Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3184), putative

Species:

Leishmania braziliensis

UniProt:

A4HDA1_LEIBR

TriTrypDb:

LbrM.24.0450 , LBRM2903_240010100

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HDA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.864
CLV_NRD_NRD_1	225	227	PF00675	0.622
CLV_NRD_NRD_1	305	307	PF00675	0.828
CLV_NRD_NRD_1	47	49	PF00675	0.567
CLV_PCSK_FUR_1	45	49	PF00082	0.568
CLV_PCSK_KEX2_1	207	209	PF00082	0.879
CLV_PCSK_KEX2_1	225	227	PF00082	0.609
CLV_PCSK_KEX2_1	305	307	PF00082	0.828
CLV_PCSK_KEX2_1	47	49	PF00082	0.567
CLV_PCSK_PC7_1	203	209	PF00082	0.877
CLV_PCSK_PC7_1	301	307	PF00082	0.835
CLV_PCSK_SKI1_1	76	80	PF00082	0.536
CLV_Separin_Metazoa	63	67	PF03568	0.756
DEG_SPOP_SBC_1	16	20	PF00917	0.567
DOC_CKS1_1	229	234	PF01111	0.640
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.632
DOC_MAPK_DCC_7	263	271	PF00069	0.607
DOC_MAPK_gen_1	73	82	PF00069	0.736
DOC_MAPK_MEF2A_6	73	82	PF00069	0.736
DOC_PP2B_LxvP_1	269	272	PF13499	0.600
DOC_PP4_FxxP_1	88	91	PF00568	0.549
DOC_PP4_MxPP_1	65	68	PF00568	0.768
DOC_SPAK_OSR1_1	263	267	PF12202	0.607
DOC_USP7_MATH_1	153	157	PF00917	0.648
DOC_USP7_MATH_1	166	170	PF00917	0.468
DOC_USP7_MATH_1	278	282	PF00917	0.631
DOC_USP7_MATH_1	283	287	PF00917	0.579
DOC_USP7_UBL2_3	337	341	PF12436	0.606
DOC_WW_Pin1_4	1	6	PF00397	0.613
DOC_WW_Pin1_4	137	142	PF00397	0.652
DOC_WW_Pin1_4	146	151	PF00397	0.541
DOC_WW_Pin1_4	228	233	PF00397	0.635
LIG_14-3-3_CanoR_1	154	160	PF00244	0.642
LIG_14-3-3_CanoR_1	165	174	PF00244	0.499
LIG_14-3-3_CanoR_1	214	218	PF00244	0.609
LIG_14-3-3_CanoR_1	66	72	PF00244	0.766
LIG_14-3-3_CanoR_1	76	81	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_2	368	372	PF00653	0.650
LIG_eIF4E_1	307	313	PF01652	0.599
LIG_FHA_1	102	108	PF00498	0.375
LIG_FHA_1	16	22	PF00498	0.568
LIG_FHA_1	77	83	PF00498	0.734
LIG_FHA_1	92	98	PF00498	0.287
LIG_FHA_2	121	127	PF00498	0.618
LIG_FHA_2	200	206	PF00498	0.661
LIG_FHA_2	292	298	PF00498	0.646
LIG_FHA_2	306	312	PF00498	0.431
LIG_LIR_Apic_2	332	338	PF02991	0.632
LIG_LIR_Apic_2	86	91	PF02991	0.650
LIG_LIR_Gen_1	215	224	PF02991	0.613
LIG_LIR_Gen_1	320	331	PF02991	0.613
LIG_LIR_Gen_1	344	354	PF02991	0.581
LIG_LIR_Gen_1	94	103	PF02991	0.549
LIG_LIR_Nem_3	169	174	PF02991	0.637
LIG_LIR_Nem_3	215	220	PF02991	0.613
LIG_LIR_Nem_3	302	307	PF02991	0.633
LIG_LIR_Nem_3	320	326	PF02991	0.381
LIG_LIR_Nem_3	344	349	PF02991	0.579
LIG_LIR_Nem_3	94	98	PF02991	0.549
LIG_NRBOX	53	59	PF00104	0.742
LIG_Pex14_2	339	343	PF04695	0.594
