Pin1_4	133	138	PF00397	0.612
DOC_WW_Pin1_4	14	19	PF00397	0.769
LIG_14-3-3_CanoR_1	27	33	PF00244	0.725
LIG_BIR_III_2	134	138	PF00653	0.429
LIG_DCNL_PONY_1	1	4	PF03556	0.598
LIG_FHA_2	126	132	PF00498	0.453
LIG_Integrin_isoDGR_2	114	116	PF01839	0.595
LIG_LIR_Gen_1	139	147	PF02991	0.604
LIG_LIR_Nem_3	139	144	PF02991	0.604
LIG_LIR_Nem_3	62	67	PF02991	0.675
LIG_Pex14_2	59	63	PF04695	0.575
LIG_REV1ctd_RIR_1	61	70	PF16727	0.727
LIG_SH2_STAT5	67	70	PF00017	0.680
LIG_SH3_3	119	125	PF00018	0.442
LIG_TRAF2_1	137	140	PF00917	0.468
MOD_CK1_1	14	20	PF00069	0.690
MOD_CK1_1	30	36	PF00069	0.716
MOD_CK2_1	133	139	PF00069	0.601
MOD_Cter_Amidation	114	117	PF01082	0.711
MOD_GlcNHglycan	34	37	PF01048	0.603
MOD_GlcNHglycan	48	51	PF01048	0.419
MOD_GlcNHglycan	69	72	PF01048	0.523
MOD_GSK3_1	14	21	PF00069	0.621
MOD_GSK3_1	27	34	PF00069	0.659
MOD_NEK2_1	2	7	PF00069	0.656
MOD_NEK2_1	69	74	PF00069	0.460
MOD_NEK2_1	86	91	PF00069	0.411
MOD_PIKK_1	18	24	PF00454	0.616
MOD_PKA_2	115	121	PF00069	0.507
MOD_PKB_1	25	33	PF00069	0.633
MOD_Plk_4	69	75	PF00069	0.460
MOD_ProDKin_1	133	139	PF00069	0.611
MOD_ProDKin_1	14	20	PF00069	0.769
TRG_DiLeu_BaEn_1	19	24	PF01217	0.635
TRG_ER_diArg_1	116	119	PF00400	0.470
TRG_ER_diArg_1	24	27	PF00400	0.640
TRG_ER_diArg_1	52	55	PF00400	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G4	Leptomonas seymouri	37%	100%
A0A3S7WYC5	Leishmania donovani	64%	100%
A4I0Q7	Leishmania infantum	63%	100%
E9AWQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
Q4QAR4	Leishmania major	66%	100%