Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDA7_LEIBR

TriTrypDb:

LbrM.24.0510 , LBRM2903_240010800

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.705
CLV_C14_Caspase3-7	65	69	PF00656	0.509
CLV_NRD_NRD_1	17	19	PF00675	0.495
CLV_NRD_NRD_1	173	175	PF00675	0.747
CLV_NRD_NRD_1	184	186	PF00675	0.723
CLV_NRD_NRD_1	211	213	PF00675	0.574
CLV_NRD_NRD_1	223	225	PF00675	0.507
CLV_NRD_NRD_1	24	26	PF00675	0.480
CLV_NRD_NRD_1	90	92	PF00675	0.623
CLV_PCSK_FUR_1	182	186	PF00082	0.646
CLV_PCSK_KEX2_1	173	175	PF00082	0.748
CLV_PCSK_KEX2_1	184	186	PF00082	0.682
CLV_PCSK_KEX2_1	211	213	PF00082	0.609
CLV_PCSK_KEX2_1	221	223	PF00082	0.504
CLV_PCSK_KEX2_1	225	227	PF00082	0.492
CLV_PCSK_KEX2_1	23	25	PF00082	0.478
CLV_PCSK_KEX2_1	90	92	PF00082	0.623
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.547
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.558
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.478
CLV_PCSK_SKI1_1	11	15	PF00082	0.544
CLV_PCSK_SKI1_1	25	29	PF00082	0.535
CLV_PCSK_SKI1_1	38	42	PF00082	0.580
CLV_PCSK_SKI1_1	91	95	PF00082	0.629
CLV_Separin_Metazoa	8	12	PF03568	0.545
DEG_Nend_UBRbox_2	1	3	PF02207	0.528
DOC_CYCLIN_RxL_1	33	45	PF00134	0.668
DOC_SPAK_OSR1_1	197	201	PF12202	0.619
DOC_USP7_MATH_1	120	124	PF00917	0.722
DOC_USP7_UBL2_3	19	23	PF12436	0.492
DOC_USP7_UBL2_3	221	225	PF12436	0.646
LIG_14-3-3_CanoR_1	226	235	PF00244	0.463
LIG_14-3-3_CanoR_1	52	59	PF00244	0.526
LIG_14-3-3_CanoR_1	72	76	PF00244	0.582
LIG_14-3-3_CanoR_1	90	94	PF00244	0.592
LIG_Actin_WH2_2	114	130	PF00022	0.669
LIG_BIR_III_4	159	163	PF00653	0.624
LIG_FHA_1	104	110	PF00498	0.711
LIG_FHA_1	149	155	PF00498	0.682
LIG_FHA_1	4	10	PF00498	0.461
LIG_FHA_1	92	98	PF00498	0.678
LIG_FHA_2	133	139	PF00498	0.697
LIG_FHA_2	227	233	PF00498	0.492
LIG_Integrin_RGD_1	185	187	PF01839	0.799
LIG_Integrin_RGD_1	66	68	PF01839	0.520
LIG_SH2_SRC	77	80	PF00017	0.656
LIG_SH2_STAP1	77	81	PF00017	0.605
LIG_SH3_2	207	212	PF14604	0.630
LIG_SH3_3	161	167	PF00018	0.672
LIG_SH3_3	201	207	PF00018	0.547
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.556
LIG_TRAF2_1	216	219	PF00917	0.597
MOD_CK1_1	144	150	PF00069	0.610
MOD_CK1_1	165	171	PF00069	0.511
MOD_CK1_1	48	54	PF00069	0.657
MOD_CK1_1	89	95	PF00069	0.608
MOD_CK2_1	144	150	PF00069	0.637
MOD_CK2_1	213	219	PF00069	0.668
MOD_CK2_1	226	232	PF00069	0.492
MOD_CK2_1	89	95	PF00069	0.647
MOD_GlcNHglycan	46	50	PF01048	0.641
MOD_GlcNHglycan	59	62	PF01048	0.687
MOD_GSK3_1	141	148	PF00069	0.715
MOD_GSK3_1	44	51	PF00069	0.625
MOD_GSK3_1	89	96	PF00069	0.618
MOD_NEK2_1	109	114	PF00069	0.714
MOD_NEK2_1	62	67	PF00069	0.529
MOD_NEK2_1	93	98	PF00069	0.682
MOD_PKA_1	226	232	PF00069	0.608
MOD_PKA_2	51	57	PF00069	0.529
MOD_PKA_2	62	68	PF00069	0.579
MOD_PKA_2	71	77	PF00069	0.609
MOD_PKA_2	89	95	PF00069	0.627
MOD_PKB_1	224	232	PF00069	0.449
MOD_Plk_1	77	83	PF00069	0.699
MOD_Plk_2-3	145	151	PF00069	0.652
MOD_Plk_4	71	77	PF00069	0.563
MOD_SUMO_for_1	160	163	PF00179	0.506
TRG_DiLeu_BaEn_1	122	127	PF01217	0.540
TRG_ER_diArg_1	173	175	PF00400	0.575
TRG_ER_diArg_1	182	185	PF00400	0.536
TRG_ER_diArg_1	210	212	PF00400	0.598
TRG_NLS_Bipartite_1	211	229	PF00514	0.628
TRG_NLS_MonoCore_2	223	228	PF00514	0.513
TRG_NLS_MonoExtC_3	220	225	PF00514	0.547
TRG_NLS_MonoExtN_4	221	228	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZZ3	Leptomonas seymouri	45%	100%
A0A3S7WYA2	Leishmania donovani	72%	100%
A4I0P0	Leishmania infantum	72%	100%
D0A718	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AWP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QAT1	Leishmania major	71%	98%
V5C0P2	Trypanosoma cruzi	35%	100%