LIG_SH2_CRK	323	327	PF00017	0.613
LIG_SH2_CRK	335	339	PF00017	0.471
LIG_SH2_GRB2like	325	328	PF00017	0.618
LIG_SH2_NCK_1	335	339	PF00017	0.621
LIG_SH2_SRC	182	185	PF00017	0.595
LIG_SH2_SRC	325	328	PF00017	0.618
LIG_SH2_STAT3	38	41	PF00017	0.549
LIG_SH2_STAT5	174	177	PF00017	0.617
LIG_SH2_STAT5	182	185	PF00017	0.495
LIG_SH2_STAT5	192	195	PF00017	0.379
LIG_SH2_STAT5	26	29	PF00017	0.252
LIG_SH2_STAT5	307	310	PF00017	0.614
LIG_SH2_STAT5	325	328	PF00017	0.392
LIG_SH2_STAT5	335	338	PF00017	0.505
LIG_SH2_STAT5	38	41	PF00017	0.339
LIG_SH2_STAT5	9	12	PF00017	0.615
LIG_SH2_STAT5	99	102	PF00017	0.549
LIG_SH3_3	139	145	PF00018	0.649
LIG_SH3_3	147	153	PF00018	0.550
LIG_SH3_3	2	8	PF00018	0.610
LIG_SH3_3	229	235	PF00018	0.632
LIG_SH3_3	367	373	PF00018	0.648
LIG_SH3_4	337	344	PF00018	0.599
LIG_TRAF2_1	123	126	PF00917	0.623
LIG_WRC_WIRS_1	194	199	PF05994	0.615
LIG_WW_2	370	373	PF00397	0.657
LIG_WW_3	66	70	PF00397	0.764
MOD_CK1_1	137	143	PF00069	0.653
MOD_CK1_1	155	161	PF00069	0.413
MOD_CK1_1	281	287	PF00069	0.639
MOD_CK1_1	329	335	PF00069	0.627
MOD_CK2_1	120	126	PF00069	0.620
MOD_CK2_1	212	218	PF00069	0.611
MOD_CK2_1	305	311	PF00069	0.618
MOD_CMANNOS	343	346	PF00535	0.784
MOD_DYRK1A_RPxSP_1	146	150	PF00069	0.654
MOD_GlcNHglycan	209	212	PF01048	0.834
MOD_GlcNHglycan	287	290	PF01048	0.849
MOD_GSK3_1	12	19	PF00069	0.585
MOD_GSK3_1	120	127	PF00069	0.619
MOD_GSK3_1	130	137	PF00069	0.513
MOD_GSK3_1	281	288	PF00069	0.640
MOD_GSK3_1	329	336	PF00069	0.629
MOD_GSK3_1	67	74	PF00069	0.760
MOD_LATS_1	303	309	PF00433	0.627
MOD_N-GLC_1	281	286	PF02516	0.838
MOD_N-GLC_1	326	331	PF02516	0.819
MOD_NEK2_1	129	134	PF00069	0.629
MOD_NEK2_1	321	326	PF00069	0.606
MOD_NEK2_1	348	353	PF00069	0.578
MOD_NEK2_1	49	54	PF00069	0.749
MOD_NEK2_1	71	76	PF00069	0.755
MOD_PKA_1	207	213	PF00069	0.645
MOD_PKA_1	305	311	PF00069	0.618
MOD_PKA_2	153	159	PF00069	0.643
MOD_PKA_2	164	170	PF00069	0.492
MOD_PKA_2	207	213	PF00069	0.645
MOD_PKA_2	305	311	PF00069	0.618
MOD_Plk_1	129	135	PF00069	0.631
MOD_Plk_4	102	108	PF00069	0.549
MOD_Plk_4	134	140	PF00069	0.649
MOD_Plk_4	321	327	PF00069	0.609
MOD_Plk_4	76	82	PF00069	0.733
MOD_ProDKin_1	1	7	PF00069	0.613
MOD_ProDKin_1	137	143	PF00069	0.653
MOD_ProDKin_1	146	152	PF00069	0.540
MOD_ProDKin_1	228	234	PF00069	0.636
TRG_ENDOCYTIC_2	217	220	PF00928	0.609
TRG_ENDOCYTIC_2	323	326	PF00928	0.609
TRG_ER_diArg_1	207	209	PF00400	0.679
TRG_ER_diArg_1	224	226	PF00400	0.424
TRG_ER_diArg_1	304	306	PF00400	0.636
TRG_ER_diArg_1	44	47	PF00400	0.766