LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HDB5_LEIBR
TriTrypDb:
LbrM.24.0580 , LBRM2903_240011500
Length:
88

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HDB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDB5

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_Nend_UBRbox_1 1 4 PF02207 0.333
DEG_SPOP_SBC_1 11 15 PF00917 0.231
DOC_MAPK_MEF2A_6 2 9 PF00069 0.303
DOC_MAPK_NFAT4_5 2 10 PF00069 0.300
DOC_WW_Pin1_4 69 74 PF00397 0.566
LIG_FHA_1 11 17 PF00498 0.405
LIG_LIR_Gen_1 4 12 PF02991 0.400
LIG_LIR_LC3C_4 47 51 PF02991 0.543
LIG_LIR_Nem_3 14 20 PF02991 0.280
LIG_LIR_Nem_3 4 9 PF02991 0.492
LIG_SH2_STAT5 84 87 PF00017 0.562
LIG_SUMO_SIM_anti_2 47 55 PF11976 0.534
MOD_GlcNHglycan 29 32 PF01048 0.231
MOD_GlcNHglycan 63 66 PF01048 0.410
MOD_GSK3_1 80 87 PF00069 0.634
MOD_N-GLC_1 67 72 PF02516 0.510
MOD_N-GLC_2 74 76 PF02516 0.371
MOD_Plk_4 12 18 PF00069 0.324
MOD_Plk_4 80 86 PF00069 0.580
MOD_ProDKin_1 69 75 PF00069 0.568

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZK7 Leptomonas seymouri 41% 96%
A0A3S7WY55 Leishmania donovani 65% 96%
E9ACS8 Leishmania major 64% 100%
E9AH56 Leishmania infantum 67% 96%
E9AWP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS