Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDA8_LEIBR

TriTrypDb:

LbrM.24.0520 , LBRM2903_240010900

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.537
CLV_C14_Caspase3-7	441	445	PF00656	0.525
CLV_C14_Caspase3-7	693	697	PF00656	0.508
CLV_C14_Caspase3-7	728	732	PF00656	0.558
CLV_NRD_NRD_1	143	145	PF00675	0.392
CLV_PCSK_KEX2_1	143	145	PF00082	0.392
CLV_PCSK_SKI1_1	143	147	PF00082	0.542
CLV_PCSK_SKI1_1	53	57	PF00082	0.457
CLV_PCSK_SKI1_1	630	634	PF00082	0.531
CLV_PCSK_SKI1_1	698	702	PF00082	0.479
DEG_APCC_DBOX_1	188	196	PF00400	0.621
DEG_APCC_DBOX_1	772	780	PF00400	0.402
DEG_Nend_UBRbox_2	1	3	PF02207	0.665
DOC_CYCLIN_RxL_1	627	637	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.411
DOC_MAPK_gen_1	716	725	PF00069	0.407
DOC_PP1_RVXF_1	239	245	PF00149	0.418
DOC_PP2B_LxvP_1	292	295	PF13499	0.615
DOC_PP2B_LxvP_1	369	372	PF13499	0.516
DOC_PP2B_LxvP_1	392	395	PF13499	0.542
DOC_PP2B_LxvP_1	717	720	PF13499	0.498
DOC_PP4_FxxP_1	308	311	PF00568	0.596
DOC_USP7_MATH_1	164	168	PF00917	0.583
DOC_USP7_MATH_1	204	208	PF00917	0.616
DOC_USP7_MATH_1	214	218	PF00917	0.641
DOC_USP7_MATH_1	220	224	PF00917	0.482
DOC_USP7_MATH_1	321	325	PF00917	0.512
DOC_USP7_MATH_1	36	40	PF00917	0.497
DOC_USP7_MATH_1	506	510	PF00917	0.514
DOC_USP7_MATH_1	690	694	PF00917	0.584
DOC_USP7_UBL2_3	49	53	PF12436	0.455
DOC_WW_Pin1_4	202	207	PF00397	0.514
DOC_WW_Pin1_4	307	312	PF00397	0.594
DOC_WW_Pin1_4	637	642	PF00397	0.609
DOC_WW_Pin1_4	672	677	PF00397	0.457
LIG_14-3-3_CanoR_1	291	295	PF00244	0.588
LIG_14-3-3_CanoR_1	30	37	PF00244	0.460
LIG_14-3-3_CanoR_1	411	416	PF00244	0.459
LIG_14-3-3_CanoR_1	609	616	PF00244	0.590
LIG_14-3-3_CanoR_1	752	756	PF00244	0.456
LIG_APCC_ABBAyCdc20_2	742	748	PF00400	0.388
LIG_BIR_III_4	659	663	PF00653	0.506
LIG_BRCT_BRCA1_1	674	678	PF00533	0.543
LIG_BRCT_BRCA1_1	720	724	PF00533	0.573
LIG_Clathr_ClatBox_1	114	118	PF01394	0.467
LIG_deltaCOP1_diTrp_1	237	244	PF00928	0.570
LIG_deltaCOP1_diTrp_1	417	422	PF00928	0.502
LIG_FHA_1	137	143	PF00498	0.463
LIG_FHA_1	226	232	PF00498	0.516
LIG_FHA_1	255	261	PF00498	0.405
LIG_FHA_1	338	344	PF00498	0.676
LIG_FHA_1	50	56	PF00498	0.453
LIG_FHA_1	645	651	PF00498	0.734
LIG_FHA_1	669	675	PF00498	0.492
LIG_FHA_1	764	770	PF00498	0.509
LIG_FHA_2	144	150	PF00498	0.466
LIG_FHA_2	268	274	PF00498	0.531
LIG_FHA_2	294	300	PF00498	0.567
LIG_FHA_2	30	36	PF00498	0.548
LIG_FHA_2	435	441	PF00498	0.509
LIG_LIR_Apic_2	284	290	PF02991	0.661
LIG_LIR_Apic_2	305	311	PF02991	0.511
