LeishMANIAdb
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WW domain binding protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
WW domain binding protein 1
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HDB4_LEIBR
TriTrypDb:
LbrM.24.0570 , LBRM2903_240011400
Length:
130

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HDB4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDB4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.535
CLV_NRD_NRD_1 127 129 PF00675 0.409
CLV_NRD_NRD_1 73 75 PF00675 0.478
CLV_NRD_NRD_1 90 92 PF00675 0.361
CLV_PCSK_FUR_1 71 75 PF00082 0.497
CLV_PCSK_KEX2_1 127 129 PF00082 0.409
CLV_PCSK_KEX2_1 73 75 PF00082 0.478
CLV_PCSK_KEX2_1 90 92 PF00082 0.361
CLV_PCSK_SKI1_1 73 77 PF00082 0.410
DOC_USP7_MATH_1 21 25 PF00917 0.468
DOC_WW_Pin1_4 32 37 PF00397 0.545
LIG_14-3-3_CanoR_1 14 21 PF00244 0.466
LIG_APCC_ABBA_1 67 72 PF00400 0.600
LIG_BIR_II_1 1 5 PF00653 0.460
LIG_FHA_2 1 7 PF00498 0.566
LIG_FHA_2 14 20 PF00498 0.383
LIG_GBD_Chelix_1 51 59 PF00786 0.299
LIG_LIR_Nem_3 122 126 PF02991 0.604
LIG_LIR_Nem_3 40 45 PF02991 0.484
LIG_LYPXL_yS_3 123 126 PF13949 0.600
LIG_SH2_CRK 42 46 PF00017 0.524
LIG_SH2_STAP1 37 41 PF00017 0.553
LIG_SH2_STAT5 15 18 PF00017 0.460
LIG_SH2_STAT5 42 45 PF00017 0.448
LIG_SH3_3 101 107 PF00018 0.804
MOD_CK2_1 32 38 PF00069 0.366
MOD_N-GLC_2 29 31 PF02516 0.664
MOD_NEK2_2 13 18 PF00069 0.468
MOD_PKA_2 13 19 PF00069 0.469
MOD_PKA_2 21 27 PF00069 0.464
MOD_Plk_1 112 118 PF00069 0.639
MOD_ProDKin_1 32 38 PF00069 0.546
TRG_DiLeu_BaEn_4 97 103 PF01217 0.627
TRG_DiLeu_BaLyEn_6 77 82 PF01217 0.549
TRG_ENDOCYTIC_2 123 126 PF00928 0.600
TRG_ENDOCYTIC_2 42 45 PF00928 0.531
TRG_ENDOCYTIC_2 79 82 PF00928 0.620
TRG_ER_diArg_1 126 128 PF00400 0.610
TRG_Pf-PMV_PEXEL_1 80 85 PF00026 0.522

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9I9 Leptomonas seymouri 48% 100%
A0A3S7WY70 Leishmania donovani 69% 100%
E9ACS7 Leishmania major 70% 100%
E9AH55 Leishmania infantum 69% 100%
E9AWP6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS