Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDC0_LEIBR

TriTrypDb:

LbrM.24.0630 , LBRM2903_240012100

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDC0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	13
GO:0006511	ubiquitin-dependent protein catabolic process	7	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0009057	macromolecule catabolic process	4	13
GO:0009987	cellular process	1	13
GO:0016579	protein deubiquitination	6	13
GO:0019538	protein metabolic process	3	13
GO:0019941	modification-dependent protein catabolic process	6	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0043632	modification-dependent macromolecule catabolic process	5	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044248	cellular catabolic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044265	obsolete cellular macromolecule catabolic process	4	13
GO:0051603	proteolysis involved in protein catabolic process	5	13
GO:0070646	protein modification by small protein removal	5	13
GO:0070647	protein modification by small protein conjugation or removal	5	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901575	organic substance catabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004843	cysteine-type deubiquitinase activity	5	13
GO:0008233	peptidase activity	3	13
GO:0008234	cysteine-type peptidase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0019783	ubiquitin-like protein peptidase activity	4	13
GO:0101005	deubiquitinase activity	5	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.362
CLV_C14_Caspase3-7	474	478	PF00656	0.362
CLV_C14_Caspase3-7	624	628	PF00656	0.738
CLV_MEL_PAP_1	720	726	PF00089	0.472
CLV_NRD_NRD_1	173	175	PF00675	0.302
CLV_NRD_NRD_1	18	20	PF00675	0.493
CLV_NRD_NRD_1	26	28	PF00675	0.472
CLV_NRD_NRD_1	295	297	PF00675	0.306
CLV_NRD_NRD_1	360	362	PF00675	0.256
CLV_NRD_NRD_1	499	501	PF00675	0.493
CLV_NRD_NRD_1	641	643	PF00675	0.615
CLV_NRD_NRD_1	698	700	PF00675	0.534
CLV_NRD_NRD_1	734	736	PF00675	0.536
CLV_NRD_NRD_1	745	747	PF00675	0.587
CLV_NRD_NRD_1	805	807	PF00675	0.580
CLV_NRD_NRD_1	90	92	PF00675	0.543
CLV_PCSK_FUR_1	298	302	PF00082	0.192
CLV_PCSK_FUR_1	801	805	PF00082	0.553
CLV_PCSK_KEX2_1	297	299	PF00082	0.330
CLV_PCSK_KEX2_1	300	302	PF00082	0.294
CLV_PCSK_KEX2_1	378	380	PF00082	0.363
CLV_PCSK_KEX2_1	437	439	PF00082	0.330
CLV_PCSK_KEX2_1	557	559	PF00082	0.488
CLV_PCSK_KEX2_1	616	618	PF00082	0.685
CLV_PCSK_KEX2_1	641	643	PF00082	0.615
CLV_PCSK_KEX2_1	698	700	PF00082	0.585
CLV_PCSK_KEX2_1	745	747	PF00082	0.675
CLV_PCSK_KEX2_1	803	805	PF00082	0.556
CLV_PCSK_KEX2_1	90	92	PF00082	0.543
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.330
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.294
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.355
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.330
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.482
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.737
CLV_PCSK_PC7_1	296	302	PF00082	0.192
CLV_PCSK_PC7_1	801	807	PF00082	0.705
CLV_PCSK_SKI1_1	14	18	PF00082	0.580
CLV_PCSK_SKI1_1	230	234	PF00082	0.292
CLV_PCSK_SKI1_1	297	301	PF00082	0.332
CLV_PCSK_SKI1_1	36	40	PF00082	0.449
CLV_PCSK_SKI1_1	683	687	PF00082	0.703
CLV_PCSK_SKI1_1	735	739	PF00082	0.705
CLV_PCSK_SKI1_1	772	776	PF00082	0.724
DEG_APCC_DBOX_1	757	765	PF00400	0.537
DEG_Nend_UBRbox_2	1	3	PF02207	0.592
DEG_SPOP_SBC_1	411	415	PF00917	0.367
DEG_SPOP_SBC_1	605	609	PF00917	0.537
DOC_CDC14_PxL_1	138	146	PF14671	0.192
DOC_CKS1_1	738	743	PF01111	0.595
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.362
DOC_MAPK_DCC_7	111	120	PF00069	0.455
DOC_MAPK_gen_1	277	287	PF00069	0.415
DOC_MAPK_gen_1	348	358	PF00069	0.330
DOC_MAPK_gen_1	359	368	PF00069	0.320
DOC_MAPK_MEF2A_6	280	289	PF00069	0.414
DOC_MAPK_RevD_3	364	379	PF00069	0.329
DOC_PP1_RVXF_1	17	24	PF00149	0.418
DOC_PP1_RVXF_1	387	394	PF00149	0.281
DOC_PP1_RVXF_1	5	12	PF00149	0.596
DOC_PP1_RVXF_1	717	723	PF00149	0.497
DOC_PP2B_LxvP_1	159	162	PF13499	0.362
DOC_USP7_MATH_1	465	469	PF00917	0.297
DOC_USP7_MATH_1	502	506	PF00917	0.427
DOC_USP7_MATH_1	520	524	PF00917	0.619
DOC_USP7_MATH_1	599	603	PF00917	0.535
DOC_USP7_MATH_1	652	656	PF00917	0.688
DOC_USP7_MATH_1	663	667	PF00917	0.629
DOC_USP7_MATH_1	685	689	PF00917	0.731
DOC_USP7_UBL2_3	288	292	PF12436	0.414
DOC_USP7_UBL2_3	773	777	PF12436	0.676
DOC_WW_Pin1_4	113	118	PF00397	0.446
DOC_WW_Pin1_4	349	354	PF00397	0.268
DOC_WW_Pin1_4	406	411	PF00397	0.446
DOC_WW_Pin1_4	412	417	PF00397	0.476
DOC_WW_Pin1_4	673	678	PF00397	0.551
DOC_WW_Pin1_4	737	742	PF00397	0.670
LIG_14-3-3_CanoR_1	105	109	PF00244	0.360
LIG_14-3-3_CanoR_1	213	220	PF00244	0.421
LIG_14-3-3_CanoR_1	301	307	PF00244	0.248
LIG_14-3-3_CanoR_1	36	41	PF00244	0.493
LIG_14-3-3_CanoR_1	401	406	PF00244	0.374
LIG_14-3-3_CanoR_1	482	488	PF00244	0.310
LIG_14-3-3_CanoR_1	611	618	PF00244	0.777
LIG_14-3-3_CanoR_1	745	751	PF00244	0.677
LIG_AP2alpha_2	318	320	PF02296	0.268
LIG_AP2alpha_2	782	784	PF02296	0.622
LIG_APCC_ABBA_1	787	792	PF00400	0.629
LIG_BIR_III_4	587	591	PF00653	0.552
LIG_BRCT_BRCA1_1	205	209	PF00533	0.302
LIG_BRCT_BRCA1_1	7	11	PF00533	0.628
LIG_EH_1	787	791	PF12763	0.712
LIG_FHA_1	247	253	PF00498	0.268
LIG_FHA_1	44	50	PF00498	0.589
LIG_FHA_1	563	569	PF00498	0.478
LIG_FHA_1	607	613	PF00498	0.493
LIG_FHA_1	684	690	PF00498	0.558
LIG_FHA_1	708	714	PF00498	0.544
LIG_FHA_2	622	628	PF00498	0.697
LIG_Integrin_RGD_1	668	670	PF01839	0.537
LIG_LIR_Apic_2	24	29	PF02991	0.539
LIG_LIR_Apic_2	349	353	PF02991	0.427
LIG_LIR_Gen_1	318	328	PF02991	0.305
LIG_LIR_Gen_1	337	345	PF02991	0.414
LIG_LIR_Gen_1	400	410	PF02991	0.330
LIG_LIR_Nem_3	15	21	PF02991	0.507
LIG_LIR_Nem_3	22	26	PF02991	0.503
LIG_LIR_Nem_3	314	320	PF02991	0.302
LIG_LIR_Nem_3	337	342	PF02991	0.414
LIG_LIR_Nem_3	400	405	PF02991	0.370
LIG_LIR_Nem_3	455	461	PF02991	0.327
LIG_LIR_Nem_3	688	693	PF02991	0.618
LIG_LIR_Nem_3	782	787	PF02991	0.746
LIG_PCNA_yPIPBox_3	268	276	PF02747	0.335
LIG_Pex14_2	148	152	PF04695	0.302
LIG_Pex14_2	163	167	PF04695	0.330
LIG_PTB_Apo_2	124	131	PF02174	0.307
