SWR1-complex protein 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDB0_LEIBR

TriTrypDb:

LbrM.24.0540 , LBRM2903_240011100

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.683
CLV_C14_Caspase3-7	154	158	PF00656	0.712
CLV_NRD_NRD_1	107	109	PF00675	0.648
CLV_NRD_NRD_1	115	117	PF00675	0.557
CLV_NRD_NRD_1	175	177	PF00675	0.705
CLV_PCSK_KEX2_1	115	117	PF00082	0.558
CLV_PCSK_KEX2_1	175	177	PF00082	0.705
CLV_PCSK_KEX2_1	217	219	PF00082	0.547
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.736
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.565
CLV_PCSK_SKI1_1	186	190	PF00082	0.636
CLV_PCSK_SKI1_1	196	200	PF00082	0.602
CLV_PCSK_SKI1_1	218	222	PF00082	0.551
DEG_APCC_DBOX_1	217	225	PF00400	0.536
DEG_Nend_UBRbox_2	1	3	PF02207	0.797
DEG_SCF_TRCP1_1	157	163	PF00400	0.520
DOC_MAPK_gen_1	217	224	PF00069	0.559
DOC_PP1_RVXF_1	194	201	PF00149	0.567
DOC_PP2B_LxvP_1	143	146	PF13499	0.629
DOC_USP7_MATH_1	182	186	PF00917	0.668
DOC_WW_Pin1_4	147	152	PF00397	0.589
DOC_WW_Pin1_4	3	8	PF00397	0.718
DOC_WW_Pin1_4	64	69	PF00397	0.640
LIG_BRCT_BRCA1_1	196	200	PF00533	0.582
LIG_FHA_1	118	124	PF00498	0.684
LIG_FHA_1	148	154	PF00498	0.595
LIG_FHA_1	161	167	PF00498	0.590
LIG_FHA_2	125	131	PF00498	0.728
LIG_Integrin_RGD_1	116	118	PF01839	0.666
LIG_MYND_1	32	36	PF01753	0.681
LIG_PDZ_Class_1	226	231	PF00595	0.712
LIG_PROFILIN_1	10	16	PF00235	0.483
LIG_SH2_CRK	144	148	PF00017	0.495
LIG_SH2_CRK	21	25	PF00017	0.698
LIG_SH2_CRK	54	58	PF00017	0.437
LIG_SH2_STAT5	131	134	PF00017	0.685
LIG_SH3_3	11	17	PF00018	0.626
LIG_SH3_3	4	10	PF00018	0.711
LIG_TRAF2_1	203	206	PF00917	0.608
LIG_TRAF2_1	46	49	PF00917	0.466
LIG_TYR_ITIM	19	24	PF00017	0.708
LIG_UBA3_1	210	217	PF00899	0.648
LIG_WW_2	14	17	PF00397	0.482
MOD_CDK_SPK_2	147	152	PF00069	0.600
MOD_CDK_SPxxK_3	64	71	PF00069	0.647
MOD_CK1_1	194	200	PF00069	0.592
MOD_CK2_1	200	206	PF00069	0.713
MOD_GlcNHglycan	109	112	PF01048	0.537
MOD_GlcNHglycan	157	160	PF01048	0.666
MOD_GlcNHglycan	192	196	PF01048	0.575
MOD_GlcNHglycan	202	205	PF01048	0.664
MOD_GSK3_1	194	201	PF00069	0.663
MOD_NEK2_1	198	203	PF00069	0.631
MOD_NEK2_2	220	225	PF00069	0.421
MOD_PKA_2	107	113	PF00069	0.652
MOD_PKA_2	161	167	PF00069	0.733
MOD_Plk_1	124	130	PF00069	0.684
MOD_Plk_2-3	124	130	PF00069	0.674
MOD_Plk_4	194	200	PF00069	0.661
MOD_ProDKin_1	147	153	PF00069	0.586
MOD_ProDKin_1	3	9	PF00069	0.714
MOD_ProDKin_1	64	70	PF00069	0.641
TRG_DiLeu_BaEn_1	206	211	PF01217	0.653
TRG_ENDOCYTIC_2	144	147	PF00928	0.501
TRG_ENDOCYTIC_2	21	24	PF00928	0.705
TRG_ENDOCYTIC_2	54	57	PF00928	0.446
TRG_NES_CRM1_1	74	89	PF08389	0.491
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI0	Leptomonas seymouri	73%	100%
A0A1X0NIJ7	Trypanosomatidae	33%	89%
A0A3S7WY43	Leishmania donovani	82%	100%
A0A422P3Y6	Trypanosoma rangeli	36%	95%
A4I0P3	Leishmania infantum	82%	100%
D0A721	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	98%
E9AWP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAS8	Leishmania major	85%	100%