Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3184), putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HDA3_LEIBR

TriTrypDb:

LbrM.24.0470 , LBRM2903_240010100 , LBRM2903_240010200

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HDA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.518
CLV_C14_Caspase3-7	539	543	PF00656	0.562
CLV_NRD_NRD_1	218	220	PF00675	0.867
CLV_NRD_NRD_1	235	237	PF00675	0.610
CLV_NRD_NRD_1	315	317	PF00675	0.782
CLV_NRD_NRD_1	389	391	PF00675	0.698
CLV_NRD_NRD_1	57	59	PF00675	0.571
CLV_NRD_NRD_1	81	83	PF00675	0.490
CLV_PCSK_FUR_1	55	59	PF00082	0.571
CLV_PCSK_KEX2_1	217	219	PF00082	0.877
CLV_PCSK_KEX2_1	235	237	PF00082	0.597
CLV_PCSK_KEX2_1	315	317	PF00082	0.782
CLV_PCSK_KEX2_1	389	391	PF00082	0.698
CLV_PCSK_KEX2_1	57	59	PF00082	0.571
CLV_PCSK_KEX2_1	71	73	PF00082	0.389
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.481
CLV_PCSK_PC7_1	213	219	PF00082	0.873
CLV_PCSK_PC7_1	311	317	PF00082	0.805
CLV_PCSK_SKI1_1	201	205	PF00082	0.723
CLV_PCSK_SKI1_1	43	47	PF00082	0.482
CLV_PCSK_SKI1_1	446	450	PF00082	0.727
CLV_PCSK_SKI1_1	482	486	PF00082	0.754
CLV_PCSK_SKI1_1	513	517	PF00082	0.799
CLV_PCSK_SKI1_1	637	641	PF00082	0.734
CLV_PCSK_SKI1_1	86	90	PF00082	0.545
CLV_Separin_Metazoa	453	457	PF03568	0.517
DEG_APCC_DBOX_1	42	50	PF00400	0.683
DEG_SPOP_SBC_1	397	401	PF00917	0.586
DOC_CKS1_1	239	244	PF01111	0.636
DOC_CKS1_1	498	503	PF01111	0.545
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.639
DOC_CYCLIN_yCln2_LP_2	575	578	PF00134	0.495
DOC_MAPK_gen_1	389	397	PF00069	0.496
DOC_MAPK_gen_1	595	604	PF00069	0.459
DOC_MAPK_gen_1	82	90	PF00069	0.747
DOC_MAPK_MEF2A_6	389	397	PF00069	0.496
DOC_MAPK_MEF2A_6	597	606	PF00069	0.451
DOC_MAPK_MEF2A_6	83	92	PF00069	0.746
DOC_PP2B_LxvP_1	279	282	PF13499	0.629
DOC_PP2B_LxvP_1	575	578	PF13499	0.495
DOC_PP4_FxxP_1	98	101	PF00568	0.549
DOC_USP7_MATH_1	163	167	PF00917	0.622
DOC_USP7_MATH_1	176	180	PF00917	0.443
DOC_USP7_MATH_1	288	292	PF00917	0.628
DOC_USP7_MATH_1	293	297	PF00917	0.581
DOC_USP7_MATH_1	38	42	PF00917	0.676
DOC_USP7_UBL2_3	347	351	PF12436	0.596
DOC_WW_Pin1_4	147	152	PF00397	0.651
DOC_WW_Pin1_4	156	161	PF00397	0.525
DOC_WW_Pin1_4	238	243	PF00397	0.629
DOC_WW_Pin1_4	398	403	PF00397	0.574
DOC_WW_Pin1_4	497	502	PF00397	0.531
LIG_14-3-3_CanoR_1	164	170	PF00244	0.619
LIG_14-3-3_CanoR_1	175	184	PF00244	0.486
LIG_14-3-3_CanoR_1	224	228	PF00244	0.635
LIG_14-3-3_CanoR_1	32	38	PF00244	0.685
LIG_14-3-3_CanoR_1	493	499	PF00244	0.527
LIG_14-3-3_CanoR_1	597	606	PF00244	0.451
LIG_14-3-3_CanoR_1	631	639	PF00244	0.529
LIG_14-3-3_CanoR_1	82	90	PF00244	0.726
LIG_Actin_WH2_2	615	633	PF00022	0.467
LIG_BIR_III_2	378	382	PF00653	0.616
LIG_BRCT_BRCA1_1	511	515	PF00533	0.597
LIG_BRCT_BRCA1_1	599	603	PF00533	0.451
LIG_EH1_1	478	486	PF00400	0.553
LIG_eIF4E_1	317	323	PF01652	0.540
LIG_FHA_1	102	108	PF00498	0.462
LIG_FHA_1	111	117	PF00498	0.392
LIG_FHA_1	26	32	PF00498	0.778
LIG_FHA_1	557	563	PF00498	0.537
LIG_FHA_1	617	623	PF00498	0.436
LIG_FHA_2	131	137	PF00498	0.635
LIG_FHA_2	210	216	PF00498	0.662
LIG_FHA_2	302	308	PF00498	0.643
LIG_FHA_2	316	322	PF00498	0.378
LIG_FHA_2	448	454	PF00498	0.602
LIG_FHA_2	636	642	PF00498	0.535
LIG_IRF3_LxIS_1	628	633	PF10401	0.513
LIG_LIR_Apic_2	342	348	PF02991	0.598
LIG_LIR_Apic_2	96	101	PF02991	0.650
LIG_LIR_Gen_1	104	112	PF02991	0.549
LIG_LIR_Gen_1	225	234	PF02991	0.618
LIG_LIR_Gen_1	330	341	PF02991	0.525
LIG_LIR_Gen_1	354	364	PF02991	0.575
LIG_LIR_Gen_1	600	611	PF02991	0.443
LIG_LIR_Nem_3	104	108	PF02991	0.549
LIG_LIR_Nem_3	179	184	PF02991	0.637
LIG_LIR_Nem_3	225	230	PF02991	0.620
LIG_LIR_Nem_3	312	317	PF02991	0.601
LIG_LIR_Nem_3	330	336	PF02991	0.274
LIG_LIR_Nem_3	354	359	PF02991	0.572
LIG_LIR_Nem_3	500	505	PF02991	0.565
LIG_NRBOX	404	410	PF00104	0.583
LIG_NRP_CendR_1	657	659	PF00754	0.803
LIG_Pex14_2	349	353	PF04695	0.593
LIG_PTB_Apo_2	604	611	PF02174	0.440
LIG_PTB_Phospho_1	604	610	PF10480	0.436
LIG_REV1ctd_RIR_1	513	522	PF16727	0.604
LIG_SH2_CRK	333	337	PF00017	0.514
LIG_SH2_CRK	345	349	PF00017	0.443
LIG_SH2_CRK	502	506	PF00017	0.573
LIG_SH2_CRK	564	568	PF00017	0.491
LIG_SH2_CRK	625	629	PF00017	0.469
LIG_SH2_GRB2like	335	338	PF00017	0.531
LIG_SH2_GRB2like	605	608	PF00017	0.422
LIG_SH2_NCK_1	345	349	PF00017	0.593
LIG_SH2_NCK_1	521	525	PF00017	0.611
LIG_SH2_PTP2	109	112	PF00017	0.433
LIG_SH2_SRC	192	195	PF00017	0.583
LIG_SH2_SRC	335	338	PF00017	0.531
LIG_SH2_STAT3	48	51	PF00017	0.768
LIG_SH2_STAT5	109	112	PF00017	0.549
LIG_SH2_STAT5	171	174	PF00017	0.545
LIG_SH2_STAT5	184	187	PF00017	0.530
LIG_SH2_STAT5	19	22	PF00017	0.821
LIG_SH2_STAT5	192	195	PF00017	0.483
LIG_SH2_STAT5	202	205	PF00017	0.378
LIG_SH2_STAT5	317	320	PF00017	0.556
LIG_SH2_STAT5	335	338	PF00017	0.306
LIG_SH2_STAT5	345	348	PF00017	0.473
LIG_SH2_STAT5	48	51	PF00017	0.717
LIG_SH2_STAT5	564	567	PF00017	0.493
LIG_SH2_STAT5	587	590	PF00017	0.469
LIG_SH2_STAT5	610	613	PF00017	0.462
LIG_SH3_3	149	155	PF00018	0.645
LIG_SH3_3	157	163	PF00018	0.533
LIG_SH3_3	239	245	PF00018	0.639
LIG_SH3_3	374	380	PF00018	0.538
LIG_SH3_3	430	436	PF00018	0.616
LIG_SH3_3	439	445	PF00018	0.527
LIG_SH3_3	495	501	PF00018	0.523
LIG_SH3_3	574	580	PF00018	0.511
LIG_SH3_4	347	354	PF00018	0.593
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.433
LIG_TRAF2_1	133	136	PF00917	0.637
LIG_TYR_ITIM	107	112	PF00017	0.433
LIG_TYR_ITIM	562	567	PF00017	0.503
LIG_TYR_ITSM	498	505	PF00017	0.551
LIG_WRC_WIRS_1	204	209	PF05994	0.625
LIG_WRC_WIRS_1	589	594	PF05994	0.456
LIG_WW_3	76	80	PF00397	0.776
MOD_CK1_1	147	153	PF00069	0.650
MOD_CK1_1	165	171	PF00069	0.387
MOD_CK1_1	26	32	PF00069	0.695
MOD_CK1_1	291	297	PF00069	0.639
MOD_CK1_1	339	345	PF00069	0.586
MOD_CK1_1	398	404	PF00069	0.568
MOD_CK1_1	635	641	PF00069	0.533
MOD_CK2_1	130	136	PF00069	0.634
MOD_CK2_1	222	228	PF00069	0.641
MOD_CK2_1	315	321	PF00069	0.566
MOD_CK2_1	447	453	PF00069	0.607
MOD_CMANNOS	353	356	PF00535	0.779
MOD_DYRK1A_RPxSP_1	156	160	PF00069	0.637
MOD_GlcNHglycan	219	222	PF01048	0.863
MOD_GlcNHglycan	297	300	PF01048	0.855
MOD_GlcNHglycan	413	416	PF01048	0.730
MOD_GlcNHglycan	534	537	PF01048	0.755
MOD_GlcNHglycan	634	637	PF01048	0.734
MOD_GSK3_1	130	137	PF00069	0.633
MOD_GSK3_1	22	29	PF00069	0.791
MOD_GSK3_1	291	298	PF00069	0.640
MOD_GSK3_1	339	346	PF00069	0.587
MOD_GSK3_1	541	548	PF00069	0.557
MOD_GSK3_1	579	586	PF00069	0.502
MOD_GSK3_1	77	84	PF00069	0.773
MOD_LATS_1	313	319	PF00433	0.587
MOD_N-GLC_1	291	296	PF02516	0.836
MOD_N-GLC_1	336	341	PF02516	0.754
MOD_N-GLC_1	509	514	PF02516	0.777
MOD_N-GLC_1	597	602	PF02516	0.669
MOD_NEK2_1	139	144	PF00069	0.639
MOD_NEK2_1	23	28	PF00069	0.710
MOD_NEK2_1	33	38	PF00069	0.598
MOD_NEK2_1	331	336	PF00069	0.498
MOD_NEK2_1	358	363	PF00069	0.571
MOD_NEK2_1	395	400	PF00069	0.587
MOD_NEK2_1	447	452	PF00069	0.607
MOD_NEK2_1	485	490	PF00069	0.554
MOD_NEK2_1	509	514	PF00069	0.577
MOD_NEK2_1	516	521	PF00069	0.522
MOD_NEK2_1	562	567	PF00069	0.503
MOD_NEK2_1	630	635	PF00069	0.526
MOD_NEK2_1	81	86	PF00069	0.764
MOD_NEK2_2	38	43	PF00069	0.678
MOD_PIKK_1	403	409	PF00454	0.573
MOD_PIKK_1	431	437	PF00454	0.623
MOD_PIKK_1	630	636	PF00454	0.528
MOD_PKA_1	217	223	PF00069	0.665
MOD_PKA_1	315	321	PF00069	0.566
MOD_PKA_2	163	169	PF00069	0.619
MOD_PKA_2	174	180	PF00069	0.471
MOD_PKA_2	217	223	PF00069	0.665
MOD_PKA_2	315	321	PF00069	0.566
MOD_PKA_2	494	500	PF00069	0.522
MOD_PKA_2	630	636	PF00069	0.528
MOD_PKA_2	81	87	PF00069	0.674
MOD_PKB_1	595	603	PF00069	0.463
MOD_Plk_1	139	145	PF00069	0.640
MOD_Plk_1	383	389	PF00069	0.504
MOD_Plk_1	422	428	PF00069	0.582
MOD_Plk_1	541	547	PF00069	0.556
MOD_Plk_1	597	603	PF00069	0.465
MOD_Plk_4	13	19	PF00069	0.741
MOD_Plk_4	144	150	PF00069	0.651
MOD_Plk_4	331	337	PF00069	0.507
MOD_Plk_4	422	428	PF00069	0.582
MOD_Plk_4	494	500	PF00069	0.522
MOD_Plk_4	541	547	PF00069	0.556
MOD_Plk_4	588	594	PF00069	0.458
MOD_Plk_4	598	604	PF00069	0.370
MOD_Plk_4	86	92	PF00069	0.745
MOD_ProDKin_1	147	153	PF00069	0.650
MOD_ProDKin_1	156	162	PF00069	0.524
MOD_ProDKin_1	238	244	PF00069	0.633
MOD_ProDKin_1	398	404	PF00069	0.568
MOD_ProDKin_1	497	503	PF00069	0.540
MOD_SUMO_for_1	639	642	PF00179	0.537
MOD_SUMO_for_1	70	73	PF00179	0.672
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.693
TRG_ENDOCYTIC_2	109	112	PF00928	0.433
TRG_ENDOCYTIC_2	227	230	PF00928	0.613
TRG_ENDOCYTIC_2	333	336	PF00928	0.503
TRG_ENDOCYTIC_2	502	505	PF00928	0.582
TRG_ENDOCYTIC_2	564	567	PF00928	0.493
TRG_ENDOCYTIC_2	610	613	PF00928	0.462
TRG_ER_diArg_1	217	219	PF00400	0.677
TRG_ER_diArg_1	234	236	PF00400	0.423
TRG_ER_diArg_1	314	316	PF00400	0.606
TRG_ER_diArg_1	389	391	PF00400	0.498
TRG_ER_diArg_1	493	496	PF00400	0.538
TRG_ER_diArg_1	54	57	PF00400	0.768
TRG_ER_diArg_1	594	597	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	456	461	PF00026	0.721
TRG_Pf-PMV_PEXEL_1	650	654	PF00026	0.779
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.480