Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania braziliensis

UniProt:

A4HDB6_LEIBR

TriTrypDb:

LbrM.24.0590 , LBRM2903_240011600

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HDB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.415
CLV_C14_Caspase3-7	77	81	PF00656	0.383
CLV_NRD_NRD_1	18	20	PF00675	0.358
CLV_NRD_NRD_1	229	231	PF00675	0.565
CLV_NRD_NRD_1	65	67	PF00675	0.683
CLV_PCSK_KEX2_1	16	18	PF00082	0.375
CLV_PCSK_KEX2_1	228	230	PF00082	0.648
CLV_PCSK_KEX2_1	237	239	PF00082	0.667
CLV_PCSK_KEX2_1	65	67	PF00082	0.616
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.375
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.664
CLV_PCSK_PC7_1	12	18	PF00082	0.356
CLV_PCSK_SKI1_1	107	111	PF00082	0.479
CLV_PCSK_SKI1_1	19	23	PF00082	0.317
CLV_PCSK_SKI1_1	229	233	PF00082	0.582
CLV_PCSK_SKI1_1	300	304	PF00082	0.595
DEG_APCC_DBOX_1	228	236	PF00400	0.315
DEG_Nend_Nbox_1	1	3	PF02207	0.612
DOC_CYCLIN_yClb5_NLxxxL_5	107	113	PF00134	0.272
DOC_MAPK_FxFP_2	313	316	PF00069	0.484
DOC_MAPK_gen_1	16	26	PF00069	0.482
DOC_MAPK_gen_1	237	244	PF00069	0.312
DOC_MAPK_MEF2A_6	124	132	PF00069	0.347
DOC_MAPK_MEF2A_6	19	28	PF00069	0.485
DOC_MAPK_MEF2A_6	237	246	PF00069	0.312
DOC_PP2B_LxvP_1	244	247	PF13499	0.420
DOC_PP2B_LxvP_1	314	317	PF13499	0.489
DOC_PP4_FxxP_1	313	316	PF00568	0.484
DOC_USP7_MATH_1	162	166	PF00917	0.345
DOC_USP7_MATH_1	262	266	PF00917	0.416
DOC_USP7_UBL2_3	213	217	PF12436	0.365
DOC_WW_Pin1_4	190	195	PF00397	0.397
DOC_WW_Pin1_4	221	226	PF00397	0.427
DOC_WW_Pin1_4	230	235	PF00397	0.457
DOC_WW_Pin1_4	288	293	PF00397	0.391
DOC_WW_Pin1_4	40	45	PF00397	0.351
LIG_14-3-3_CanoR_1	17	22	PF00244	0.552
LIG_14-3-3_CanoR_1	300	306	PF00244	0.383
LIG_deltaCOP1_diTrp_1	172	180	PF00928	0.383
LIG_deltaCOP1_diTrp_1	67	75	PF00928	0.303
LIG_FHA_1	108	114	PF00498	0.415
LIG_FHA_1	153	159	PF00498	0.306
LIG_FHA_1	27	33	PF00498	0.310
LIG_FHA_1	301	307	PF00498	0.361
LIG_FHA_1	330	336	PF00498	0.490
LIG_FHA_1	48	54	PF00498	0.343
LIG_FHA_1	84	90	PF00498	0.324
LIG_FHA_2	100	106	PF00498	0.341
LIG_FHA_2	284	290	PF00498	0.412
LIG_GBD_Chelix_1	31	39	PF00786	0.237
LIG_LIR_Nem_3	273	278	PF02991	0.357
LIG_LIR_Nem_3	294	298	PF02991	0.415
LIG_LYPXL_S_1	314	318	PF13949	0.690
LIG_LYPXL_yS_3	315	318	PF13949	0.487
LIG_NRBOX	108	114	PF00104	0.289
LIG_NRBOX	181	187	PF00104	0.368
LIG_PTB_Apo_2	115	122	PF02174	0.316
LIG_PTB_Apo_2	51	58	PF02174	0.336
LIG_PTB_Phospho_1	115	121	PF10480	0.345
LIG_PTB_Phospho_1	51	57	PF10480	0.336
LIG_SH2_CRK	207	211	PF00017	0.323
LIG_SH2_CRK	321	325	PF00017	0.367
LIG_SH2_STAP1	121	125	PF00017	0.386
LIG_SH2_STAP1	154	158	PF00017	0.412
LIG_SH2_STAT5	154	157	PF00017	0.297
LIG_SH3_3	139	145	PF00018	0.384
LIG_SH3_3	342	348	PF00018	0.421
LIG_SUMO_SIM_anti_2	29	36	PF11976	0.273
LIG_SUMO_SIM_par_1	255	261	PF11976	0.343
LIG_SUMO_SIM_par_1	32	38	PF11976	0.298
LIG_UBA3_1	231	237	PF00899	0.298
MOD_CDK_SPxxK_3	221	228	PF00069	0.368
MOD_CDK_SPxxK_3	230	237	PF00069	0.289
MOD_CK1_1	119	125	PF00069	0.377
MOD_CK1_1	160	166	PF00069	0.371
MOD_CK1_1	211	217	PF00069	0.461
MOD_CK1_1	233	239	PF00069	0.410
MOD_CK1_1	265	271	PF00069	0.373
MOD_CK1_1	3	9	PF00069	0.613
MOD_CK1_1	47	53	PF00069	0.414
MOD_CK2_1	175	181	PF00069	0.346
MOD_CK2_1	221	227	PF00069	0.396
MOD_CK2_1	99	105	PF00069	0.353
MOD_CMANNOS	196	199	PF00535	0.522
MOD_Cter_Amidation	14	17	PF01082	0.352
MOD_GlcNHglycan	138	141	PF01048	0.617
MOD_GlcNHglycan	162	165	PF01048	0.532
MOD_GlcNHglycan	188	191	PF01048	0.602
MOD_GlcNHglycan	201	204	PF01048	0.531
MOD_GlcNHglycan	210	213	PF01048	0.619
MOD_GlcNHglycan	239	242	PF01048	0.573
MOD_GlcNHglycan	260	263	PF01048	0.605
MOD_GlcNHglycan	264	267	PF01048	0.548
MOD_GSK3_1	116	123	PF00069	0.396
MOD_GSK3_1	186	193	PF00069	0.383
MOD_GSK3_1	219	226	PF00069	0.442
MOD_GSK3_1	233	240	PF00069	0.301
MOD_GSK3_1	258	265	PF00069	0.419
MOD_GSK3_1	270	277	PF00069	0.415
MOD_GSK3_1	40	47	PF00069	0.360
MOD_N-GLC_1	107	112	PF02516	0.640
MOD_N-GLC_1	119	124	PF02516	0.520
MOD_N-GLC_1	136	141	PF02516	0.602
MOD_N-GLC_1	160	165	PF02516	0.643
MOD_N-GLC_1	329	334	PF02516	0.577
MOD_NEK2_1	116	121	PF00069	0.331
MOD_NEK2_1	184	189	PF00069	0.380
MOD_NEK2_1	270	275	PF00069	0.374
MOD_NEK2_1	298	303	PF00069	0.469
MOD_NEK2_1	306	311	PF00069	0.471
MOD_NEK2_2	60	65	PF00069	0.334
MOD_PK_1	17	23	PF00069	0.405
MOD_PKA_1	17	23	PF00069	0.405
MOD_PKA_1	237	243	PF00069	0.315
MOD_PKA_2	17	23	PF00069	0.429
MOD_PKA_2	237	243	PF00069	0.315
MOD_PKB_1	281	289	PF00069	0.391
MOD_Plk_1	107	113	PF00069	0.427
MOD_Plk_1	136	142	PF00069	0.411
MOD_Plk_1	329	335	PF00069	0.377
MOD_Plk_1	47	53	PF00069	0.440
MOD_Plk_4	211	217	PF00069	0.411
MOD_Plk_4	255	261	PF00069	0.514
MOD_Plk_4	265	271	PF00069	0.385
MOD_Plk_4	27	33	PF00069	0.347
MOD_Plk_4	274	280	PF00069	0.343
MOD_Plk_4	301	307	PF00069	0.361
MOD_Plk_4	35	41	PF00069	0.350
MOD_Plk_4	78	84	PF00069	0.481
MOD_ProDKin_1	190	196	PF00069	0.391
MOD_ProDKin_1	221	227	PF00069	0.430
MOD_ProDKin_1	230	236	PF00069	0.454
MOD_ProDKin_1	288	294	PF00069	0.388
MOD_ProDKin_1	40	46	PF00069	0.351
TRG_DiLeu_BaEn_1	181	186	PF01217	0.364
TRG_DiLeu_BaEn_1	227	232	PF01217	0.347
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.304
TRG_DiLeu_LyEn_5	227	232	PF01217	0.347
TRG_ENDOCYTIC_2	207	210	PF00928	0.314
TRG_ENDOCYTIC_2	315	318	PF00928	0.487
TRG_ENDOCYTIC_2	321	324	PF00928	0.468
TRG_ER_diArg_1	17	19	PF00400	0.569
TRG_ER_diArg_1	228	230	PF00400	0.452
TRG_ER_diArg_1	281	284	PF00400	0.390
TRG_ER_diArg_1	64	66	PF00400	0.351
TRG_ER_diArg_1	93	96	PF00400	0.314
TRG_NES_CRM1_1	340	352	PF08389	0.371
TRG_NES_CRM1_1	91	103	PF08389	0.295
TRG_NLS_MonoCore_2	15	20	PF00514	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9U7	Leptomonas seymouri	40%	98%
A0A1X0NJ17	Trypanosomatidae	26%	100%
A0A3S7WY91	Leishmania donovani	59%	99%
A4I0P6	Leishmania infantum	59%	99%
E9AWP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	99%
Q4QAS5	Leishmania major	59%	100%