LIG_LIR_Gen_1	34	45	PF02991	0.492
LIG_LIR_Gen_1	498	507	PF02991	0.455
LIG_LIR_Gen_1	675	683	PF02991	0.551
LIG_LIR_Nem_3	34	40	PF02991	0.508
LIG_LIR_Nem_3	498	503	PF02991	0.446
LIG_LIR_Nem_3	675	681	PF02991	0.521
LIG_MLH1_MIPbox_1	674	678	PF16413	0.471
LIG_NRBOX	151	157	PF00104	0.480
LIG_NRBOX	170	176	PF00104	0.500
LIG_PCNA_PIPBox_1	362	371	PF02747	0.472
LIG_Pex14_1	412	416	PF04695	0.370
LIG_Pex14_2	141	145	PF04695	0.470
LIG_SH2_STAP1	482	486	PF00017	0.471
LIG_SH2_STAT5	482	485	PF00017	0.386
LIG_SH3_3	2	8	PF00018	0.505
LIG_SUMO_SIM_anti_2	768	775	PF11976	0.525
LIG_SUMO_SIM_par_1	346	351	PF11976	0.501
LIG_SUMO_SIM_par_1	647	656	PF11976	0.621
LIG_TRAF2_1	234	237	PF00917	0.402
LIG_TRAF2_1	269	272	PF00917	0.689
LIG_TRAF2_1	32	35	PF00917	0.505
LIG_TRAF2_1	466	469	PF00917	0.408
LIG_TRAF2_1	754	757	PF00917	0.496
LIG_TRAF2_1	778	781	PF00917	0.579
LIG_UBA3_1	152	158	PF00899	0.394
LIG_WRC_WIRS_1	195	200	PF05994	0.664
MOD_CK1_1	293	299	PF00069	0.521
MOD_CK1_1	312	318	PF00069	0.619
MOD_CK1_1	324	330	PF00069	0.553
MOD_CK1_1	337	343	PF00069	0.487
MOD_CK1_1	508	514	PF00069	0.430
MOD_CK1_1	515	521	PF00069	0.554
MOD_CK1_1	586	592	PF00069	0.603
MOD_CK1_1	596	602	PF00069	0.611
MOD_CK1_1	672	678	PF00069	0.544
MOD_CK2_1	164	170	PF00069	0.561
MOD_CK2_1	266	272	PF00069	0.650
MOD_CK2_1	29	35	PF00069	0.551
MOD_CK2_1	293	299	PF00069	0.564
MOD_CK2_1	401	407	PF00069	0.394
MOD_CK2_1	411	417	PF00069	0.457
MOD_CK2_1	434	440	PF00069	0.404
MOD_CK2_1	463	469	PF00069	0.446
MOD_CK2_1	751	757	PF00069	0.441
MOD_CK2_1	775	781	PF00069	0.558
MOD_CMANNOS	419	422	PF00535	0.520
MOD_GlcNHglycan	111	114	PF01048	0.623
MOD_GlcNHglycan	129	132	PF01048	0.400
MOD_GlcNHglycan	166	169	PF01048	0.535
MOD_GlcNHglycan	206	209	PF01048	0.613
MOD_GlcNHglycan	222	225	PF01048	0.461
MOD_GlcNHglycan	27	30	PF01048	0.493
MOD_GlcNHglycan	595	598	PF01048	0.691
MOD_GlcNHglycan	634	637	PF01048	0.510
MOD_GlcNHglycan	664	668	PF01048	0.525
MOD_GSK3_1	160	167	PF00069	0.573
MOD_GSK3_1	194	201	PF00069	0.608
MOD_GSK3_1	204	211	PF00069	0.569
MOD_GSK3_1	216	223	PF00069	0.711
MOD_GSK3_1	225	232	PF00069	0.453
MOD_GSK3_1	25	32	PF00069	0.613
MOD_GSK3_1	262	269	PF00069	0.609
MOD_GSK3_1	309	316	PF00069	0.665
MOD_GSK3_1	319	326	PF00069	0.568
MOD_GSK3_1	401	408	PF00069	0.468
MOD_GSK3_1	426	433	PF00069	0.423
MOD_GSK3_1	434	441	PF00069	0.469
MOD_GSK3_1	480	487	PF00069	0.490
MOD_GSK3_1	49	56	PF00069	0.454
MOD_GSK3_1	501	508	PF00069	0.478
MOD_GSK3_1	512	519	PF00069	0.483
MOD_GSK3_1	592	599	PF00069	0.597
MOD_GSK3_1	628	635	PF00069	0.501
MOD_GSK3_1	668	675	PF00069	0.648
MOD_GSK3_1	763	770	PF00069	0.564
MOD_GSK3_1	77	84	PF00069	0.369
MOD_GSK3_1	771	778	PF00069	0.461
MOD_N-GLC_1	224	229	PF02516	0.458
MOD_N-GLC_1	30	35	PF02516	0.469
MOD_NEK2_1	198	203	PF00069	0.576
MOD_NEK2_1	210	215	PF00069	0.647
MOD_NEK2_1	313	318	PF00069	0.509
MOD_NEK2_1	401	406	PF00069	0.476
MOD_NEK2_1	546	551	PF00069	0.555
MOD_NEK2_1	592	597	PF00069	0.529
MOD_NEK2_1	632	637	PF00069	0.586
MOD_NEK2_1	669	674	PF00069	0.627
MOD_NEK2_1	677	682	PF00069	0.436
MOD_NEK2_1	701	706	PF00069	0.423
MOD_NEK2_1	77	82	PF00069	0.371
MOD_NEK2_2	36	41	PF00069	0.494
MOD_PIKK_1	102	108	PF00454	0.388
MOD_PIKK_1	254	260	PF00454	0.559
MOD_PIKK_1	267	273	PF00454	0.536
MOD_PIKK_1	405	411	PF00454	0.434
MOD_PIKK_1	426	432	PF00454	0.553
MOD_PIKK_1	60	66	PF00454	0.474
MOD_PIKK_1	603	609	PF00454	0.567
MOD_PIKK_1	81	87	PF00454	0.639
MOD_PK_1	512	518	PF00069	0.382
MOD_PKA_1	143	149	PF00069	0.393
MOD_PKA_2	102	108	PF00069	0.455
MOD_PKA_2	143	149	PF00069	0.387
MOD_PKA_2	29	35	PF00069	0.528
MOD_PKA_2	290	296	PF00069	0.584
MOD_PKA_2	496	502	PF00069	0.457
MOD_PKA_2	608	614	PF00069	0.670
MOD_PKA_2	741	747	PF00069	0.494
MOD_PKA_2	751	757	PF00069	0.448
MOD_PKB_1	716	724	PF00069	0.405
MOD_Plk_1	512	518	PF00069	0.539
MOD_Plk_1	53	59	PF00069	0.458
MOD_Plk_1	767	773	PF00069	0.518
MOD_Plk_2-3	300	306	PF00069	0.512
MOD_Plk_2-3	652	658	PF00069	0.476
MOD_Plk_2-3	775	781	PF00069	0.425
MOD_Plk_4	309	315	PF00069	0.566
MOD_Plk_4	411	417	PF00069	0.370
MOD_Plk_4	512	518	PF00069	0.477
MOD_Plk_4	677	683	PF00069	0.456
MOD_ProDKin_1	202	208	PF00069	0.516
MOD_ProDKin_1	307	313	PF00069	0.594
MOD_ProDKin_1	637	643	PF00069	0.609
MOD_ProDKin_1	672	678	PF00069	0.457
MOD_SUMO_rev_2	693	700	PF00179	0.498
TRG_DiLeu_BaEn_1	170	175	PF01217	0.578
TRG_DiLeu_BaEn_3	756	762	PF01217	0.366
TRG_DiLeu_BaEn_4	469	475	PF01217	0.387
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.410
TRG_DiLeu_LyEn_5	170	175	PF01217	0.578
TRG_ER_diArg_1	142	144	PF00400	0.391
TRG_ER_diArg_1	550	553	PF00400	0.513
TRG_ER_diArg_1	716	719	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	491	496	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	630	634	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L7	Leptomonas seymouri	34%	100%
A0A3Q8ICS5	Leishmania donovani	71%	100%
A4I0P1	Leishmania infantum	71%	100%
E9AWP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QAT0	Leishmania major	69%	99%