SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HD96_LEIBR

TriTrypDb:

LbrM.24.0400 , LBRM2903_240009000

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005576	extracellular region	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HD96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD96

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0040029	epigenetic regulation of gene expression	6	1
GO:0045814	negative regulation of gene expression, epigenetic	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0042799	histone H4K20 methyltransferase activity	6	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0005102	signaling receptor binding	3	3
GO:0005179	hormone activity	5	3
GO:0005184	neuropeptide hormone activity	6	3
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0030545	signaling receptor regulator activity	2	3
GO:0030546	signaling receptor activator activity	3	3
GO:0048018	receptor ligand activity	4	3
GO:0098772	molecular function regulator activity	1	3
GO:0140677	molecular function activator activity	2	3
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1
GO:0051879	Hsp90 protein binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	585	589	PF00656	0.501
CLV_NRD_NRD_1	112	114	PF00675	0.423
CLV_NRD_NRD_1	184	186	PF00675	0.464
CLV_NRD_NRD_1	357	359	PF00675	0.353
CLV_PCSK_KEX2_1	111	113	PF00082	0.416
CLV_PCSK_KEX2_1	139	141	PF00082	0.528
CLV_PCSK_KEX2_1	184	186	PF00082	0.477
CLV_PCSK_KEX2_1	29	31	PF00082	0.294
CLV_PCSK_KEX2_1	356	358	PF00082	0.346
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.476
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.294
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.365
CLV_PCSK_SKI1_1	129	133	PF00082	0.411
CLV_PCSK_SKI1_1	139	143	PF00082	0.490
CLV_PCSK_SKI1_1	240	244	PF00082	0.435
CLV_PCSK_SKI1_1	30	34	PF00082	0.449
CLV_PCSK_SKI1_1	358	362	PF00082	0.486
CLV_PCSK_SKI1_1	430	434	PF00082	0.503
CLV_PCSK_SKI1_1	477	481	PF00082	0.344
CLV_PCSK_SKI1_1	512	516	PF00082	0.502
CLV_PCSK_SKI1_1	565	569	PF00082	0.235
CLV_PCSK_SKI1_1	592	596	PF00082	0.406
CLV_PCSK_SKI1_1	654	658	PF00082	0.456
CLV_Separin_Metazoa	359	363	PF03568	0.506
DEG_Nend_UBRbox_2	1	3	PF02207	0.577
DEG_SPOP_SBC_1	442	446	PF00917	0.317
DOC_CYCLIN_RxL_1	123	135	PF00134	0.436
DOC_CYCLIN_RxL_1	355	363	PF00134	0.455
DOC_CYCLIN_RxL_1	562	572	PF00134	0.238
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.386
DOC_MAPK_gen_1	29	35	PF00069	0.296
DOC_MAPK_MEF2A_6	165	172	PF00069	0.431
DOC_PP1_RVXF_1	188	195	PF00149	0.536
DOC_PP2B_LxvP_1	573	576	PF13499	0.522
DOC_USP7_MATH_1	213	217	PF00917	0.537
DOC_USP7_MATH_1	233	237	PF00917	0.565
DOC_USP7_MATH_1	307	311	PF00917	0.369
DOC_USP7_MATH_1	48	52	PF00917	0.698
DOC_USP7_MATH_1	656	660	PF00917	0.336
DOC_USP7_UBL2_3	654	658	PF12436	0.467
DOC_WW_Pin1_4	164	169	PF00397	0.480
DOC_WW_Pin1_4	423	428	PF00397	0.502
LIG_14-3-3_CanoR_1	493	501	PF00244	0.568
LIG_14-3-3_CanoR_1	502	508	PF00244	0.487
LIG_14-3-3_CanoR_1	639	643	PF00244	0.584
LIG_APCC_ABBA_1	467	472	PF00400	0.402
LIG_APCC_ABBAyCdc20_2	190	196	PF00400	0.525
LIG_APCC_ABBAyCdc20_2	466	472	PF00400	0.498
LIG_BRCT_BRCA1_1	297	301	PF00533	0.403
LIG_BRCT_BRCA1_1	362	366	PF00533	0.391
LIG_CSL_BTD_1	424	427	PF09270	0.553
LIG_deltaCOP1_diTrp_1	472	480	PF00928	0.460
LIG_eIF4E_1	28	34	PF01652	0.292
LIG_FHA_1	215	221	PF00498	0.451
LIG_FHA_1	301	307	PF00498	0.461
LIG_FHA_1	462	468	PF00498	0.518
LIG_FHA_1	486	492	PF00498	0.351
LIG_FHA_1	520	526	PF00498	0.524
LIG_FHA_2	209	215	PF00498	0.609
LIG_FHA_2	447	453	PF00498	0.489
LIG_FHA_2	56	62	PF00498	0.582
LIG_FHA_2	92	98	PF00498	0.417
LIG_GBD_Chelix_1	607	615	PF00786	0.527
LIG_HCF-1_HBM_1	196	199	PF13415	0.510
LIG_LIR_Apic_2	124	130	PF02991	0.483
LIG_LIR_Apic_2	522	526	PF02991	0.462
LIG_LIR_Gen_1	196	204	PF02991	0.473
LIG_LIR_Gen_1	278	289	PF02991	0.289
LIG_LIR_Gen_1	74	83	PF02991	0.467
LIG_LIR_Nem_3	196	202	PF02991	0.483
LIG_LIR_Nem_3	236	242	PF02991	0.405
LIG_LIR_Nem_3	271	276	PF02991	0.528
LIG_LIR_Nem_3	278	284	PF02991	0.406
LIG_LIR_Nem_3	478	483	PF02991	0.320
LIG_LIR_Nem_3	74	80	PF02991	0.461
LIG_MLH1_MIPbox_1	297	301	PF16413	0.403
LIG_NRBOX	563	569	PF00104	0.465
LIG_NRBOX	64	70	PF00104	0.497
LIG_Pex14_1	631	635	PF04695	0.401
LIG_Pex14_2	242	246	PF04695	0.416
LIG_Pex14_2	296	300	PF04695	0.434
LIG_Pex14_2	83	87	PF04695	0.481
LIG_PTB_Apo_2	338	345	PF02174	0.388
LIG_PTB_Phospho_1	338	344	PF10480	0.389
LIG_REV1ctd_RIR_1	298	306	PF16727	0.350
LIG_SH2_CRK	199	203	PF00017	0.574
LIG_SH2_CRK	476	480	PF00017	0.372
LIG_SH2_GRB2like	70	73	PF00017	0.365
LIG_SH2_NCK_1	199	203	PF00017	0.574
LIG_SH2_NCK_1	319	323	PF00017	0.543
LIG_SH2_STAT5	127	130	PF00017	0.433
LIG_SH2_STAT5	199	202	PF00017	0.543
LIG_SH2_STAT5	223	226	PF00017	0.453
LIG_SH2_STAT5	268	271	PF00017	0.376
LIG_SH2_STAT5	344	347	PF00017	0.393
LIG_SH2_STAT5	448	451	PF00017	0.516
LIG_SH2_STAT5	481	484	PF00017	0.370
LIG_SH2_STAT5	524	527	PF00017	0.472
LIG_SH2_STAT5	622	625	PF00017	0.411
LIG_SH2_STAT5	77	80	PF00017	0.437
LIG_SH3_3	421	427	PF00018	0.554
LIG_SH3_3	573	579	PF00018	0.364
LIG_SH3_3	641	647	PF00018	0.527
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.496
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.488
LIG_SUMO_SIM_par_1	31	36	PF11976	0.296
LIG_SUMO_SIM_par_1	327	332	PF11976	0.438
LIG_SUMO_SIM_par_1	543	549	PF11976	0.524
LIG_SUMO_SIM_par_1	566	572	PF11976	0.468
LIG_TRAF2_1	321	324	PF00917	0.579
LIG_TRAF2_1	58	61	PF00917	0.602
LIG_WRC_WIRS_1	438	443	PF05994	0.444
LIG_WRPW_2	101	104	PF00400	0.503
MOD_CDK_SPxxK_3	423	430	PF00069	0.429
MOD_CK1_1	207	213	PF00069	0.570
MOD_CK1_1	216	222	PF00069	0.439
MOD_CK1_1	377	383	PF00069	0.439
MOD_CK1_1	443	449	PF00069	0.488
MOD_CK1_1	51	57	PF00069	0.650
MOD_CK1_1	606	612	PF00069	0.289
MOD_CK1_1	71	77	PF00069	0.185
MOD_CK2_1	317	323	PF00069	0.506
MOD_CK2_1	446	452	PF00069	0.495
MOD_CK2_1	55	61	PF00069	0.598
MOD_CMANNOS	101	104	PF00535	0.503
MOD_CMANNOS	364	367	PF00535	0.388
MOD_Cter_Amidation	354	357	PF01082	0.350
MOD_GlcNHglycan	17	20	PF01048	0.528
MOD_GlcNHglycan	205	209	PF01048	0.540
MOD_GlcNHglycan	297	300	PF01048	0.402
MOD_GlcNHglycan	387	391	PF01048	0.515
