Putative DNAJ domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDA9_LEIBR

TriTrypDb:

LbrM.24.0530 , LBRM2903_240011000

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HDA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.377
CLV_C14_Caspase3-7	462	466	PF00656	0.359
CLV_C14_Caspase3-7	695	699	PF00656	0.563
CLV_NRD_NRD_1	133	135	PF00675	0.601
CLV_NRD_NRD_1	548	550	PF00675	0.534
CLV_NRD_NRD_1	579	581	PF00675	0.554
CLV_NRD_NRD_1	65	67	PF00675	0.549
CLV_NRD_NRD_1	673	675	PF00675	0.326
CLV_PCSK_FUR_1	546	550	PF00082	0.504
CLV_PCSK_KEX2_1	546	548	PF00082	0.534
CLV_PCSK_KEX2_1	555	557	PF00082	0.573
CLV_PCSK_KEX2_1	578	580	PF00082	0.554
CLV_PCSK_KEX2_1	65	67	PF00082	0.549
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.573
CLV_PCSK_SKI1_1	123	127	PF00082	0.439
CLV_PCSK_SKI1_1	210	214	PF00082	0.471
CLV_PCSK_SKI1_1	239	243	PF00082	0.496
CLV_PCSK_SKI1_1	39	43	PF00082	0.459
CLV_PCSK_SKI1_1	395	399	PF00082	0.486
CLV_PCSK_SKI1_1	594	598	PF00082	0.357
CLV_PCSK_SKI1_1	603	607	PF00082	0.291
CLV_PCSK_SKI1_1	623	627	PF00082	0.281
CLV_PCSK_SKI1_1	694	698	PF00082	0.414
CLV_PCSK_SKI1_1	74	78	PF00082	0.455
DEG_APCC_DBOX_1	209	217	PF00400	0.319
DEG_APCC_DBOX_1	73	81	PF00400	0.260
DEG_SPOP_SBC_1	414	418	PF00917	0.325
DOC_CKS1_1	277	282	PF01111	0.384
DOC_CYCLIN_yClb1_LxF_4	167	173	PF00134	0.219
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.276
DOC_CYCLIN_yCln2_LP_2	626	632	PF00134	0.588
DOC_MAPK_gen_1	132	142	PF00069	0.376
DOC_MAPK_gen_1	203	213	PF00069	0.310
DOC_MAPK_gen_1	499	506	PF00069	0.463
DOC_MAPK_gen_1	600	610	PF00069	0.517
DOC_MAPK_gen_1	71	80	PF00069	0.271
DOC_MAPK_MEF2A_6	206	213	PF00069	0.255
DOC_MAPK_MEF2A_6	499	506	PF00069	0.451
DOC_MAPK_MEF2A_6	603	610	PF00069	0.507
DOC_MAPK_NFAT4_5	603	611	PF00069	0.512
DOC_PP2B_LxvP_1	199	202	PF13499	0.401
DOC_PP2B_LxvP_1	619	622	PF13499	0.638
DOC_PP4_FxxP_1	512	515	PF00568	0.357
DOC_USP7_MATH_1	233	237	PF00917	0.281
DOC_USP7_MATH_1	297	301	PF00917	0.450
DOC_USP7_MATH_1	302	306	PF00917	0.389
DOC_USP7_MATH_1	414	418	PF00917	0.475
DOC_USP7_MATH_1	476	480	PF00917	0.427
DOC_USP7_MATH_1	484	488	PF00917	0.449
DOC_USP7_MATH_1	515	519	PF00917	0.355
DOC_USP7_MATH_1	567	571	PF00917	0.641
DOC_USP7_MATH_1	615	619	PF00917	0.559
DOC_USP7_MATH_1	664	668	PF00917	0.696
