Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HDC2_LEIBR

TriTrypDb:

LbrM.24.0650 , LBRM2903_240012200

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0097542	ciliary tip	2	1

Expansion

Sequence features

A4HDC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDC2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	13
GO:0007018	microtubule-based movement	3	13
GO:0009987	cellular process	1	13
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007019	microtubule depolymerization	5	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0031109	microtubule polymerization or depolymerization	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0051261	protein depolymerization	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003774	cytoskeletal motor activity	1	13
GO:0003777	microtubule motor activity	2	13
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0005524	ATP binding	5	13
GO:0008017	microtubule binding	5	13
GO:0008092	cytoskeletal protein binding	3	13
GO:0015631	tubulin binding	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140657	ATP-dependent activity	1	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	522	526	PF00656	0.462
CLV_NRD_NRD_1	135	137	PF00675	0.255
CLV_NRD_NRD_1	216	218	PF00675	0.274
CLV_NRD_NRD_1	243	245	PF00675	0.255
CLV_NRD_NRD_1	344	346	PF00675	0.604
CLV_NRD_NRD_1	350	352	PF00675	0.595
CLV_NRD_NRD_1	408	410	PF00675	0.666
CLV_NRD_NRD_1	478	480	PF00675	0.440
CLV_NRD_NRD_1	501	503	PF00675	0.388
CLV_NRD_NRD_1	9	11	PF00675	0.323
CLV_PCSK_FUR_1	406	410	PF00082	0.628
CLV_PCSK_KEX2_1	11	13	PF00082	0.360
CLV_PCSK_KEX2_1	216	218	PF00082	0.274
CLV_PCSK_KEX2_1	344	346	PF00082	0.603
CLV_PCSK_KEX2_1	350	352	PF00082	0.586
CLV_PCSK_KEX2_1	408	410	PF00082	0.666
CLV_PCSK_KEX2_1	501	503	PF00082	0.399
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.345
CLV_PCSK_SKI1_1	113	117	PF00082	0.255
CLV_PCSK_SKI1_1	136	140	PF00082	0.242
CLV_PCSK_SKI1_1	255	259	PF00082	0.242
CLV_PCSK_SKI1_1	432	436	PF00082	0.400
CLV_PCSK_SKI1_1	535	539	PF00082	0.379
CLV_PCSK_SKI1_1	567	571	PF00082	0.481
CLV_Separin_Metazoa	283	287	PF03568	0.242
DEG_APCC_DBOX_1	66	74	PF00400	0.394
DOC_CKS1_1	22	27	PF01111	0.509
DOC_CYCLIN_RxL_1	252	262	PF00134	0.242
DOC_CYCLIN_RxL_1	532	543	PF00134	0.280
DOC_MAPK_gen_1	216	227	PF00069	0.274
DOC_MAPK_gen_1	350	359	PF00069	0.477
DOC_MAPK_MEF2A_6	198	207	PF00069	0.315
DOC_MAPK_RevD_3	124	137	PF00069	0.290
DOC_PP1_RVXF_1	222	228	PF00149	0.255
DOC_USP7_MATH_1	194	198	PF00917	0.348
DOC_USP7_MATH_1	358	362	PF00917	0.505
DOC_USP7_MATH_1	443	447	PF00917	0.626
DOC_USP7_MATH_1	517	521	PF00917	0.482
DOC_USP7_UBL2_3	491	495	PF12436	0.421
DOC_WW_Pin1_4	21	26	PF00397	0.413
DOC_WW_Pin1_4	299	304	PF00397	0.255
DOC_WW_Pin1_4	337	342	PF00397	0.663
DOC_WW_Pin1_4	371	376	PF00397	0.667
DOC_WW_Pin1_4	415	420	PF00397	0.701
LIG_14-3-3_CanoR_1	224	228	PF00244	0.255
LIG_14-3-3_CanoR_1	294	298	PF00244	0.270
LIG_14-3-3_CanoR_1	316	324	PF00244	0.255
LIG_14-3-3_CanoR_1	46	52	PF00244	0.307
LIG_Actin_WH2_2	273	288	PF00022	0.255
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_deltaCOP1_diTrp_1	364	369	PF00928	0.459
LIG_FHA_1	280	286	PF00498	0.277
LIG_FHA_1	293	299	PF00498	0.276
LIG_FHA_1	316	322	PF00498	0.263
LIG_FHA_1	568	574	PF00498	0.513
LIG_FHA_2	244	250	PF00498	0.281
LIG_FHA_2	48	54	PF00498	0.376
LIG_LIR_Gen_1	173	183	PF02991	0.350
LIG_LIR_Gen_1	226	231	PF02991	0.255
LIG_LIR_Gen_1	48	55	PF02991	0.276
LIG_LIR_Nem_3	129	134	PF02991	0.304
LIG_LIR_Nem_3	173	178	PF02991	0.350
LIG_LIR_Nem_3	226	230	PF02991	0.255
LIG_LIR_Nem_3	48	54	PF02991	0.276
LIG_LIR_Nem_3	95	99	PF02991	0.412
LIG_NRP_CendR_1	576	578	PF00754	0.652
LIG_Pex14_1	365	369	PF04695	0.458
LIG_Pex14_2	51	55	PF04695	0.348
LIG_SH2_CRK	96	100	PF00017	0.394
LIG_SH2_NCK_1	108	112	PF00017	0.255
LIG_SH2_SRC	108	111	PF00017	0.270
LIG_SH2_STAP1	108	112	PF00017	0.255
LIG_SH2_STAP1	317	321	PF00017	0.271
LIG_SH2_STAT5	127	130	PF00017	0.292
LIG_SH2_STAT5	317	320	PF00017	0.255
LIG_SH2_STAT5	43	46	PF00017	0.266
LIG_SH2_STAT5	456	459	PF00017	0.546
LIG_SH2_STAT5	484	487	PF00017	0.521
LIG_SH2_STAT5	530	533	PF00017	0.382
LIG_SH2_STAT5	96	99	PF00017	0.394
LIG_SH3_2	346	351	PF14604	0.642
LIG_SH3_3	19	25	PF00018	0.395
LIG_SH3_3	28	34	PF00018	0.282
LIG_SH3_3	343	349	PF00018	0.667
LIG_SH3_3	399	405	PF00018	0.503
LIG_SH3_3	425	431	PF00018	0.483
LIG_SUMO_SIM_anti_2	547	552	PF11976	0.324
LIG_SUMO_SIM_par_1	256	262	PF11976	0.242
LIG_TRAF2_1	520	523	PF00917	0.586
LIG_UBA3_1	257	261	PF00899	0.242
LIG_WRC_WIRS_1	127	132	PF05994	0.270
LIG_WRC_WIRS_1	518	523	PF05994	0.508
MOD_CDK_SPK_2	23	28	PF00069	0.440
MOD_CDK_SPxxK_3	21	28	PF00069	0.471
MOD_CDK_SPxxK_3	337	344	PF00069	0.686
MOD_CK1_1	196	202	PF00069	0.319
MOD_CK1_1	279	285	PF00069	0.242
MOD_CK1_1	293	299	PF00069	0.242
MOD_CK1_1	302	308	PF00069	0.233
MOD_CK1_1	371	377	PF00069	0.714
MOD_CK1_1	41	47	PF00069	0.369
MOD_CK1_1	415	421	PF00069	0.683
MOD_CK1_1	506	512	PF00069	0.544
MOD_CK1_1	92	98	PF00069	0.260
MOD_CK2_1	126	132	PF00069	0.270
MOD_CK2_1	243	249	PF00069	0.278
MOD_CK2_1	358	364	PF00069	0.550
MOD_CK2_1	375	381	PF00069	0.752
MOD_CK2_1	47	53	PF00069	0.366
MOD_CK2_1	517	523	PF00069	0.470
MOD_CK2_1	98	104	PF00069	0.394
MOD_Cter_Amidation	134	137	PF01082	0.255
MOD_Cter_Amidation	342	345	PF01082	0.641
MOD_Cter_Amidation	406	409	PF01082	0.504
MOD_GlcNHglycan	181	184	PF01048	0.261
MOD_GlcNHglycan	190	193	PF01048	0.220
MOD_GlcNHglycan	414	417	PF01048	0.672
MOD_GlcNHglycan	422	425	PF01048	0.605
MOD_GlcNHglycan	91	94	PF01048	0.283
MOD_GSK3_1	293	300	PF00069	0.251
MOD_GSK3_1	311	318	PF00069	0.189
MOD_GSK3_1	364	371	PF00069	0.619
MOD_GSK3_1	408	415	PF00069	0.772
MOD_GSK3_1	41	48	PF00069	0.412
MOD_GSK3_1	513	520	PF00069	0.582
MOD_GSK3_1	563	570	PF00069	0.416
MOD_GSK3_1	94	101	PF00069	0.399
MOD_N-GLC_1	253	258	PF02516	0.263
MOD_N-GLC_1	400	405	PF02516	0.520
MOD_N-GLC_1	80	85	PF02516	0.255
MOD_N-GLC_2	159	161	PF02516	0.255
MOD_NEK2_1	269	274	PF00069	0.273
MOD_NEK2_1	276	281	PF00069	0.149
MOD_NEK2_1	285	290	PF00069	0.242
MOD_NEK2_1	297	302	PF00069	0.242
MOD_NEK2_1	315	320	PF00069	0.255
MOD_NEK2_1	55	60	PF00069	0.411
MOD_NEK2_1	565	570	PF00069	0.394
MOD_NEK2_1	72	77	PF00069	0.198
MOD_NEK2_1	98	103	PF00069	0.399
MOD_NEK2_2	80	85	PF00069	0.242
MOD_PIKK_1	302	308	PF00454	0.320
MOD_PIKK_1	315	321	PF00454	0.186
MOD_PIKK_1	98	104	PF00454	0.318
MOD_PK_1	408	414	PF00069	0.757
MOD_PKA_1	408	414	PF00069	0.630
MOD_PKA_2	207	213	PF00069	0.292
MOD_PKA_2	223	229	PF00069	0.255
MOD_PKA_2	243	249	PF00069	0.113
MOD_PKA_2	276	282	PF00069	0.242
MOD_PKA_2	285	291	PF00069	0.242
MOD_PKA_2	293	299	PF00069	0.242
MOD_PKA_2	315	321	PF00069	0.255
MOD_PKA_2	408	414	PF00069	0.550
MOD_PKA_2	45	51	PF00069	0.394
MOD_PKB_1	406	414	PF00069	0.704
MOD_Plk_1	253	259	PF00069	0.281
MOD_Plk_1	38	44	PF00069	0.247
MOD_Plk_1	513	519	PF00069	0.552
MOD_Plk_1	80	86	PF00069	0.255
MOD_Plk_2-3	523	529	PF00069	0.426
MOD_Plk_4	126	132	PF00069	0.319
MOD_Plk_4	253	259	PF00069	0.267
MOD_Plk_4	276	282	PF00069	0.255
MOD_Plk_4	293	299	PF00069	0.255
MOD_Plk_4	432	438	PF00069	0.384
MOD_Plk_4	554	560	PF00069	0.405
MOD_Plk_4	72	78	PF00069	0.252
MOD_Plk_4	94	100	PF00069	0.242
MOD_ProDKin_1	21	27	PF00069	0.416
MOD_ProDKin_1	299	305	PF00069	0.255
MOD_ProDKin_1	337	343	PF00069	0.668
MOD_ProDKin_1	371	377	PF00069	0.668
MOD_ProDKin_1	415	421	PF00069	0.699
MOD_SUMO_for_1	332	335	PF00179	0.605
MOD_SUMO_for_1	490	493	PF00179	0.412
MOD_SUMO_for_1	511	514	PF00179	0.407
MOD_SUMO_rev_2	238	246	PF00179	0.255
MOD_SUMO_rev_2	487	497	PF00179	0.382
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.348
TRG_ENDOCYTIC_2	127	130	PF00928	0.290
TRG_ENDOCYTIC_2	96	99	PF00928	0.394
TRG_ER_diArg_1	145	148	PF00400	0.428
TRG_ER_diArg_1	344	346	PF00400	0.605
TRG_ER_diArg_1	349	351	PF00400	0.592
TRG_ER_diArg_1	405	408	PF00400	0.703
TRG_ER_diArg_1	575	578	PF00400	0.409
TRG_ER_diArg_1	9	12	PF00400	0.330
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G5	Leptomonas seymouri	81%	100%
A0A0N0P6P6	Leptomonas seymouri	41%	87%
A0A0S4IP49	Bodo saltans	28%	72%
A0A0S4IR67	Bodo saltans	28%	74%
A0A0S4IYW0	Bodo saltans	59%	99%
A0A1X0NIJ1	Trypanosomatidae	64%	98%
A0A1X0NJ40	Trypanosomatidae	45%	68%
A0A1X0NQ03	Trypanosomatidae	27%	70%
A0A3R7MDH9	Trypanosoma rangeli	27%	81%
A0A3R7NVF2	Trypanosoma rangeli	66%	100%
A0A3S5H4S8	Leishmania donovani	41%	86%
A0A3S7WY84	Leishmania donovani	92%	100%
A0A3S7X9Y1	Leishmania donovani	31%	100%
A0A422MZ05	Trypanosoma rangeli	26%	86%
A0A422NEQ8	Trypanosoma rangeli	30%	77%
A0A422P055	Trypanosoma rangeli	39%	81%
A0A422P4C5	Trypanosoma rangeli	38%	80%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HCT2	Leishmania braziliensis	32%	80%
A4HND6	Leishmania braziliensis	30%	100%
A4HRC5	Leishmania infantum	41%	86%
A4I0Q2	Leishmania infantum	92%	100%
A4IC09	Leishmania infantum	31%	100%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	77%
C9ZXH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	84%
D0A729	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9ABZ2	Leishmania major	40%	87%
E9AFU7	Leishmania major	30%	100%
E9AJ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	86%
E9AWQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4QAR9	Leishmania major	91%	100%
Q5R9Y9	Pongo abelii	37%	78%
Q6P3R1	Xenopus tropicalis	29%	90%
Q940Y8	Arabidopsis thaliana	38%	85%
Q9W1U4	Drosophila melanogaster	43%	92%
V5B8X9	Trypanosoma cruzi	26%	82%
V5BK25	Trypanosoma cruzi	27%	80%
V5D733	Trypanosoma cruzi	29%	77%
V5DSJ9	Trypanosoma cruzi	67%	100%