Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDC4_LEIBR

TriTrypDb:

LbrM.24.0670 , LBRM2903_240012400

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	369	373	PF00656	0.574
CLV_C14_Caspase3-7	629	633	PF00656	0.374
CLV_C14_Caspase3-7	649	653	PF00656	0.577
CLV_C14_Caspase3-7	723	727	PF00656	0.584
CLV_C14_Caspase3-7	734	738	PF00656	0.514
CLV_NRD_NRD_1	129	131	PF00675	0.501
CLV_NRD_NRD_1	178	180	PF00675	0.444
CLV_NRD_NRD_1	379	381	PF00675	0.463
CLV_NRD_NRD_1	395	397	PF00675	0.436
CLV_NRD_NRD_1	712	714	PF00675	0.520
CLV_PCSK_FUR_1	130	134	PF00082	0.363
CLV_PCSK_KEX2_1	129	131	PF00082	0.412
CLV_PCSK_KEX2_1	132	134	PF00082	0.437
CLV_PCSK_KEX2_1	395	397	PF00082	0.415
CLV_PCSK_KEX2_1	405	407	PF00082	0.414
CLV_PCSK_KEX2_1	477	479	PF00082	0.476
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.520
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.509
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.307
CLV_PCSK_SKI1_1	3	7	PF00082	0.679
CLV_PCSK_SKI1_1	318	322	PF00082	0.551
CLV_PCSK_SKI1_1	354	358	PF00082	0.464
CLV_PCSK_SKI1_1	374	378	PF00082	0.416
CLV_PCSK_SKI1_1	406	410	PF00082	0.445
CLV_Separin_Metazoa	144	148	PF03568	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.679
DEG_SCF_FBW7_1	613	619	PF00400	0.592
DEG_SPOP_SBC_1	518	522	PF00917	0.281
DOC_CKS1_1	613	618	PF01111	0.616
DOC_CYCLIN_RxL_1	313	325	PF00134	0.491
DOC_CYCLIN_RxL_1	617	627	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	408	414	PF00134	0.271
DOC_MAPK_gen_1	127	136	PF00069	0.632
DOC_MAPK_gen_1	380	386	PF00069	0.556
DOC_MAPK_gen_1	477	485	PF00069	0.440
DOC_MAPK_JIP1_4	130	136	PF00069	0.516
DOC_MAPK_MEF2A_6	477	485	PF00069	0.440
DOC_PP1_RVXF_1	457	463	PF00149	0.330
DOC_PP1_RVXF_1	95	101	PF00149	0.460
DOC_PP2B_LxvP_1	408	411	PF13499	0.273
DOC_PP2B_LxvP_1	628	631	PF13499	0.356
DOC_USP7_MATH_1	178	182	PF00917	0.559
DOC_USP7_MATH_1	205	209	PF00917	0.398
DOC_USP7_MATH_1	244	248	PF00917	0.344
DOC_USP7_MATH_1	379	383	PF00917	0.271
DOC_USP7_MATH_1	398	402	PF00917	0.322
DOC_USP7_MATH_1	519	523	PF00917	0.434
DOC_USP7_MATH_1	545	549	PF00917	0.381
DOC_USP7_MATH_1	616	620	PF00917	0.562
DOC_USP7_MATH_1	650	654	PF00917	0.568
DOC_USP7_MATH_1	692	696	PF00917	0.449
DOC_WW_Pin1_4	192	197	PF00397	0.484
DOC_WW_Pin1_4	412	417	PF00397	0.373
DOC_WW_Pin1_4	46	51	PF00397	0.608
DOC_WW_Pin1_4	575	580	PF00397	0.555
DOC_WW_Pin1_4	612	617	PF00397	0.550
DOC_WW_Pin1_4	676	681	PF00397	0.473
DOC_WW_Pin1_4	76	81	PF00397	0.529
LIG_14-3-3_CanoR_1	12	18	PF00244	0.544
LIG_14-3-3_CanoR_1	179	184	PF00244	0.575
LIG_14-3-3_CanoR_1	340	348	PF00244	0.476
LIG_14-3-3_CanoR_1	367	372	PF00244	0.564
LIG_14-3-3_CanoR_1	374	383	PF00244	0.438
LIG_14-3-3_CanoR_1	385	394	PF00244	0.358
LIG_14-3-3_CanoR_1	478	482	PF00244	0.352
LIG_14-3-3_CanoR_1	516	525	PF00244	0.446
LIG_14-3-3_CanoR_1	570	579	PF00244	0.500
LIG_14-3-3_CanoR_1	662	670	PF00244	0.686
LIG_14-3-3_CanoR_1	97	101	PF00244	0.343
LIG_Actin_WH2_1	142	158	PF00022	0.295
LIG_APCC_ABBA_1	321	326	PF00400	0.392
LIG_BRCT_BRCA1_1	551	555	PF00533	0.418
LIG_deltaCOP1_diTrp_1	683	687	PF00928	0.570
LIG_eIF4E_1	258	264	PF01652	0.437
LIG_eIF4E_1	509	515	PF01652	0.457
LIG_FHA_1	209	215	PF00498	0.373
LIG_FHA_1	251	257	PF00498	0.459
LIG_FHA_1	273	279	PF00498	0.456
LIG_FHA_1	295	301	PF00498	0.475
LIG_FHA_1	417	423	PF00498	0.488
LIG_FHA_1	42	48	PF00498	0.563
LIG_FHA_1	470	476	PF00498	0.438
LIG_FHA_1	478	484	PF00498	0.435
LIG_FHA_1	58	64	PF00498	0.418
LIG_FHA_1	702	708	PF00498	0.419
LIG_FHA_1	77	83	PF00498	0.645
LIG_FHA_2	187	193	PF00498	0.634
LIG_FHA_2	294	300	PF00498	0.539
LIG_FHA_2	367	373	PF00498	0.613
LIG_FHA_2	627	633	PF00498	0.570
LIG_FHA_2	82	88	PF00498	0.566
LIG_GBD_Chelix_1	728	736	PF00786	0.477
LIG_IRF3_LxIS_1	408	415	PF10401	0.484
LIG_LIR_Gen_1	105	113	PF02991	0.504
LIG_LIR_Gen_1	293	303	PF02991	0.427
LIG_LIR_Gen_1	418	427	PF02991	0.274
LIG_LIR_Gen_1	69	80	PF02991	0.570
LIG_LIR_Nem_3	105	110	PF02991	0.465
LIG_LIR_Nem_3	123	128	PF02991	0.522
LIG_LIR_Nem_3	195	200	PF02991	0.376
LIG_LIR_Nem_3	293	298	PF02991	0.502
LIG_LIR_Nem_3	418	424	PF02991	0.328
LIG_LIR_Nem_3	505	509	PF02991	0.405
LIG_LIR_Nem_3	683	689	PF02991	0.468
LIG_LIR_Nem_3	69	75	PF02991	0.641
LIG_NRBOX	259	265	PF00104	0.440
LIG_PCNA_yPIPBox_3	636	645	PF02747	0.482
LIG_Rb_LxCxE_1	726	746	PF01857	0.539
LIG_REV1ctd_RIR_1	443	451	PF16727	0.261
LIG_SH2_CRK	128	132	PF00017	0.526
LIG_SH2_CRK	509	513	PF00017	0.462
LIG_SH2_CRK	72	76	PF00017	0.565
LIG_SH2_PTP2	421	424	PF00017	0.254
LIG_SH2_SRC	645	648	PF00017	0.338
LIG_SH2_STAP1	324	328	PF00017	0.585
LIG_SH2_STAT3	596	599	PF00017	0.530
LIG_SH2_STAT5	295	298	PF00017	0.537
LIG_SH2_STAT5	310	313	PF00017	0.402
LIG_SH2_STAT5	421	424	PF00017	0.396
LIG_SH2_STAT5	454	457	PF00017	0.413
LIG_SH2_STAT5	596	599	PF00017	0.607
LIG_SH2_STAT5	62	65	PF00017	0.551
LIG_SH2_STAT5	645	648	PF00017	0.338
LIG_SH3_2	283	288	PF14604	0.486
LIG_SH3_3	190	196	PF00018	0.402
LIG_SH3_3	280	286	PF00018	0.536
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.506
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.473
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.319
LIG_SUMO_SIM_par_1	163	170	PF11976	0.420
LIG_SUMO_SIM_par_1	296	302	PF11976	0.436
LIG_TRAF2_1	151	154	PF00917	0.458
LIG_TYR_ITIM	684	689	PF00017	0.344
LIG_UBA3_1	164	173	PF00899	0.354
LIG_UBA3_1	300	306	PF00899	0.368
LIG_WRC_WIRS_1	122	127	PF05994	0.511
LIG_WRC_WIRS_1	424	429	PF05994	0.403
LIG_WRC_WIRS_1	703	708	PF05994	0.433
MOD_CDK_SPK_2	46	51	PF00069	0.450
MOD_CDK_SPxK_1	612	618	PF00069	0.574
MOD_CK1_1	208	214	PF00069	0.528
MOD_CK1_1	293	299	PF00069	0.446
MOD_CK1_1	329	335	PF00069	0.612
MOD_CK1_1	415	421	PF00069	0.497
MOD_CK1_1	426	432	PF00069	0.388
MOD_CK1_1	664	670	PF00069	0.630
MOD_CK1_1	695	701	PF00069	0.561
MOD_CK1_1	70	76	PF00069	0.533
MOD_CK1_1	702	708	PF00069	0.619
MOD_CK1_1	743	749	PF00069	0.685
MOD_CK2_1	229	235	PF00069	0.402
MOD_CK2_1	301	307	PF00069	0.452
MOD_CK2_1	570	576	PF00069	0.530
MOD_CK2_1	650	656	PF00069	0.573
MOD_CK2_1	668	674	PF00069	0.672
MOD_CK2_1	695	701	PF00069	0.551
MOD_CK2_1	81	87	PF00069	0.530
MOD_GlcNHglycan	117	120	PF01048	0.406
MOD_GlcNHglycan	169	172	PF01048	0.402
MOD_GlcNHglycan	246	249	PF01048	0.604
MOD_GlcNHglycan	3	6	PF01048	0.442
MOD_GlcNHglycan	303	306	PF01048	0.573
MOD_GlcNHglycan	334	337	PF01048	0.390
MOD_GlcNHglycan	39	42	PF01048	0.638
MOD_GlcNHglycan	430	433	PF01048	0.487
MOD_GlcNHglycan	468	472	PF01048	0.390
MOD_GlcNHglycan	647	651	PF01048	0.550
MOD_GlcNHglycan	755	758	PF01048	0.601
MOD_GlcNHglycan	93	96	PF01048	0.493
MOD_GSK3_1	184	191	PF00069	0.525
MOD_GSK3_1	246	253	PF00069	0.474
MOD_GSK3_1	290	297	PF00069	0.435
MOD_GSK3_1	322	329	PF00069	0.570
MOD_GSK3_1	33	40	PF00069	0.669
MOD_GSK3_1	332	339	PF00069	0.567
MOD_GSK3_1	363	370	PF00069	0.638
MOD_GSK3_1	412	419	PF00069	0.503
MOD_GSK3_1	463	470	PF00069	0.482
MOD_GSK3_1	514	521	PF00069	0.381
MOD_GSK3_1	545	552	PF00069	0.509
MOD_GSK3_1	57	64	PF00069	0.499
MOD_GSK3_1	588	595	PF00069	0.535
MOD_GSK3_1	612	619	PF00069	0.563
MOD_GSK3_1	626	633	PF00069	0.571
MOD_GSK3_1	646	653	PF00069	0.493
MOD_GSK3_1	66	73	PF00069	0.515
MOD_GSK3_1	664	671	PF00069	0.660
MOD_GSK3_1	692	699	PF00069	0.467
MOD_GSK3_1	739	746	PF00069	0.670
MOD_GSK3_1	87	94	PF00069	0.686
MOD_N-GLC_1	41	46	PF02516	0.477
MOD_N-GLC_1	695	700	PF02516	0.414
MOD_N-GLC_1	87	92	PF02516	0.522
MOD_N-GLC_2	585	587	PF02516	0.483
MOD_NEK2_1	1	6	PF00069	0.450
MOD_NEK2_1	120	125	PF00069	0.424
MOD_NEK2_1	145	150	PF00069	0.412
MOD_NEK2_1	155	160	PF00069	0.412
MOD_NEK2_1	206	211	PF00069	0.401
MOD_NEK2_1	301	306	PF00069	0.491
MOD_NEK2_1	33	38	PF00069	0.748
MOD_NEK2_1	341	346	PF00069	0.506
MOD_NEK2_1	386	391	PF00069	0.304
MOD_NEK2_1	514	519	PF00069	0.306
MOD_NEK2_1	55	60	PF00069	0.570
MOD_NEK2_1	624	629	PF00069	0.546
MOD_NEK2_1	646	651	PF00069	0.527
MOD_NEK2_1	655	660	PF00069	0.505
MOD_NEK2_1	66	71	PF00069	0.456
MOD_NEK2_1	753	758	PF00069	0.527
MOD_NEK2_2	423	428	PF00069	0.428
MOD_PIKK_1	326	332	PF00454	0.574
MOD_PIKK_1	387	393	PF00454	0.343
MOD_PIKK_1	488	494	PF00454	0.532
MOD_PIKK_1	519	525	PF00454	0.306
MOD_PIKK_1	577	583	PF00454	0.501
MOD_PIKK_1	661	667	PF00454	0.662
MOD_PIKK_1	668	674	PF00454	0.712
MOD_PKA_1	179	185	PF00069	0.378
MOD_PKA_1	477	483	PF00069	0.343
MOD_PKA_2	178	184	PF00069	0.369
MOD_PKA_2	33	39	PF00069	0.496
MOD_PKA_2	366	372	PF00069	0.515
MOD_PKA_2	379	385	PF00069	0.451
MOD_PKA_2	387	393	PF00069	0.420
MOD_PKA_2	477	483	PF00069	0.349
MOD_PKA_2	650	656	PF00069	0.567
MOD_PKA_2	661	667	PF00069	0.610
MOD_PKA_2	674	680	PF00069	0.533
MOD_PKA_2	715	721	PF00069	0.617
MOD_PKA_2	96	102	PF00069	0.346
MOD_Plk_1	156	162	PF00069	0.514
MOD_Plk_1	655	661	PF00069	0.584
MOD_Plk_1	695	701	PF00069	0.511
MOD_Plk_1	87	93	PF00069	0.460
MOD_Plk_2-3	229	235	PF00069	0.331
MOD_Plk_4	121	127	PF00069	0.514
MOD_Plk_4	229	235	PF00069	0.320
MOD_Plk_4	379	385	PF00069	0.540
MOD_Plk_4	398	404	PF00069	0.244
MOD_Plk_4	477	483	PF00069	0.421
MOD_Plk_4	502	508	PF00069	0.376
MOD_Plk_4	523	529	PF00069	0.462
MOD_Plk_4	592	598	PF00069	0.544
MOD_Plk_4	650	656	PF00069	0.511
MOD_Plk_4	67	73	PF00069	0.616
MOD_Plk_4	702	708	PF00069	0.432
MOD_Plk_4	87	93	PF00069	0.360
MOD_Plk_4	96	102	PF00069	0.381
MOD_ProDKin_1	192	198	PF00069	0.468
MOD_ProDKin_1	412	418	PF00069	0.376
MOD_ProDKin_1	46	52	PF00069	0.605
MOD_ProDKin_1	575	581	PF00069	0.561
MOD_ProDKin_1	612	618	PF00069	0.550
MOD_ProDKin_1	676	682	PF00069	0.469
MOD_ProDKin_1	76	82	PF00069	0.531
MOD_SUMO_rev_2	153	158	PF00179	0.513
MOD_SUMO_rev_2	195	203	PF00179	0.301
MOD_SUMO_rev_2	270	278	PF00179	0.571
TRG_DiLeu_BaEn_1	352	357	PF01217	0.436
TRG_DiLeu_BaEn_1	87	92	PF01217	0.565
TRG_DiLeu_BaEn_2	95	101	PF01217	0.479
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.439
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.612
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.444
TRG_ENDOCYTIC_2	200	203	PF00928	0.417
TRG_ENDOCYTIC_2	261	264	PF00928	0.495
TRG_ENDOCYTIC_2	295	298	PF00928	0.479
TRG_ENDOCYTIC_2	421	424	PF00928	0.254
TRG_ENDOCYTIC_2	509	512	PF00928	0.465
TRG_ENDOCYTIC_2	686	689	PF00928	0.334
TRG_ENDOCYTIC_2	72	75	PF00928	0.562
TRG_ENDOCYTIC_2	750	753	PF00928	0.609
TRG_ER_diArg_1	128	130	PF00400	0.475
TRG_ER_diArg_1	133	136	PF00400	0.410
TRG_ER_diArg_1	394	396	PF00400	0.381
TRG_NES_CRM1_1	229	241	PF08389	0.444
TRG_NLS_MonoCore_2	712	717	PF00514	0.642
TRG_NLS_MonoExtN_4	129	136	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G6	Leptomonas seymouri	45%	100%
A0A1X0NK62	Trypanosomatidae	26%	92%
A0A3S5IQT2	Trypanosoma rangeli	27%	100%
A0A3S7WY64	Leishmania donovani	72%	100%
A4I0Q4	Leishmania infantum	72%	100%
D0A732	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
E9AWQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4QAR7	Leishmania major	71%	100%
V5C0M8	Trypanosoma cruzi	28%	100%