DOC_USP7_UBL2_3	675	679	PF12436	0.540
DOC_WW_Pin1_4	276	281	PF00397	0.348
DOC_WW_Pin1_4	298	303	PF00397	0.456
DOC_WW_Pin1_4	46	51	PF00397	0.374
DOC_WW_Pin1_4	52	57	PF00397	0.349
LIG_14-3-3_CanoR_1	200	209	PF00244	0.357
LIG_14-3-3_CanoR_1	666	671	PF00244	0.623
LIG_14-3-3_CanoR_1	90	100	PF00244	0.344
LIG_AP2alpha_1	177	181	PF02296	0.330
LIG_APCC_ABBA_1	78	83	PF00400	0.264
LIG_BIR_II_1	1	5	PF00653	0.246
LIG_BRCT_BRCA1_1	48	52	PF00533	0.415
LIG_BRCT_BRCA1_2	48	54	PF00533	0.420
LIG_Clathr_ClatBox_1	607	611	PF01394	0.550
LIG_CtBP_PxDLS_1	442	446	PF00389	0.373
LIG_deltaCOP1_diTrp_1	595	605	PF00928	0.615
LIG_EVH1_1	277	281	PF00568	0.458
LIG_FAT_LD_1	192	200	PF03623	0.243
LIG_FHA_1	145	151	PF00498	0.300
LIG_FHA_1	182	188	PF00498	0.391
LIG_FHA_1	272	278	PF00498	0.372
LIG_FHA_1	344	350	PF00498	0.384
LIG_FHA_1	400	406	PF00498	0.402
LIG_FHA_1	629	635	PF00498	0.581
LIG_FHA_1	684	690	PF00498	0.599
LIG_FHA_2	188	194	PF00498	0.418
LIG_FHA_2	35	41	PF00498	0.362
LIG_FHA_2	407	413	PF00498	0.395
LIG_FHA_2	444	450	PF00498	0.412
LIG_FHA_2	92	98	PF00498	0.270
LIG_LIR_Apic_2	511	515	PF02991	0.410
LIG_LIR_Gen_1	163	174	PF02991	0.252
LIG_LIR_Gen_1	247	256	PF02991	0.405
LIG_LIR_Gen_1	268	277	PF02991	0.313
LIG_LIR_Gen_1	346	354	PF02991	0.385
LIG_LIR_Gen_1	379	387	PF02991	0.366
LIG_LIR_Gen_1	429	439	PF02991	0.454
LIG_LIR_Gen_1	449	458	PF02991	0.217
LIG_LIR_Gen_1	602	610	PF02991	0.593
LIG_LIR_Gen_1	93	104	PF02991	0.341
LIG_LIR_Nem_3	146	151	PF02991	0.372
LIG_LIR_Nem_3	163	169	PF02991	0.248
LIG_LIR_Nem_3	175	181	PF02991	0.308
LIG_LIR_Nem_3	268	272	PF02991	0.298
LIG_LIR_Nem_3	346	351	PF02991	0.340
LIG_LIR_Nem_3	379	383	PF02991	0.321
LIG_LIR_Nem_3	40	45	PF02991	0.321
LIG_LIR_Nem_3	429	435	PF02991	0.380
LIG_LIR_Nem_3	449	454	PF02991	0.204
LIG_LIR_Nem_3	518	524	PF02991	0.348
LIG_LIR_Nem_3	602	608	PF02991	0.594
LIG_LIR_Nem_3	79	84	PF02991	0.308
LIG_NRBOX	191	197	PF00104	0.251
LIG_NRBOX	692	698	PF00104	0.557
LIG_Pex14_1	96	100	PF04695	0.376
LIG_Pex14_2	172	176	PF04695	0.262
LIG_Pex14_2	177	181	PF04695	0.276
LIG_SH2_CRK	229	233	PF00017	0.261
LIG_SH2_CRK	432	436	PF00017	0.453
LIG_SH2_CRK	451	455	PF00017	0.245
LIG_SH2_NCK_1	229	233	PF00017	0.383
LIG_SH2_NCK_1	319	323	PF00017	0.249
LIG_SH2_NCK_1	81	85	PF00017	0.330
LIG_SH2_PTP2	503	506	PF00017	0.249
LIG_SH2_SRC	20	23	PF00017	0.397
LIG_SH2_SRC	527	530	PF00017	0.393
LIG_SH2_SRC	81	84	PF00017	0.318
LIG_SH2_STAP1	510	514	PF00017	0.410
LIG_SH2_STAP1	92	96	PF00017	0.376
LIG_SH2_STAT3	44	47	PF00017	0.336
LIG_SH2_STAT5	138	141	PF00017	0.368
LIG_SH2_STAT5	249	252	PF00017	0.314
LIG_SH2_STAT5	380	383	PF00017	0.316
LIG_SH2_STAT5	503	506	PF00017	0.330
LIG_SH2_STAT5	510	513	PF00017	0.320
LIG_SH2_STAT5	527	530	PF00017	0.331
LIG_SH3_1	587	593	PF00018	0.658
LIG_SH3_3	208	214	PF00018	0.273
LIG_SH3_3	261	267	PF00018	0.306
LIG_SH3_3	275	281	PF00018	0.406
LIG_SH3_3	436	442	PF00018	0.398
LIG_SH3_3	470	476	PF00018	0.516
LIG_SH3_3	587	593	PF00018	0.658
LIG_SH3_3	648	654	PF00018	0.643
LIG_SUMO_SIM_anti_2	667	672	PF11976	0.540
LIG_SUMO_SIM_par_1	138	144	PF11976	0.318
LIG_SUMO_SIM_par_1	605	612	PF11976	0.556
LIG_SUMO_SIM_par_1	76	83	PF11976	0.203
LIG_TRAF2_1	441	444	PF00917	0.384
LIG_TRAF2_1	460	463	PF00917	0.325
LIG_TRAF2_1	540	543	PF00917	0.701
LIG_TRAF2_1	599	602	PF00917	0.611
LIG_TRAF2_1	657	660	PF00917	0.636
LIG_TYR_ITIM	430	435	PF00017	0.339
LIG_UBA3_1	670	675	PF00899	0.606
LIG_WRC_WIRS_1	173	178	PF05994	0.324
LIG_WRC_WIRS_1	195	200	PF05994	0.349
LIG_WRC_WIRS_1	380	385	PF05994	0.386
LIG_WRC_WIRS_1	509	514	PF05994	0.424
LIG_WRC_WIRS_1	689	694	PF05994	0.454
MOD_CDK_SPxK_1	298	304	PF00069	0.451
MOD_CK1_1	508	514	PF00069	0.277
MOD_CK1_1	570	576	PF00069	0.708
MOD_CK2_1	149	155	PF00069	0.433
MOD_CK2_1	182	188	PF00069	0.350
MOD_CK2_1	457	463	PF00069	0.417
MOD_CK2_1	91	97	PF00069	0.286
MOD_CMANNOS	642	645	PF00535	0.336
MOD_Cter_Amidation	13	16	PF01082	0.473
MOD_Cter_Amidation	552	555	PF01082	0.353
MOD_GlcNHglycan	21	25	PF01048	0.657
MOD_GlcNHglycan	417	420	PF01048	0.619
MOD_GlcNHglycan	496	499	PF01048	0.550
MOD_GlcNHglycan	557	562	PF01048	0.427
MOD_GlcNHglycan	567	570	PF01048	0.495
MOD_GlcNHglycan	572	575	PF01048	0.478
MOD_GlcNHglycan	611	616	PF01048	0.525
MOD_GSK3_1	183	190	PF00069	0.389
MOD_GSK3_1	285	292	PF00069	0.410
MOD_GSK3_1	298	305	PF00069	0.415
MOD_GSK3_1	46	53	PF00069	0.361
MOD_GSK3_1	484	491	PF00069	0.330
MOD_GSK3_1	611	618	PF00069	0.608
MOD_GSK3_1	681	688	PF00069	0.551
MOD_GSK3_1	697	704	PF00069	0.496
MOD_GSK3_1	91	98	PF00069	0.301
MOD_N-GLC_1	426	431	PF02516	0.575
MOD_NEK2_1	172	177	PF00069	0.309
MOD_NEK2_1	181	186	PF00069	0.325
MOD_NEK2_1	187	192	PF00069	0.308
MOD_NEK2_1	260	265	PF00069	0.442
MOD_NEK2_1	325	330	PF00069	0.331
MOD_NEK2_1	697	702	PF00069	0.635
MOD_NEK2_1	99	104	PF00069	0.302
MOD_NEK2_2	302	307	PF00069	0.414
MOD_NEK2_2	95	100	PF00069	0.254
MOD_PIKK_1	187	193	PF00454	0.419
MOD_PIKK_1	683	689	PF00454	0.455
MOD_PKA_2	202	208	PF00069	0.275
MOD_PKA_2	673	679	PF00069	0.590
MOD_Plk_1	187	193	PF00069	0.374
MOD_Plk_1	391	397	PF00069	0.394
MOD_Plk_1	426	432	PF00069	0.376
MOD_Plk_1	443	449	PF00069	0.413
MOD_Plk_1	664	670	PF00069	0.488
MOD_Plk_2-3	289	295	PF00069	0.368
MOD_Plk_2-3	443	449	PF00069	0.339
MOD_Plk_2-3	685	691	PF00069	0.530
MOD_Plk_4	172	178	PF00069	0.348
MOD_Plk_4	194	200	PF00069	0.399
MOD_Plk_4	452	458	PF00069	0.380
MOD_Plk_4	484	490	PF00069	0.363
MOD_Plk_4	505	511	PF00069	0.271
MOD_Plk_4	688	694	PF00069	0.462
MOD_Plk_4	95	101	PF00069	0.298
MOD_ProDKin_1	276	282	PF00069	0.357
MOD_ProDKin_1	298	304	PF00069	0.451
MOD_ProDKin_1	46	52	PF00069	0.377
MOD_SUMO_for_1	390	393	PF00179	0.240
MOD_SUMO_for_1	599	602	PF00179	0.613
MOD_SUMO_rev_2	595	605	PF00179	0.565
MOD_SUMO_rev_2	644	652	PF00179	0.552
TRG_DiLeu_BaEn_1	602	607	PF01217	0.598
TRG_DiLeu_BaEn_2	600	606	PF01217	0.612
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.232
TRG_ENDOCYTIC_2	178	181	PF00928	0.311
TRG_ENDOCYTIC_2	229	232	PF00928	0.307
TRG_ENDOCYTIC_2	249	252	PF00928	0.395
TRG_ENDOCYTIC_2	380	383	PF00928	0.296
TRG_ENDOCYTIC_2	387	390	PF00928	0.268
TRG_ENDOCYTIC_2	432	435	PF00928	0.387
TRG_ENDOCYTIC_2	451	454	PF00928	0.394
TRG_ENDOCYTIC_2	503	506	PF00928	0.250
TRG_ENDOCYTIC_2	8	11	PF00928	0.311
TRG_ENDOCYTIC_2	81	84	PF00928	0.299
TRG_ER_diArg_1	533	536	PF00400	0.569
TRG_ER_diArg_1	546	549	PF00400	0.552
TRG_ER_diArg_1	577	580	PF00400	0.753
TRG_ER_diArg_1	64	66	PF00400	0.349
TRG_NES_CRM1_1	428	443	PF08389	0.247
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	694	698	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW3	Leptomonas seymouri	65%	89%
A0A1X0NIM6	Trypanosomatidae	34%	92%
A0A3Q8IB91	Leishmania donovani	82%	90%
A0A422P3X6	Trypanosoma rangeli	36%	94%
A4I0P2	Leishmania infantum	82%	90%
D0A720	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	93%
E9AWP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	90%
Q4QAS9	Leishmania major	82%	100%
V5DSK9	Trypanosoma cruzi	36%	100%