Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD97_LEIBR

TriTrypDb:

LbrM.24.0410 , LBRM2903_240009100

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	479	483	PF00656	0.473
CLV_NRD_NRD_1	361	363	PF00675	0.557
CLV_NRD_NRD_1	695	697	PF00675	0.613
CLV_NRD_NRD_1	87	89	PF00675	0.592
CLV_PCSK_KEX2_1	87	89	PF00082	0.592
CLV_PCSK_SKI1_1	110	114	PF00082	0.586
CLV_PCSK_SKI1_1	254	258	PF00082	0.693
CLV_PCSK_SKI1_1	324	328	PF00082	0.610
CLV_PCSK_SKI1_1	464	468	PF00082	0.388
CLV_PCSK_SKI1_1	488	492	PF00082	0.631
CLV_PCSK_SKI1_1	654	658	PF00082	0.695
CLV_PCSK_SKI1_1	697	701	PF00082	0.514
DEG_APCC_DBOX_1	205	213	PF00400	0.689
DEG_APCC_DBOX_1	423	431	PF00400	0.553
DEG_SPOP_SBC_1	163	167	PF00917	0.813
DEG_SPOP_SBC_1	268	272	PF00917	0.672
DEG_SPOP_SBC_1	297	301	PF00917	0.728
DEG_SPOP_SBC_1	396	400	PF00917	0.716
DOC_CKS1_1	729	734	PF01111	0.415
DOC_CYCLIN_RxL_1	461	470	PF00134	0.386
DOC_CYCLIN_RxL_1	693	703	PF00134	0.472
DOC_CYCLIN_yClb3_PxF_3	512	518	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	729	735	PF00134	0.660
DOC_MAPK_gen_1	206	214	PF00069	0.607
DOC_MAPK_gen_1	306	314	PF00069	0.545
DOC_MAPK_gen_1	669	677	PF00069	0.530
DOC_MAPK_gen_1	693	701	PF00069	0.619
DOC_MAPK_MEF2A_6	522	530	PF00069	0.346
DOC_MAPK_MEF2A_6	560	568	PF00069	0.457
DOC_MAPK_MEF2A_6	671	679	PF00069	0.543
DOC_PP1_RVXF_1	307	314	PF00149	0.544
DOC_PP1_RVXF_1	426	433	PF00149	0.573
DOC_PP2B_LxvP_1	460	463	PF13499	0.442
DOC_PP2B_LxvP_1	699	702	PF13499	0.637
DOC_USP7_MATH_1	164	168	PF00917	0.768
DOC_USP7_MATH_1	228	232	PF00917	0.700
DOC_USP7_MATH_1	246	250	PF00917	0.810
DOC_USP7_MATH_1	268	272	PF00917	0.789
DOC_USP7_MATH_1	297	301	PF00917	0.565
DOC_USP7_MATH_1	396	400	PF00917	0.716
DOC_USP7_MATH_1	627	631	PF00917	0.642
DOC_USP7_MATH_1	644	648	PF00917	0.449
DOC_USP7_MATH_1	99	103	PF00917	0.684
DOC_USP7_MATH_2	572	578	PF00917	0.552
DOC_USP7_UBL2_3	693	697	PF12436	0.487
DOC_WW_Pin1_4	104	109	PF00397	0.800
DOC_WW_Pin1_4	123	128	PF00397	0.749
DOC_WW_Pin1_4	198	203	PF00397	0.616
DOC_WW_Pin1_4	304	309	PF00397	0.599
DOC_WW_Pin1_4	345	350	PF00397	0.514
DOC_WW_Pin1_4	550	555	PF00397	0.516
DOC_WW_Pin1_4	728	733	PF00397	0.425
LIG_14-3-3_CanoR_1	110	115	PF00244	0.587
LIG_14-3-3_CanoR_1	140	144	PF00244	0.614
LIG_14-3-3_CanoR_1	227	233	PF00244	0.648
LIG_14-3-3_CanoR_1	254	260	PF00244	0.692
LIG_14-3-3_CanoR_1	369	375	PF00244	0.642
LIG_14-3-3_CanoR_1	412	422	PF00244	0.672
LIG_14-3-3_CanoR_1	54	60	PF00244	0.412
LIG_14-3-3_CanoR_1	696	702	PF00244	0.631
LIG_Actin_WH2_2	29	45	PF00022	0.639
LIG_Actin_WH2_2	473	490	PF00022	0.494
LIG_Actin_WH2_2	564	582	PF00022	0.560
LIG_BRCT_BRCA1_1	384	388	PF00533	0.589
LIG_BRCT_BRCA1_1	577	581	PF00533	0.476
LIG_Clathr_ClatBox_1	443	447	PF01394	0.592
LIG_CSL_BTD_1	190	193	PF09270	0.748
LIG_FHA_1	261	267	PF00498	0.820
LIG_FHA_1	275	281	PF00498	0.573
LIG_FHA_1	328	334	PF00498	0.681
LIG_FHA_1	35	41	PF00498	0.523
LIG_FHA_1	374	380	PF00498	0.630
LIG_FHA_1	551	557	PF00498	0.527
LIG_FHA_1	620	626	PF00498	0.483
LIG_FHA_1	634	640	PF00498	0.605
LIG_FHA_1	646	652	PF00498	0.623
LIG_FHA_1	696	702	PF00498	0.733
LIG_FHA_1	73	79	PF00498	0.482
LIG_FHA_1	745	751	PF00498	0.450
LIG_FHA_2	26	32	PF00498	0.511
LIG_FHA_2	477	483	PF00498	0.350
LIG_LIR_Gen_1	382	392	PF02991	0.603
LIG_LIR_Gen_1	447	452	PF02991	0.355
LIG_LIR_Gen_1	470	481	PF02991	0.344
LIG_LIR_Gen_1	535	544	PF02991	0.568
LIG_LIR_Nem_3	290	296	PF02991	0.547
LIG_LIR_Nem_3	382	387	PF02991	0.599
LIG_LIR_Nem_3	447	451	PF02991	0.505
LIG_LIR_Nem_3	470	476	PF02991	0.345
LIG_LIR_Nem_3	535	539	PF02991	0.482
LIG_LIR_Nem_3	541	547	PF02991	0.447
LIG_LIR_Nem_3	565	571	PF02991	0.446
LIG_LIR_Nem_3	578	584	PF02991	0.481
LIG_LYPXL_S_1	543	547	PF13949	0.577
LIG_LYPXL_yS_3	544	547	PF13949	0.584
LIG_NRBOX	355	361	PF00104	0.700
LIG_NRBOX	737	743	PF00104	0.552
LIG_PCNA_yPIPBox_3	474	488	PF02747	0.558
LIG_Pex14_2	384	388	PF04695	0.448
LIG_SH2_CRK	367	371	PF00017	0.623
LIG_SH2_CRK	473	477	PF00017	0.453
LIG_SH2_CRK	53	57	PF00017	0.502
LIG_SH2_CRK	569	573	PF00017	0.443
LIG_SH2_GRB2like	7	10	PF00017	0.473
LIG_SH2_NCK_1	569	573	PF00017	0.443
LIG_SH2_SRC	569	572	PF00017	0.440
LIG_SH2_SRC	638	641	PF00017	0.698
LIG_SH2_SRC	7	10	PF00017	0.473
LIG_SH2_STAP1	293	297	PF00017	0.553
LIG_SH2_STAP1	725	729	PF00017	0.576
LIG_SH2_STAT5	274	277	PF00017	0.555
LIG_SH2_STAT5	35	38	PF00017	0.609
LIG_SH2_STAT5	426	429	PF00017	0.652
LIG_SH2_STAT5	586	589	PF00017	0.428
LIG_SH2_STAT5	638	641	PF00017	0.698
LIG_SH2_STAT5	684	687	PF00017	0.554
LIG_SH2_STAT5	7	10	PF00017	0.473
LIG_SH3_1	319	325	PF00018	0.711
LIG_SH3_3	105	111	PF00018	0.779
LIG_SH3_3	189	195	PF00018	0.756
LIG_SH3_3	319	325	PF00018	0.586
LIG_SH3_3	336	342	PF00018	0.508
LIG_SH3_3	343	349	PF00018	0.488
LIG_SH3_3	38	44	PF00018	0.563
LIG_SH3_3	404	410	PF00018	0.551
LIG_SH3_3	431	437	PF00018	0.711
LIG_SH3_3	502	508	PF00018	0.434
LIG_SH3_3	509	515	PF00018	0.538
LIG_SH3_3	599	605	PF00018	0.604
