Putative CMP-sialic acid transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactose transporter

Species:

Leishmania braziliensis

UniProt:

A4HDA0_LEIBR

TriTrypDb:

LbrM.24.0440 , LBRM2903_240009500 , LBRM2903_240009600

Length:

451

Annotations

LeishMANIAdb annotations

Homologous to animal UDP-N-acetylglucosamine, UDP-galactose and CMP-sialic acid transporters. Only expanded in the Leptomonas lineage. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 16
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	19
GO:0016020	membrane	2	19
GO:0031090	organelle membrane	3	19
GO:0098588	bounding membrane of organelle	4	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A4HDA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDA0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0008643	carbohydrate transport	5	1
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0071702	organic substance transport	4	2
GO:0006811	monoatomic ion transport	4	1
GO:0006820	monoatomic anion transport	5	1
GO:0009987	cellular process	1	1
GO:0015711	organic anion transport	5	1
GO:0015780	nucleotide-sugar transmembrane transport	3	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0055085	transmembrane transport	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072334	UDP-galactose transmembrane transport	5	1
GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	4	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:1901264	carbohydrate derivative transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	19
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	19
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	19
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	19
GO:0022857	transmembrane transporter activity	2	19
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	19
GO:0005459	UDP-galactose transmembrane transporter activity	6	1
GO:0015136	sialic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.588
CLV_NRD_NRD_1	11	13	PF00675	0.470
CLV_NRD_NRD_1	165	167	PF00675	0.354
CLV_PCSK_FUR_1	9	13	PF00082	0.321
CLV_PCSK_KEX2_1	11	13	PF00082	0.453
CLV_PCSK_KEX2_1	167	169	PF00082	0.361
CLV_PCSK_KEX2_1	325	327	PF00082	0.342
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.267
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.332
CLV_PCSK_SKI1_1	188	192	PF00082	0.226
CLV_PCSK_SKI1_1	226	230	PF00082	0.338
CLV_PCSK_SKI1_1	78	82	PF00082	0.264
DEG_Nend_UBRbox_1	1	4	PF02207	0.627
DOC_MAPK_gen_1	166	174	PF00069	0.480
DOC_MAPK_gen_1	176	183	PF00069	0.513
DOC_MAPK_gen_1	186	194	PF00069	0.540
DOC_MAPK_MEF2A_6	246	255	PF00069	0.238
DOC_MAPK_RevD_3	155	168	PF00069	0.373
DOC_PP1_RVXF_1	224	230	PF00149	0.411
DOC_USP7_MATH_1	260	264	PF00917	0.419
DOC_USP7_MATH_1	279	283	PF00917	0.351
DOC_WW_Pin1_4	103	108	PF00397	0.596
DOC_WW_Pin1_4	124	129	PF00397	0.757
DOC_WW_Pin1_4	136	141	PF00397	0.668
DOC_WW_Pin1_4	240	245	PF00397	0.534
LIG_AP2alpha_1	372	376	PF02296	0.332
LIG_BRCT_BRCA1_1	314	318	PF00533	0.428
LIG_BRCT_BRCA1_1	369	373	PF00533	0.332
LIG_BRCT_BRCA1_1	408	412	PF00533	0.406
LIG_EH1_1	199	207	PF00400	0.408
LIG_eIF4E_1	187	193	PF01652	0.532
LIG_eIF4E_1	200	206	PF01652	0.408
LIG_FHA_1	294	300	PF00498	0.218
LIG_FHA_1	375	381	PF00498	0.344
LIG_FHA_1	429	435	PF00498	0.257
LIG_FHA_1	71	77	PF00498	0.331
LIG_FHA_2	265	271	PF00498	0.254
LIG_FHA_2	369	375	PF00498	0.331
LIG_GBD_Chelix_1	344	352	PF00786	0.315
LIG_GBD_Chelix_1	76	84	PF00786	0.192
LIG_HCF-1_HBM_1	184	187	PF13415	0.475
LIG_LIR_Gen_1	216	227	PF02991	0.271
LIG_LIR_Gen_1	315	323	PF02991	0.438
LIG_LIR_Gen_1	374	384	PF02991	0.332
LIG_LIR_Gen_1	409	420	PF02991	0.344
LIG_LIR_Gen_1	82	93	PF02991	0.341
LIG_LIR_Nem_3	216	222	PF02991	0.261
LIG_LIR_Nem_3	315	321	PF02991	0.439
LIG_LIR_Nem_3	343	349	PF02991	0.290
LIG_LIR_Nem_3	370	376	PF02991	0.269
LIG_LIR_Nem_3	378	384	PF02991	0.348
LIG_LIR_Nem_3	409	415	PF02991	0.358
LIG_LIR_Nem_3	82	88	PF02991	0.320
LIG_MLH1_MIPbox_1	369	373	PF16413	0.332
LIG_Pex14_2	169	173	PF04695	0.532
LIG_Pex14_2	347	351	PF04695	0.408
LIG_Pex14_2	368	372	PF04695	0.277
LIG_Pex14_2	408	412	PF04695	0.391
LIG_PTB_Apo_2	26	33	PF02174	0.400
LIG_PTB_Phospho_1	26	32	PF10480	0.379
LIG_SH2_STAP1	209	213	PF00017	0.422
LIG_SH2_STAP1	38	42	PF00017	0.323
LIG_SH2_STAT3	200	203	PF00017	0.279
LIG_SH2_STAT3	38	41	PF00017	0.336
LIG_SH2_STAT5	32	35	PF00017	0.281
LIG_SH2_STAT5	346	349	PF00017	0.343
LIG_SH2_STAT5	400	403	PF00017	0.532
LIG_Sin3_3	19	26	PF02671	0.307
LIG_SUMO_SIM_anti_2	302	307	PF11976	0.185
LIG_TRFH_1	240	244	PF08558	0.475
LIG_TYR_ITIM	344	349	PF00017	0.328
LIG_UBA3_1	33	37	PF00899	0.185
LIG_UBA3_1	445	450	PF00899	0.185
LIG_WRC_WIRS_1	369	374	PF05994	0.248
LIG_WRC_WIRS_1	405	410	PF05994	0.452
MOD_CDC14_SPxK_1	243	246	PF00782	0.475
MOD_CDK_SPxK_1	240	246	PF00069	0.475
MOD_CK1_1	263	269	PF00069	0.231
MOD_CK1_1	295	301	PF00069	0.348
MOD_CK1_1	312	318	PF00069	0.219
MOD_CK1_1	407	413	PF00069	0.373
MOD_CK2_1	264	270	PF00069	0.249
MOD_GlcNHglycan	119	122	PF01048	0.502
MOD_GlcNHglycan	262	265	PF01048	0.368
MOD_GlcNHglycan	311	314	PF01048	0.348
MOD_GlcNHglycan	332	335	PF01048	0.291
MOD_GlcNHglycan	97	100	PF01048	0.344
MOD_GSK3_1	260	267	PF00069	0.272
MOD_GSK3_1	291	298	PF00069	0.285
MOD_GSK3_1	375	382	PF00069	0.173
MOD_GSK3_1	424	431	PF00069	0.288
MOD_N-GLC_1	429	434	PF02516	0.475
MOD_NEK2_1	213	218	PF00069	0.251
MOD_NEK2_1	255	260	PF00069	0.341
MOD_NEK2_1	330	335	PF00069	0.455
MOD_NEK2_1	368	373	PF00069	0.327
MOD_NEK2_1	379	384	PF00069	0.333
MOD_NEK2_1	424	429	PF00069	0.279
MOD_NEK2_1	65	70	PF00069	0.332
MOD_NEK2_1	79	84	PF00069	0.293
MOD_NEK2_2	418	423	PF00069	0.400
MOD_Plk_1	214	220	PF00069	0.255
MOD_Plk_1	269	275	PF00069	0.254
MOD_Plk_1	429	435	PF00069	0.191
MOD_Plk_4	214	220	PF00069	0.239
MOD_Plk_4	368	374	PF00069	0.276
MOD_Plk_4	375	381	PF00069	0.293
MOD_Plk_4	418	424	PF00069	0.295
MOD_Plk_4	429	435	PF00069	0.242
MOD_Plk_4	440	446	PF00069	0.235
MOD_Plk_4	79	85	PF00069	0.321
MOD_ProDKin_1	103	109	PF00069	0.596
MOD_ProDKin_1	124	130	PF00069	0.758
MOD_ProDKin_1	136	142	PF00069	0.667
MOD_ProDKin_1	240	246	PF00069	0.534
TRG_DiLeu_BaEn_1	75	80	PF01217	0.257
TRG_ENDOCYTIC_2	32	35	PF00928	0.397
TRG_ENDOCYTIC_2	346	349	PF00928	0.320
TRG_ER_diArg_1	166	169	PF00400	0.557
TRG_ER_diArg_1	8	11	PF00400	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L9	Leptomonas seymouri	49%	100%
A0A0N1HVQ8	Leptomonas seymouri	23%	84%
A0A0S4JHP4	Bodo saltans	29%	94%
A0A1X0NTD6	Trypanosomatidae	30%	100%
A0A3Q8IES0	Leishmania donovani	71%	84%
A0A3S7WUS3	Leishmania donovani	28%	80%
A0A3S7WVZ3	Leishmania donovani	71%	100%
A0A3S7WY47	Leishmania donovani	60%	81%
A0A422P321	Trypanosoma rangeli	31%	100%
A4HD92	Leishmania braziliensis	99%	100%
A4HXR5	Leishmania infantum	28%	80%
A4I0N2	Leishmania infantum	60%	81%
B8A7Q8	Oryza sativa subsp. indica	24%	100%
D0AAP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AH47	Leishmania infantum	71%	84%
E9AWM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	96%
E9AWM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QAU5	Leishmania major	70%	100%
Q5N855	Oryza sativa subsp. japonica	24%	100%
V5BLB8	Trypanosoma cruzi	30%	100%