Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HDB7_LEIBR

TriTrypDb:

LbrM.24.0600 , LBRM2903_240011700

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.534
CLV_C14_Caspase3-7	286	290	PF00656	0.629
CLV_C14_Caspase3-7	68	72	PF00656	0.507
CLV_NRD_NRD_1	146	148	PF00675	0.486
CLV_NRD_NRD_1	172	174	PF00675	0.728
CLV_NRD_NRD_1	183	185	PF00675	0.607
CLV_NRD_NRD_1	381	383	PF00675	0.738
CLV_NRD_NRD_1	442	444	PF00675	0.651
CLV_NRD_NRD_1	599	601	PF00675	0.649
CLV_NRD_NRD_1	623	625	PF00675	0.522
CLV_PCSK_KEX2_1	172	174	PF00082	0.728
CLV_PCSK_KEX2_1	200	202	PF00082	0.769
CLV_PCSK_KEX2_1	381	383	PF00082	0.738
CLV_PCSK_KEX2_1	442	444	PF00082	0.651
CLV_PCSK_KEX2_1	599	601	PF00082	0.649
CLV_PCSK_KEX2_1	851	853	PF00082	0.617
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.769
CLV_PCSK_PC1ET2_1	851	853	PF00082	0.617
CLV_PCSK_PC7_1	377	383	PF00082	0.731
CLV_PCSK_PC7_1	847	853	PF00082	0.611
CLV_PCSK_SKI1_1	175	179	PF00082	0.741
CLV_PCSK_SKI1_1	695	699	PF00082	0.578
CLV_PCSK_SKI1_1	730	734	PF00082	0.615
CLV_Separin_Metazoa	386	390	PF03568	0.704
DEG_SCF_FBW7_2	207	212	PF00400	0.730
DOC_ANK_TNKS_1	758	765	PF00023	0.617
DOC_CKS1_1	28	33	PF01111	0.747
DOC_CKS1_1	612	617	PF01111	0.438
DOC_CYCLIN_RxL_1	693	705	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.533
DOC_MAPK_gen_1	145	154	PF00069	0.457
DOC_MAPK_gen_1	354	363	PF00069	0.563
DOC_MAPK_gen_1	501	509	PF00069	0.540
DOC_MAPK_gen_1	674	684	PF00069	0.746
DOC_MAPK_MEF2A_6	147	156	PF00069	0.446
DOC_MAPK_MEF2A_6	304	313	PF00069	0.715
DOC_MAPK_MEF2A_6	429	436	PF00069	0.729
DOC_PP1_RVXF_1	260	266	PF00149	0.698
DOC_PP1_RVXF_1	622	629	PF00149	0.677
DOC_PP2B_LxvP_1	565	568	PF13499	0.789
DOC_PP2B_LxvP_1	733	736	PF13499	0.608
DOC_PP4_FxxP_1	701	704	PF00568	0.585
DOC_USP7_MATH_1	165	169	PF00917	0.739
DOC_USP7_MATH_1	187	191	PF00917	0.530
DOC_USP7_MATH_1	221	225	PF00917	0.581
DOC_USP7_MATH_1	284	288	PF00917	0.728
DOC_USP7_MATH_1	714	718	PF00917	0.597
DOC_USP7_MATH_1	795	799	PF00917	0.613
DOC_USP7_MATH_1	80	84	PF00917	0.645
DOC_USP7_MATH_1	815	819	PF00917	0.550
DOC_WW_Pin1_4	205	210	PF00397	0.776
DOC_WW_Pin1_4	27	32	PF00397	0.690
DOC_WW_Pin1_4	356	361	PF00397	0.525
DOC_WW_Pin1_4	396	401	PF00397	0.720
DOC_WW_Pin1_4	435	440	PF00397	0.468
DOC_WW_Pin1_4	611	616	PF00397	0.447
LIG_14-3-3_CanoR_1	175	183	PF00244	0.757
LIG_14-3-3_CanoR_1	188	196	PF00244	0.578
LIG_14-3-3_CanoR_1	262	268	PF00244	0.690
LIG_14-3-3_CanoR_1	538	544	PF00244	0.502
LIG_14-3-3_CanoR_1	583	591	PF00244	0.421
LIG_14-3-3_CanoR_1	604	612	PF00244	0.456
LIG_14-3-3_CanoR_1	62	66	PF00244	0.472
LIG_14-3-3_CanoR_1	677	683	PF00244	0.618
LIG_14-3-3_CterR_2	852	857	PF00244	0.619
LIG_Actin_WH2_2	455	473	PF00022	0.662
LIG_APCC_ABBA_1	416	421	PF00400	0.690
LIG_APCC_ABBAyCdc20_2	100	106	PF00400	0.554
LIG_APCC_ABBAyCdc20_2	415	421	PF00400	0.695
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BIR_III_4	472	476	PF00653	0.699
LIG_BIR_III_4	586	590	PF00653	0.616
LIG_BRCT_BRCA1_1	223	227	PF00533	0.640
LIG_FHA_1	106	112	PF00498	0.783
LIG_FHA_1	238	244	PF00498	0.426
LIG_FHA_1	3	9	PF00498	0.517
LIG_FHA_1	345	351	PF00498	0.773
LIG_FHA_1	612	618	PF00498	0.430
LIG_FHA_1	703	709	PF00498	0.586
LIG_FHA_1	833	839	PF00498	0.600
LIG_FHA_2	108	114	PF00498	0.695
LIG_FHA_2	217	223	PF00498	0.523
LIG_FHA_2	273	279	PF00498	0.699
LIG_FHA_2	583	589	PF00498	0.436
LIG_FHA_2	62	68	PF00498	0.479
LIG_FHA_2	644	650	PF00498	0.559
LIG_Integrin_isoDGR_2	581	583	PF01839	0.446
LIG_Integrin_RGD_1	674	676	PF01839	0.694
LIG_Integrin_RGD_1	761	763	PF01839	0.624
LIG_LIR_Apic_2	202	207	PF02991	0.554
LIG_LIR_Apic_2	266	270	PF02991	0.439
LIG_LIR_Apic_2	323	329	PF02991	0.558
LIG_LIR_Gen_1	190	199	PF02991	0.551
LIG_LIR_Gen_1	208	217	PF02991	0.517
LIG_LIR_Gen_1	303	313	PF02991	0.688
LIG_LIR_Gen_1	401	411	PF02991	0.506
LIG_LIR_Gen_1	444	453	PF02991	0.666
LIG_LIR_Gen_1	458	466	PF02991	0.442
LIG_LIR_Gen_1	492	503	PF02991	0.719
LIG_LIR_LC3C_4	150	154	PF02991	0.661
LIG_LIR_Nem_3	138	143	PF02991	0.682
LIG_LIR_Nem_3	190	196	PF02991	0.574
LIG_LIR_Nem_3	303	308	PF02991	0.705
LIG_LIR_Nem_3	401	406	PF02991	0.652
LIG_LIR_Nem_3	444	448	PF02991	0.661
LIG_LIR_Nem_3	458	463	PF02991	0.432
LIG_LIR_Nem_3	48	53	PF02991	0.521
LIG_LIR_Nem_3	480	486	PF02991	0.715
LIG_LIR_Nem_3	492	498	PF02991	0.538
LIG_LIR_Nem_3	505	509	PF02991	0.538
LIG_LIR_Nem_3	837	843	PF02991	0.608
LIG_LYPXL_S_1	430	434	PF13949	0.689
LIG_LYPXL_yS_3	431	434	PF13949	0.698
LIG_PCNA_yPIPBox_3	500	513	PF02747	0.536
LIG_RPA_C_Fungi	377	389	PF08784	0.718
LIG_SH2_CRK	204	208	PF00017	0.553
LIG_SH2_CRK	305	309	PF00017	0.694
LIG_SH2_CRK	326	330	PF00017	0.555
LIG_SH2_CRK	9	13	PF00017	0.512
LIG_SH2_GRB2like	539	542	PF00017	0.698
LIG_SH2_NCK_1	204	208	PF00017	0.553
LIG_SH2_NCK_1	789	793	PF00017	0.620
LIG_SH2_PTP2	267	270	PF00017	0.440
LIG_SH2_PTP2	403	406	PF00017	0.647
LIG_SH2_SRC	453	456	PF00017	0.602
LIG_SH2_STAP1	211	215	PF00017	0.543
LIG_SH2_STAP1	217	221	PF00017	0.510
LIG_SH2_STAP1	254	258	PF00017	0.720
LIG_SH2_STAP1	486	490	PF00017	0.680
LIG_SH2_STAP1	606	610	PF00017	0.490
LIG_SH2_STAP1	618	622	PF00017	0.559
LIG_SH2_STAP1	789	793	PF00017	0.620
LIG_SH2_STAT5	217	220	PF00017	0.771
LIG_SH2_STAT5	264	267	PF00017	0.694
LIG_SH2_STAT5	312	315	PF00017	0.616
LIG_SH2_STAT5	403	406	PF00017	0.647
LIG_SH2_STAT5	483	486	PF00017	0.714
LIG_SH2_STAT5	494	497	PF00017	0.566
LIG_SH2_STAT5	50	53	PF00017	0.713
LIG_SH2_STAT5	506	509	PF00017	0.580
LIG_SH2_STAT5	618	621	PF00017	0.520
LIG_SH3_2	736	741	PF14604	0.609
LIG_SH3_3	240	246	PF00018	0.669
LIG_SH3_3	333	339	PF00018	0.762
LIG_SH3_3	346	352	PF00018	0.575
LIG_SH3_3	463	469	PF00018	0.682
LIG_SH3_3	609	615	PF00018	0.686
LIG_SH3_3	628	634	PF00018	0.671
LIG_SH3_3	656	662	PF00018	0.574
LIG_SH3_3	71	77	PF00018	0.750
LIG_SH3_3	733	739	PF00018	0.608
LIG_SH3_4	730	737	PF00018	0.610
LIG_SH3_5	207	211	PF00018	0.545
LIG_SH3_5	502	506	PF00018	0.731
LIG_UBA3_1	17	25	PF00899	0.524
LIG_WRC_WIRS_1	193	198	PF05994	0.554
LIG_WRC_WIRS_1	617	622	PF05994	0.612
MOD_CDK_SPxK_1	396	402	PF00069	0.636
MOD_CDK_SPxxK_3	435	442	PF00069	0.468
MOD_CK1_1	2	8	PF00069	0.519
MOD_CK1_1	205	211	PF00069	0.775
MOD_CK1_1	225	231	PF00069	0.368
MOD_CK1_1	24	30	PF00069	0.524
MOD_CK1_1	344	350	PF00069	0.666
MOD_CK1_1	356	362	PF00069	0.535
MOD_CK1_1	373	379	PF00069	0.449
MOD_CK1_1	555	561	PF00069	0.551
MOD_CK1_1	643	649	PF00069	0.556
MOD_CK1_1	702	708	PF00069	0.586
MOD_CK1_1	810	816	PF00069	0.614
MOD_CK2_1	107	113	PF00069	0.555
MOD_CK2_1	216	222	PF00069	0.530
MOD_CK2_1	272	278	PF00069	0.701
MOD_CK2_1	342	348	PF00069	0.541
MOD_CK2_1	582	588	PF00069	0.427
MOD_CK2_1	643	649	PF00069	0.556
MOD_CK2_1	80	86	PF00069	0.736
MOD_Cter_Amidation	597	600	PF01082	0.667
MOD_GlcNHglycan	1	4	PF01048	0.626
MOD_GlcNHglycan	204	207	PF01048	0.587
MOD_GlcNHglycan	222	227	PF01048	0.389
MOD_GlcNHglycan	270	273	PF01048	0.437
MOD_GlcNHglycan	344	347	PF01048	0.539
MOD_GlcNHglycan	559	562	PF01048	0.783
MOD_GlcNHglycan	607	610	PF01048	0.442
MOD_GlcNHglycan	722	725	PF01048	0.601
MOD_GlcNHglycan	751	754	PF01048	0.617
MOD_GlcNHglycan	817	820	PF01048	0.614
MOD_GSK3_1	221	228	PF00069	0.609
MOD_GSK3_1	268	275	PF00069	0.465
MOD_GSK3_1	318	325	PF00069	0.520
MOD_GSK3_1	806	813	PF00069	0.610
MOD_GSK3_1	828	835	PF00069	0.595
MOD_N-GLC_1	202	207	PF02516	0.554
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	18	23	PF00069	0.478
MOD_NEK2_1	341	346	PF00069	0.761
MOD_NEK2_1	41	46	PF00069	0.600
MOD_NEK2_1	448	453	PF00069	0.666
MOD_NEK2_1	616	621	PF00069	0.503
MOD_NEK2_1	626	631	PF00069	0.610
MOD_NEK2_2	192	197	PF00069	0.551
MOD_NEK2_2	714	719	PF00069	0.599
MOD_OFUCOSY	93	99	PF10250	0.726
MOD_PIKK_1	187	193	PF00454	0.626
MOD_PIKK_1	370	376	PF00454	0.552
MOD_PIKK_1	780	786	PF00454	0.617
MOD_PIKK_1	795	801	PF00454	0.561
MOD_PKA_2	187	193	PF00069	0.615
MOD_PKA_2	268	274	PF00069	0.437
MOD_PKA_2	353	359	PF00069	0.651
MOD_PKA_2	582	588	PF00069	0.427
MOD_PKA_2	61	67	PF00069	0.477
MOD_PKB_1	173	181	PF00069	0.745
MOD_Plk_1	643	649	PF00069	0.561
MOD_Plk_1	80	86	PF00069	0.736
MOD_Plk_2-3	552	558	PF00069	0.517
MOD_Plk_4	107	113	PF00069	0.678
MOD_Plk_4	210	216	PF00069	0.773
MOD_Plk_4	237	243	PF00069	0.645
MOD_Plk_4	24	30	PF00069	0.746
MOD_Plk_4	568	574	PF00069	0.525
MOD_Plk_4	61	67	PF00069	0.477
MOD_Plk_4	616	622	PF00069	0.609
MOD_Plk_4	828	834	PF00069	0.579
MOD_ProDKin_1	205	211	PF00069	0.775
MOD_ProDKin_1	27	33	PF00069	0.689
MOD_ProDKin_1	356	362	PF00069	0.529
MOD_ProDKin_1	396	402	PF00069	0.724
MOD_ProDKin_1	435	441	PF00069	0.466
MOD_ProDKin_1	611	617	PF00069	0.444
MOD_SUMO_for_1	546	549	PF00179	0.724
TRG_ENDOCYTIC_2	193	196	PF00928	0.780
TRG_ENDOCYTIC_2	211	214	PF00928	0.503
TRG_ENDOCYTIC_2	305	308	PF00928	0.700
TRG_ENDOCYTIC_2	403	406	PF00928	0.647
TRG_ENDOCYTIC_2	431	434	PF00928	0.698
TRG_ENDOCYTIC_2	494	497	PF00928	0.713
TRG_ENDOCYTIC_2	506	509	PF00928	0.552
TRG_ENDOCYTIC_2	789	792	PF00928	0.622
TRG_ENDOCYTIC_2	9	12	PF00928	0.517
TRG_ER_diArg_1	172	175	PF00400	0.725
TRG_ER_diArg_1	380	382	PF00400	0.667
TRG_ER_diArg_1	388	391	PF00400	0.629
TRG_ER_diArg_1	599	601	PF00400	0.649
TRG_ER_diArg_1	692	695	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.675
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.734
TRG_Pf-PMV_PEXEL_1	639	644	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	648	652	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBT9	Leishmania donovani	72%	100%
A4I0P7	Leishmania infantum	72%	100%
E9AWP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QAS4	Leishmania major	71%	100%