LIG_SH3_3	623	629	PF00018	0.482
LIG_SH3_3	83	89	PF00018	0.483
LIG_SH3_4	507	514	PF00018	0.695
LIG_SH3_4	693	700	PF00018	0.466
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.522
LIG_SUMO_SIM_anti_2	441	447	PF11976	0.335
LIG_SUMO_SIM_par_1	102	107	PF11976	0.697
LIG_SUMO_SIM_par_1	441	447	PF11976	0.486
LIG_SUMO_SIM_par_1	465	470	PF11976	0.355
LIG_SUMO_SIM_par_1	555	561	PF11976	0.359
LIG_SUMO_SIM_par_1	697	703	PF11976	0.642
LIG_SUMO_SIM_par_1	74	79	PF11976	0.477
LIG_TRAF2_1	202	205	PF00917	0.560
LIG_UBA3_1	387	394	PF00899	0.727
LIG_UBA3_1	687	693	PF00899	0.450
LIG_WRC_WIRS_1	518	523	PF05994	0.542
LIG_WW_3	259	263	PF00397	0.575
LIG_WW_3	409	413	PF00397	0.623
LIG_WW_3	461	465	PF00397	0.676
MOD_CDK_SPK_2	304	309	PF00069	0.550
MOD_CDK_SPxK_1	104	110	PF00069	0.714
MOD_CDK_SPxxK_3	127	134	PF00069	0.744
MOD_CK1_1	142	148	PF00069	0.655
MOD_CK1_1	171	177	PF00069	0.580
MOD_CK1_1	300	306	PF00069	0.656
MOD_CK1_1	332	338	PF00069	0.777
MOD_CK1_1	348	354	PF00069	0.640
MOD_CK1_1	395	401	PF00069	0.544
MOD_CK1_1	413	419	PF00069	0.630
MOD_CK1_1	686	692	PF00069	0.655
MOD_CK2_1	198	204	PF00069	0.826
MOD_CK2_1	246	252	PF00069	0.709
MOD_CK2_1	25	31	PF00069	0.524
MOD_CK2_1	351	357	PF00069	0.621
MOD_GlcNHglycan	127	130	PF01048	0.710
MOD_GlcNHglycan	144	147	PF01048	0.581
MOD_GlcNHglycan	170	173	PF01048	0.710
MOD_GlcNHglycan	176	179	PF01048	0.745
MOD_GlcNHglycan	223	226	PF01048	0.716
MOD_GlcNHglycan	244	247	PF01048	0.814
MOD_GlcNHglycan	282	285	PF01048	0.719
MOD_GlcNHglycan	302	305	PF01048	0.724
MOD_GlcNHglycan	394	397	PF01048	0.594
MOD_GlcNHglycan	399	402	PF01048	0.567
MOD_GlcNHglycan	407	410	PF01048	0.565
MOD_GlcNHglycan	412	415	PF01048	0.551
MOD_GlcNHglycan	468	472	PF01048	0.340
MOD_GlcNHglycan	560	563	PF01048	0.357
MOD_GlcNHglycan	581	584	PF01048	0.481
MOD_GlcNHglycan	688	691	PF01048	0.559
MOD_GlcNHglycan	706	709	PF01048	0.521
MOD_GlcNHglycan	715	719	PF01048	0.579
MOD_GSK3_1	123	130	PF00069	0.699
MOD_GSK3_1	164	171	PF00069	0.823
MOD_GSK3_1	183	190	PF00069	0.531
MOD_GSK3_1	228	235	PF00069	0.752
MOD_GSK3_1	242	249	PF00069	0.745
MOD_GSK3_1	296	303	PF00069	0.714
MOD_GSK3_1	347	354	PF00069	0.547
MOD_GSK3_1	369	376	PF00069	0.534
MOD_GSK3_1	392	399	PF00069	0.560
MOD_GSK3_1	410	417	PF00069	0.659
MOD_GSK3_1	575	582	PF00069	0.474
MOD_GSK3_1	700	707	PF00069	0.640
MOD_GSK3_1	72	79	PF00069	0.490
MOD_N-GLC_1	335	340	PF02516	0.524
MOD_N-GLC_1	438	443	PF02516	0.371
MOD_N-GLC_1	516	521	PF02516	0.509
MOD_N-GLC_1	90	95	PF02516	0.526
MOD_NEK2_1	210	215	PF00069	0.581
MOD_NEK2_1	236	241	PF00069	0.620
MOD_NEK2_1	255	260	PF00069	0.828
MOD_NEK2_1	280	285	PF00069	0.665
MOD_NEK2_1	327	332	PF00069	0.690
MOD_NEK2_1	370	375	PF00069	0.633
MOD_NEK2_1	387	392	PF00069	0.497
MOD_NEK2_1	438	443	PF00069	0.582
MOD_NEK2_1	467	472	PF00069	0.364
MOD_NEK2_1	55	60	PF00069	0.397
MOD_NEK2_1	575	580	PF00069	0.466
MOD_NEK2_1	695	700	PF00069	0.724
MOD_NEK2_1	704	709	PF00069	0.586
MOD_NEK2_1	744	749	PF00069	0.431
MOD_PIKK_1	110	116	PF00454	0.587
MOD_PIKK_1	228	234	PF00454	0.742
MOD_PK_1	208	214	PF00069	0.730
MOD_PKA_2	139	145	PF00069	0.582
MOD_PKA_2	220	226	PF00069	0.633
MOD_PKA_2	268	274	PF00069	0.720
MOD_PKA_2	600	606	PF00069	0.606
MOD_PKA_2	695	701	PF00069	0.726
MOD_PKB_1	206	214	PF00069	0.728
MOD_PKB_1	219	227	PF00069	0.756
MOD_Plk_1	187	193	PF00069	0.596
MOD_Plk_1	335	341	PF00069	0.574
MOD_Plk_1	438	444	PF00069	0.362
MOD_Plk_1	467	473	PF00069	0.328
MOD_Plk_1	516	522	PF00069	0.493
MOD_Plk_1	90	96	PF00069	0.530
MOD_Plk_2-3	183	189	PF00069	0.591
MOD_Plk_4	2	8	PF00069	0.361
MOD_Plk_4	232	238	PF00069	0.577
MOD_Plk_4	335	341	PF00069	0.522
MOD_Plk_4	387	393	PF00069	0.469
MOD_Plk_4	417	423	PF00069	0.665
MOD_Plk_4	438	444	PF00069	0.513
MOD_Plk_4	633	639	PF00069	0.638
MOD_Plk_4	683	689	PF00069	0.607
MOD_Plk_4	744	750	PF00069	0.439
MOD_Plk_4	99	105	PF00069	0.562
MOD_ProDKin_1	104	110	PF00069	0.802
MOD_ProDKin_1	123	129	PF00069	0.749
MOD_ProDKin_1	198	204	PF00069	0.611
MOD_ProDKin_1	304	310	PF00069	0.597
MOD_ProDKin_1	345	351	PF00069	0.509
MOD_ProDKin_1	550	556	PF00069	0.517
MOD_ProDKin_1	728	734	PF00069	0.421
TRG_DiLeu_BaEn_1	493	498	PF01217	0.590
TRG_DiLeu_BaEn_3	739	745	PF01217	0.405
TRG_DiLeu_BaLyEn_6	461	466	PF01217	0.414
TRG_DiLeu_BaLyEn_6	608	613	PF01217	0.607
TRG_ENDOCYTIC_2	367	370	PF00928	0.640
TRG_ENDOCYTIC_2	473	476	PF00928	0.455
TRG_ENDOCYTIC_2	53	56	PF00928	0.510
TRG_ENDOCYTIC_2	544	547	PF00928	0.584
TRG_ENDOCYTIC_2	684	687	PF00928	0.576
TRG_ER_diArg_1	218	221	PF00400	0.747
TRG_ER_diArg_1	666	669	PF00400	0.536
TRG_ER_diArg_1	86	88	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	428	433	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	736	740	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I868	Leptomonas seymouri	52%	95%
A0A3S7WY82	Leishmania donovani	77%	99%
E9AH52	Leishmania infantum	77%	99%
E9AWN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QAU0	Leishmania major	76%	100%