MOD_GlcNHglycan	396	399	PF01048	0.391
MOD_GlcNHglycan	419	422	PF01048	0.499
MOD_GlcNHglycan	494	497	PF01048	0.523
MOD_GlcNHglycan	51	54	PF01048	0.674
MOD_GlcNHglycan	515	518	PF01048	0.465
MOD_GlcNHglycan	556	559	PF01048	0.545
MOD_GlcNHglycan	627	630	PF01048	0.316
MOD_GSK3_1	204	211	PF00069	0.538
MOD_GSK3_1	264	271	PF00069	0.455
MOD_GSK3_1	318	325	PF00069	0.438
MOD_GSK3_1	376	383	PF00069	0.344
MOD_GSK3_1	437	444	PF00069	0.450
MOD_GSK3_1	48	55	PF00069	0.651
MOD_GSK3_1	599	606	PF00069	0.531
MOD_GSK3_1	633	640	PF00069	0.584
MOD_N-GLC_1	307	312	PF02516	0.346
MOD_N-GLC_1	71	76	PF02516	0.362
MOD_N-GLC_1	81	86	PF02516	0.400
MOD_NEK2_1	121	126	PF00069	0.452
MOD_NEK2_1	204	209	PF00069	0.497
MOD_NEK2_1	284	289	PF00069	0.439
MOD_NEK2_1	300	305	PF00069	0.349
MOD_NEK2_1	317	322	PF00069	0.525
MOD_NEK2_1	360	365	PF00069	0.471
MOD_NEK2_1	394	399	PF00069	0.470
MOD_NEK2_1	437	442	PF00069	0.438
MOD_NEK2_1	563	568	PF00069	0.454
MOD_NEK2_1	607	612	PF00069	0.348
MOD_NEK2_1	637	642	PF00069	0.493
MOD_NEK2_1	68	73	PF00069	0.398
MOD_NEK2_1	8	13	PF00069	0.479
MOD_NEK2_1	83	88	PF00069	0.486
MOD_NEK2_2	307	312	PF00069	0.445
MOD_OFUCOSY	304	311	PF10250	0.358
MOD_PIKK_1	208	214	PF00454	0.548
MOD_PIKK_1	233	239	PF00454	0.466
MOD_PIKK_1	374	380	PF00454	0.505
MOD_PIKK_1	501	507	PF00454	0.554
MOD_PK_1	318	324	PF00069	0.519
MOD_PKA_2	261	267	PF00069	0.502
MOD_PKA_2	374	380	PF00069	0.458
MOD_PKA_2	492	498	PF00069	0.511
MOD_PKA_2	501	507	PF00069	0.504
MOD_PKA_2	552	558	PF00069	0.354
MOD_PKA_2	638	644	PF00069	0.588
MOD_Plk_1	322	328	PF00069	0.471
MOD_Plk_1	603	609	PF00069	0.500
MOD_Plk_2-3	582	588	PF00069	0.488
MOD_Plk_4	216	222	PF00069	0.505
MOD_Plk_4	264	270	PF00069	0.434
MOD_Plk_4	443	449	PF00069	0.462
MOD_Plk_4	519	525	PF00069	0.477
MOD_Plk_4	563	569	PF00069	0.502
MOD_ProDKin_1	164	170	PF00069	0.473
MOD_ProDKin_1	423	429	PF00069	0.499
MOD_SUMO_rev_2	135	141	PF00179	0.333
MOD_SUMO_rev_2	191	200	PF00179	0.504
MOD_SUMO_rev_2	2	11	PF00179	0.339
MOD_SUMO_rev_2	504	514	PF00179	0.539
TRG_DiLeu_BaEn_3	323	329	PF01217	0.530
TRG_DiLeu_BaEn_4	60	66	PF01217	0.563
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.386
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.488
TRG_ENDOCYTIC_2	199	202	PF00928	0.561
TRG_ENDOCYTIC_2	319	322	PF00928	0.568
TRG_ENDOCYTIC_2	476	479	PF00928	0.342
TRG_ENDOCYTIC_2	70	73	PF00928	0.365
TRG_ENDOCYTIC_2	77	80	PF00928	0.396
TRG_ER_diArg_1	111	113	PF00400	0.435
TRG_ER_diArg_1	227	230	PF00400	0.534
TRG_ER_diArg_1	269	272	PF00400	0.490
TRG_NES_CRM1_1	155	169	PF08389	0.418
TRG_NLS_MonoExtN_4	136	143	PF00514	0.347
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9W0	Leptomonas seymouri	64%	100%
A0A0S4J867	Bodo saltans	31%	100%
A0A1X0NIX9	Trypanosomatidae	37%	98%
A0A3S5H7C8	Leishmania donovani	85%	100%
A0A422P403	Trypanosoma rangeli	39%	100%
D0A710	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AH51	Leishmania infantum	85%	100%
E9AWN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAU1	Leishmania major	84%	100%
V5BRA0	Trypanosoma cruzi	40%	99%