LeishMANIAdb
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3'a2rel-related protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
3'a2rel-related protein
Gene product:
3'a2rel-related protein
Species:
Leishmania braziliensis
UniProt:
A4HDA2_LEIBR
TriTrypDb:
LbrM.24.0460 , LBRM2903_240009700
Length:
623

Annotations

LeishMANIAdb annotations

A very special family of kinetoplastid proteins, carrying multiply amyloid-like segments on their disordered extracellular domain, alongside with RGD motifs. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 4, no: 5
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4HDA2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDA2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 103 107 PF00656 0.421
CLV_C14_Caspase3-7 535 539 PF00656 0.844
CLV_NRD_NRD_1 213 215 PF00675 0.737
CLV_NRD_NRD_1 244 246 PF00675 0.477
CLV_NRD_NRD_1 329 331 PF00675 0.563
CLV_NRD_NRD_1 334 336 PF00675 0.510
CLV_NRD_NRD_1 619 621 PF00675 0.488
CLV_PCSK_FUR_1 332 336 PF00082 0.576
CLV_PCSK_KEX2_1 213 215 PF00082 0.737
CLV_PCSK_KEX2_1 218 220 PF00082 0.648
CLV_PCSK_KEX2_1 244 246 PF00082 0.514
CLV_PCSK_KEX2_1 331 333 PF00082 0.567
CLV_PCSK_KEX2_1 334 336 PF00082 0.533
CLV_PCSK_KEX2_1 619 621 PF00082 0.488
CLV_PCSK_PC1ET2_1 218 220 PF00082 0.577
CLV_PCSK_PC1ET2_1 331 333 PF00082 0.567
CLV_PCSK_PC7_1 214 220 PF00082 0.590
CLV_PCSK_PC7_1 330 336 PF00082 0.572
CLV_PCSK_PC7_1 615 621 PF00082 0.482
CLV_PCSK_SKI1_1 219 223 PF00082 0.520
CLV_PCSK_SKI1_1 29 33 PF00082 0.371
CLV_PCSK_SKI1_1 458 462 PF00082 0.587
CLV_PCSK_SKI1_1 76 80 PF00082 0.634
DEG_APCC_DBOX_1 218 226 PF00400 0.433
DEG_APCC_DBOX_1 28 36 PF00400 0.504
DEG_APCC_DBOX_1 75 83 PF00400 0.429
DOC_CDC14_PxL_1 440 448 PF14671 0.649
DOC_CYCLIN_RxL_1 247 260 PF00134 0.775
DOC_CYCLIN_RxL_1 29 39 PF00134 0.256
DOC_CYCLIN_yCln2_LP_2 228 234 PF00134 0.527
DOC_CYCLIN_yCln2_LP_2 78 84 PF00134 0.548
DOC_MAPK_DCC_7 76 84 PF00069 0.427
DOC_MAPK_gen_1 17 26 PF00069 0.587
DOC_MAPK_gen_1 218 225 PF00069 0.322
DOC_MAPK_gen_1 249 257 PF00069 0.756
DOC_MAPK_gen_1 328 338 PF00069 0.748
DOC_MAPK_HePTP_8 26 38 PF00069 0.440
DOC_MAPK_MEF2A_6 29 38 PF00069 0.375
DOC_MAPK_MEF2A_6 76 84 PF00069 0.578
DOC_MAPK_RevD_3 200 214 PF00069 0.449
DOC_PP2B_LxvP_1 202 205 PF13499 0.571
DOC_PP2B_LxvP_1 228 231 PF13499 0.527
DOC_PP2B_LxvP_1 410 413 PF13499 0.652
DOC_PP2B_LxvP_1 478 481 PF13499 0.688
DOC_PP2B_LxvP_1 546 549 PF13499 0.846
DOC_PP2B_PxIxI_1 230 236 PF00149 0.278
DOC_PP4_FxxP_1 84 87 PF00568 0.417
DOC_USP7_MATH_1 130 134 PF00917 0.515
DOC_USP7_MATH_1 139 143 PF00917 0.451
DOC_USP7_MATH_1 172 176 PF00917 0.567
DOC_USP7_MATH_1 181 185 PF00917 0.456
DOC_USP7_MATH_1 295 299 PF00917 0.635
DOC_USP7_MATH_1 369 373 PF00917 0.752
DOC_USP7_MATH_1 399 403 PF00917 0.839
DOC_USP7_MATH_1 420 424 PF00917 0.726
DOC_USP7_MATH_1 426 430 PF00917 0.652