LIG_SH2_CRK	26	30	PF00017	0.523
LIG_SH2_CRK	350	354	PF00017	0.243
LIG_SH2_CRK	402	406	PF00017	0.330
LIG_SH2_CRK	690	694	PF00017	0.576
LIG_SH2_STAP1	443	447	PF00017	0.268
LIG_SH2_STAP1	639	643	PF00017	0.729
LIG_SH2_STAT5	109	112	PF00017	0.263
LIG_SH2_STAT5	147	150	PF00017	0.330
LIG_SH2_STAT5	259	262	PF00017	0.276
LIG_SH2_STAT5	402	405	PF00017	0.384
LIG_SH2_STAT5	462	465	PF00017	0.398
LIG_SH3_3	29	35	PF00018	0.550
LIG_SH3_3	365	371	PF00018	0.414
LIG_SH3_3	37	43	PF00018	0.544
LIG_SH3_3	388	394	PF00018	0.367
LIG_SH3_3	404	410	PF00018	0.367
LIG_SH3_3	674	680	PF00018	0.606
LIG_SH3_3	741	747	PF00018	0.545
LIG_SH3_3	775	781	PF00018	0.548
LIG_SUMO_SIM_par_1	321	326	PF11976	0.297
LIG_SUMO_SIM_par_1	393	398	PF11976	0.366
LIG_TRAF2_1	267	270	PF00917	0.327
LIG_TRAF2_1	789	792	PF00917	0.669
LIG_UBA3_1	198	207	PF00899	0.327
LIG_UBA3_1	232	241	PF00899	0.364
LIG_WRC_WIRS_1	149	154	PF05994	0.414
MOD_CDK_SPK_2	349	354	PF00069	0.268
MOD_CDK_SPK_2	673	678	PF00069	0.517
MOD_CK1_1	262	268	PF00069	0.342
MOD_CK1_1	349	355	PF00069	0.414
MOD_CK1_1	414	420	PF00069	0.414
MOD_CK1_1	432	438	PF00069	0.432
MOD_CK1_1	478	484	PF00069	0.370
MOD_CK1_1	52	58	PF00069	0.699
MOD_CK1_1	524	530	PF00069	0.604
MOD_CK1_1	531	537	PF00069	0.605
MOD_CK1_1	571	577	PF00069	0.584
MOD_CK1_1	586	592	PF00069	0.768
MOD_CK1_1	623	629	PF00069	0.622
MOD_CK1_1	708	714	PF00069	0.630
MOD_CK2_1	264	270	PF00069	0.312
MOD_CK2_1	300	306	PF00069	0.211
MOD_CK2_1	544	550	PF00069	0.383
MOD_CK2_1	652	658	PF00069	0.675
MOD_Cter_Amidation	801	804	PF01082	0.549
MOD_GlcNHglycan	153	156	PF01048	0.432
MOD_GlcNHglycan	187	190	PF01048	0.306
MOD_GlcNHglycan	36	39	PF01048	0.602
MOD_GlcNHglycan	417	420	PF01048	0.266
MOD_GlcNHglycan	432	435	PF01048	0.298
MOD_GlcNHglycan	504	507	PF01048	0.467
MOD_GlcNHglycan	516	519	PF01048	0.669
MOD_GlcNHglycan	524	527	PF01048	0.489
MOD_GlcNHglycan	577	580	PF01048	0.591
MOD_GlcNHglycan	587	591	PF01048	0.730
MOD_GlcNHglycan	636	639	PF01048	0.549
MOD_GlcNHglycan	683	686	PF01048	0.538
MOD_GlcNHglycan	748	751	PF01048	0.779
MOD_GSK3_1	224	231	PF00069	0.390
MOD_GSK3_1	397	404	PF00069	0.325
MOD_GSK3_1	406	413	PF00069	0.317
MOD_GSK3_1	428	435	PF00069	0.404
MOD_GSK3_1	496	503	PF00069	0.479
MOD_GSK3_1	510	517	PF00069	0.588
MOD_GSK3_1	520	527	PF00069	0.568
MOD_GSK3_1	568	575	PF00069	0.735
MOD_GSK3_1	595	602	PF00069	0.683
MOD_GSK3_1	621	628	PF00069	0.671
MOD_GSK3_1	681	688	PF00069	0.591
MOD_GSK3_1	705	712	PF00069	0.769
MOD_N-GLC_1	113	118	PF02516	0.292
MOD_N-GLC_1	475	480	PF02516	0.350
MOD_N-GLC_1	5	10	PF02516	0.618
MOD_N-GLC_1	514	519	PF02516	0.610
MOD_N-GLC_1	568	573	PF02516	0.510
MOD_N-GLC_2	127	129	PF02516	0.316
MOD_N-GLC_2	648	650	PF02516	0.633
MOD_NEK2_1	104	109	PF00069	0.531
MOD_NEK2_1	125	130	PF00069	0.285
MOD_NEK2_1	148	153	PF00069	0.306
MOD_NEK2_1	224	229	PF00069	0.390
MOD_NEK2_1	236	241	PF00069	0.283
MOD_NEK2_1	397	402	PF00069	0.376
MOD_NEK2_1	430	435	PF00069	0.197
MOD_NEK2_1	475	480	PF00069	0.415
MOD_NEK2_1	49	54	PF00069	0.528
MOD_NEK2_1	496	501	PF00069	0.336
MOD_NEK2_1	521	526	PF00069	0.518
MOD_NEK2_1	568	573	PF00069	0.510
MOD_NEK2_1	606	611	PF00069	0.726
MOD_NEK2_1	681	686	PF00069	0.620
MOD_NEK2_1	693	698	PF00069	0.517
MOD_NEK2_1	707	712	PF00069	0.773
MOD_NEK2_2	685	690	PF00069	0.617
MOD_PIKK_1	259	265	PF00454	0.362
MOD_PIKK_1	300	306	PF00454	0.192
MOD_PIKK_1	423	429	PF00454	0.440
MOD_PIKK_1	52	58	PF00454	0.737
MOD_PIKK_1	642	648	PF00454	0.683
MOD_PIKK_1	663	669	PF00454	0.581
MOD_PK_1	362	368	PF00069	0.330
MOD_PKA_1	300	306	PF00069	0.192
MOD_PKA_1	362	368	PF00069	0.330
MOD_PKA_1	500	506	PF00069	0.565
MOD_PKA_1	634	640	PF00069	0.491
MOD_PKA_2	104	110	PF00069	0.412
MOD_PKA_2	212	218	PF00069	0.414
MOD_PKA_2	300	306	PF00069	0.358
MOD_PKA_2	481	487	PF00069	0.336
MOD_PKA_2	49	55	PF00069	0.530
MOD_PKA_2	562	568	PF00069	0.460
MOD_PKA_2	583	589	PF00069	0.643
MOD_Plk_1	397	403	PF00069	0.407
MOD_Plk_1	475	481	PF00069	0.377
MOD_Plk_1	5	11	PF00069	0.600
MOD_Plk_1	708	714	PF00069	0.577
MOD_Plk_2-3	452	458	PF00069	0.330
MOD_Plk_2-3	621	627	PF00069	0.650
MOD_Plk_4	104	110	PF00069	0.468
MOD_Plk_4	130	136	PF00069	0.327
MOD_Plk_4	228	234	PF00069	0.362
MOD_Plk_4	36	42	PF00069	0.443
MOD_Plk_4	685	691	PF00069	0.651
MOD_ProDKin_1	113	119	PF00069	0.441
MOD_ProDKin_1	349	355	PF00069	0.268
MOD_ProDKin_1	406	412	PF00069	0.446
MOD_ProDKin_1	673	679	PF00069	0.542
MOD_ProDKin_1	737	743	PF00069	0.675
MOD_SUMO_for_1	287	290	PF00179	0.414
MOD_SUMO_rev_2	283	289	PF00179	0.327
MOD_SUMO_rev_2	290	299	PF00179	0.327
MOD_SUMO_rev_2	54	62	PF00179	0.626
MOD_SUMO_rev_2	627	637	PF00179	0.497
TRG_DiLeu_BaEn_1	271	276	PF01217	0.327
TRG_DiLeu_BaEn_1	550	555	PF01217	0.483
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.414
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.634
TRG_ENDOCYTIC_2	317	320	PF00928	0.268
TRG_ENDOCYTIC_2	402	405	PF00928	0.354
TRG_ENDOCYTIC_2	461	464	PF00928	0.268
TRG_ENDOCYTIC_2	494	497	PF00928	0.296
TRG_ENDOCYTIC_2	690	693	PF00928	0.578
TRG_ER_diArg_1	358	361	PF00400	0.311
TRG_ER_diArg_1	641	643	PF00400	0.611
TRG_ER_diArg_1	697	699	PF00400	0.513
TRG_ER_diArg_1	717	720	PF00400	0.684
TRG_ER_diArg_1	744	746	PF00400	0.637
TRG_ER_diArg_1	800	803	PF00400	0.557
TRG_ER_diArg_1	804	806	PF00400	0.560
TRG_ER_diArg_1	89	91	PF00400	0.538
TRG_NES_CRM1_1	158	171	PF08389	0.330
TRG_NES_CRM1_1	755	767	PF08389	0.691
TRG_NLS_MonoExtC_3	296	301	PF00514	0.192
TRG_NLS_MonoExtN_4	296	301	PF00514	0.192
TRG_NLS_MonoExtN_4	359	365	PF00514	0.414
TRG_NLS_MonoExtN_4	770	776	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	641	646	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z2	Leptomonas seymouri	60%	100%
A0A0S4JHR5	Bodo saltans	34%	99%
A0A1X0NIL8	Trypanosomatidae	38%	100%
A0A3S7WY54	Leishmania donovani	76%	100%
A0A422P3Z4	Trypanosoma rangeli	38%	100%
A4HZ39	Leishmania infantum	22%	100%
A4I0Q0	Leishmania infantum	76%	100%
D0A726	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AWQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QAS1	Leishmania major	75%	99%
V5BR83	Trypanosoma cruzi	42%	100%