DOC_USP7_MATH_1 434 438 PF00917 0.677
DOC_USP7_MATH_1 447 451 PF00917 0.676
DOC_USP7_MATH_1 487 491 PF00917 0.834
DOC_USP7_MATH_1 618 622 PF00917 0.683
DOC_USP7_MATH_2 172 178 PF00917 0.441
DOC_WW_Pin1_4 168 173 PF00397 0.441
DOC_WW_Pin1_4 212 217 PF00397 0.432
DOC_WW_Pin1_4 343 348 PF00397 0.683
DOC_WW_Pin1_4 46 51 PF00397 0.537
DOC_WW_Pin1_4 594 599 PF00397 0.688
LIG_14-3-3_CanoR_1 15 20 PF00244 0.689
LIG_14-3-3_CanoR_1 350 359 PF00244 0.665
LIG_14-3-3_CanoR_1 619 623 PF00244 0.685
LIG_BIR_III_4 67 71 PF00653 0.438
LIG_BRCT_BRCA1_1 174 178 PF00533 0.451
LIG_BRCT_BRCA1_1 449 453 PF00533 0.629
LIG_CtBP_PxDLS_1 199 203 PF00389 0.447
LIG_FHA_1 215 221 PF00498 0.397
LIG_FHA_1 3 9 PF00498 0.630
LIG_FHA_1 346 352 PF00498 0.754
LIG_FHA_1 406 412 PF00498 0.761
LIG_FHA_1 454 460 PF00498 0.626
LIG_FHA_1 486 492 PF00498 0.772
LIG_FHA_2 101 107 PF00498 0.420
LIG_FHA_2 112 118 PF00498 0.384
LIG_FHA_2 390 396 PF00498 0.663
LIG_Integrin_RGD_1 533 535 PF01839 0.658
LIG_LIR_Gen_1 279 287 PF02991 0.800
LIG_LIR_Gen_1 507 517 PF02991 0.766
LIG_LIR_Gen_1 572 581 PF02991 0.682
LIG_LIR_Nem_3 117 121 PF02991 0.438
LIG_LIR_Nem_3 279 283 PF02991 0.795
LIG_LIR_Nem_3 314 320 PF02991 0.705
LIG_LIR_Nem_3 361 366 PF02991 0.771
LIG_LIR_Nem_3 507 513 PF02991 0.774
LIG_LIR_Nem_3 572 578 PF02991 0.683
LIG_MLH1_MIPbox_1 449 453 PF16413 0.624
LIG_NRBOX 31 37 PF00104 0.492
LIG_NRP_CendR_1 620 623 PF00754 0.483
LIG_PCNA_yPIPBox_3 22 35 PF02747 0.538
LIG_Rb_pABgroove_1 110 118 PF01858 0.423
LIG_SH2_GRB2like 452 455 PF00017 0.792
LIG_SH2_SRC 606 609 PF00017 0.784
LIG_SH2_STAP1 406 410 PF00017 0.656
LIG_SH2_STAT5 452 455 PF00017 0.792
LIG_SH2_STAT5 606 609 PF00017 0.784
LIG_SH3_2 80 85 PF14604 0.419
LIG_SH3_3 439 445 PF00018 0.653
LIG_SH3_3 537 543 PF00018 0.696
LIG_SH3_3 77 83 PF00018 0.488
LIG_SUMO_SIM_anti_2 184 192 PF11976 0.603
LIG_SUMO_SIM_anti_2 437 444 PF11976 0.656
LIG_SUMO_SIM_par_1 184 192 PF11976 0.603
LIG_SUMO_SIM_par_1 33 39 PF11976 0.342
LIG_SUMO_SIM_par_1 476 482 PF11976 0.686
LIG_TRAF2_1 377 380 PF00917 0.828
MOD_CDC14_SPxK_1 215 218 PF00782 0.391
MOD_CDK_SPxK_1 212 218 PF00069 0.412
MOD_CDK_SPxxK_3 212 219 PF00069 0.416
MOD_CDK_SPxxK_3 343 350 PF00069 0.646
MOD_CK1_1 129 135 PF00069 0.616
MOD_CK1_1 155 161 PF00069 0.626
MOD_CK1_1 164 170 PF00069 0.507
MOD_CK1_1 176 182 PF00069 0.500
MOD_CK1_1 303 309 PF00069 0.661
MOD_CK1_1 389 395 PF00069 0.665
MOD_CK1_1 438 444 PF00069 0.832
MOD_CK1_1 536 542 PF00069 0.687
MOD_CK1_1 602 608 PF00069 0.696
MOD_CK2_1 139 145 PF00069 0.456
MOD_CK2_1 156 162 PF00069 0.424
MOD_CK2_1 168 174 PF00069 0.411
MOD_CK2_1 373 379 PF00069 0.837
MOD_CK2_1 508 514 PF00069 0.661
MOD_GlcNHglycan 126 129 PF01048 0.721
MOD_GlcNHglycan 141 144 PF01048 0.815
MOD_GlcNHglycan 179 182 PF01048 0.768
MOD_GlcNHglycan 183 186 PF01048 0.684
MOD_GlcNHglycan 302 305 PF01048 0.441
MOD_GlcNHglycan 355 358 PF01048 0.551
MOD_GlcNHglycan 365 369 PF01048 0.541
MOD_GlcNHglycan 38 41 PF01048 0.256
MOD_GlcNHglycan 388 391 PF01048 0.582
MOD_GlcNHglycan 401 404 PF01048 0.479
MOD_GlcNHglycan 437 440 PF01048 0.608
MOD_GlcNHglycan 469 472 PF01048 0.587
MOD_GlcNHglycan 510 513 PF01048 0.456
MOD_GlcNHglycan 535 538 PF01048 0.608
MOD_GlcNHglycan 602 605 PF01048 0.581
MOD_GlcNHglycan 611 614 PF01048 0.506
MOD_GlcNHglycan 67 71 PF01048 0.762
MOD_GSK3_1 107 114 PF00069 0.493
MOD_GSK3_1 126 133 PF00069 0.486
MOD_GSK3_1 149 156 PF00069 0.630
MOD_GSK3_1 157 164 PF00069 0.522
MOD_GSK3_1 168 175 PF00069 0.553
MOD_GSK3_1 177 184 PF00069 0.534
MOD_GSK3_1 300 307 PF00069 0.633
MOD_GSK3_1 369 376 PF00069 0.792
MOD_GSK3_1 41 48 PF00069 0.522
MOD_GSK3_1 434 441 PF00069 0.839
MOD_GSK3_1 494 501 PF00069 0.735
MOD_GSK3_1 504 511 PF00069 0.709
MOD_LATS_1 531 537 PF00433 0.702
MOD_N-GLC_1 257 262 PF02516 0.603
MOD_N-GLC_1 295 300 PF02516 0.478
MOD_N-GLC_1 352 357 PF02516 0.464
MOD_N-GLC_1 453 458 PF02516 0.582
MOD_N-GLC_1 467 472 PF02516 0.468
MOD_NEK2_1 161 166 PF00069 0.513
MOD_NEK2_1 173 178 PF00069 0.529
MOD_NEK2_1 257 262 PF00069 0.802
MOD_NEK2_1 300 305 PF00069 0.644
MOD_NEK2_1 359 364 PF00069 0.656
MOD_NEK2_1 36 41 PF00069 0.407
MOD_NEK2_1 42 47 PF00069 0.496
MOD_NEK2_1 453 458 PF00069 0.759
MOD_NEK2_1 506 511 PF00069 0.648
MOD_NEK2_1 517 522 PF00069 0.594
MOD_NEK2_2 295 300 PF00069 0.636
MOD_NEK2_2 618 623 PF00069 0.682
MOD_PIKK_1 447 453 PF00454 0.628
MOD_PIKK_1 485 491 PF00454 0.772
MOD_PKA_2 243 249 PF00069 0.721
MOD_PKA_2 447 453 PF00069 0.652
MOD_Plk_1 107 113 PF00069 0.435
MOD_Plk_1 161 167 PF00069 0.498
MOD_Plk_1 173 179 PF00069 0.445
MOD_Plk_1 189 195 PF00069 0.432
MOD_Plk_1 295 301 PF00069 0.654
MOD_Plk_2-3 279 285 PF00069 0.621
MOD_Plk_4 111 117 PF00069 0.448
MOD_Plk_4 130 136 PF00069 0.398
MOD_Plk_4 406 412 PF00069 0.823
MOD_Plk_4 602 608 PF00069 0.696
MOD_ProDKin_1 168 174 PF00069 0.442
MOD_ProDKin_1 212 218 PF00069 0.428
MOD_ProDKin_1 343 349 PF00069 0.686
MOD_ProDKin_1 46 52 PF00069 0.540
MOD_ProDKin_1 594 600 PF00069 0.689
MOD_SUMO_for_1 466 469 PF00179 0.646
TRG_ENDOCYTIC_2 510 513 PF00928 0.620
TRG_ER_diArg_1 19 22 PF00400 0.600
TRG_ER_diArg_1 244 247 PF00400 0.717
TRG_ER_diArg_1 248 251 PF00400 0.699
TRG_ER_diArg_1 290 293 PF00400 0.674
TRG_ER_diArg_1 332 335 PF00400 0.776
TRG_ER_diArg_1 618 620 PF00400 0.685
TRG_NLS_MonoExtC_3 329 334 PF00514 0.769
TRG_NLS_MonoExtN_4 328 335 PF00514 0.770

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ILH2 Leishmania donovani 57% 100%
A0A3S7WX43 Leishmania donovani 57% 100%
A4HCB1 Leishmania braziliensis 99% 100%
E9AGZ2 Leishmania infantum 58% 100%
E9AGZ3 Leishmania infantum 58% 100%
E9AVQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 100%
Q4QBR2 Leishmania major 57% 100%
Q4QBS8 Leishmania major 57% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS